Katanin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Fidgetin, putative

Species:

Leishmania braziliensis

UniProt:

A4H820_LEIBR

TriTrypDb:

LbrM.15.0500 , LBRM2903_150011100

Length:

959

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005819	spindle	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H820

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H820

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016462	pyrophosphatase activity	5	7
GO:0016787	hydrolase activity	2	7
GO:0016817	hydrolase activity, acting on acid anhydrides	3	7
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	7
GO:0016887	ATP hydrolysis activity	7	7
GO:0017076	purine nucleotide binding	4	7
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0008233	peptidase activity	3	1
GO:0008237	metallopeptidase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	777	781	PF00656	0.319
CLV_C14_Caspase3-7	868	872	PF00656	0.530
CLV_C14_Caspase3-7	893	897	PF00656	0.449
CLV_NRD_NRD_1	246	248	PF00675	0.716
CLV_NRD_NRD_1	48	50	PF00675	0.549
CLV_NRD_NRD_1	557	559	PF00675	0.638
CLV_NRD_NRD_1	699	701	PF00675	0.455
CLV_NRD_NRD_1	795	797	PF00675	0.319
CLV_NRD_NRD_1	834	836	PF00675	0.321
CLV_NRD_NRD_1	850	852	PF00675	0.486
CLV_NRD_NRD_1	9	11	PF00675	0.632
CLV_NRD_NRD_1	946	948	PF00675	0.465
CLV_PCSK_KEX2_1	246	248	PF00082	0.689
CLV_PCSK_KEX2_1	452	454	PF00082	0.660
CLV_PCSK_KEX2_1	48	50	PF00082	0.516
CLV_PCSK_KEX2_1	549	551	PF00082	0.602
CLV_PCSK_KEX2_1	557	559	PF00082	0.638
CLV_PCSK_KEX2_1	66	68	PF00082	0.707
CLV_PCSK_KEX2_1	699	701	PF00082	0.455
CLV_PCSK_KEX2_1	795	797	PF00082	0.319
CLV_PCSK_KEX2_1	833	835	PF00082	0.328
CLV_PCSK_KEX2_1	838	840	PF00082	0.341
CLV_PCSK_KEX2_1	850	852	PF00082	0.349
CLV_PCSK_KEX2_1	9	11	PF00082	0.632
CLV_PCSK_KEX2_1	955	957	PF00082	0.460
CLV_PCSK_PC1ET2_1	452	454	PF00082	0.653
CLV_PCSK_PC1ET2_1	549	551	PF00082	0.602
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.525
CLV_PCSK_PC1ET2_1	838	840	PF00082	0.319
CLV_PCSK_PC1ET2_1	955	957	PF00082	0.460
CLV_PCSK_PC7_1	834	840	PF00082	0.319
CLV_PCSK_PC7_1	951	957	PF00082	0.505
CLV_PCSK_SKI1_1	205	209	PF00082	0.712
CLV_PCSK_SKI1_1	656	660	PF00082	0.503
CLV_PCSK_SKI1_1	712	716	PF00082	0.319
CLV_PCSK_SKI1_1	760	764	PF00082	0.319
CLV_PCSK_SKI1_1	795	799	PF00082	0.319
CLV_PCSK_SKI1_1	815	819	PF00082	0.183
CLV_PCSK_SKI1_1	856	860	PF00082	0.528
CLV_PCSK_SKI1_1	951	955	PF00082	0.462
DEG_APCC_DBOX_1	950	958	PF00400	0.504
