Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H819_LEIBR

TriTrypDb:

LbrM.15.0490 , LBRM2903_150011000

Length:

718

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H819

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H819

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	456	460	PF00656	0.578
CLV_C14_Caspase3-7	94	98	PF00656	0.778
CLV_NRD_NRD_1	138	140	PF00675	0.654
CLV_NRD_NRD_1	3	5	PF00675	0.678
CLV_NRD_NRD_1	335	337	PF00675	0.819
CLV_NRD_NRD_1	450	452	PF00675	0.569
CLV_NRD_NRD_1	55	57	PF00675	0.714
CLV_NRD_NRD_1	558	560	PF00675	0.600
CLV_PCSK_FUR_1	332	336	PF00082	0.798
CLV_PCSK_KEX2_1	138	140	PF00082	0.738
CLV_PCSK_KEX2_1	3	5	PF00082	0.694
CLV_PCSK_KEX2_1	334	336	PF00082	0.669
CLV_PCSK_KEX2_1	558	560	PF00082	0.718
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.657
CLV_PCSK_SKI1_1	444	448	PF00082	0.757
CLV_PCSK_SKI1_1	61	65	PF00082	0.843
DEG_APCC_DBOX_1	138	146	PF00400	0.614
DEG_APCC_KENBOX_2	119	123	PF00400	0.616
DEG_Nend_Nbox_1	1	3	PF02207	0.833
DEG_SPOP_SBC_1	105	109	PF00917	0.613
DOC_CKS1_1	357	362	PF01111	0.602
DOC_CYCLIN_RxL_1	441	449	PF00134	0.753
DOC_CYCLIN_RxL_1	56	66	PF00134	0.845
DOC_CYCLIN_yCln2_LP_2	345	351	PF00134	0.594
DOC_MAPK_gen_1	334	345	PF00069	0.819
DOC_MAPK_gen_1	558	564	PF00069	0.702
DOC_PP4_FxxP_1	609	612	PF00568	0.549
DOC_USP7_MATH_1	105	109	PF00917	0.650
DOC_USP7_MATH_1	161	165	PF00917	0.792
DOC_USP7_MATH_1	253	257	PF00917	0.694
DOC_USP7_MATH_1	266	270	PF00917	0.607
DOC_USP7_MATH_1	304	308	PF00917	0.645
DOC_USP7_MATH_1	391	395	PF00917	0.557
DOC_USP7_MATH_1	454	458	PF00917	0.769
DOC_USP7_MATH_1	467	471	PF00917	0.513
DOC_USP7_MATH_1	52	56	PF00917	0.833
DOC_USP7_MATH_1	525	529	PF00917	0.747
DOC_USP7_MATH_1	59	63	PF00917	0.702
DOC_USP7_MATH_1	595	599	PF00917	0.643
DOC_USP7_MATH_1	612	616	PF00917	0.696
DOC_USP7_UBL2_3	334	338	PF12436	0.583
DOC_WW_Pin1_4	164	169	PF00397	0.842
DOC_WW_Pin1_4	233	238	PF00397	0.737
DOC_WW_Pin1_4	245	250	PF00397	0.764
DOC_WW_Pin1_4	254	259	PF00397	0.515
DOC_WW_Pin1_4	290	295	PF00397	0.714
DOC_WW_Pin1_4	296	301	PF00397	0.753
DOC_WW_Pin1_4	344	349	PF00397	0.571
DOC_WW_Pin1_4	356	361	PF00397	0.544
DOC_WW_Pin1_4	416	421	PF00397	0.759
DOC_WW_Pin1_4	457	462	PF00397	0.582
DOC_WW_Pin1_4	541	546	PF00397	0.721
DOC_WW_Pin1_4	615	620	PF00397	0.546
DOC_WW_Pin1_4	7	12	PF00397	0.612
DOC_WW_Pin1_4	71	76	PF00397	0.616
DOC_WW_Pin1_4	98	103	PF00397	0.658
LIG_14-3-3_CanoR_1	12	19	PF00244	0.783
LIG_14-3-3_CanoR_1	3	11	PF00244	0.679
LIG_14-3-3_CanoR_1	397	401	PF00244	0.769
LIG_14-3-3_CanoR_1	469	475	PF00244	0.508
LIG_14-3-3_CanoR_1	543	553	PF00244	0.632
LIG_14-3-3_CanoR_1	558	563	PF00244	0.626
LIG_14-3-3_CanoR_1	569	573	PF00244	0.630
LIG_BIR_III_2	165	169	PF00653	0.757
LIG_deltaCOP1_diTrp_1	178	186	PF00928	0.746
