Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H813_LEIBR

TriTrypDb:

LbrM.15.0430 , LBRM2903_150009900

Length:

695

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H813

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H813

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	415	419	PF00656	0.484
CLV_NRD_NRD_1	161	163	PF00675	0.337
CLV_NRD_NRD_1	212	214	PF00675	0.340
CLV_NRD_NRD_1	3	5	PF00675	0.432
CLV_NRD_NRD_1	306	308	PF00675	0.262
CLV_NRD_NRD_1	38	40	PF00675	0.360
CLV_NRD_NRD_1	450	452	PF00675	0.421
CLV_NRD_NRD_1	483	485	PF00675	0.387
CLV_PCSK_KEX2_1	160	162	PF00082	0.336
CLV_PCSK_KEX2_1	212	214	PF00082	0.394
CLV_PCSK_KEX2_1	260	262	PF00082	0.337
CLV_PCSK_KEX2_1	3	5	PF00082	0.432
CLV_PCSK_KEX2_1	306	308	PF00082	0.262
CLV_PCSK_KEX2_1	38	40	PF00082	0.360
CLV_PCSK_KEX2_1	483	485	PF00082	0.346
CLV_PCSK_PC1ET2_1	260	262	PF00082	0.380
CLV_PCSK_PC7_1	157	163	PF00082	0.347
CLV_PCSK_SKI1_1	353	357	PF00082	0.599
CLV_PCSK_SKI1_1	452	456	PF00082	0.438
CLV_PCSK_SKI1_1	465	469	PF00082	0.544
CLV_PCSK_SKI1_1	639	643	PF00082	0.302
CLV_PCSK_SKI1_1	88	92	PF00082	0.332
CLV_PCSK_SKI1_1	93	97	PF00082	0.327
DEG_APCC_DBOX_1	160	168	PF00400	0.521
DEG_APCC_DBOX_1	195	203	PF00400	0.523
DEG_APCC_DBOX_1	2	10	PF00400	0.550
DEG_APCC_DBOX_1	306	314	PF00400	0.487
DEG_Nend_Nbox_1	1	3	PF02207	0.656
DEG_SPOP_SBC_1	439	443	PF00917	0.475
DOC_CKS1_1	52	57	PF01111	0.540
DOC_CYCLIN_RxL_1	682	694	PF00134	0.528
DOC_CYCLIN_yCln2_LP_2	250	256	PF00134	0.572
DOC_MAPK_gen_1	108	117	PF00069	0.405
DOC_MAPK_gen_1	157	167	PF00069	0.533
DOC_MAPK_gen_1	212	220	PF00069	0.615
DOC_MAPK_gen_1	3	9	PF00069	0.604
DOC_MAPK_gen_1	306	312	PF00069	0.476
DOC_MAPK_gen_1	44	50	PF00069	0.550
DOC_MAPK_gen_1	53	61	PF00069	0.545
DOC_MAPK_gen_1	680	689	PF00069	0.555
DOC_MAPK_gen_1	88	97	PF00069	0.531
DOC_MAPK_MEF2A_6	407	414	PF00069	0.412
DOC_MAPK_MEF2A_6	91	99	PF00069	0.534
DOC_PP1_RVXF_1	686	692	PF00149	0.526
DOC_PP2B_LxvP_1	250	253	PF13499	0.540
DOC_USP7_MATH_1	416	420	PF00917	0.450
DOC_USP7_MATH_1	439	443	PF00917	0.413
DOC_USP7_MATH_1	574	578	PF00917	0.710
DOC_WW_Pin1_4	204	209	PF00397	0.525
DOC_WW_Pin1_4	391	396	PF00397	0.344
DOC_WW_Pin1_4	51	56	PF00397	0.540
LIG_14-3-3_CanoR_1	3	7	PF00244	0.717
LIG_14-3-3_CanoR_1	301	310	PF00244	0.543
LIG_14-3-3_CanoR_1	60	64	PF00244	0.579
LIG_14-3-3_CanoR_1	75	81	PF00244	0.462
LIG_Actin_WH2_2	479	495	PF00022	0.649
LIG_AP2alpha_2	391	393	PF02296	0.377
LIG_APCC_ABBA_1	121	126	PF00400	0.506
LIG_BRCT_BRCA1_1	402	406	PF00533	0.440
LIG_CSL_BTD_1	392	395	PF09270	0.344
LIG_deltaCOP1_diTrp_1	391	400	PF00928	0.257
LIG_deltaCOP1_diTrp_1	57	61	PF00928	0.566
LIG_EH1_1	181	189	PF00400	0.570
LIG_eIF4E_1	182	188	PF01652	0.454
LIG_FHA_1	487	493	PF00498	0.545
