Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H812_LEIBR

TriTrypDb:

LbrM.15.0420 , LBRM2903_150009800

Length:

526

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H812

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H812

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	184	188	PF00656	0.485
CLV_NRD_NRD_1	194	196	PF00675	0.530
CLV_NRD_NRD_1	286	288	PF00675	0.783
CLV_PCSK_KEX2_1	194	196	PF00082	0.465
CLV_PCSK_KEX2_1	286	288	PF00082	0.783
CLV_PCSK_SKI1_1	503	507	PF00082	0.611
DOC_CYCLIN_yCln2_LP_2	120	123	PF00134	0.570
DOC_MAPK_gen_1	171	181	PF00069	0.586
DOC_MAPK_gen_1	74	83	PF00069	0.659
DOC_MAPK_MEF2A_6	355	362	PF00069	0.420
DOC_PP2B_LxvP_1	120	123	PF13499	0.536
DOC_PP2B_LxvP_1	235	238	PF13499	0.431
DOC_USP7_MATH_1	154	158	PF00917	0.655
DOC_USP7_MATH_1	17	21	PF00917	0.624
DOC_USP7_MATH_1	231	235	PF00917	0.552
DOC_USP7_MATH_1	256	260	PF00917	0.577
DOC_USP7_MATH_1	386	390	PF00917	0.369
DOC_USP7_MATH_1	472	476	PF00917	0.638
DOC_WW_Pin1_4	108	113	PF00397	0.362
DOC_WW_Pin1_4	198	203	PF00397	0.548
LIG_14-3-3_CanoR_1	174	182	PF00244	0.553
LIG_14-3-3_CanoR_1	232	238	PF00244	0.700
LIG_14-3-3_CanoR_1	267	273	PF00244	0.443
LIG_14-3-3_CanoR_1	278	282	PF00244	0.594
LIG_14-3-3_CanoR_1	337	343	PF00244	0.320
LIG_14-3-3_CanoR_1	385	391	PF00244	0.501
LIG_14-3-3_CanoR_1	93	97	PF00244	0.556
LIG_APCC_ABBA_1	94	99	PF00400	0.435
LIG_APCC_ABBAyCdc20_2	93	99	PF00400	0.455
LIG_BRCT_BRCA1_1	485	489	PF00533	0.462
LIG_BRCT_BRCA1_1	493	497	PF00533	0.391
LIG_BRCT_BRCA1_1	54	58	PF00533	0.661
LIG_Clathr_ClatBox_1	331	335	PF01394	0.296
LIG_FHA_1	174	180	PF00498	0.555
LIG_FHA_1	261	267	PF00498	0.519
LIG_FHA_1	348	354	PF00498	0.472
LIG_FHA_1	366	372	PF00498	0.486
LIG_FHA_1	5	11	PF00498	0.588
LIG_FHA_2	283	289	PF00498	0.602
LIG_FHA_2	493	499	PF00498	0.659
LIG_Integrin_isoDGR_2	31	33	PF01839	0.446
LIG_LIR_Gen_1	327	334	PF02991	0.402
LIG_LIR_Gen_1	494	505	PF02991	0.562
LIG_LIR_Gen_1	77	87	PF02991	0.341
LIG_LIR_Nem_3	327	332	PF02991	0.384
LIG_LIR_Nem_3	494	500	PF02991	0.565
LIG_LIR_Nem_3	77	83	PF02991	0.631
LIG_NRBOX	224	230	PF00104	0.633
LIG_SH2_NCK_1	509	513	PF00017	0.688
LIG_SH2_STAP1	102	106	PF00017	0.561
LIG_SH2_STAT5	102	105	PF00017	0.272
LIG_SH2_STAT5	48	51	PF00017	0.535
LIG_SH2_STAT5	82	85	PF00017	0.433
LIG_SH3_3	116	122	PF00018	0.535
LIG_SH3_3	216	222	PF00018	0.389
LIG_SH3_3	297	303	PF00018	0.395
LIG_SH3_3	416	422	PF00018	0.473
LIG_SUMO_SIM_anti_2	201	207	PF11976	0.555
LIG_SUMO_SIM_anti_2	223	230	PF11976	0.363
LIG_SUMO_SIM_anti_2	318	323	PF11976	0.455
LIG_TRAF2_1	289	292	PF00917	0.767
MOD_CDK_SPxxK_3	108	115	PF00069	0.306
MOD_CK1_1	209	215	PF00069	0.608
MOD_CK1_1	223	229	PF00069	0.517
MOD_CK1_1	282	288	PF00069	0.693
MOD_CK1_1	327	333	PF00069	0.462
MOD_CK1_1	389	395	PF00069	0.497
MOD_CK1_1	57	63	PF00069	0.617
MOD_CK1_1	95	101	PF00069	0.517
MOD_CK2_1	153	159	PF00069	0.659
MOD_CK2_1	233	239	PF00069	0.694
MOD_CK2_1	282	288	PF00069	0.714
MOD_GlcNHglycan	156	159	PF01048	0.660
MOD_GlcNHglycan	183	186	PF01048	0.499
MOD_GlcNHglycan	19	22	PF01048	0.683
MOD_GlcNHglycan	222	225	PF01048	0.577
MOD_GlcNHglycan	229	232	PF01048	0.630
MOD_GlcNHglycan	27	30	PF01048	0.688
MOD_GlcNHglycan	306	309	PF01048	0.570
MOD_GlcNHglycan	365	368	PF01048	0.433
MOD_GlcNHglycan	414	417	PF01048	0.434
MOD_GlcNHglycan	465	468	PF01048	0.679
MOD_GlcNHglycan	474	477	PF01048	0.634
MOD_GlcNHglycan	54	57	PF01048	0.560
MOD_GlcNHglycan	59	62	PF01048	0.620
MOD_GlcNHglycan	70	73	PF01048	0.560
MOD_GSK3_1	13	20	PF00069	0.421
MOD_GSK3_1	137	144	PF00069	0.716
MOD_GSK3_1	149	156	PF00069	0.580
MOD_GSK3_1	223	230	PF00069	0.496
MOD_GSK3_1	244	251	PF00069	0.620
MOD_GSK3_1	256	263	PF00069	0.482
MOD_GSK3_1	276	283	PF00069	0.740
MOD_GSK3_1	294	301	PF00069	0.601
MOD_GSK3_1	302	309	PF00069	0.508
MOD_GSK3_1	370	377	PF00069	0.561
MOD_GSK3_1	401	408	PF00069	0.435
MOD_GSK3_1	480	487	PF00069	0.748
MOD_GSK3_1	52	59	PF00069	0.552
MOD_GSK3_1	98	105	PF00069	0.594
MOD_NEK2_1	136	141	PF00069	0.753
MOD_NEK2_1	161	166	PF00069	0.580
MOD_NEK2_1	181	186	PF00069	0.476
MOD_NEK2_1	196	201	PF00069	0.374
MOD_NEK2_1	281	286	PF00069	0.724
MOD_NEK2_1	298	303	PF00069	0.386
MOD_NEK2_1	354	359	PF00069	0.452
MOD_NEK2_1	405	410	PF00069	0.505
MOD_NEK2_1	448	453	PF00069	0.605
MOD_NEK2_1	481	486	PF00069	0.482
MOD_NEK2_1	54	59	PF00069	0.617
MOD_NEK2_1	97	102	PF00069	0.590
MOD_NEK2_2	92	97	PF00069	0.554
MOD_PIKK_1	173	179	PF00454	0.599
MOD_PIKK_1	347	353	PF00454	0.492
MOD_PIKK_1	4	10	PF00454	0.672
MOD_PK_1	286	292	PF00069	0.773
MOD_PKA_1	286	292	PF00069	0.773
MOD_PKA_2	13	19	PF00069	0.625
MOD_PKA_2	141	147	PF00069	0.561
MOD_PKA_2	170	176	PF00069	0.540
MOD_PKA_2	206	212	PF00069	0.587
MOD_PKA_2	231	237	PF00069	0.607
MOD_PKA_2	277	283	PF00069	0.637
MOD_PKA_2	286	292	PF00069	0.726
MOD_PKA_2	336	342	PF00069	0.457
MOD_PKA_2	354	360	PF00069	0.477
MOD_PKA_2	92	98	PF00069	0.563
MOD_Plk_1	98	104	PF00069	0.560
MOD_Plk_4	206	212	PF00069	0.395
MOD_Plk_4	223	229	PF00069	0.352
MOD_Plk_4	317	323	PF00069	0.469
MOD_Plk_4	324	330	PF00069	0.401
MOD_Plk_4	401	407	PF00069	0.477
MOD_Plk_4	485	491	PF00069	0.669
MOD_Plk_4	92	98	PF00069	0.520
MOD_ProDKin_1	108	114	PF00069	0.366
MOD_ProDKin_1	198	204	PF00069	0.548
TRG_DiLeu_BaEn_3	513	519	PF01217	0.683
TRG_DiLeu_BaLyEn_6	500	505	PF01217	0.635
TRG_ER_diArg_1	193	195	PF00400	0.512
TRG_ER_diArg_1	264	267	PF00400	0.466
TRG_Pf-PMV_PEXEL_1	194	198	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	432	436	PF00026	0.642

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD21	Leptomonas seymouri	50%	80%
A0A0S4JR70	Bodo saltans	27%	94%
A0A1X0NU73	Trypanosomatidae	27%	93%
A0A3R7NGV0	Trypanosoma rangeli	26%	97%
A0A3S7WTC1	Leishmania donovani	72%	77%
A4HWE2	Leishmania infantum	71%	77%
C9ZNY2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AQ42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	78%
Q4QFE0	Leishmania major	70%	100%
V5DCS7	Trypanosoma cruzi	28%	98%