LeishMANIAdb
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Abhydrolase_3 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Abhydrolase_3 domain-containing protein
Gene product:
alpha/beta hydrolase fold, putative
Species:
Leishmania braziliensis
UniProt:
A4H807_LEIBR
TriTrypDb:
LbrM.15.0370 , LBRM2903_150008900
Length:
1064

Annotations

LeishMANIAdb annotations

A hydrolase similar to plant isoprenylcysteine alpha-carbonyl methylesterase (ICME). These might have a very special topology, with 2TMs on the N-terminus.. The family has 2 paralogs in Leishmaniids.. Localization: ER (by homology) / Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

A4H807
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H807

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 7
GO:0016787 hydrolase activity 2 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 357 361 PF00656 0.674
CLV_C14_Caspase3-7 624 628 PF00656 0.304
CLV_MEL_PAP_1 60 66 PF00089 0.368
CLV_NRD_NRD_1 124 126 PF00675 0.526
CLV_NRD_NRD_1 263 265 PF00675 0.570
CLV_NRD_NRD_1 384 386 PF00675 0.635
CLV_NRD_NRD_1 474 476 PF00675 0.629
CLV_NRD_NRD_1 483 485 PF00675 0.524
CLV_NRD_NRD_1 487 489 PF00675 0.500
CLV_NRD_NRD_1 496 498 PF00675 0.589
CLV_NRD_NRD_1 568 570 PF00675 0.322
CLV_NRD_NRD_1 62 64 PF00675 0.380
CLV_NRD_NRD_1 74 76 PF00675 0.412
CLV_NRD_NRD_1 753 755 PF00675 0.624
CLV_NRD_NRD_1 807 809 PF00675 0.675
CLV_NRD_NRD_1 816 818 PF00675 0.688
CLV_NRD_NRD_1 823 825 PF00675 0.699
CLV_NRD_NRD_1 855 857 PF00675 0.756
CLV_NRD_NRD_1 92 94 PF00675 0.536
CLV_PCSK_FUR_1 121 125 PF00082 0.531
CLV_PCSK_FUR_1 484 488 PF00082 0.651
CLV_PCSK_FUR_1 499 503 PF00082 0.501
CLV_PCSK_FUR_1 566 570 PF00082 0.486
CLV_PCSK_FUR_1 821 825 PF00082 0.688
CLV_PCSK_KEX2_1 121 123 PF00082 0.533
CLV_PCSK_KEX2_1 124 126 PF00082 0.524
CLV_PCSK_KEX2_1 263 265 PF00082 0.578
CLV_PCSK_KEX2_1 384 386 PF00082 0.657
CLV_PCSK_KEX2_1 474 476 PF00082 0.629
CLV_PCSK_KEX2_1 483 485 PF00082 0.524
CLV_PCSK_KEX2_1 486 488 PF00082 0.507
CLV_PCSK_KEX2_1 496 498 PF00082 0.589
CLV_PCSK_KEX2_1 501 503 PF00082 0.580
CLV_PCSK_KEX2_1 565 567 PF00082 0.495
CLV_PCSK_KEX2_1 568 570 PF00082 0.347
CLV_PCSK_KEX2_1 62 64 PF00082 0.380
CLV_PCSK_KEX2_1 73 75 PF00082 0.408
