Putative ecotin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative ecotin

Gene product:

Isoprenylcysteine alpha-carbonyl methylesterase, putative

Species:

Leishmania braziliensis

UniProt:

A4H806_LEIBR

TriTrypDb:

LbrM.15.0360 , LBRM2903_150008800

Length:

728

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4H806

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H806

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0016787	hydrolase activity	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	237	241	PF00656	0.741
CLV_C14_Caspase3-7	376	380	PF00656	0.254
CLV_C14_Caspase3-7	586	590	PF00656	0.373
CLV_C14_Caspase3-7	638	642	PF00656	0.423
CLV_C14_Caspase3-7	700	704	PF00656	0.459
CLV_MEL_PAP_1	64	70	PF00089	0.334
CLV_NRD_NRD_1	125	127	PF00675	0.427
CLV_NRD_NRD_1	277	279	PF00675	0.446
CLV_NRD_NRD_1	295	297	PF00675	0.504
CLV_NRD_NRD_1	305	307	PF00675	0.414
CLV_NRD_NRD_1	315	317	PF00675	0.487
CLV_NRD_NRD_1	320	322	PF00675	0.417
CLV_NRD_NRD_1	505	507	PF00675	0.606
CLV_NRD_NRD_1	616	618	PF00675	0.628
CLV_NRD_NRD_1	66	68	PF00675	0.318
CLV_PCSK_KEX2_1	125	127	PF00082	0.471
CLV_PCSK_KEX2_1	305	307	PF00082	0.502
CLV_PCSK_KEX2_1	314	316	PF00082	0.601
CLV_PCSK_KEX2_1	322	324	PF00082	0.297
CLV_PCSK_KEX2_1	505	507	PF00082	0.604
CLV_PCSK_KEX2_1	616	618	PF00082	0.629
CLV_PCSK_KEX2_1	66	68	PF00082	0.318
CLV_PCSK_PC1ET2_1	314	316	PF00082	0.517
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.177
CLV_PCSK_PC7_1	318	324	PF00082	0.333
CLV_PCSK_SKI1_1	32	36	PF00082	0.556
CLV_PCSK_SKI1_1	39	43	PF00082	0.445
CLV_PCSK_SKI1_1	480	484	PF00082	0.508
CLV_PCSK_SKI1_1	525	529	PF00082	0.500
CLV_PCSK_SKI1_1	573	577	PF00082	0.591
CLV_PCSK_SKI1_1	624	628	PF00082	0.610
DEG_APCC_DBOX_1	479	487	PF00400	0.330
DEG_APCC_DBOX_1	714	722	PF00400	0.422
DOC_CYCLIN_yClb5_NLxxxL_5	77	85	PF00134	0.577
DOC_CYCLIN_yCln2_LP_2	571	577	PF00134	0.400
DOC_MAPK_DCC_7	569	577	PF00069	0.413
DOC_MAPK_gen_1	318	328	PF00069	0.454
DOC_MAPK_HePTP_8	253	265	PF00069	0.535
DOC_MAPK_MEF2A_6	125	134	PF00069	0.629
DOC_MAPK_MEF2A_6	256	265	PF00069	0.511
DOC_MAPK_MEF2A_6	321	330	PF00069	0.454
DOC_PP1_RVXF_1	37	44	PF00149	0.279
DOC_PP2B_LxvP_1	132	135	PF13499	0.631
DOC_PP2B_LxvP_1	263	266	PF13499	0.533
DOC_USP7_MATH_1	121	125	PF00917	0.642
