Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H815_LEIBR

TriTrypDb:

LbrM.15.0450 , LBRM2903_150010100

Length:

316

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H815

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H815

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	76	78	PF00675	0.717
CLV_PCSK_KEX2_1	76	78	PF00082	0.717
CLV_PCSK_SKI1_1	33	37	PF00082	0.583
DEG_Nend_UBRbox_3	1	3	PF02207	0.630
DEG_SCF_FBW7_1	244	249	PF00400	0.555
DEG_SPOP_SBC_1	236	240	PF00917	0.584
DOC_USP7_MATH_1	105	109	PF00917	0.671
DOC_USP7_MATH_1	180	184	PF00917	0.699
DOC_USP7_MATH_1	196	200	PF00917	0.604
DOC_USP7_MATH_1	246	250	PF00917	0.677
DOC_USP7_MATH_1	255	259	PF00917	0.626
DOC_USP7_UBL2_3	49	53	PF12436	0.695
DOC_WW_Pin1_4	108	113	PF00397	0.656
DOC_WW_Pin1_4	217	222	PF00397	0.599
DOC_WW_Pin1_4	242	247	PF00397	0.699
DOC_WW_Pin1_4	94	99	PF00397	0.547
LIG_14-3-3_CanoR_1	130	138	PF00244	0.733
LIG_14-3-3_CanoR_1	256	262	PF00244	0.549
LIG_eIF4E_1	4	10	PF01652	0.652
LIG_FHA_1	124	130	PF00498	0.667
LIG_FHA_1	15	21	PF00498	0.650
LIG_FHA_1	199	205	PF00498	0.809
LIG_FHA_1	211	217	PF00498	0.634
LIG_FHA_1	255	261	PF00498	0.768
LIG_FHA_1	277	283	PF00498	0.538
LIG_FHA_1	55	61	PF00498	0.797
LIG_FHA_1	99	105	PF00498	0.797
LIG_FHA_2	268	274	PF00498	0.734
LIG_FHA_2	284	290	PF00498	0.478
LIG_LIR_Nem_3	111	116	PF02991	0.627
LIG_LIR_Nem_3	30	35	PF02991	0.538
LIG_LIR_Nem_3	85	90	PF02991	0.702
LIG_PDZ_Class_1	311	316	PF00595	0.502
LIG_SH2_CRK	80	84	PF00017	0.558
LIG_SH2_STAT5	100	103	PF00017	0.672
LIG_SH2_STAT5	4	7	PF00017	0.657
LIG_SH3_1	170	176	PF00018	0.777
LIG_SH3_3	170	176	PF00018	0.724
LIG_SH3_3	215	221	PF00018	0.573
LIG_SH3_3	89	95	PF00018	0.708
LIG_SUMO_SIM_anti_2	103	109	PF11976	0.696
MOD_CDK_SPxxK_3	217	224	PF00069	0.571
MOD_CK1_1	108	114	PF00069	0.736
MOD_CK1_1	12	18	PF00069	0.527
MOD_CK1_1	240	246	PF00069	0.700
MOD_CK1_1	267	273	PF00069	0.644
MOD_CK2_1	267	273	PF00069	0.644
MOD_CK2_1	283	289	PF00069	0.601
MOD_CK2_1	56	62	PF00069	0.573
MOD_CK2_1	90	96	PF00069	0.700
MOD_GlcNHglycan	108	111	PF01048	0.690
MOD_GlcNHglycan	11	14	PF01048	0.579
MOD_GlcNHglycan	133	136	PF01048	0.718
MOD_GlcNHglycan	153	156	PF01048	0.754
MOD_GlcNHglycan	182	185	PF01048	0.721
MOD_GlcNHglycan	239	242	PF01048	0.803
MOD_GlcNHglycan	248	251	PF01048	0.635
MOD_GlcNHglycan	257	260	PF01048	0.701
MOD_GlcNHglycan	266	269	PF01048	0.742
MOD_GlcNHglycan	64	67	PF01048	0.699
MOD_GSK3_1	14	21	PF00069	0.767
MOD_GSK3_1	176	183	PF00069	0.547
MOD_GSK3_1	196	203	PF00069	0.726
MOD_GSK3_1	231	238	PF00069	0.712
MOD_GSK3_1	240	247	PF00069	0.719
MOD_GSK3_1	260	267	PF00069	0.606
MOD_GSK3_1	307	314	PF00069	0.696
MOD_GSK3_1	54	61	PF00069	0.716
MOD_GSK3_1	82	89	PF00069	0.677
MOD_GSK3_1	90	97	PF00069	0.717
MOD_N-GLC_1	151	156	PF02516	0.689
MOD_N-GLC_1	204	209	PF02516	0.808
MOD_N-GLC_1	236	241	PF02516	0.713
MOD_N-GLC_2	156	158	PF02516	0.664
MOD_NEK2_1	116	121	PF00069	0.651
MOD_NEK2_1	200	205	PF00069	0.769
MOD_NEK2_1	235	240	PF00069	0.725
MOD_NEK2_1	260	265	PF00069	0.527
MOD_NEK2_1	283	288	PF00069	0.593
MOD_NEK2_1	307	312	PF00069	0.707
MOD_NEK2_1	9	14	PF00069	0.711
MOD_PK_1	27	33	PF00069	0.424
MOD_PKA_2	255	261	PF00069	0.550
MOD_Plk_1	288	294	PF00069	0.754
MOD_Plk_4	27	33	PF00069	0.424
MOD_Plk_4	86	92	PF00069	0.691
MOD_ProDKin_1	108	114	PF00069	0.648
MOD_ProDKin_1	217	223	PF00069	0.600
MOD_ProDKin_1	242	248	PF00069	0.699
MOD_ProDKin_1	94	100	PF00069	0.549
MOD_SUMO_rev_2	219	227	PF00179	0.574
TRG_DiLeu_BaLyEn_6	24	29	PF01217	0.433
TRG_DiLeu_BaLyEn_6	301	306	PF01217	0.639
TRG_ENDOCYTIC_2	113	116	PF00928	0.585
TRG_ENDOCYTIC_2	32	35	PF00928	0.578
TRG_ENDOCYTIC_2	80	83	PF00928	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU81	Leptomonas seymouri	46%	100%
A0A3S5H6U3	Leishmania donovani	69%	92%
A4HWE5	Leishmania infantum	69%	92%
E9AQ45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	91%
Q4QFD7	Leishmania major	67%	100%