LIG_deltaCOP1_diTrp_1	672	678	PF00928	0.698
LIG_EH1_1	401	409	PF00400	0.698
LIG_EVH1_1	356	360	PF00568	0.579
LIG_FHA_1	128	134	PF00498	0.822
LIG_FHA_1	188	194	PF00498	0.601
LIG_FHA_1	210	216	PF00498	0.596
LIG_FHA_1	268	274	PF00498	0.679
LIG_FHA_1	435	441	PF00498	0.755
LIG_FHA_1	528	534	PF00498	0.544
LIG_FHA_1	559	565	PF00498	0.555
LIG_FHA_1	712	718	PF00498	0.580
LIG_FHA_2	109	115	PF00498	0.612
LIG_FHA_2	214	220	PF00498	0.586
LIG_FHA_2	433	439	PF00498	0.596
LIG_FHA_2	545	551	PF00498	0.833
LIG_FHA_2	611	617	PF00498	0.637
LIG_GBD_Chelix_1	588	596	PF00786	0.716
LIG_LIR_Apic_2	183	189	PF02991	0.681
LIG_LIR_Apic_2	243	249	PF02991	0.590
LIG_LIR_Gen_1	470	479	PF02991	0.500
LIG_LIR_LC3C_4	130	133	PF02991	0.621
LIG_LIR_Nem_3	470	474	PF02991	0.503
LIG_Pex14_1	675	679	PF04695	0.693
LIG_SH2_CRK	246	250	PF00017	0.589
LIG_SH2_CRK	471	475	PF00017	0.739
LIG_SH2_STAP1	471	475	PF00017	0.499
LIG_SH2_STAT5	246	249	PF00017	0.828
LIG_SH2_STAT5	679	682	PF00017	0.692
LIG_SH3_1	696	702	PF00018	0.525
LIG_SH3_3	196	202	PF00018	0.651
LIG_SH3_3	277	283	PF00018	0.564
LIG_SH3_3	345	351	PF00018	0.616
LIG_SH3_3	354	360	PF00018	0.603
LIG_SH3_3	433	439	PF00018	0.615
LIG_SH3_3	46	52	PF00018	0.836
LIG_SH3_3	513	519	PF00018	0.727
LIG_SH3_3	696	702	PF00018	0.607
LIG_SH3_3	99	105	PF00018	0.617
LIG_SUMO_SIM_par_1	560	566	PF11976	0.494
LIG_SUMO_SIM_par_1	642	649	PF11976	0.639
LIG_WRC_WIRS_1	564	569	PF05994	0.496
MOD_CDC14_SPxK_1	460	463	PF00782	0.574
MOD_CDK_SPK_2	7	12	PF00069	0.612
MOD_CDK_SPxK_1	457	463	PF00069	0.579
MOD_CDK_SPxxK_3	164	171	PF00069	0.737
MOD_CK1_1	108	114	PF00069	0.757
MOD_CK1_1	164	170	PF00069	0.677
MOD_CK1_1	254	260	PF00069	0.622
MOD_CK1_1	290	296	PF00069	0.629
MOD_CK1_1	43	49	PF00069	0.633
MOD_CK1_1	457	463	PF00069	0.771
MOD_CK1_1	470	476	PF00069	0.482
MOD_CK1_1	5	11	PF00069	0.666
MOD_CK1_1	544	550	PF00069	0.614
MOD_CK1_1	615	621	PF00069	0.545
MOD_CK1_1	62	68	PF00069	0.718
MOD_CK1_1	71	77	PF00069	0.680
MOD_CK2_1	320	326	PF00069	0.608
MOD_CK2_1	432	438	PF00069	0.599
MOD_CK2_1	525	531	PF00069	0.554
MOD_CK2_1	544	550	PF00069	0.765
MOD_CK2_1	610	616	PF00069	0.801
MOD_CMANNOS	675	678	PF00535	0.699
MOD_GlcNHglycan	12	15	PF01048	0.798
MOD_GlcNHglycan	253	256	PF01048	0.658
MOD_GlcNHglycan	262	265	PF01048	0.692
MOD_GlcNHglycan	306	309	PF01048	0.790
MOD_GlcNHglycan	313	316	PF01048	0.541
MOD_GlcNHglycan	318	321	PF01048	0.759
MOD_GlcNHglycan	322	325	PF01048	0.700
MOD_GlcNHglycan	456	459	PF01048	0.707
MOD_GlcNHglycan	527	530	PF01048	0.727
MOD_GlcNHglycan	574	577	PF01048	0.566
MOD_GlcNHglycan	65	68	PF01048	0.688
MOD_GlcNHglycan	7	10	PF01048	0.794
MOD_GlcNHglycan	78	81	PF01048	0.693
MOD_GlcNHglycan	90	93	PF01048	0.671
MOD_GSK3_1	104	111	PF00069	0.674
MOD_GSK3_1	133	140	PF00069	0.611