CLV_PCSK_KEX2_1 753 755 PF00082 0.624
CLV_PCSK_KEX2_1 807 809 PF00082 0.675
CLV_PCSK_KEX2_1 816 818 PF00082 0.688
CLV_PCSK_KEX2_1 823 825 PF00082 0.699
CLV_PCSK_KEX2_1 855 857 PF00082 0.756
CLV_PCSK_PC1ET2_1 501 503 PF00082 0.479
CLV_PCSK_PC1ET2_1 565 567 PF00082 0.494
CLV_PCSK_PC1ET2_1 570 572 PF00082 0.348
CLV_PCSK_PC1ET2_1 73 75 PF00082 0.380
CLV_PCSK_PC7_1 483 489 PF00082 0.584
CLV_PCSK_PC7_1 497 503 PF00082 0.426
CLV_PCSK_PC7_1 566 572 PF00082 0.419
CLV_PCSK_PC7_1 803 809 PF00082 0.657
CLV_PCSK_SKI1_1 444 448 PF00082 0.540
CLV_PCSK_SKI1_1 728 732 PF00082 0.512
CLV_PCSK_SKI1_1 75 79 PF00082 0.451
CLV_PCSK_SKI1_1 773 777 PF00082 0.560
CLV_PCSK_SKI1_1 823 827 PF00082 0.725
CLV_PCSK_SKI1_1 89 93 PF00082 0.461
CLV_Separin_Metazoa 90 94 PF03568 0.627
DEG_APCC_DBOX_1 727 735 PF00400 0.312
DEG_APCC_DBOX_1 74 82 PF00400 0.652
DEG_APCC_DBOX_1 822 830 PF00400 0.399
DEG_SPOP_SBC_1 256 260 PF00917 0.835
DEG_SPOP_SBC_1 837 841 PF00917 0.641
DOC_CKS1_1 155 160 PF01111 0.642
DOC_CKS1_1 509 514 PF01111 0.655
DOC_MAPK_gen_1 121 128 PF00069 0.693
DOC_MAPK_gen_1 565 576 PF00069 0.505
DOC_MAPK_gen_1 71 80 PF00069 0.615
DOC_MAPK_gen_1 855 862 PF00069 0.527
DOC_MAPK_gen_1 938 948 PF00069 0.563
DOC_MAPK_MEF2A_6 540 547 PF00069 0.559
DOC_MAPK_MEF2A_6 569 578 PF00069 0.504
DOC_MAPK_MEF2A_6 941 950 PF00069 0.530
DOC_PP1_RVXF_1 5 12 PF00149 0.546
DOC_PP2B_LxvP_1 1044 1047 PF13499 0.436
DOC_PP2B_LxvP_1 547 550 PF13499 0.567
DOC_PP4_FxxP_1 274 277 PF00568 0.684
DOC_PP4_MxPP_1 101 104 PF00568 0.632
DOC_SPAK_OSR1_1 329 333 PF12202 0.683
DOC_USP7_MATH_1 1029 1033 PF00917 0.619
DOC_USP7_MATH_1 255 259 PF00917 0.829
DOC_USP7_MATH_1 267 271 PF00917 0.814
DOC_USP7_MATH_1 309 313 PF00917 0.777
DOC_USP7_MATH_1 337 341 PF00917 0.762
DOC_USP7_MATH_1 371 375 PF00917 0.803
DOC_USP7_MATH_1 399 403 PF00917 0.856
DOC_USP7_MATH_1 435 439 PF00917 0.797
DOC_USP7_MATH_1 561 565 PF00917 0.555
DOC_USP7_MATH_1 698 702 PF00917 0.344
DOC_USP7_MATH_1 781 785 PF00917 0.431
DOC_USP7_MATH_1 819 823 PF00917 0.478
DOC_USP7_MATH_1 837 841 PF00917 0.569
DOC_USP7_MATH_1 969 973 PF00917 0.414
DOC_USP7_MATH_2 1047 1053 PF00917 0.473
DOC_WW_Pin1_4 1021 1026 PF00397 0.529
DOC_WW_Pin1_4 1059 1064 PF00397 0.375
DOC_WW_Pin1_4 154 159 PF00397 0.643