DEG_Nend_Nbox_1	1	3	PF02207	0.565
DEG_SCF_FBW7_2	501	508	PF00400	0.527
DOC_CKS1_1	290	295	PF01111	0.545
DOC_CKS1_1	433	438	PF01111	0.611
DOC_CYCLIN_RxL_1	202	209	PF00134	0.702
DOC_CYCLIN_RxL_1	757	767	PF00134	0.319
DOC_CYCLIN_yCln2_LP_2	283	286	PF00134	0.658
DOC_MAPK_gen_1	262	271	PF00069	0.536
DOC_MAPK_gen_1	549	556	PF00069	0.608
DOC_MAPK_gen_1	699	707	PF00069	0.441
DOC_MAPK_gen_1	795	805	PF00069	0.350
DOC_MAPK_gen_1	833	844	PF00069	0.319
DOC_MAPK_MEF2A_6	549	556	PF00069	0.608
DOC_MAPK_MEF2A_6	699	707	PF00069	0.441
DOC_MAPK_MEF2A_6	835	844	PF00069	0.319
DOC_PP1_RVXF_1	33	39	PF00149	0.477
DOC_PP1_RVXF_1	671	678	PF00149	0.467
DOC_PP2B_LxvP_1	283	286	PF13499	0.658
DOC_PP2B_LxvP_1	639	642	PF13499	0.443
DOC_PP2B_LxvP_1	840	843	PF13499	0.319
DOC_PP4_FxxP_1	562	565	PF00568	0.626
DOC_PP4_FxxP_1	717	720	PF00568	0.319
DOC_USP7_MATH_1	298	302	PF00917	0.712
DOC_USP7_MATH_1	468	472	PF00917	0.590
DOC_USP7_MATH_1	512	516	PF00917	0.630
DOC_USP7_MATH_1	52	56	PF00917	0.645
DOC_USP7_MATH_1	541	545	PF00917	0.563
DOC_USP7_MATH_1	583	587	PF00917	0.687
DOC_USP7_MATH_1	602	606	PF00917	0.532
DOC_USP7_MATH_1	619	623	PF00917	0.606
DOC_USP7_MATH_1	642	646	PF00917	0.495
DOC_USP7_MATH_1	686	690	PF00917	0.398
DOC_WW_Pin1_4	172	177	PF00397	0.688
DOC_WW_Pin1_4	247	252	PF00397	0.701
DOC_WW_Pin1_4	278	283	PF00397	0.539
DOC_WW_Pin1_4	289	294	PF00397	0.587
DOC_WW_Pin1_4	304	309	PF00397	0.685
DOC_WW_Pin1_4	313	318	PF00397	0.606
DOC_WW_Pin1_4	393	398	PF00397	0.598
DOC_WW_Pin1_4	411	416	PF00397	0.745
DOC_WW_Pin1_4	432	437	PF00397	0.623
DOC_WW_Pin1_4	451	456	PF00397	0.608
DOC_WW_Pin1_4	501	506	PF00397	0.582
DOC_WW_Pin1_4	514	519	PF00397	0.650
DOC_WW_Pin1_4	548	553	PF00397	0.601
DOC_WW_Pin1_4	878	883	PF00397	0.535
LIG_14-3-3_CanoR_1	151	161	PF00244	0.663
LIG_14-3-3_CanoR_1	311	320	PF00244	0.657
LIG_14-3-3_CanoR_1	335	345	PF00244	0.756
LIG_14-3-3_CanoR_1	420	425	PF00244	0.600
LIG_14-3-3_CanoR_1	481	489	PF00244	0.731
LIG_14-3-3_CanoR_1	734	740	PF00244	0.319
LIG_14-3-3_CanoR_1	795	805	PF00244	0.319
LIG_14-3-3_CanoR_1	856	862	PF00244	0.466
LIG_14-3-3_CanoR_1	889	895	PF00244	0.389
LIG_14-3-3_CanoR_1	93	97	PF00244	0.530
LIG_Actin_WH2_2	930	945	PF00022	0.465
LIG_ActinCP_CPI_1	533	554	PF01115	0.662
LIG_BIR_III_4	209	213	PF00653	0.718
LIG_BRCT_BRCA1_1	771	775	PF00533	0.319
LIG_Clathr_ClatBox_1	650	654	PF01394	0.445
LIG_Clathr_ClatBox_1	802	806	PF01394	0.319
LIG_EABR_CEP55_1	77	86	PF12180	0.490
