Calpain catalytic domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4H817_LEIBR

TriTrypDb:

LbrM.15.0470 , LBRM2903_150010800

Length:

894

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H817

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H817

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	6	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	443	447	PF00656	0.599
CLV_NRD_NRD_1	12	14	PF00675	0.736
CLV_NRD_NRD_1	18	20	PF00675	0.668
CLV_NRD_NRD_1	271	273	PF00675	0.582
CLV_NRD_NRD_1	282	284	PF00675	0.521
CLV_NRD_NRD_1	341	343	PF00675	0.562
CLV_NRD_NRD_1	45	47	PF00675	0.624
CLV_NRD_NRD_1	490	492	PF00675	0.509
CLV_NRD_NRD_1	50	52	PF00675	0.637
CLV_NRD_NRD_1	514	516	PF00675	0.466
CLV_NRD_NRD_1	670	672	PF00675	0.590
CLV_NRD_NRD_1	676	678	PF00675	0.675
CLV_NRD_NRD_1	703	705	PF00675	0.457
CLV_NRD_NRD_1	708	710	PF00675	0.432
CLV_NRD_NRD_1	881	883	PF00675	0.638
CLV_NRD_NRD_1	890	892	PF00675	0.623
CLV_PCSK_FUR_1	16	20	PF00082	0.743
CLV_PCSK_FUR_1	48	52	PF00082	0.672
CLV_PCSK_FUR_1	674	678	PF00082	0.581
CLV_PCSK_FUR_1	706	710	PF00082	0.469
CLV_PCSK_KEX2_1	12	14	PF00082	0.736
CLV_PCSK_KEX2_1	16	18	PF00082	0.703
CLV_PCSK_KEX2_1	271	273	PF00082	0.582
CLV_PCSK_KEX2_1	282	284	PF00082	0.521
CLV_PCSK_KEX2_1	341	343	PF00082	0.562
CLV_PCSK_KEX2_1	385	387	PF00082	0.570
CLV_PCSK_KEX2_1	45	47	PF00082	0.624
CLV_PCSK_KEX2_1	490	492	PF00082	0.523
CLV_PCSK_KEX2_1	50	52	PF00082	0.637
CLV_PCSK_KEX2_1	513	515	PF00082	0.527
CLV_PCSK_KEX2_1	612	614	PF00082	0.405
CLV_PCSK_KEX2_1	670	672	PF00082	0.607
CLV_PCSK_KEX2_1	674	676	PF00082	0.641
CLV_PCSK_KEX2_1	703	705	PF00082	0.457
CLV_PCSK_KEX2_1	708	710	PF00082	0.432
CLV_PCSK_KEX2_1	881	883	PF00082	0.638
CLV_PCSK_KEX2_1	890	892	PF00082	0.623
CLV_PCSK_PC1ET2_1	385	387	PF00082	0.616
CLV_PCSK_PC1ET2_1	513	515	PF00082	0.527
CLV_PCSK_PC1ET2_1	612	614	PF00082	0.405
CLV_PCSK_PC7_1	12	18	PF00082	0.743
CLV_PCSK_PC7_1	46	52	PF00082	0.671
CLV_PCSK_PC7_1	670	676	PF00082	0.536
CLV_PCSK_PC7_1	704	710	PF00082	0.464
CLV_PCSK_SKI1_1	193	197	PF00082	0.582
CLV_PCSK_SKI1_1	249	253	PF00082	0.530
CLV_PCSK_SKI1_1	491	495	PF00082	0.490
CLV_PCSK_SKI1_1	514	518	PF00082	0.381
CLV_PCSK_SKI1_1	619	623	PF00082	0.403
CLV_PCSK_SKI1_1	851	855	PF00082	0.463
DEG_APCC_DBOX_1	192	200	PF00400	0.541
DEG_APCC_DBOX_1	221	229	PF00400	0.636
DEG_APCC_DBOX_1	850	858	PF00400	0.449