DOC_WW_Pin1_4 165 170 PF00397 0.615
DOC_WW_Pin1_4 216 221 PF00397 0.805
DOC_WW_Pin1_4 265 270 PF00397 0.780
DOC_WW_Pin1_4 433 438 PF00397 0.793
DOC_WW_Pin1_4 508 513 PF00397 0.665
DOC_WW_Pin1_4 54 59 PF00397 0.429
DOC_WW_Pin1_4 923 928 PF00397 0.556
LIG_14-3-3_CanoR_1 1056 1061 PF00244 0.443
LIG_14-3-3_CanoR_1 207 212 PF00244 0.826
LIG_14-3-3_CanoR_1 515 524 PF00244 0.716
LIG_14-3-3_CanoR_1 540 544 PF00244 0.567
LIG_14-3-3_CanoR_1 62 67 PF00244 0.598
LIG_14-3-3_CanoR_1 803 810 PF00244 0.533
LIG_14-3-3_CanoR_1 838 844 PF00244 0.466
LIG_14-3-3_CanoR_1 855 862 PF00244 0.527
LIG_Actin_WH2_1 74 91 PF00022 0.626
LIG_Actin_WH2_2 73 91 PF00022 0.723
LIG_AP2alpha_2 896 898 PF02296 0.432
LIG_APCC_ABBA_1 775 780 PF00400 0.400
LIG_BIR_III_2 901 905 PF00653 0.463
LIG_BIR_III_4 452 456 PF00653 0.647
LIG_BRCT_BRCA1_1 894 898 PF00533 0.435
LIG_BRCT_BRCA1_1 958 962 PF00533 0.438
LIG_EH1_1 3 11 PF00400 0.614
LIG_EH1_1 711 719 PF00400 0.343
LIG_eIF4E_1 4 10 PF01652 0.527
LIG_eIF4E_1 712 718 PF01652 0.340
LIG_FHA_1 12 18 PF00498 0.411
LIG_FHA_1 23 29 PF00498 0.411
LIG_FHA_1 301 307 PF00498 0.809
LIG_FHA_1 457 463 PF00498 0.825
LIG_FHA_1 540 546 PF00498 0.561
LIG_FHA_1 620 626 PF00498 0.346
LIG_FHA_1 756 762 PF00498 0.403
LIG_FHA_1 843 849 PF00498 0.520
LIG_FHA_1 855 861 PF00498 0.396
LIG_FHA_2 1017 1023 PF00498 0.437
LIG_FHA_2 291 297 PF00498 0.759
LIG_FHA_2 514 520 PF00498 0.728
LIG_FHA_2 614 620 PF00498 0.304
LIG_FHA_2 869 875 PF00498 0.618
LIG_GBD_Chelix_1 9 17 PF00786 0.438
LIG_IRF3_LxIS_1 948 954 PF10401 0.324
LIG_LIR_Apic_2 272 277 PF02991 0.682
LIG_LIR_Gen_1 520 530 PF02991 0.774
LIG_LIR_Gen_1 587 598 PF02991 0.355
LIG_LIR_Gen_1 688 698 PF02991 0.389
LIG_LIR_Gen_1 764 775 PF02991 0.388
LIG_LIR_Nem_3 520 526 PF02991 0.781
LIG_LIR_Nem_3 609 613 PF02991 0.304
LIG_LIR_Nem_3 679 683 PF02991 0.394
LIG_LIR_Nem_3 688 694 PF02991 0.381
LIG_LIR_Nem_3 764 770 PF02991 0.388
LIG_LIR_Nem_3 947 953 PF02991 0.385
LIG_PDZ_Class_1 1059 1064 PF00595 0.375
LIG_SH2_CRK 691 695 PF00017 0.418
LIG_SH2_PTP2 705 708 PF00017 0.335
LIG_SH2_SRC 732 735 PF00017 0.390
LIG_SH2_STAP1 39 43 PF00017 0.261
LIG_SH2_STAP1 744 748 PF00017 0.389
LIG_SH2_STAP1 915 919 PF00017 0.446
LIG_SH2_STAP1 981 985 PF00017 0.478