LIG_eIF4E_1	635	641	PF01652	0.379
LIG_FHA_1	117	123	PF00498	0.680
LIG_FHA_1	254	260	PF00498	0.548
LIG_FHA_1	278	284	PF00498	0.612
LIG_FHA_1	31	37	PF00498	0.484
LIG_FHA_1	342	348	PF00498	0.585
LIG_FHA_1	352	358	PF00498	0.639
LIG_FHA_1	797	803	PF00498	0.328
LIG_FHA_1	881	887	PF00498	0.736
LIG_FHA_1	889	895	PF00498	0.602
LIG_FHA_2	525	531	PF00498	0.653
LIG_FHA_2	891	897	PF00498	0.620
LIG_Integrin_RGD_1	157	159	PF01839	0.489
LIG_Integrin_RGD_1	812	814	PF01839	0.407
LIG_LIR_Apic_2	560	565	PF02991	0.629
LIG_LIR_Gen_1	508	518	PF02991	0.526
LIG_LIR_Gen_1	738	747	PF02991	0.319
LIG_LIR_Nem_3	144	149	PF02991	0.630
LIG_LIR_Nem_3	508	513	PF02991	0.538
LIG_LIR_Nem_3	702	707	PF02991	0.445
LIG_LIR_Nem_3	738	742	PF02991	0.319
LIG_MYND_1	648	652	PF01753	0.464
LIG_NRBOX	203	209	PF00104	0.705
LIG_PCNA_yPIPBox_3	420	428	PF02747	0.689
LIG_PROFILIN_1	317	323	PF00235	0.538
LIG_SH2_CRK	94	98	PF00017	0.668
LIG_SH2_NCK_1	466	470	PF00017	0.618
LIG_SH2_PTP2	841	844	PF00017	0.319
LIG_SH2_STAP1	476	480	PF00017	0.604
LIG_SH2_STAT3	439	442	PF00017	0.548
LIG_SH2_STAT3	566	569	PF00017	0.658
LIG_SH2_STAT5	510	513	PF00017	0.535
LIG_SH2_STAT5	546	549	PF00017	0.602
LIG_SH2_STAT5	841	844	PF00017	0.319
LIG_SH3_2	415	420	PF14604	0.689
LIG_SH3_3	245	251	PF00018	0.659
LIG_SH3_3	279	285	PF00018	0.534
LIG_SH3_3	314	320	PF00018	0.644
LIG_SH3_3	412	418	PF00018	0.710
LIG_SH3_3	441	447	PF00018	0.742
LIG_SH3_3	568	574	PF00018	0.733
LIG_SH3_3	649	655	PF00018	0.451
LIG_SH3_3	765	771	PF00018	0.319
LIG_SUMO_SIM_anti_2	132	138	PF11976	0.676
LIG_SUMO_SIM_anti_2	814	820	PF11976	0.324
LIG_SUMO_SIM_anti_2	928	933	PF11976	0.225
LIG_TRAF2_1	689	692	PF00917	0.421
LIG_TRAF2_2	944	949	PF00917	0.418
LIG_UBA3_1	649	656	PF00899	0.445
LIG_UBA3_1	853	859	PF00899	0.504
LIG_WRC_WIRS_1	522	527	PF05994	0.501
LIG_WW_2	285	288	PF00397	0.618
LIG_WW_2	320	323	PF00397	0.538
LIG_WW_3	709	713	PF00397	0.396
MOD_CDK_SPK_2	393	398	PF00069	0.555
MOD_CDK_SPxK_1	289	295	PF00069	0.546
MOD_CDK_SPxxK_3	172	179	PF00069	0.694
MOD_CDK_SPxxK_3	304	311	PF00069	0.738
MOD_CK1_1	106	112	PF00069	0.516
MOD_CK1_1	217	223	PF00069	0.553
MOD_CK1_1	23	29	PF00069	0.518
MOD_CK1_1	278	284	PF00069	0.719
MOD_CK1_1	309	315	PF00069	0.567
MOD_CK1_1	339	345	PF00069	0.668
MOD_CK1_1	350	356	PF00069	0.720
MOD_CK1_1	431	437	PF00069	0.770
MOD_CK1_1	516	522	PF00069	0.666
MOD_CK1_1	524	530	PF00069	0.543
MOD_CK1_1	548	554	PF00069	0.604
MOD_CK1_1	617	623	PF00069	0.628
MOD_CK1_1	743	749	PF00069	0.350