DEG_Nend_UBRbox_1	1	4	PF02207	0.586
DOC_ANK_TNKS_1	281	288	PF00023	0.406
DOC_CKS1_1	189	194	PF01111	0.576
DOC_CKS1_1	847	852	PF01111	0.491
DOC_CYCLIN_RxL_1	469	481	PF00134	0.576
DOC_MAPK_DCC_7	222	230	PF00069	0.527
DOC_MAPK_gen_1	222	230	PF00069	0.527
DOC_MAPK_gen_1	385	392	PF00069	0.609
DOC_MAPK_MEF2A_6	222	230	PF00069	0.527
DOC_MAPK_MEF2A_6	331	340	PF00069	0.387
DOC_PP2B_LxvP_1	476	479	PF13499	0.409
DOC_PP2B_LxvP_1	872	875	PF13499	0.537
DOC_PP4_FxxP_1	154	157	PF00568	0.462
DOC_PP4_FxxP_1	812	815	PF00568	0.404
DOC_USP7_MATH_1	205	209	PF00917	0.504
DOC_USP7_MATH_1	33	37	PF00917	0.657
DOC_USP7_MATH_1	691	695	PF00917	0.580
DOC_USP7_MATH_1	863	867	PF00917	0.411
DOC_USP7_MATH_1	877	881	PF00917	0.543
DOC_WW_Pin1_4	185	190	PF00397	0.570
DOC_WW_Pin1_4	340	345	PF00397	0.526
DOC_WW_Pin1_4	413	418	PF00397	0.543
DOC_WW_Pin1_4	647	652	PF00397	0.431
DOC_WW_Pin1_4	843	848	PF00397	0.633
DOC_WW_Pin1_4	873	878	PF00397	0.611
DOC_WW_Pin1_4	881	886	PF00397	0.658
LIG_14-3-3_CanoR_1	342	348	PF00244	0.438
LIG_14-3-3_CanoR_1	746	750	PF00244	0.454
LIG_14-3-3_CanoR_1	862	872	PF00244	0.622
LIG_14-3-3_CanoR_1	88	92	PF00244	0.539
LIG_Actin_WH2_2	171	188	PF00022	0.520
LIG_Actin_WH2_2	326	343	PF00022	0.394
LIG_Actin_WH2_2	829	846	PF00022	0.417
LIG_APCC_ABBA_1	462	467	PF00400	0.620
LIG_BIR_III_4	298	302	PF00653	0.485
LIG_EH_1	459	463	PF12763	0.625
LIG_FHA_1	620	626	PF00498	0.402
LIG_FHA_1	73	79	PF00498	0.572
LIG_FHA_1	731	737	PF00498	0.702
LIG_FHA_1	882	888	PF00498	0.657
LIG_FHA_2	449	455	PF00498	0.395
LIG_FHA_2	504	510	PF00498	0.527
LIG_FHA_2	62	68	PF00498	0.589
LIG_FHA_2	720	726	PF00498	0.685
LIG_GSK3_LRP6_1	873	879	PF00069	0.593
LIG_LIR_Gen_1	400	411	PF02991	0.613
LIG_LIR_Gen_1	481	492	PF02991	0.522
LIG_LIR_Gen_1	749	758	PF02991	0.522
LIG_LIR_Gen_1	91	100	PF02991	0.503
LIG_LIR_Nem_3	172	178	PF02991	0.494
LIG_LIR_Nem_3	304	309	PF02991	0.628
LIG_LIR_Nem_3	327	333	PF02991	0.503
LIG_LIR_Nem_3	400	406	PF02991	0.604
LIG_LIR_Nem_3	481	487	PF02991	0.493
LIG_LIR_Nem_3	749	755	PF02991	0.518
LIG_LIR_Nem_3	830	836	PF02991	0.411
LIG_LIR_Nem_3	91	97	PF02991	0.499
LIG_LYPXL_yS_3	152	155	PF13949	0.603
LIG_LYPXL_yS_3	380	383	PF13949	0.609
LIG_LYPXL_yS_3	534	537	PF13949	0.521
LIG_LYPXL_yS_3	810	813	PF13949	0.509
LIG_MYND_1	153	157	PF01753	0.503
LIG_MYND_1	811	815	PF01753	0.412
LIG_NRP_CendR_1	891	894	PF00754	0.623
LIG_Rb_LxCxE_1	114	132	PF01857	0.511
LIG_Rb_LxCxE_1	191	213	PF01857	0.523
LIG_Rb_LxCxE_1	772	790	PF01857	0.445
LIG_Rb_LxCxE_1	849	871	PF01857	0.435
LIG_SH2_CRK	484	488	PF00017	0.515
LIG_SH2_STAP1	484	488	PF00017	0.515
LIG_SH3_1	17	23	PF00018	0.731
LIG_SH3_1	186	192	PF00018	0.570
LIG_SH3_1	675	681	PF00018	0.591
LIG_SH3_1	844	850	PF00018	0.483
LIG_SH3_2	20	25	PF14604	0.720
LIG_SH3_2	678	683	PF14604	0.592
LIG_SH3_3	17	23	PF00018	0.731
LIG_SH3_3	186	192	PF00018	0.570
LIG_SH3_3	304	310	PF00018	0.633
LIG_SH3_3	312	318	PF00018	0.497
LIG_SH3_3	458	464	PF00018	0.630
LIG_SH3_3	476	482	PF00018	0.337
LIG_SH3_3	675	681	PF00018	0.591
LIG_SH3_3	844	850	PF00018	0.483
LIG_SH3_3	871	877	PF00018	0.551
LIG_SH3_CIN85_PxpxPR_1	873	878	PF14604	0.588
LIG_SUMO_SIM_anti_2	162	168	PF11976	0.387
LIG_SUMO_SIM_anti_2	820	826	PF11976	0.412
LIG_SUMO_SIM_par_1	754	761	PF11976	0.404
LIG_SUMO_SIM_par_1	96	103	PF11976	0.396
LIG_TRAF2_1	215	218	PF00917	0.528
LIG_TRAF2_1	353	356	PF00917	0.494
LIG_TRAF2_1	372	375	PF00917	0.520
LIG_TRAF2_1	599	602	PF00917	0.541
LIG_UBA3_1	251	260	PF00899	0.657
LIG_WW_3	22	26	PF00397	0.718
LIG_WW_3	680	684	PF00397	0.565
MOD_CDK_SPK_2	188	193	PF00069	0.573
MOD_CDK_SPK_2	413	418	PF00069	0.543
MOD_CDK_SPK_2	846	851	PF00069	0.488
MOD_CDK_SPK_2	873	878	PF00069	0.588
MOD_CK1_1	343	349	PF00069	0.442
MOD_CK1_1	416	422	PF00069	0.554
MOD_CK1_1	643	649	PF00069	0.432
MOD_CK1_1	876	882	PF00069	0.624
MOD_CK1_1	886	892	PF00069	0.626
MOD_CK2_1	503	509	PF00069	0.529
MOD_CK2_1	61	67	PF00069	0.595
MOD_CK2_1	719	725	PF00069	0.682
MOD_Cter_Amidation	10	13	PF01082	0.732
MOD_Cter_Amidation	668	671	PF01082	0.477
MOD_GlcNHglycan	35	38	PF01048	0.745
MOD_GlcNHglycan	667	670	PF01048	0.463
MOD_GlcNHglycan	693	696	PF01048	0.558
MOD_GlcNHglycan	9	12	PF01048	0.613
MOD_GSK3_1	340	347	PF00069	0.533
MOD_GSK3_1	545	552	PF00069	0.501
MOD_GSK3_1	643	650	PF00069	0.436
MOD_GSK3_1	873	880	PF00069	0.709
MOD_GSK3_1	881	888	PF00069	0.657
MOD_N-GLC_1	647	652	PF02516	0.431
MOD_NEK2_1	100	105	PF00069	0.518
MOD_NEK2_1	545	550	PF00069	0.492
MOD_NEK2_1	61	66	PF00069	0.746
MOD_NEK2_1	630	635	PF00069	0.577
MOD_NEK2_1	719	724	PF00069	0.587
MOD_NEK2_1	758	763	PF00069	0.521
MOD_PKA_1	514	520	PF00069	0.375
MOD_PKA_2	100	106	PF00069	0.453
MOD_PKA_2	205	211	PF00069	0.502
MOD_PKA_2	370	376	PF00069	0.629
MOD_PKA_2	448	454	PF00069	0.392
MOD_PKA_2	514	520	PF00069	0.491
MOD_PKA_2	745	751	PF00069	0.454
MOD_PKA_2	758	764	PF00069	0.423
MOD_PKA_2	863	869	PF00069	0.414
MOD_PKA_2	87	93	PF00069	0.534
MOD_PKA_2	877	883	PF00069	0.547
MOD_Plk_1	503	509	PF00069	0.529
MOD_Plk_2-3	504	510	PF00069	0.410
MOD_Plk_4	100	106	PF00069	0.526
MOD_Plk_4	162	168	PF00069	0.387
MOD_Plk_4	758	764	PF00069	0.528
MOD_Plk_4	820	826	PF00069	0.600
MOD_ProDKin_1	185	191	PF00069	0.563
MOD_ProDKin_1	340	346	PF00069	0.522
MOD_ProDKin_1	413	419	PF00069	0.547
MOD_ProDKin_1	647	653	PF00069	0.433
MOD_ProDKin_1	843	849	PF00069	0.627
MOD_ProDKin_1	873	879	PF00069	0.617
MOD_ProDKin_1	881	887	PF00069	0.659
MOD_SUMO_rev_2	241	251	PF00179	0.526
MOD_SUMO_rev_2	518	525	PF00179	0.567
MOD_SUMO_rev_2	70	78	PF00179	0.767
MOD_SUMO_rev_2	728	736	PF00179	0.761
TRG_AP2beta_CARGO_1	400	410	PF09066	0.610
TRG_DiLeu_BaEn_1	483	488	PF01217	0.518
TRG_DiLeu_BaEn_2	222	228	PF01217	0.637
TRG_DiLeu_BaEn_2	303	309	PF01217	0.622
TRG_DiLeu_BaLyEn_6	22	27	PF01217	0.716
TRG_DiLeu_BaLyEn_6	247	252	PF01217	0.518
TRG_DiLeu_BaLyEn_6	409	414	PF01217	0.518
TRG_DiLeu_BaLyEn_6	552	557	PF01217	0.453
TRG_DiLeu_BaLyEn_6	680	685	PF01217	0.559
TRG_ENDOCYTIC_2	152	155	PF00928	0.595
TRG_ENDOCYTIC_2	380	383	PF00928	0.609
TRG_ENDOCYTIC_2	484	487	PF00928	0.517
TRG_ENDOCYTIC_2	534	537	PF00928	0.521
TRG_ENDOCYTIC_2	752	755	PF00928	0.512
TRG_ENDOCYTIC_2	810	813	PF00928	0.476
TRG_ENDOCYTIC_2	94	97	PF00928	0.502
TRG_ER_diArg_1	16	19	PF00400	0.658
TRG_ER_diArg_1	203	206	PF00400	0.607
TRG_ER_diArg_1	271	273	PF00400	0.529
TRG_ER_diArg_1	293	296	PF00400	0.410
TRG_ER_diArg_1	340	342	PF00400	0.550
TRG_ER_diArg_1	45	48	PF00400	0.653
TRG_ER_diArg_1	456	459	PF00400	0.510
TRG_ER_diArg_1	490	492	PF00400	0.620
TRG_ER_diArg_1	50	53	PF00400	0.576
TRG_ER_diArg_1	674	677	PF00400	0.688
TRG_ER_diArg_1	703	706	PF00400	0.466
TRG_ER_diArg_1	708	711	PF00400	0.429
TRG_ER_diArg_1	737	740	PF00400	0.552
TRG_ER_diArg_1	79	82	PF00400	0.669
TRG_ER_diArg_1	861	864	PF00400	0.392
TRG_NLS_MonoExtC_3	512	518	PF00514	0.382
TRG_Pf-PMV_PEXEL_1	436	440	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	53	58	PF00026	0.713
TRG_Pf-PMV_PEXEL_1	711	716	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NDF7	Trypanosomatidae	27%	71%
E8NHH1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
E8NHS4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%