LIG_SH2_STAT3 560 563 PF00017 0.734
LIG_SH2_STAT3 905 908 PF00017 0.495
LIG_SH2_STAT5 54 57 PF00017 0.445
LIG_SH2_STAT5 603 606 PF00017 0.304
LIG_SH2_STAT5 705 708 PF00017 0.335
LIG_SH2_STAT5 749 752 PF00017 0.374
LIG_SH2_STAT5 804 807 PF00017 0.437
LIG_SH2_STAT5 905 908 PF00017 0.467
LIG_SH3_3 152 158 PF00018 0.666
LIG_SH3_3 319 325 PF00018 0.738
LIG_SH3_3 602 608 PF00018 0.304
LIG_SH3_3 680 686 PF00018 0.473
LIG_SH3_3 901 907 PF00018 0.463
LIG_SH3_3 929 935 PF00018 0.581
LIG_SUMO_SIM_anti_2 252 260 PF11976 0.657
LIG_SUMO_SIM_anti_2 542 547 PF11976 0.592
LIG_SUMO_SIM_anti_2 887 893 PF11976 0.442
LIG_SUMO_SIM_par_1 572 577 PF11976 0.353
LIG_SUMO_SIM_par_1 621 627 PF11976 0.304
LIG_TRAF2_1 1047 1050 PF00917 0.397
LIG_TRAF2_1 402 405 PF00917 0.868
LIG_TRAF2_1 799 802 PF00917 0.421
LIG_TYR_ITAM 688 708 PF00017 0.306
LIG_TYR_ITIM 427 432 PF00017 0.765
LIG_TYR_ITIM 689 694 PF00017 0.355
MOD_CDC14_SPxK_1 219 222 PF00782 0.653
MOD_CDK_SPK_2 154 159 PF00069 0.643
MOD_CDK_SPxK_1 216 222 PF00069 0.653
MOD_CDK_SPxxK_3 508 515 PF00069 0.661
MOD_CK1_1 1012 1018 PF00069 0.566
MOD_CK1_1 1032 1038 PF00069 0.427
MOD_CK1_1 110 116 PF00069 0.708
MOD_CK1_1 168 174 PF00069 0.652
MOD_CK1_1 216 222 PF00069 0.833
MOD_CK1_1 354 360 PF00069 0.743
MOD_CK1_1 369 375 PF00069 0.833
MOD_CK1_1 436 442 PF00069 0.646
MOD_CK1_1 65 71 PF00069 0.600
MOD_CK1_1 661 667 PF00069 0.338
MOD_CK1_1 839 845 PF00069 0.624
MOD_CK1_1 923 929 PF00069 0.542
MOD_CK2_1 290 296 PF00069 0.760
MOD_CK2_1 371 377 PF00069 0.696
MOD_CK2_1 399 405 PF00069 0.781
MOD_CK2_1 513 519 PF00069 0.732
MOD_CK2_1 613 619 PF00069 0.304
MOD_CK2_1 868 874 PF00069 0.608
MOD_CK2_1 933 939 PF00069 0.502
MOD_GlcNHglycan 1004 1007 PF01048 0.793
MOD_GlcNHglycan 1009 1012 PF01048 0.757
MOD_GlcNHglycan 112 115 PF01048 0.433
MOD_GlcNHglycan 14 17 PF01048 0.411
MOD_GlcNHglycan 170 173 PF01048 0.476
MOD_GlcNHglycan 190 193 PF01048 0.413
MOD_GlcNHglycan 225 229 PF01048 0.605
MOD_GlcNHglycan 271 274 PF01048 0.544
MOD_GlcNHglycan 310 314 PF01048 0.583
MOD_GlcNHglycan 353 356 PF01048 0.496
MOD_GlcNHglycan 373 376 PF01048 0.649
MOD_GlcNHglycan 385 388 PF01048 0.521
MOD_GlcNHglycan 39 42 PF01048 0.261
MOD_GlcNHglycan 468 471 PF01048 0.597
MOD_GlcNHglycan 488 491 PF01048 0.640
MOD_GlcNHglycan 503 507 PF01048 0.482
MOD_GlcNHglycan 577 581 PF01048 0.513
MOD_GlcNHglycan 651 654 PF01048 0.504
MOD_GlcNHglycan 668 671 PF01048 0.549
MOD_GlcNHglycan 708 711 PF01048 0.536
MOD_GlcNHglycan 782 786 PF01048 0.598
MOD_GlcNHglycan 850 853 PF01048 0.733
MOD_GlcNHglycan 953 956 PF01048 0.532
MOD_GlcNHglycan 982 985 PF01048 0.619
MOD_GSK3_1 1012 1019 PF00069 0.562
MOD_GSK3_1 140 147 PF00069 0.813
MOD_GSK3_1 212 219 PF00069 0.771
MOD_GSK3_1 265 272 PF00069 0.714
MOD_GSK3_1 279 286 PF00069 0.667
MOD_GSK3_1 309 316 PF00069 0.760
MOD_GSK3_1 328 335 PF00069 0.660
MOD_GSK3_1 365 372 PF00069 0.677
MOD_GSK3_1 456 463 PF00069 0.852
MOD_GSK3_1 466 473 PF00069 0.647
MOD_GSK3_1 474 481 PF00069 0.717
MOD_GSK3_1 550 557 PF00069 0.640
MOD_GSK3_1 584 591 PF00069 0.411
MOD_GSK3_1 619 626 PF00069 0.346
MOD_GSK3_1 62 69 PF00069 0.586
MOD_GSK3_1 802 809 PF00069 0.529
MOD_GSK3_1 838 845 PF00069 0.597
MOD_GSK3_1 846 853 PF00069 0.626
MOD_GSK3_1 864 871 PF00069 0.585
MOD_GSK3_1 989 996 PF00069 0.514
MOD_LATS_1 472 478 PF00433 0.682
MOD_LATS_1 513 519 PF00433 0.656
MOD_N-GLC_1 644 649 PF02516 0.546
MOD_N-GLC_1 989 994 PF02516 0.637
MOD_N-GLC_2 408 410 PF02516 0.635
MOD_NEK2_1 1009 1014 PF00069 0.570
MOD_NEK2_1 109 114 PF00069 0.636
MOD_NEK2_1 12 17 PF00069 0.411
MOD_NEK2_1 298 303 PF00069 0.690
MOD_NEK2_1 37 42 PF00069 0.261
MOD_NEK2_1 383 388 PF00069 0.760
MOD_NEK2_1 589 594 PF00069 0.346
MOD_NEK2_1 951 956 PF00069 0.332
MOD_NEK2_2 698 703 PF00069 0.347
MOD_NEK2_2 742 747 PF00069 0.363
MOD_OFUCOSY 966 973 PF10250 0.657
MOD_PIKK_1 412 418 PF00454 0.668
MOD_PIKK_1 460 466 PF00454 0.858
MOD_PIKK_1 661 667 PF00454 0.304
MOD_PIKK_1 802 808 PF00454 0.345
MOD_PK_1 93 99 PF00069 0.688
MOD_PKA_1 474 480 PF00069 0.709
MOD_PKA_1 486 492 PF00069 0.741
MOD_PKA_1 62 68 PF00069 0.586
MOD_PKA_1 93 99 PF00069 0.688
MOD_PKA_2 245 251 PF00069 0.837
MOD_PKA_2 328 334 PF00069 0.706
MOD_PKA_2 383 389 PF00069 0.758
MOD_PKA_2 474 480 PF00069 0.709
MOD_PKA_2 486 492 PF00069 0.818
MOD_PKA_2 539 545 PF00069 0.572
MOD_PKA_2 62 68 PF00069 0.586
MOD_PKA_2 698 704 PF00069 0.345
MOD_PKA_2 742 748 PF00069 0.389
MOD_PKA_2 802 808 PF00069 0.465
MOD_PKA_2 837 843 PF00069 0.463
MOD_PKA_2 854 860 PF00069 0.607