LIG_FHA_2	142	148	PF00498	0.549
LIG_FHA_2	272	278	PF00498	0.569
LIG_FHA_2	433	439	PF00498	0.309
LIG_FHA_2	52	58	PF00498	0.541
LIG_FHA_2	77	83	PF00498	0.576
LIG_Integrin_isoDGR_2	684	686	PF01839	0.423
LIG_LIR_Gen_1	118	129	PF02991	0.511
LIG_LIR_Gen_1	166	176	PF02991	0.516
LIG_LIR_Gen_1	57	66	PF02991	0.559
LIG_LIR_Gen_1	593	602	PF02991	0.505
LIG_LIR_Gen_1	629	638	PF02991	0.493
LIG_LIR_Gen_1	643	652	PF02991	0.534
LIG_LIR_LC3C_4	632	637	PF02991	0.556
LIG_LIR_Nem_3	118	124	PF02991	0.507
LIG_LIR_Nem_3	166	171	PF02991	0.518
LIG_LIR_Nem_3	209	214	PF02991	0.513
LIG_LIR_Nem_3	364	370	PF02991	0.359
LIG_LIR_Nem_3	391	396	PF02991	0.356
LIG_LIR_Nem_3	403	409	PF02991	0.340
LIG_LIR_Nem_3	57	61	PF02991	0.553
LIG_LIR_Nem_3	593	598	PF02991	0.510
LIG_LIR_Nem_3	62	66	PF02991	0.539
LIG_LIR_Nem_3	643	647	PF02991	0.558
LIG_Pex14_1	27	31	PF04695	0.569
LIG_Pex14_2	400	404	PF04695	0.274
LIG_PTB_Apo_2	62	69	PF02174	0.548
LIG_PTB_Phospho_1	62	68	PF10480	0.547
LIG_Rb_pABgroove_1	118	126	PF01858	0.509
LIG_SH2_CRK	63	67	PF00017	0.560
LIG_SH2_NCK_1	112	116	PF00017	0.555
LIG_SH2_SRC	112	115	PF00017	0.628
LIG_SH2_STAP1	31	35	PF00017	0.579
LIG_SH2_STAP1	323	327	PF00017	0.328
LIG_SH2_STAT5	214	217	PF00017	0.504
LIG_SH2_STAT5	235	238	PF00017	0.617
LIG_SH2_STAT5	309	312	PF00017	0.413
LIG_SH2_STAT5	386	389	PF00017	0.305
LIG_SH3_3	389	395	PF00018	0.316
LIG_SH3_3	49	55	PF00018	0.542
LIG_SH3_3	8	14	PF00018	0.620
LIG_SUMO_SIM_anti_2	458	464	PF11976	0.609
LIG_SUMO_SIM_par_1	216	223	PF11976	0.547
LIG_SUMO_SIM_par_1	484	490	PF11976	0.651
LIG_TRAF2_1	172	175	PF00917	0.519
LIG_TRAF2_1	508	511	PF00917	0.664
LIG_TRAF2_2	20	25	PF00917	0.492
LIG_UBA3_1	327	336	PF00899	0.385
MOD_CDK_SPK_2	51	56	PF00069	0.552
MOD_CK1_1	138	144	PF00069	0.591
MOD_CK1_1	30	36	PF00069	0.581
MOD_CK1_1	359	365	PF00069	0.446
MOD_CK1_1	419	425	PF00069	0.545
MOD_CK1_1	441	447	PF00069	0.461
MOD_CK1_1	579	585	PF00069	0.689
MOD_CK2_1	141	147	PF00069	0.577
MOD_CK2_1	271	277	PF00069	0.552
MOD_CK2_1	432	438	PF00069	0.269
MOD_CK2_1	444	450	PF00069	0.456
MOD_CK2_1	76	82	PF00069	0.534
MOD_GlcNHglycan	188	191	PF01048	0.416
MOD_GlcNHglycan	202	205	PF01048	0.313
MOD_GlcNHglycan	262	265	PF01048	0.286
MOD_GlcNHglycan	318	321	PF01048	0.321
MOD_GlcNHglycan	323	326	PF01048	0.315
MOD_GlcNHglycan	359	362	PF01048	0.538
MOD_GlcNHglycan	414	417	PF01048	0.674
MOD_GlcNHglycan	581	584	PF01048	0.439
MOD_GlcNHglycan	667	670	PF01048	0.396
MOD_GSK3_1	200	207	PF00069	0.529
MOD_GSK3_1	27	34	PF00069	0.476
MOD_GSK3_1	276	283	PF00069	0.543
MOD_GSK3_1	297	304	PF00069	0.570
MOD_GSK3_1	311	318	PF00069	0.393
MOD_GSK3_1	412	419	PF00069	0.469
MOD_GSK3_1	440	447	PF00069	0.332
MOD_GSK3_1	498	505	PF00069	0.685
MOD_GSK3_1	556	563	PF00069	0.740
MOD_GSK3_1	575	582	PF00069	0.733
