LeishMANIAdb
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Protein transport protein Sec61 subunit beta

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Protein transport protein Sec61 subunit beta
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4H814_LEIBR
TriTrypDb:
LbrM.15.0440 , LBRM2903_150010000
Length:
138

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

A4H814
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H814

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 122 124 PF00675 0.464
CLV_NRD_NRD_1 76 78 PF00675 0.687
CLV_PCSK_KEX2_1 122 124 PF00082 0.466
CLV_PCSK_PC7_1 118 124 PF00082 0.487
CLV_PCSK_SKI1_1 123 127 PF00082 0.452
CLV_PCSK_SKI1_1 78 82 PF00082 0.612
DEG_Nend_UBRbox_1 1 4 PF02207 0.607
DOC_CKS1_1 19 24 PF01111 0.617
DOC_MAPK_DCC_7 52 62 PF00069 0.562
DOC_MAPK_RevD_3 64 78 PF00069 0.447
DOC_PP2B_PxIxI_1 57 63 PF00149 0.441
DOC_WW_Pin1_4 18 23 PF00397 0.620
DOC_WW_Pin1_4 28 33 PF00397 0.762
DOC_WW_Pin1_4 82 87 PF00397 0.362
LIG_14-3-3_CanoR_1 122 131 PF00244 0.682
LIG_14-3-3_CanoR_1 2 9 PF00244 0.611
LIG_14-3-3_CanoR_1 77 87 PF00244 0.460
LIG_FHA_1 124 130 PF00498 0.682
LIG_FHA_1 79 85 PF00498 0.462
LIG_GBD_Chelix_1 61 69 PF00786 0.419
LIG_LIR_Gen_1 67 75 PF02991 0.480
LIG_LIR_Nem_3 67 73 PF02991 0.410
LIG_REV1ctd_RIR_1 93 103 PF16727 0.349
LIG_SH2_CRK 70 74 PF00017 0.462
LIG_SH2_STAT5 46 49 PF00017 0.615
LIG_SH3_3 29 35 PF00018 0.749
LIG_SH3_3 6 12 PF00018 0.685
LIG_SUMO_SIM_par_1 70 76 PF11976 0.227
LIG_SxIP_EBH_1 52 63 PF03271 0.558
LIG_TYR_ITIM 68 73 PF00017 0.227
MOD_CK1_1 124 130 PF00069 0.663
MOD_GlcNHglycan 15 18 PF01048 0.418
MOD_GlcNHglycan 3 6 PF01048 0.557
MOD_GSK3_1 78 85 PF00069 0.451
MOD_NEK2_1 1 6 PF00069 0.725
MOD_NEK2_1 64 69 PF00069 0.438
MOD_NEK2_1 80 85 PF00069 0.425
MOD_PIKK_1 38 44 PF00454 0.723
MOD_PIKK_1 52 58 PF00454 0.507
MOD_PKA_2 1 7 PF00069 0.711
MOD_PKA_2 121 127 PF00069 0.685
MOD_Plk_1 38 44 PF00069 0.722
MOD_Plk_4 46 52 PF00069 0.629
MOD_Plk_4 64 70 PF00069 0.250
MOD_ProDKin_1 18 24 PF00069 0.619
MOD_ProDKin_1 28 34 PF00069 0.756
MOD_ProDKin_1 82 88 PF00069 0.362
TRG_ENDOCYTIC_2 70 73 PF00928 0.398
TRG_Pf-PMV_PEXEL_1 99 103 PF00026 0.464

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PAK1 Leptomonas seymouri 66% 100%
A0A0S4JX73 Bodo saltans 37% 100%
A0A1X0NVE4 Trypanosomatidae 45% 100%
A0A3R7RL81 Trypanosoma rangeli 42% 85%
A0A3S7WTD5 Leishmania donovani 80% 95%
A4HWE4 Leishmania infantum 81% 95%
C9ZNY5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
E9AQ44 Leishmania mexicana (strain MHOM/GT/2001/U1103) 77% 95%
Q4QFD8 Leishmania major 78% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS