PseudoU_synth_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA pseudouridylate synthase, putative

Species:

Leishmania braziliensis

UniProt:

A4H810_LEIBR

TriTrypDb:

LbrM.15.0400 , LBRM2903_150009400

Length:

1015

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H810

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H810

Function

Biological processes
Term	Name	Level	Count
GO:0001522	pseudouridine synthesis	6	6
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009451	RNA modification	5	6
GO:0009987	cellular process	1	6
GO:0016070	RNA metabolic process	5	6
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0046483	heterocycle metabolic process	3	6
GO:0071704	organic substance metabolic process	2	6
GO:0090304	nucleic acid metabolic process	4	6
GO:1901360	organic cyclic compound metabolic process	3	6
GO:0000154	rRNA modification	6	1
GO:0000455	enzyme-directed rRNA pseudouridine synthesis	8	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0016072	rRNA metabolic process	7	1
GO:0031118	rRNA pseudouridine synthesis	7	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0003824	catalytic activity	1	6
GO:0005488	binding	1	6
GO:0009982	pseudouridine synthase activity	4	6
GO:0016853	isomerase activity	2	6
GO:0016866	intramolecular transferase activity	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	467	471	PF00656	0.458
CLV_C14_Caspase3-7	622	626	PF00656	0.525
CLV_NRD_NRD_1	157	159	PF00675	0.502
CLV_NRD_NRD_1	187	189	PF00675	0.392
CLV_NRD_NRD_1	399	401	PF00675	0.445
CLV_NRD_NRD_1	422	424	PF00675	0.538
CLV_NRD_NRD_1	463	465	PF00675	0.524
CLV_NRD_NRD_1	612	614	PF00675	0.502
CLV_NRD_NRD_1	663	665	PF00675	0.399
CLV_NRD_NRD_1	805	807	PF00675	0.543
CLV_NRD_NRD_1	840	842	PF00675	0.295
CLV_NRD_NRD_1	896	898	PF00675	0.489
CLV_PCSK_KEX2_1	157	159	PF00082	0.502
CLV_PCSK_KEX2_1	187	189	PF00082	0.392
CLV_PCSK_KEX2_1	216	218	PF00082	0.560
CLV_PCSK_KEX2_1	422	424	PF00082	0.538
CLV_PCSK_KEX2_1	463	465	PF00082	0.542
CLV_PCSK_KEX2_1	542	544	PF00082	0.628
CLV_PCSK_KEX2_1	612	614	PF00082	0.491
CLV_PCSK_KEX2_1	761	763	PF00082	0.430
CLV_PCSK_KEX2_1	805	807	PF00082	0.606
CLV_PCSK_KEX2_1	840	842	PF00082	0.295
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.533
CLV_PCSK_PC1ET2_1	542	544	PF00082	0.630
CLV_PCSK_PC1ET2_1	761	763	PF00082	0.433
CLV_PCSK_PC7_1	183	189	PF00082	0.384
CLV_PCSK_PC7_1	459	465	PF00082	0.494
CLV_PCSK_SKI1_1	14	18	PF00082	0.479
CLV_PCSK_SKI1_1	157	161	PF00082	0.463
CLV_PCSK_SKI1_1	267	271	PF00082	0.598
CLV_PCSK_SKI1_1	500	504	PF00082	0.436
CLV_PCSK_SKI1_1	507	511	PF00082	0.594