MOD_PKB_1 186 194 PF00069 0.668
MOD_PKB_1 484 492 PF00069 0.782
MOD_Plk_1 1049 1055 PF00069 0.417
MOD_Plk_1 644 650 PF00069 0.304
MOD_Plk_1 788 794 PF00069 0.374
MOD_Plk_2-3 619 625 PF00069 0.346
MOD_Plk_2-3 676 682 PF00069 0.376
MOD_Plk_4 1009 1015 PF00069 0.627
MOD_Plk_4 1032 1038 PF00069 0.580
MOD_Plk_4 1056 1062 PF00069 0.443
MOD_Plk_4 207 213 PF00069 0.647
MOD_Plk_4 550 556 PF00069 0.525
MOD_Plk_4 589 595 PF00069 0.311
MOD_Plk_4 644 650 PF00069 0.324
MOD_Plk_4 655 661 PF00069 0.275
MOD_Plk_4 789 795 PF00069 0.485
MOD_Plk_4 93 99 PF00069 0.590
MOD_ProDKin_1 1021 1027 PF00069 0.532
MOD_ProDKin_1 154 160 PF00069 0.644
MOD_ProDKin_1 165 171 PF00069 0.616
MOD_ProDKin_1 216 222 PF00069 0.806
MOD_ProDKin_1 265 271 PF00069 0.783
MOD_ProDKin_1 433 439 PF00069 0.793
MOD_ProDKin_1 508 514 PF00069 0.662
MOD_ProDKin_1 54 60 PF00069 0.423
MOD_ProDKin_1 923 929 PF00069 0.556
MOD_SUMO_for_1 500 503 PF00179 0.677
TRG_DiLeu_BaEn_1 789 794 PF01217 0.481
TRG_DiLeu_BaEn_1 947 952 PF01217 0.502
TRG_DiLeu_BaEn_2 518 524 PF01217 0.610
TRG_DiLeu_BaLyEn_6 821 826 PF01217 0.491
TRG_ENDOCYTIC_2 429 432 PF00928 0.769
TRG_ENDOCYTIC_2 603 606 PF00928 0.304
TRG_ENDOCYTIC_2 610 613 PF00928 0.304
TRG_ENDOCYTIC_2 680 683 PF00928 0.396
TRG_ENDOCYTIC_2 691 694 PF00928 0.419
TRG_ENDOCYTIC_2 705 708 PF00928 0.324
TRG_ENDOCYTIC_2 727 730 PF00928 0.328
TRG_ER_diArg_1 121 124 PF00400 0.732
TRG_ER_diArg_1 148 151 PF00400 0.638
TRG_ER_diArg_1 263 265 PF00400 0.773
TRG_ER_diArg_1 383 385 PF00400 0.862
TRG_ER_diArg_1 483 486 PF00400 0.775
TRG_ER_diArg_1 496 499 PF00400 0.792
TRG_ER_diArg_1 566 569 PF00400 0.650
TRG_ER_diArg_1 61 63 PF00400 0.575
TRG_ER_diArg_1 821 824 PF00400 0.502
TRG_NLS_Bipartite_1 62 77 PF00514 0.610
TRG_NLS_MonoExtC_3 564 569 PF00514 0.646
TRG_NLS_MonoExtN_4 566 573 PF00514 0.504
TRG_NLS_MonoExtN_4 71 77 PF00514 0.635
TRG_Pf-PMV_PEXEL_1 596 600 PF00026 0.546
TRG_Pf-PMV_PEXEL_1 79 84 PF00026 0.455

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P440 Leptomonas seymouri 47% 92%
A0A3S5H6U1 Leishmania donovani 70% 100%
A4HWD5 Leishmania infantum 70% 100%
E9AQ35 Leishmania mexicana (strain MHOM/GT/2001/U1103) 67% 100%
Q4QFE7 Leishmania major 69% 95%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS