SCP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H809_LEIBR

TriTrypDb:

LbrM.15.0390 , LBRM2903_150009300

Length:

676

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4H809

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H809

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	136	140	PF00656	0.378
CLV_C14_Caspase3-7	344	348	PF00656	0.485
CLV_NRD_NRD_1	12	14	PF00675	0.565
CLV_NRD_NRD_1	424	426	PF00675	0.592
CLV_NRD_NRD_1	542	544	PF00675	0.590
CLV_NRD_NRD_1	626	628	PF00675	0.556
CLV_NRD_NRD_1	651	653	PF00675	0.389
CLV_NRD_NRD_1	670	672	PF00675	0.533
CLV_PCSK_KEX2_1	12	14	PF00082	0.455
CLV_PCSK_KEX2_1	542	544	PF00082	0.556
CLV_PCSK_KEX2_1	626	628	PF00082	0.556
CLV_PCSK_KEX2_1	651	653	PF00082	0.392
CLV_PCSK_KEX2_1	670	672	PF00082	0.533
CLV_PCSK_PC7_1	666	672	PF00082	0.368
CLV_PCSK_SKI1_1	162	166	PF00082	0.693
CLV_PCSK_SKI1_1	191	195	PF00082	0.641
CLV_PCSK_SKI1_1	244	248	PF00082	0.695
CLV_PCSK_SKI1_1	483	487	PF00082	0.581
CLV_PCSK_SKI1_1	534	538	PF00082	0.751
CLV_PCSK_SKI1_1	59	63	PF00082	0.238
CLV_PCSK_SKI1_1	610	614	PF00082	0.678
CLV_Separin_Metazoa	120	124	PF03568	0.359
DEG_APCC_DBOX_1	58	66	PF00400	0.438
DEG_Nend_UBRbox_1	1	4	PF02207	0.624
DEG_SPOP_SBC_1	92	96	PF00917	0.334
DOC_CDC14_PxL_1	457	465	PF14671	0.480
DOC_CKS1_1	226	231	PF01111	0.455
DOC_CYCLIN_RxL_1	241	250	PF00134	0.474
DOC_CYCLIN_yCln2_LP_2	42	48	PF00134	0.704
DOC_CYCLIN_yCln2_LP_2	448	454	PF00134	0.323
DOC_MAPK_gen_1	626	632	PF00069	0.238
DOC_MAPK_MEF2A_6	143	151	PF00069	0.350
DOC_MAPK_MEF2A_6	522	530	PF00069	0.537
DOC_PP1_RVXF_1	189	196	PF00149	0.589
DOC_PP1_RVXF_1	495	502	PF00149	0.315
DOC_PP2B_LxvP_1	565	568	PF13499	0.536
DOC_PP4_FxxP_1	51	54	PF00568	0.632
DOC_PP4_MxPP_1	175	178	PF00568	0.360
DOC_USP7_MATH_1	121	125	PF00917	0.454
DOC_USP7_MATH_1	141	145	PF00917	0.434
DOC_USP7_MATH_1	296	300	PF00917	0.542
DOC_USP7_MATH_1	307	311	PF00917	0.619
DOC_USP7_MATH_1	318	322	PF00917	0.547
DOC_USP7_MATH_1	77	81	PF00917	0.477
DOC_USP7_MATH_1	92	96	PF00917	0.278
DOC_WW_Pin1_4	143	148	PF00397	0.364
DOC_WW_Pin1_4	225	230	PF00397	0.412
DOC_WW_Pin1_4	314	319	PF00397	0.443
DOC_WW_Pin1_4	405	410	PF00397	0.404
DOC_WW_Pin1_4	490	495	PF00397	0.514
DOC_WW_Pin1_4	621	626	PF00397	0.532
DOC_WW_Pin1_4	73	78	PF00397	0.482
LIG_14-3-3_CanoR_1	16	21	PF00244	0.717
LIG_14-3-3_CanoR_1	32	40	PF00244	0.708
LIG_14-3-3_CanoR_1	500	508	PF00244	0.510
LIG_14-3-3_CanoR_1	513	519	PF00244	0.366
LIG_14-3-3_CanoR_1	534	539	PF00244	0.474
LIG_14-3-3_CanoR_1	59	65	PF00244	0.560
LIG_14-3-3_CanoR_1	626	630	PF00244	0.238
LIG_14-3-3_CanoR_1	651	660	PF00244	0.529
LIG_14-3-3_CanoR_1	78	86	PF00244	0.538
LIG_BIR_III_4	131	135	PF00653	0.358
LIG_BRCT_BRCA1_1	110	114	PF00533	0.404
LIG_BRCT_BRCA1_1	82	86	PF00533	0.494
LIG_BRCT_BRCA1_2	82	88	PF00533	0.351
LIG_eIF4E_1	160	166	PF01652	0.318
LIG_eIF4E_1	241	247	PF01652	0.438
LIG_eIF4E_1	502	508	PF01652	0.443
LIG_EVH1_2	333	337	PF00568	0.398
LIG_FHA_1	235	241	PF00498	0.415
LIG_FHA_1	362	368	PF00498	0.465
LIG_FHA_1	378	384	PF00498	0.533
LIG_FHA_1	429	435	PF00498	0.389
LIG_FHA_1	48	54	PF00498	0.633
LIG_FHA_1	502	508	PF00498	0.523
LIG_FHA_1	535	541	PF00498	0.447
LIG_FHA_1	641	647	PF00498	0.311
LIG_FHA_2	382	388	PF00498	0.577
LIG_FHA_2	515	521	PF00498	0.416
LIG_GBD_Chelix_1	484	492	PF00786	0.554
LIG_LIR_Apic_2	50	54	PF02991	0.633
LIG_LIR_Apic_2	520	524	PF02991	0.490
LIG_LIR_Apic_2	555	561	PF02991	0.377
LIG_LIR_Gen_1	169	180	PF02991	0.528
LIG_LIR_Gen_1	263	270	PF02991	0.377
LIG_LIR_Gen_1	323	334	PF02991	0.508
LIG_LIR_Gen_1	635	646	PF02991	0.369
LIG_LIR_Gen_1	83	93	PF02991	0.523
LIG_LIR_Nem_3	118	122	PF02991	0.391
LIG_LIR_Nem_3	236	241	PF02991	0.408
LIG_LIR_Nem_3	263	269	PF02991	0.375
LIG_LIR_Nem_3	323	329	PF02991	0.508
LIG_LIR_Nem_3	595	600	PF02991	0.524
LIG_LIR_Nem_3	628	632	PF02991	0.390
LIG_LIR_Nem_3	635	641	PF02991	0.315
LIG_LIR_Nem_3	83	89	PF02991	0.465
LIG_LYPXL_S_1	596	600	PF13949	0.686
LIG_LYPXL_yS_3	597	600	PF13949	0.483
LIG_Pex14_1	156	160	PF04695	0.309
LIG_Pex14_2	612	616	PF04695	0.395
LIG_Pex14_2	629	633	PF04695	0.322
LIG_SH2_CRK	266	270	PF00017	0.533
LIG_SH2_CRK	379	383	PF00017	0.509
LIG_SH2_CRK	558	562	PF00017	0.374
LIG_SH2_STAP1	200	204	PF00017	0.480
LIG_SH2_STAP1	266	270	PF00017	0.565
LIG_SH2_STAP1	379	383	PF00017	0.581
LIG_SH2_STAP1	614	618	PF00017	0.525
LIG_SH2_STAT5	127	130	PF00017	0.402
LIG_SH2_STAT5	379	382	PF00017	0.543
LIG_SH2_STAT5	447	450	PF00017	0.493
LIG_SH2_STAT5	564	567	PF00017	0.415
LIG_SH2_STAT5	605	608	PF00017	0.489
LIG_SH2_STAT5	649	652	PF00017	0.539
LIG_SH3_3	223	229	PF00018	0.482
LIG_SH3_3	448	454	PF00018	0.323
LIG_SUMO_SIM_par_1	461	466	PF11976	0.483
LIG_SUMO_SIM_par_1	536	541	PF11976	0.531
LIG_TYR_ITIM	562	567	PF00017	0.530
LIG_WRC_WIRS_1	613	618	PF05994	0.526
MOD_CDK_SPK_2	621	626	PF00069	0.532
MOD_CDK_SPK_2	73	78	PF00069	0.482
MOD_CDK_SPxK_1	314	320	PF00069	0.444
MOD_CDK_SPxK_1	621	627	PF00069	0.355
MOD_CDK_SPxxK_3	490	497	PF00069	0.333
MOD_CK1_1	186	192	PF00069	0.486
MOD_CK1_1	233	239	PF00069	0.462
MOD_CK1_1	287	293	PF00069	0.570
MOD_CK1_1	299	305	PF00069	0.422
MOD_CK1_1	340	346	PF00069	0.578
MOD_CK1_1	401	407	PF00069	0.358
MOD_CK1_1	437	443	PF00069	0.449
MOD_CK1_1	490	496	PF00069	0.381
MOD_CK1_1	503	509	PF00069	0.311
MOD_CK1_1	547	553	PF00069	0.399
MOD_CK1_1	80	86	PF00069	0.498
MOD_CK1_1	95	101	PF00069	0.301
MOD_CK2_1	307	313	PF00069	0.444
MOD_CK2_1	381	387	PF00069	0.577
MOD_CK2_1	471	477	PF00069	0.580
MOD_CK2_1	506	512	PF00069	0.391
MOD_CK2_1	670	676	PF00069	0.624
MOD_DYRK1A_RPxSP_1	143	147	PF00069	0.372
MOD_GlcNHglycan	143	146	PF01048	0.749
MOD_GlcNHglycan	211	214	PF01048	0.624
MOD_GlcNHglycan	249	252	PF01048	0.673
MOD_GlcNHglycan	289	292	PF01048	0.732
MOD_GlcNHglycan	339	342	PF01048	0.814
MOD_GlcNHglycan	453	457	PF01048	0.575
MOD_GlcNHglycan	550	553	PF01048	0.717
MOD_GlcNHglycan	586	589	PF01048	0.707
MOD_GlcNHglycan	79	82	PF01048	0.632
MOD_GSK3_1	108	115	PF00069	0.430
MOD_GSK3_1	166	173	PF00069	0.453
MOD_GSK3_1	182	189	PF00069	0.458
MOD_GSK3_1	23	30	PF00069	0.632
MOD_GSK3_1	230	237	PF00069	0.417
MOD_GSK3_1	297	304	PF00069	0.471
MOD_GSK3_1	314	321	PF00069	0.441
MOD_GSK3_1	350	357	PF00069	0.566
MOD_GSK3_1	377	384	PF00069	0.515
MOD_GSK3_1	401	408	PF00069	0.484
MOD_GSK3_1	437	444	PF00069	0.405
MOD_GSK3_1	471	478	PF00069	0.465
MOD_GSK3_1	486	493	PF00069	0.431
MOD_GSK3_1	534	541	PF00069	0.470
MOD_GSK3_1	544	551	PF00069	0.494
MOD_GSK3_1	592	599	PF00069	0.603
MOD_GSK3_1	617	624	PF00069	0.470
MOD_GSK3_1	632	639	PF00069	0.411
MOD_GSK3_1	73	80	PF00069	0.562
MOD_GSK3_1	91	98	PF00069	0.357
MOD_LATS_1	14	20	PF00433	0.641
MOD_N-GLC_1	112	117	PF02516	0.620
MOD_N-GLC_1	166	171	PF02516	0.556
MOD_N-GLC_1	183	188	PF02516	0.578
MOD_N-GLC_1	234	239	PF02516	0.636
MOD_N-GLC_1	27	32	PF02516	0.473
MOD_N-GLC_1	354	359	PF02516	0.686
MOD_N-GLC_1	410	415	PF02516	0.794
MOD_N-GLC_1	434	439	PF02516	0.708
MOD_N-GLC_2	280	282	PF02516	0.659
MOD_N-GLC_2	480	482	PF02516	0.618
MOD_N-GLC_2	601	603	PF02516	0.714
MOD_NEK2_1	182	187	PF00069	0.450
MOD_NEK2_1	224	229	PF00069	0.559
MOD_NEK2_1	240	245	PF00069	0.331
MOD_NEK2_1	247	252	PF00069	0.464
MOD_NEK2_1	265	270	PF00069	0.322
MOD_NEK2_1	297	302	PF00069	0.521