MOD_GSK3_1	9	16	PF00069	0.638
MOD_N-GLC_1	422	427	PF02516	0.773
MOD_N-GLC_1	575	580	PF02516	0.568
MOD_NEK2_1	2	7	PF00069	0.640
MOD_NEK2_1	202	207	PF00069	0.525
MOD_NEK2_1	220	225	PF00069	0.462
MOD_NEK2_1	254	259	PF00069	0.525
MOD_NEK2_1	297	302	PF00069	0.573
MOD_NEK2_1	315	320	PF00069	0.365
MOD_NEK2_1	356	361	PF00069	0.344
MOD_NEK2_1	400	405	PF00069	0.332
MOD_NEK2_1	412	417	PF00069	0.377
MOD_NEK2_1	498	503	PF00069	0.648
MOD_NEK2_1	59	64	PF00069	0.549
MOD_NEK2_1	646	651	PF00069	0.627
MOD_NEK2_1	665	670	PF00069	0.568
MOD_PIKK_1	266	272	PF00454	0.623
MOD_PIKK_1	506	512	PF00454	0.717
MOD_PIKK_1	646	652	PF00454	0.576
MOD_PK_1	44	50	PF00069	0.574
MOD_PKA_1	260	266	PF00069	0.577
MOD_PKA_1	44	50	PF00069	0.561
MOD_PKA_2	156	162	PF00069	0.623
MOD_PKA_2	2	8	PF00069	0.714
MOD_PKA_2	260	266	PF00069	0.539
MOD_PKA_2	356	362	PF00069	0.349
MOD_PKA_2	59	65	PF00069	0.617
MOD_Plk_1	125	131	PF00069	0.543
MOD_Plk_1	400	406	PF00069	0.427
MOD_Plk_2-3	135	141	PF00069	0.603
MOD_Plk_4	141	147	PF00069	0.529
MOD_Plk_4	206	212	PF00069	0.505
MOD_Plk_4	220	226	PF00069	0.511
MOD_Plk_4	254	260	PF00069	0.541
MOD_Plk_4	280	286	PF00069	0.518
MOD_Plk_4	311	317	PF00069	0.393
MOD_ProDKin_1	204	210	PF00069	0.521
MOD_ProDKin_1	391	397	PF00069	0.344
MOD_ProDKin_1	51	57	PF00069	0.539
MOD_SUMO_rev_2	447	454	PF00179	0.718
TRG_DiLeu_BaEn_2	226	232	PF01217	0.557
TRG_DiLeu_BaEn_4	174	180	PF01217	0.524
TRG_DiLeu_BaLyEn_6	347	352	PF01217	0.352
TRG_DiLeu_BaLyEn_6	481	486	PF01217	0.501
TRG_DiLeu_BaLyEn_6	594	599	PF01217	0.535
TRG_ENDOCYTIC_2	112	115	PF00928	0.554
TRG_ENDOCYTIC_2	168	171	PF00928	0.509
TRG_ENDOCYTIC_2	214	217	PF00928	0.577
TRG_ENDOCYTIC_2	309	312	PF00928	0.449
TRG_ENDOCYTIC_2	367	370	PF00928	0.365
TRG_ENDOCYTIC_2	536	539	PF00928	0.674
TRG_ENDOCYTIC_2	63	66	PF00928	0.568
TRG_ENDOCYTIC_2	87	90	PF00928	0.511
TRG_ER_diArg_1	160	162	PF00400	0.537
TRG_ER_diArg_1	2	4	PF00400	0.638
TRG_ER_diArg_1	211	213	PF00400	0.541
TRG_ER_diArg_1	306	308	PF00400	0.450
TRG_ER_diArg_1	482	484	PF00400	0.546
TRG_ER_diArg_1	680	683	PF00400	0.533
TRG_ER_diArg_1	686	689	PF00400	0.530
TRG_NES_CRM1_1	163	177	PF08389	0.524
TRG_Pf-PMV_PEXEL_1	162	166	PF00026	0.352
TRG_Pf-PMV_PEXEL_1	483	487	PF00026	0.403
TRG_Pf-PMV_PEXEL_1	639	643	PF00026	0.360
TRG_Pf-PMV_PEXEL_1	688	693	PF00026	0.332

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1B6	Leptomonas seymouri	74%	100%
A0A0S4JZM2	Bodo saltans	44%	100%
A0A1X0NV52	Trypanosomatidae	55%	97%
A0A3S7WTC9	Leishmania donovani	86%	100%
A0A422NLJ2	Trypanosoma rangeli	56%	100%
A4HWE3	Leishmania infantum	86%	100%
C9ZNY4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9AQ43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QFD9	Leishmania major	85%	100%
V5BGN8	Trypanosoma cruzi	55%	100%