MOD_CK1_1	781	787	PF00069	0.319
MOD_CK1_1	880	886	PF00069	0.783
MOD_CK2_1	247	253	PF00069	0.741
MOD_CK2_1	52	58	PF00069	0.560
MOD_CK2_1	524	530	PF00069	0.660
MOD_CK2_1	686	692	PF00069	0.404
MOD_Cter_Amidation	64	67	PF01082	0.695
MOD_DYRK1A_RPxSP_1	247	251	PF00069	0.648
MOD_DYRK1A_RPxSP_1	304	308	PF00069	0.698
MOD_DYRK1A_RPxSP_1	313	317	PF00069	0.608
MOD_GlcNHglycan	108	111	PF01048	0.567
MOD_GlcNHglycan	119	122	PF01048	0.496
MOD_GlcNHglycan	25	28	PF01048	0.521
MOD_GlcNHglycan	275	278	PF01048	0.744
MOD_GlcNHglycan	338	341	PF01048	0.711
MOD_GlcNHglycan	349	353	PF01048	0.578
MOD_GlcNHglycan	415	418	PF01048	0.615
MOD_GlcNHglycan	430	433	PF01048	0.625
MOD_GlcNHglycan	448	451	PF01048	0.603
MOD_GlcNHglycan	466	469	PF01048	0.527
MOD_GlcNHglycan	505	508	PF01048	0.747
MOD_GlcNHglycan	518	521	PF01048	0.525
MOD_GlcNHglycan	543	546	PF01048	0.597
MOD_GlcNHglycan	590	593	PF01048	0.712
MOD_GlcNHglycan	604	607	PF01048	0.692
MOD_GlcNHglycan	616	619	PF01048	0.598
MOD_GlcNHglycan	629	634	PF01048	0.703
MOD_GlcNHglycan	792	795	PF01048	0.240
MOD_GlcNHglycan	909	912	PF01048	0.319
MOD_GlcNHglycan	934	937	PF01048	0.558
MOD_GSK3_1	111	118	PF00069	0.703
MOD_GSK3_1	141	148	PF00069	0.653
MOD_GSK3_1	214	221	PF00069	0.627
MOD_GSK3_1	273	280	PF00069	0.735
MOD_GSK3_1	298	305	PF00069	0.647
MOD_GSK3_1	307	314	PF00069	0.643
MOD_GSK3_1	347	354	PF00069	0.680
MOD_GSK3_1	428	435	PF00069	0.525
MOD_GSK3_1	464	471	PF00069	0.581
MOD_GSK3_1	495	502	PF00069	0.713
MOD_GSK3_1	512	519	PF00069	0.668
MOD_GSK3_1	541	548	PF00069	0.593
MOD_GSK3_1	575	582	PF00069	0.659
MOD_GSK3_1	588	595	PF00069	0.592
MOD_GSK3_1	596	603	PF00069	0.658
MOD_GSK3_1	742	749	PF00069	0.339
MOD_GSK3_1	877	884	PF00069	0.619
MOD_GSK3_1	888	895	PF00069	0.475
MOD_GSK3_1	898	905	PF00069	0.380
MOD_N-GLC_1	513	518	PF02516	0.513
MOD_N-GLC_1	740	745	PF02516	0.319
MOD_NEK2_1	1	6	PF00069	0.455
MOD_NEK2_1	116	121	PF00069	0.504
MOD_NEK2_1	145	150	PF00069	0.661
MOD_NEK2_1	152	157	PF00069	0.586
MOD_NEK2_1	341	346	PF00069	0.530
MOD_NEK2_1	385	390	PF00069	0.604
MOD_NEK2_1	480	485	PF00069	0.623
MOD_NEK2_1	513	518	PF00069	0.513
MOD_NEK2_1	740	745	PF00069	0.319
MOD_NEK2_1	857	862	PF00069	0.487
MOD_NEK2_1	92	97	PF00069	0.629
MOD_NEK2_1	932	937	PF00069	0.567
MOD_NEK2_1	98	103	PF00069	0.588
MOD_NEK2_2	112	117	PF00069	0.497
MOD_NEK2_2	764	769	PF00069	0.308
MOD_PIKK_1	103	109	PF00454	0.770
MOD_PIKK_1	311	317	PF00454	0.716
MOD_PIKK_1	362	368	PF00454	0.536
MOD_PIKK_1	403	409	PF00454	0.732
MOD_PIKK_1	656	662	PF00454	0.412
MOD_PIKK_1	92	98	PF00454	0.567
MOD_PK_1	769	775	PF00069	0.308
MOD_PK_1	927	933	PF00069	0.319
MOD_PKA_1	557	563	PF00069	0.731
MOD_PKA_2	226	232	PF00069	0.779
MOD_PKA_2	336	342	PF00069	0.781
MOD_PKA_2	480	486	PF00069	0.640
MOD_PKA_2	495	501	PF00069	0.684
MOD_PKA_2	557	563	PF00069	0.648
MOD_PKA_2	600	606	PF00069	0.719
MOD_PKA_2	612	618	PF00069	0.697
MOD_PKA_2	888	894	PF00069	0.580
MOD_PKA_2	92	98	PF00069	0.668
MOD_PKB_1	304	312	PF00069	0.557
MOD_Plk_1	131	137	PF00069	0.596
MOD_Plk_1	20	26	PF00069	0.515
MOD_Plk_1	927	933	PF00069	0.319
MOD_Plk_2-3	253	259	PF00069	0.665
MOD_Plk_4	112	118	PF00069	0.497
MOD_Plk_4	131	137	PF00069	0.620
MOD_Plk_4	141	147	PF00069	0.516
MOD_Plk_4	521	527	PF00069	0.504
MOD_Plk_4	635	641	PF00069	0.478
MOD_Plk_4	722	728	PF00069	0.325
MOD_Plk_4	735	741	PF00069	0.319
MOD_Plk_4	743	749	PF00069	0.328
MOD_Plk_4	769	775	PF00069	0.338
MOD_Plk_4	778	784	PF00069	0.326
MOD_Plk_4	898	904	PF00069	0.434
MOD_Plk_4	927	933	PF00069	0.407
MOD_ProDKin_1	172	178	PF00069	0.691
MOD_ProDKin_1	247	253	PF00069	0.702
MOD_ProDKin_1	278	284	PF00069	0.539
MOD_ProDKin_1	289	295	PF00069	0.592
MOD_ProDKin_1	304	310	PF00069	0.686
MOD_ProDKin_1	313	319	PF00069	0.604
MOD_ProDKin_1	393	399	PF00069	0.595
MOD_ProDKin_1	411	417	PF00069	0.742
MOD_ProDKin_1	432	438	PF00069	0.625
MOD_ProDKin_1	451	457	PF00069	0.606
MOD_ProDKin_1	501	507	PF00069	0.584
MOD_ProDKin_1	514	520	PF00069	0.648
MOD_ProDKin_1	548	554	PF00069	0.604
MOD_ProDKin_1	878	884	PF00069	0.532
MOD_SUMO_for_1	797	800	PF00179	0.319
MOD_SUMO_rev_2	907	917	PF00179	0.333
TRG_DiLeu_BaEn_1	778	783	PF01217	0.319
TRG_ENDOCYTIC_2	510	513	PF00928	0.535
TRG_ENDOCYTIC_2	841	844	PF00928	0.319
TRG_ER_diArg_1	246	249	PF00400	0.705
TRG_ER_diArg_1	262	265	PF00400	0.533
TRG_ER_diArg_1	303	306	PF00400	0.546
TRG_ER_diArg_1	48	51	PF00400	0.551
TRG_ER_diArg_1	556	558	PF00400	0.634
TRG_ER_diArg_1	698	700	PF00400	0.422
TRG_ER_diArg_1	795	797	PF00400	0.338
TRG_ER_diArg_1	8	10	PF00400	0.624
TRG_ER_diArg_1	833	835	PF00400	0.326
TRG_NLS_MonoExtC_3	954	959	PF00514	0.462
TRG_Pf-PMV_PEXEL_1	205	209	PF00026	0.712
TRG_Pf-PMV_PEXEL_1	851	855	PF00026	0.399

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P749	Leptomonas seymouri	48%	99%
A0A3S5H6U4	Leishmania donovani	75%	96%
A4HWE8	Leishmania infantum	75%	96%
E9AQ48	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	95%
Q4QFD5	Leishmania major	75%	100%