Rix1 complex component

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H822_LEIBR

TriTrypDb:

LbrM.15.0530 , LBRM2903_150010700

Length:

474

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H822

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H822

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	337	341	PF00656	0.658
CLV_NRD_NRD_1	118	120	PF00675	0.439
CLV_NRD_NRD_1	205	207	PF00675	0.541
CLV_NRD_NRD_1	255	257	PF00675	0.559
CLV_NRD_NRD_1	284	286	PF00675	0.562
CLV_NRD_NRD_1	288	290	PF00675	0.637
CLV_PCSK_FUR_1	203	207	PF00082	0.489
CLV_PCSK_KEX2_1	199	201	PF00082	0.491
CLV_PCSK_KEX2_1	205	207	PF00082	0.556
CLV_PCSK_KEX2_1	255	257	PF00082	0.559
CLV_PCSK_KEX2_1	284	286	PF00082	0.564
CLV_PCSK_KEX2_1	288	290	PF00082	0.640
CLV_PCSK_PC1ET2_1	199	201	PF00082	0.468
CLV_PCSK_PC1ET2_1	284	286	PF00082	0.529
CLV_PCSK_SKI1_1	383	387	PF00082	0.664
CLV_Separin_Metazoa	95	99	PF03568	0.473
DEG_SPOP_SBC_1	310	314	PF00917	0.531
DEG_SPOP_SBC_1	328	332	PF00917	0.492
DEG_SPOP_SBC_1	396	400	PF00917	0.692
DOC_ANK_TNKS_1	254	261	PF00023	0.477
DOC_CKS1_1	77	82	PF01111	0.546
DOC_CYCLIN_yCln2_LP_2	109	115	PF00134	0.402
DOC_MAPK_gen_1	288	298	PF00069	0.603
DOC_PP2B_LxvP_1	109	112	PF13499	0.412
DOC_PP2B_LxvP_1	242	245	PF13499	0.536
DOC_PP2B_LxvP_1	84	87	PF13499	0.616
DOC_PP4_FxxP_1	83	86	PF00568	0.627
DOC_PP4_MxPP_1	108	111	PF00568	0.436
DOC_PP4_MxPP_1	244	247	PF00568	0.525
DOC_USP7_MATH_1	15	19	PF00917	0.529
DOC_USP7_MATH_1	207	211	PF00917	0.436
DOC_USP7_MATH_1	227	231	PF00917	0.548
DOC_USP7_MATH_1	328	332	PF00917	0.532
DOC_USP7_MATH_1	396	400	PF00917	0.618
DOC_USP7_MATH_1	448	452	PF00917	0.529
DOC_WW_Pin1_4	236	241	PF00397	0.680
DOC_WW_Pin1_4	247	252	PF00397	0.543
DOC_WW_Pin1_4	35	40	PF00397	0.619
DOC_WW_Pin1_4	404	409	PF00397	0.724
DOC_WW_Pin1_4	76	81	PF00397	0.617
LIG_14-3-3_CanoR_1	183	191	PF00244	0.424
LIG_BRCT_BRCA1_1	450	454	PF00533	0.651
LIG_FHA_1	112	118	PF00498	0.427
LIG_FHA_1	237	243	PF00498	0.541
LIG_FHA_1	311	317	PF00498	0.667
LIG_FHA_1	411	417	PF00498	0.555
LIG_FHA_1	463	469	PF00498	0.520
LIG_FHA_2	230	236	PF00498	0.548
LIG_FHA_2	448	454	PF00498	0.626
LIG_IBAR_NPY_1	356	358	PF08397	0.525
LIG_LIR_Apic_2	82	86	PF02991	0.632
LIG_LIR_Gen_1	384	393	PF02991	0.616
LIG_LIR_Gen_1	41	50	PF02991	0.657
LIG_LIR_Nem_3	175	180	PF02991	0.445
LIG_LIR_Nem_3	381	385	PF02991	0.622
LIG_LIR_Nem_3	41	45	PF02991	0.603
LIG_SH2_CRK	177	181	PF00017	0.384
LIG_SH2_CRK	42	46	PF00017	0.703
LIG_SH2_CRK	56	60	PF00017	0.505
LIG_SH2_GRB2like	364	367	PF00017	0.624
LIG_SH2_NCK_1	358	362	PF00017	0.593
LIG_SH2_NCK_1	42	46	PF00017	0.663
LIG_SH2_SRC	364	367	PF00017	0.611
LIG_SH2_STAT5	358	361	PF00017	0.614
LIG_SH3_1	74	80	PF00018	0.540
LIG_SH3_3	218	224	PF00018	0.580
LIG_SH3_3	374	380	PF00018	0.582
LIG_SH3_3	415	421	PF00018	0.629
LIG_SH3_3	74	80	PF00018	0.659
LIG_SUMO_SIM_par_1	311	320	PF11976	0.539
LIG_TRAF2_1	210	213	PF00917	0.419
LIG_TRAF2_1	471	474	PF00917	0.540
LIG_WRC_WIRS_1	382	387	PF05994	0.602
MOD_CK1_1	312	318	PF00069	0.587
MOD_CK1_1	38	44	PF00069	0.607
MOD_CK1_1	381	387	PF00069	0.603
MOD_CK2_1	120	126	PF00069	0.523
MOD_CK2_1	207	213	PF00069	0.561
MOD_CK2_1	468	474	PF00069	0.534
MOD_CMANNOS	276	279	PF00535	0.390
MOD_GlcNHglycan	11	14	PF01048	0.760
MOD_GlcNHglycan	155	159	PF01048	0.728
MOD_GlcNHglycan	304	307	PF01048	0.647
MOD_GlcNHglycan	340	343	PF01048	0.656
MOD_GlcNHglycan	399	402	PF01048	0.680
MOD_GlcNHglycan	71	74	PF01048	0.731
MOD_GSK3_1	154	161	PF00069	0.663
MOD_GSK3_1	20	27	PF00069	0.757
MOD_GSK3_1	304	311	PF00069	0.625
MOD_GSK3_1	344	351	PF00069	0.599
MOD_GSK3_1	356	363	PF00069	0.780
MOD_GSK3_1	40	47	PF00069	0.542
MOD_GSK3_1	458	465	PF00069	0.503
MOD_LATS_1	118	124	PF00433	0.449
MOD_N-GLC_1	322	327	PF02516	0.554
MOD_N-GLC_1	410	415	PF02516	0.556
MOD_NEK2_1	24	29	PF00069	0.803
MOD_NEK2_1	348	353	PF00069	0.708
MOD_NEK2_1	439	444	PF00069	0.536
MOD_NEK2_1	44	49	PF00069	0.472
MOD_NEK2_1	99	104	PF00069	0.508
MOD_NEK2_2	279	284	PF00069	0.431
MOD_NEK2_2	432	437	PF00069	0.634
MOD_PIKK_1	416	422	PF00454	0.693
MOD_PIKK_1	44	50	PF00454	0.514
MOD_Plk_4	20	26	PF00069	0.698
MOD_Plk_4	322	328	PF00069	0.549
MOD_Plk_4	40	46	PF00069	0.748
MOD_Plk_4	432	438	PF00069	0.659
MOD_Plk_4	79	85	PF00069	0.690
MOD_ProDKin_1	236	242	PF00069	0.681
MOD_ProDKin_1	247	253	PF00069	0.543
MOD_ProDKin_1	35	41	PF00069	0.618
MOD_ProDKin_1	404	410	PF00069	0.725
MOD_ProDKin_1	76	82	PF00069	0.620
MOD_SUMO_rev_2	186	195	PF00179	0.402
TRG_DiLeu_BaEn_4	390	396	PF01217	0.533
TRG_ENDOCYTIC_2	177	180	PF00928	0.434
TRG_ENDOCYTIC_2	185	188	PF00928	0.372
TRG_ENDOCYTIC_2	382	385	PF00928	0.651
TRG_ENDOCYTIC_2	42	45	PF00928	0.707
TRG_ER_diArg_1	202	205	PF00400	0.550
TRG_ER_diArg_1	254	256	PF00400	0.495
TRG_ER_diArg_1	287	289	PF00400	0.627
TRG_NLS_MonoCore_2	284	289	PF00514	0.556
TRG_NLS_MonoExtC_3	283	288	PF00514	0.528
TRG_NLS_MonoExtN_4	284	289	PF00514	0.556
TRG_Pf-PMV_PEXEL_1	470	474	PF00026	0.541

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEA5	Leptomonas seymouri	48%	75%
A0A3Q8IA81	Leishmania donovani	78%	100%
A4HWG4	Leishmania infantum	78%	100%
E9AQ64	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	98%
Q4QFB9	Leishmania major	77%	100%