CLV_PCSK_SKI1_1	539	543	PF00082	0.692
CLV_PCSK_SKI1_1	798	802	PF00082	0.579
CLV_PCSK_SKI1_1	850	854	PF00082	0.267
CLV_Separin_Metazoa	351	355	PF03568	0.341
DEG_APCC_DBOX_1	673	681	PF00400	0.366
DEG_APCC_DBOX_1	882	890	PF00400	0.467
DEG_SCF_FBW7_1	928	934	PF00400	0.593
DEG_SPOP_SBC_1	121	125	PF00917	0.540
DEG_SPOP_SBC_1	142	146	PF00917	0.490
DEG_SPOP_SBC_1	291	295	PF00917	0.398
DEG_SPOP_SBC_1	3	7	PF00917	0.533
DOC_CKS1_1	239	244	PF01111	0.518
DOC_CKS1_1	928	933	PF01111	0.603
DOC_CYCLIN_RxL_1	497	506	PF00134	0.420
DOC_MAPK_DCC_7	130	138	PF00069	0.537
DOC_MAPK_gen_1	187	196	PF00069	0.353
DOC_MAPK_gen_1	850	858	PF00069	0.456
DOC_MAPK_gen_1	895	902	PF00069	0.364
DOC_MAPK_MEF2A_6	130	138	PF00069	0.581
DOC_MAPK_MEF2A_6	343	352	PF00069	0.407
DOC_MAPK_MEF2A_6	878	886	PF00069	0.470
DOC_MAPK_RevD_3	884	898	PF00069	0.548
DOC_PP1_RVXF_1	265	272	PF00149	0.499
DOC_PP2B_LxvP_1	33	36	PF13499	0.579
DOC_PP2B_LxvP_1	656	659	PF13499	0.600
DOC_PP2B_LxvP_1	814	817	PF13499	0.616
DOC_PP2B_PxIxI_1	65	71	PF00149	0.365
DOC_PP4_FxxP_1	159	162	PF00568	0.421
DOC_PP4_FxxP_1	345	348	PF00568	0.387
DOC_PP4_FxxP_1	77	80	PF00568	0.393
DOC_USP7_MATH_1	142	146	PF00917	0.611
DOC_USP7_MATH_1	2	6	PF00917	0.637
DOC_USP7_MATH_1	240	244	PF00917	0.549
DOC_USP7_MATH_1	257	261	PF00917	0.532
DOC_USP7_MATH_1	292	296	PF00917	0.444
DOC_USP7_MATH_1	303	307	PF00917	0.531
DOC_USP7_MATH_1	37	41	PF00917	0.553
DOC_USP7_MATH_1	444	448	PF00917	0.465
DOC_USP7_MATH_1	469	473	PF00917	0.578
DOC_USP7_MATH_1	579	583	PF00917	0.427
DOC_USP7_MATH_1	596	600	PF00917	0.487
DOC_USP7_MATH_1	60	64	PF00917	0.522
DOC_USP7_MATH_1	617	621	PF00917	0.568
DOC_USP7_MATH_1	918	922	PF00917	0.576
DOC_USP7_MATH_1	931	935	PF00917	0.597
DOC_USP7_MATH_1	962	966	PF00917	0.523
DOC_WW_Pin1_4	238	243	PF00397	0.519
DOC_WW_Pin1_4	317	322	PF00397	0.473
DOC_WW_Pin1_4	362	367	PF00397	0.527
DOC_WW_Pin1_4	369	374	PF00397	0.566
DOC_WW_Pin1_4	523	528	PF00397	0.602
DOC_WW_Pin1_4	550	555	PF00397	0.623
DOC_WW_Pin1_4	741	746	PF00397	0.581
DOC_WW_Pin1_4	812	817	PF00397	0.541
DOC_WW_Pin1_4	927	932	PF00397	0.582
LIG_14-3-3_CanoR_1	157	162	PF00244	0.425
LIG_14-3-3_CanoR_1	287	296	PF00244	0.378
LIG_14-3-3_CanoR_1	400	405	PF00244	0.447
LIG_14-3-3_CanoR_1	464	474	PF00244	0.460
LIG_14-3-3_CanoR_1	612	618	PF00244	0.519
LIG_14-3-3_CanoR_1	690	695	PF00244	0.520
LIG_14-3-3_CanoR_1	71	76	PF00244	0.514
LIG_14-3-3_CanoR_1	850	859	PF00244	0.472
LIG_BIR_II_1	1	5	PF00653	0.580
LIG_BIR_III_1	1	5	PF00653	0.580
LIG_BIR_III_3	1	5	PF00653	0.580
LIG_BRCT_BRCA1_1	73	77	PF00533	0.407
LIG_Clathr_ClatBox_1	1003	1007	PF01394	0.517
LIG_deltaCOP1_diTrp_1	261	265	PF00928	0.527