MOD_NEK2_1	337	342	PF00069	0.591
MOD_NEK2_1	398	403	PF00069	0.496
MOD_NEK2_1	434	439	PF00069	0.421
MOD_NEK2_1	463	468	PF00069	0.446
MOD_NEK2_1	486	491	PF00069	0.446
MOD_NEK2_1	501	506	PF00069	0.427
MOD_NEK2_1	583	588	PF00069	0.522
MOD_NEK2_1	636	641	PF00069	0.351
MOD_NEK2_1	93	98	PF00069	0.462
MOD_OFUCOSY	197	202	PF10250	0.686
MOD_PIKK_1	23	29	PF00454	0.635
MOD_PIKK_1	434	440	PF00454	0.537
MOD_PKA_1	651	657	PF00069	0.629
MOD_PKA_1	670	676	PF00069	0.597
MOD_PKA_2	15	21	PF00069	0.644
MOD_PKA_2	282	288	PF00069	0.464
MOD_PKA_2	297	303	PF00069	0.431
MOD_PKA_2	544	550	PF00069	0.391
MOD_PKA_2	568	574	PF00069	0.488
MOD_PKA_2	625	631	PF00069	0.238
MOD_PKA_2	651	657	PF00069	0.588
MOD_PKA_2	670	676	PF00069	0.597
MOD_PKA_2	77	83	PF00069	0.550
MOD_Plk_1	112	118	PF00069	0.417
MOD_Plk_1	166	172	PF00069	0.381
MOD_Plk_1	183	189	PF00069	0.541
MOD_Plk_1	234	240	PF00069	0.438
MOD_Plk_1	354	360	PF00069	0.520
MOD_Plk_1	370	376	PF00069	0.426
MOD_Plk_1	390	396	PF00069	0.369
MOD_Plk_1	419	425	PF00069	0.376
MOD_Plk_4	183	189	PF00069	0.420
MOD_Plk_4	234	240	PF00069	0.438
MOD_Plk_4	265	271	PF00069	0.432
MOD_Plk_4	332	338	PF00069	0.512
MOD_Plk_4	370	376	PF00069	0.585
MOD_Plk_4	38	44	PF00069	0.807
MOD_Plk_4	401	407	PF00069	0.442
MOD_Plk_4	419	425	PF00069	0.557
MOD_Plk_4	503	509	PF00069	0.453
MOD_Plk_4	592	598	PF00069	0.599
MOD_Plk_4	60	66	PF00069	0.513
MOD_ProDKin_1	143	149	PF00069	0.355
MOD_ProDKin_1	225	231	PF00069	0.407
MOD_ProDKin_1	314	320	PF00069	0.444
MOD_ProDKin_1	405	411	PF00069	0.408
MOD_ProDKin_1	490	496	PF00069	0.511
MOD_ProDKin_1	621	627	PF00069	0.536
MOD_ProDKin_1	73	79	PF00069	0.480
MOD_SUMO_rev_2	489	499	PF00179	0.329
TRG_DiLeu_BaLyEn_6	558	563	PF01217	0.391
TRG_ENDOCYTIC_2	104	107	PF00928	0.337
TRG_ENDOCYTIC_2	266	269	PF00928	0.565
TRG_ENDOCYTIC_2	379	382	PF00928	0.513
TRG_ENDOCYTIC_2	564	567	PF00928	0.537
TRG_ENDOCYTIC_2	597	600	PF00928	0.579
TRG_ER_diArg_1	542	545	PF00400	0.367
TRG_ER_diArg_1	625	627	PF00400	0.352
TRG_ER_diArg_1	650	652	PF00400	0.598
TRG_Pf-PMV_PEXEL_1	191	196	PF00026	0.791
TRG_Pf-PMV_PEXEL_1	244	249	PF00026	0.620
TRG_Pf-PMV_PEXEL_1	32	36	PF00026	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3W1	Leptomonas seymouri	45%	100%
A0A3S5H6U2	Leishmania donovani	67%	100%
A4HWD7	Leishmania infantum	67%	100%
E9AQ37	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
Q4QFE5	Leishmania major	67%	100%