MOD_GSK3_1	209	216	PF00069	0.791
MOD_GSK3_1	22	29	PF00069	0.754
MOD_GSK3_1	262	269	PF00069	0.645
MOD_GSK3_1	3	10	PF00069	0.609
MOD_GSK3_1	311	318	PF00069	0.639
MOD_GSK3_1	38	45	PF00069	0.617
MOD_GSK3_1	453	460	PF00069	0.751
MOD_GSK3_1	541	548	PF00069	0.614
MOD_GSK3_1	568	575	PF00069	0.551
MOD_GSK3_1	59	66	PF00069	0.765
MOD_GSK3_1	595	602	PF00069	0.581
MOD_GSK3_1	702	709	PF00069	0.745
MOD_GSK3_1	711	718	PF00069	0.681
MOD_LATS_1	86	92	PF00433	0.855
MOD_NEK2_1	106	111	PF00069	0.727
MOD_NEK2_1	155	160	PF00069	0.613
MOD_NEK2_1	169	174	PF00069	0.569
MOD_NEK2_1	244	249	PF00069	0.589
MOD_NEK2_1	267	272	PF00069	0.587
MOD_NEK2_1	289	294	PF00069	0.601
MOD_NEK2_1	40	45	PF00069	0.629
MOD_NEK2_1	446	451	PF00069	0.522
MOD_NEK2_1	510	515	PF00069	0.478
MOD_NEK2_1	568	573	PF00069	0.731
MOD_NEK2_1	599	604	PF00069	0.722
MOD_NEK2_1	63	68	PF00069	0.651
MOD_NEK2_2	59	64	PF00069	0.798
MOD_NEK2_2	629	634	PF00069	0.494
MOD_PIKK_1	143	149	PF00454	0.856
MOD_PIKK_1	281	287	PF00454	0.671
MOD_PIKK_1	479	485	PF00454	0.752
MOD_PKA_1	3	9	PF00069	0.610
MOD_PKA_1	558	564	PF00069	0.490
MOD_PKA_2	116	122	PF00069	0.617
MOD_PKA_2	137	143	PF00069	0.611
MOD_PKA_2	187	193	PF00069	0.593
MOD_PKA_2	2	8	PF00069	0.609
MOD_PKA_2	396	402	PF00069	0.770
MOD_PKA_2	52	58	PF00069	0.653
MOD_PKA_2	557	563	PF00069	0.668
MOD_PKA_2	568	574	PF00069	0.633
MOD_Plk_1	242	248	PF00069	0.702
MOD_Plk_1	391	397	PF00069	0.536
MOD_Plk_1	629	635	PF00069	0.492
MOD_Plk_2-3	178	184	PF00069	0.593
MOD_Plk_4	108	114	PF00069	0.845
MOD_Plk_4	127	133	PF00069	0.534
MOD_Plk_4	268	274	PF00069	0.611
MOD_Plk_4	396	402	PF00069	0.573
MOD_Plk_4	470	476	PF00069	0.743
MOD_Plk_4	563	569	PF00069	0.740
MOD_Plk_4	595	601	PF00069	0.498
MOD_ProDKin_1	164	170	PF00069	0.844
MOD_ProDKin_1	233	239	PF00069	0.736
MOD_ProDKin_1	245	251	PF00069	0.764
MOD_ProDKin_1	254	260	PF00069	0.516
MOD_ProDKin_1	290	296	PF00069	0.713
MOD_ProDKin_1	344	350	PF00069	0.569
MOD_ProDKin_1	356	362	PF00069	0.548
MOD_ProDKin_1	416	422	PF00069	0.763
MOD_ProDKin_1	457	463	PF00069	0.579
MOD_ProDKin_1	541	547	PF00069	0.721
MOD_ProDKin_1	615	621	PF00069	0.537
MOD_ProDKin_1	7	13	PF00069	0.614
MOD_ProDKin_1	71	77	PF00069	0.614
MOD_ProDKin_1	98	104	PF00069	0.657
TRG_ENDOCYTIC_2	471	474	PF00928	0.741
TRG_ER_diArg_1	148	151	PF00400	0.846
TRG_ER_diArg_1	2	4	PF00400	0.608
TRG_ER_diArg_1	384	387	PF00400	0.755
TRG_NLS_MonoCore_2	333	338	PF00514	0.782
TRG_NLS_MonoExtC_3	333	338	PF00514	0.659
TRG_NLS_MonoExtN_4	332	338	PF00514	0.655
TRG_Pf-PMV_PEXEL_1	444	448	PF00026	0.757

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IC82	Leishmania donovani	54%	100%
A4HWE7	Leishmania infantum	54%	83%
E9AQ47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	100%
Q4QFD6	Leishmania major	55%	98%