LIG_deltaCOP1_diTrp_1	494	503	PF00928	0.462
LIG_EH1_1	720	728	PF00400	0.380
LIG_eIF4E_1	998	1004	PF01652	0.531
LIG_EVH1_1	440	444	PF00568	0.444
LIG_FHA_1	124	130	PF00498	0.514
LIG_FHA_1	242	248	PF00498	0.519
LIG_FHA_1	4	10	PF00498	0.617
LIG_FHA_1	403	409	PF00498	0.393
LIG_FHA_1	596	602	PF00498	0.563
LIG_FHA_1	651	657	PF00498	0.531
LIG_FHA_1	690	696	PF00498	0.466
LIG_FHA_1	877	883	PF00498	0.495
LIG_FHA_2	45	51	PF00498	0.658
LIG_FHA_2	482	488	PF00498	0.552
LIG_FHA_2	5	11	PF00498	0.539
LIG_FHA_2	508	514	PF00498	0.538
LIG_FHA_2	697	703	PF00498	0.521
LIG_FHA_2	720	726	PF00498	0.435
LIG_LIR_Apic_2	156	162	PF02991	0.460
LIG_LIR_Apic_2	739	745	PF02991	0.447
LIG_LIR_Apic_2	74	80	PF02991	0.400
LIG_LIR_Gen_1	452	462	PF02991	0.411
LIG_LIR_Gen_1	494	504	PF02991	0.582
LIG_LIR_Gen_1	64	75	PF02991	0.478
LIG_LIR_Gen_1	896	906	PF02991	0.443
LIG_LIR_Gen_1	97	106	PF02991	0.480
LIG_LIR_Nem_3	452	458	PF02991	0.419
LIG_LIR_Nem_3	494	499	PF02991	0.426
LIG_LIR_Nem_3	64	70	PF02991	0.442
LIG_LIR_Nem_3	896	902	PF02991	0.496
LIG_LIR_Nem_3	97	103	PF02991	0.469
LIG_PCNA_yPIPBox_3	183	197	PF02747	0.332
LIG_Pex14_2	94	98	PF04695	0.401
LIG_SH2_CRK	445	449	PF00017	0.376
LIG_SH2_CRK	73	77	PF00017	0.407
LIG_SH2_NCK_1	861	865	PF00017	0.467
LIG_SH2_NCK_1	994	998	PF00017	0.397
LIG_SH2_PTP2	899	902	PF00017	0.491
LIG_SH2_SRC	998	1001	PF00017	0.470
LIG_SH2_STAP1	445	449	PF00017	0.459
LIG_SH2_STAP1	584	588	PF00017	0.506
LIG_SH2_STAP1	73	77	PF00017	0.407
LIG_SH2_STAP1	942	946	PF00017	0.482
LIG_SH2_STAP1	994	998	PF00017	0.409
LIG_SH2_STAT5	15	18	PF00017	0.473
LIG_SH2_STAT5	164	167	PF00017	0.373
LIG_SH2_STAT5	584	587	PF00017	0.517
LIG_SH2_STAT5	667	670	PF00017	0.376
LIG_SH2_STAT5	75	78	PF00017	0.402
LIG_SH2_STAT5	845	848	PF00017	0.572
LIG_SH2_STAT5	899	902	PF00017	0.426
LIG_SH2_STAT5	994	997	PF00017	0.407
LIG_SH3_3	1003	1009	PF00018	0.453
LIG_SH3_3	382	388	PF00018	0.395
LIG_SH3_3	389	395	PF00018	0.453
LIG_SH3_3	438	444	PF00018	0.525
LIG_SH3_3	575	581	PF00018	0.450
LIG_SH3_3	725	731	PF00018	0.375
LIG_SH3_3	925	931	PF00018	0.590
LIG_SUMO_SIM_par_1	1002	1007	PF11976	0.518
LIG_SUMO_SIM_par_1	381	386	PF11976	0.416
LIG_TRAF2_1	510	513	PF00917	0.605
LIG_TRAF2_1	620	623	PF00917	0.487
LIG_TRAF2_1	912	915	PF00917	0.569
LIG_UBA3_1	90	96	PF00899	0.295
LIG_WW_3	916	920	PF00397	0.543
MOD_CK1_1	123	129	PF00069	0.580
MOD_CK1_1	253	259	PF00069	0.637
MOD_CK1_1	290	296	PF00069	0.495
MOD_CK1_1	297	303	PF00069	0.585
MOD_CK1_1	313	319	PF00069	0.532
MOD_CK1_1	362	368	PF00069	0.577
MOD_CK1_1	403	409	PF00069	0.401
MOD_CK1_1	433	439	PF00069	0.573
MOD_CK1_1	44	50	PF00069	0.526
MOD_CK1_1	480	486	PF00069	0.554
MOD_CK1_1	553	559	PF00069	0.555
MOD_CK1_1	582	588	PF00069	0.470
MOD_CK1_1	693	699	PF00069	0.679
MOD_CK1_1	716	722	PF00069	0.543
MOD_CK1_1	836	842	PF00069	0.419
MOD_CK1_1	851	857	PF00069	0.221
MOD_CK1_1	944	950	PF00069	0.579
MOD_CK2_1	274	280	PF00069	0.476
MOD_CK2_1	4	10	PF00069	0.549
MOD_CK2_1	403	409	PF00069	0.393
MOD_CK2_1	507	513	PF00069	0.560
MOD_CK2_1	617	623	PF00069	0.454
MOD_CK2_1	624	630	PF00069	0.519
MOD_CK2_1	696	702	PF00069	0.519
MOD_CK2_1	719	725	PF00069	0.475
MOD_CK2_1	909	915	PF00069	0.495
MOD_CMANNOS	262	265	PF00535	0.508
MOD_Cter_Amidation	185	188	PF01082	0.382
MOD_Cter_Amidation	803	806	PF01082	0.518
MOD_GlcNHglycan	130	133	PF01048	0.705
MOD_GlcNHglycan	149	152	PF01048	0.781
MOD_GlcNHglycan	218	222	PF01048	0.631
MOD_GlcNHglycan	254	258	PF01048	0.666
MOD_GlcNHglycan	289	292	PF01048	0.501
MOD_GlcNHglycan	29	32	PF01048	0.579
MOD_GlcNHglycan	299	302	PF01048	0.572
MOD_GlcNHglycan	305	308	PF01048	0.550
MOD_GlcNHglycan	310	313	PF01048	0.557
MOD_GlcNHglycan	317	320	PF01048	0.614
MOD_GlcNHglycan	361	364	PF01048	0.557
MOD_GlcNHglycan	42	46	PF01048	0.572
MOD_GlcNHglycan	432	435	PF01048	0.503
MOD_GlcNHglycan	437	440	PF01048	0.581
MOD_GlcNHglycan	467	470	PF01048	0.508
MOD_GlcNHglycan	471	474	PF01048	0.579
MOD_GlcNHglycan	491	494	PF01048	0.357
MOD_GlcNHglycan	56	59	PF01048	0.542
MOD_GlcNHglycan	572	575	PF01048	0.574
MOD_GlcNHglycan	598	601	PF01048	0.488
MOD_GlcNHglycan	628	634	PF01048	0.659
MOD_GlcNHglycan	715	718	PF01048	0.667
MOD_GlcNHglycan	776	779	PF01048	0.668
MOD_GlcNHglycan	831	834	PF01048	0.665
MOD_GlcNHglycan	850	853	PF01048	0.304
MOD_GlcNHglycan	911	914	PF01048	0.518
MOD_GlcNHglycan	978	981	PF01048	0.548
MOD_GSK3_1	121	128	PF00069	0.594
MOD_GSK3_1	143	150	PF00069	0.624
MOD_GSK3_1	203	210	PF00069	0.600
MOD_GSK3_1	246	253	PF00069	0.716
MOD_GSK3_1	270	277	PF00069	0.421
MOD_GSK3_1	287	294	PF00069	0.556
MOD_GSK3_1	308	315	PF00069	0.555
MOD_GSK3_1	37	44	PF00069	0.540
MOD_GSK3_1	429	436	PF00069	0.464
MOD_GSK3_1	465	472	PF00069	0.608
MOD_GSK3_1	477	484	PF00069	0.599
MOD_GSK3_1	562	569	PF00069	0.546
MOD_GSK3_1	607	614	PF00069	0.449
MOD_GSK3_1	650	657	PF00069	0.519
MOD_GSK3_1	689	696	PF00069	0.518
MOD_GSK3_1	712	719	PF00069	0.592
MOD_GSK3_1	737	744	PF00069	0.558
MOD_GSK3_1	768	775	PF00069	0.635
MOD_GSK3_1	829	836	PF00069	0.639
MOD_GSK3_1	927	934	PF00069	0.574
MOD_GSK3_1	941	948	PF00069	0.491
MOD_N-GLC_1	772	777	PF02516	0.651
MOD_N-GLC_1	953	958	PF02516	0.538
MOD_N-GLC_1	974	979	PF02516	0.503
MOD_N-GLC_2	607	609	PF02516	0.368
MOD_NEK2_1	147	152	PF00069	0.511
MOD_NEK2_1	246	251	PF00069	0.511
MOD_NEK2_1	383	388	PF00069	0.448
MOD_NEK2_1	41	46	PF00069	0.531
MOD_NEK2_1	689	694	PF00069	0.459
MOD_NEK2_1	695	700	PF00069	0.616
MOD_NEK2_1	835	840	PF00069	0.385
MOD_NEK2_1	941	946	PF00069	0.547
MOD_NEK2_2	143	148	PF00069	0.500
MOD_NEK2_2	845	850	PF00069	0.306
MOD_PIKK_1	508	514	PF00454	0.632
MOD_PIKK_1	693	699	PF00454	0.644
MOD_PIKK_1	783	789	PF00454	0.508
MOD_PK_1	400	406	PF00069	0.401
MOD_PK_1	805	811	PF00069	0.555
MOD_PKA_1	157	163	PF00069	0.447
MOD_PKA_1	400	406	PF00069	0.401
MOD_PKA_1	805	811	PF00069	0.550
MOD_PKA_2	157	163	PF00069	0.438
MOD_PKA_2	297	303	PF00069	0.506
MOD_PKA_2	611	617	PF00069	0.502
MOD_PKA_2	689	695	PF00069	0.522
MOD_PKA_2	805	811	PF00069	0.582
MOD_PKA_2	918	924	PF00069	0.554
MOD_PKB_1	398	406	PF00069	0.351
MOD_PKB_1	505	513	PF00069	0.617
MOD_PKB_1	796	804	PF00069	0.561
MOD_Plk_1	41	47	PF00069	0.530
MOD_Plk_1	51	57	PF00069	0.513
MOD_Plk_1	529	535	PF00069	0.632
MOD_Plk_1	865	871	PF00069	0.302
MOD_Plk_1	974	980	PF00069	0.502
MOD_Plk_2-3	1002	1008	PF00069	0.514
MOD_Plk_2-3	274	280	PF00069	0.554
MOD_Plk_4	403	409	PF00069	0.438
MOD_Plk_4	444	450	PF00069	0.568
MOD_Plk_4	690	696	PF00069	0.588
MOD_Plk_4	71	77	PF00069	0.422
MOD_Plk_4	737	743	PF00069	0.517
MOD_Plk_4	822	828	PF00069	0.635
MOD_Plk_4	865	871	PF00069	0.436
MOD_ProDKin_1	238	244	PF00069	0.517
MOD_ProDKin_1	317	323	PF00069	0.460
MOD_ProDKin_1	362	368	PF00069	0.535
MOD_ProDKin_1	369	375	PF00069	0.566
MOD_ProDKin_1	523	529	PF00069	0.601
MOD_ProDKin_1	550	556	PF00069	0.622
MOD_ProDKin_1	741	747	PF00069	0.584
MOD_ProDKin_1	812	818	PF00069	0.535
MOD_ProDKin_1	927	933	PF00069	0.576
MOD_SUMO_for_1	792	795	PF00179	0.517
TRG_DiLeu_BaEn_1	280	285	PF01217	0.532
TRG_DiLeu_BaEn_1	795	800	PF01217	0.491
TRG_DiLeu_BaEn_1	999	1004	PF01217	0.405
TRG_DiLeu_BaLyEn_6	132	137	PF01217	0.616
TRG_DiLeu_BaLyEn_6	320	325	PF01217	0.530
TRG_DiLeu_LyEn_5	109	114	PF01217	0.488
TRG_DiLeu_LyEn_5	795	800	PF01217	0.491
TRG_ENDOCYTIC_2	445	448	PF00928	0.393
TRG_ENDOCYTIC_2	73	76	PF00928	0.407
TRG_ENDOCYTIC_2	899	902	PF00928	0.426
TRG_ER_diArg_1	157	159	PF00400	0.502
TRG_ER_diArg_1	187	189	PF00400	0.392
TRG_ER_diArg_1	422	424	PF00400	0.531
TRG_ER_diArg_1	462	464	PF00400	0.499
TRG_ER_diArg_1	796	799	PF00400	0.489
TRG_ER_diArg_1	840	842	PF00400	0.341
TRG_Pf-PMV_PEXEL_1	14	19	PF00026	0.454
TRG_Pf-PMV_PEXEL_1	191	195	PF00026	0.351

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P442	Leptomonas seymouri	42%	100%
A0A3S7WTI6	Leishmania donovani	66%	99%
E9AQ38	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	97%
Q4QFE4	Leishmania major	65%	100%