DOC_USP7_MATH_1	133	137	PF00917	0.600
DOC_USP7_MATH_1	174	178	PF00917	0.622
DOC_USP7_MATH_1	220	224	PF00917	0.674
DOC_USP7_MATH_1	231	235	PF00917	0.735
DOC_USP7_MATH_1	266	270	PF00917	0.647
DOC_USP7_MATH_1	450	454	PF00917	0.329
DOC_USP7_MATH_1	533	537	PF00917	0.352
DOC_USP7_MATH_1	709	713	PF00917	0.356
DOC_USP7_MATH_1	93	97	PF00917	0.620
DOC_USP7_UBL2_3	569	573	PF12436	0.438
DOC_WW_Pin1_4	126	131	PF00397	0.730
DOC_WW_Pin1_4	169	174	PF00397	0.668
DOC_WW_Pin1_4	58	63	PF00397	0.376
DOC_WW_Pin1_4	677	682	PF00397	0.501
DOC_WW_Pin1_4	684	689	PF00397	0.505
DOC_WW_Pin1_4	705	710	PF00397	0.398
LIG_14-3-3_CanoR_1	178	185	PF00244	0.664
LIG_14-3-3_CanoR_1	256	260	PF00244	0.531
LIG_14-3-3_CanoR_1	39	44	PF00244	0.316
LIG_14-3-3_CanoR_1	495	499	PF00244	0.372
LIG_14-3-3_CanoR_1	646	651	PF00244	0.546
LIG_14-3-3_CanoR_1	66	71	PF00244	0.564
LIG_14-3-3_CanoR_1	720	725	PF00244	0.415
LIG_APCC_ABBA_1	527	532	PF00400	0.318
LIG_BRCT_BRCA1_1	99	103	PF00533	0.579
LIG_CaM_IQ_9	193	209	PF13499	0.698
LIG_Clathr_ClatBox_1	669	673	PF01394	0.447
LIG_CtBP_PxDLS_1	164	168	PF00389	0.606
LIG_EH1_1	463	471	PF00400	0.295
LIG_eIF4E_1	340	346	PF01652	0.385
LIG_eIF4E_1	464	470	PF01652	0.229
LIG_FHA_1	256	262	PF00498	0.506
LIG_FHA_1	372	378	PF00498	0.321
LIG_FHA_1	508	514	PF00498	0.357
LIG_FHA_1	586	592	PF00498	0.337
LIG_FHA_1	645	651	PF00498	0.532
LIG_FHA_1	73	79	PF00498	0.643
LIG_FHA_2	166	172	PF00498	0.615
LIG_FHA_2	237	243	PF00498	0.735
LIG_FHA_2	366	372	PF00498	0.254
LIG_FHA_2	584	590	PF00498	0.387
LIG_FHA_2	698	704	PF00498	0.457
LIG_LIR_Apic_2	47	53	PF02991	0.291
LIG_LIR_Apic_2	689	695	PF02991	0.503
LIG_LIR_Apic_2	723	727	PF02991	0.388
LIG_LIR_Gen_1	42	51	PF02991	0.385
LIG_LIR_Gen_1	5	14	PF02991	0.543
LIG_LIR_Gen_1	516	527	PF02991	0.329
LIG_LIR_Gen_1	576	585	PF02991	0.320
LIG_LIR_Nem_3	260	265	PF02991	0.504
LIG_LIR_Nem_3	361	365	PF02991	0.254
LIG_LIR_Nem_3	42	46	PF02991	0.286
LIG_LIR_Nem_3	431	435	PF02991	0.341
LIG_LIR_Nem_3	5	9	PF02991	0.548
LIG_LIR_Nem_3	516	522	PF02991	0.336
LIG_LIR_Nem_3	576	582	PF02991	0.313
LIG_LIR_Nem_3	604	608	PF02991	0.365
LIG_LRP6_Inhibitor_1	60	66	PF00058	0.338
LIG_NRBOX	55	61	PF00104	0.210
LIG_NRBOX	80	86	PF00104	0.643
LIG_PCNA_TLS_4	256	263	PF02747	0.506
LIG_PCNA_yPIPBox_3	343	353	PF02747	0.321
LIG_Pex14_2	6	10	PF04695	0.604
LIG_SH2_CRK	443	447	PF00017	0.412
LIG_SH2_CRK	692	696	PF00017	0.480
LIG_SH2_PTP2	457	460	PF00017	0.275
LIG_SH2_PTP2	579	582	PF00017	0.329
LIG_SH2_PTP2	724	727	PF00017	0.389
LIG_SH2_SRC	262	265	PF00017	0.512
LIG_SH2_SRC	484	487	PF00017	0.320
LIG_SH2_STAP1	496	500	PF00017	0.361
LIG_SH2_STAT3	8	11	PF00017	0.533
LIG_SH2_STAT5	262	265	PF00017	0.540
LIG_SH2_STAT5	340	343	PF00017	0.351
LIG_SH2_STAT5	355	358	PF00017	0.203
LIG_SH2_STAT5	457	460	PF00017	0.275
LIG_SH2_STAT5	496	499	PF00017	0.303
LIG_SH2_STAT5	50	53	PF00017	0.291
LIG_SH2_STAT5	501	504	PF00017	0.316
LIG_SH2_STAT5	547	550	PF00017	0.349
LIG_SH2_STAT5	579	582	PF00017	0.329
LIG_SH2_STAT5	58	61	PF00017	0.366
LIG_SH2_STAT5	724	727	PF00017	0.396
LIG_SH2_STAT5	8	11	PF00017	0.533
LIG_SH3_1	305	311	PF00018	0.629
LIG_SH3_1	692	698	PF00018	0.484
LIG_SH3_3	127	133	PF00018	0.756
LIG_SH3_3	305	311	PF00018	0.629
LIG_SH3_3	354	360	PF00018	0.254
LIG_SH3_3	432	438	PF00018	0.472
LIG_SH3_3	692	698	PF00018	0.484
LIG_SUMO_SIM_par_1	324	329	PF11976	0.291
LIG_SUMO_SIM_par_1	373	379	PF11976	0.254
LIG_SUMO_SIM_par_1	573	578	PF11976	0.339
LIG_TRAF2_1	168	171	PF00917	0.648
LIG_TRAF2_1	560	563	PF00917	0.304
LIG_TRFH_1	579	583	PF08558	0.311
LIG_TRFH_1	58	62	PF08558	0.472
LIG_TRFH_1	705	709	PF08558	0.319
LIG_TYR_ITIM	577	582	PF00017	0.365
LIG_TYR_ITIM	606	611	PF00017	0.418
LIG_UBA3_1	23	32	PF00899	0.291
LIG_UBA3_1	270	279	PF00899	0.611
LIG_UBA3_1	669	677	PF00899	0.395
MOD_CK1_1	104	110	PF00069	0.689
MOD_CK1_1	172	178	PF00069	0.720
MOD_CK1_1	222	228	PF00069	0.809
MOD_CK1_1	234	240	PF00069	0.754
MOD_CK1_1	280	286	PF00069	0.695
MOD_CK1_1	292	298	PF00069	0.698
MOD_CK1_1	413	419	PF00069	0.274
MOD_CK1_1	645	651	PF00069	0.562
MOD_CK1_1	664	670	PF00069	0.597
MOD_CK1_1	684	690	PF00069	0.345
MOD_CK1_1	69	75	PF00069	0.552
MOD_CK1_1	713	719	PF00069	0.485
MOD_CK2_1	133	139	PF00069	0.619
MOD_CK2_1	165	171	PF00069	0.611
MOD_CK2_1	215	221	PF00069	0.748
MOD_CK2_1	238	244	PF00069	0.745
MOD_CK2_1	365	371	PF00069	0.254
MOD_CK2_1	587	593	PF00069	0.380
MOD_DYRK1A_RPxSP_1	126	130	PF00069	0.628
MOD_GlcNHglycan	135	138	PF01048	0.471
MOD_GlcNHglycan	18	21	PF01048	0.210
MOD_GlcNHglycan	227	230	PF01048	0.524
MOD_GlcNHglycan	403	406	PF01048	0.467
MOD_GlcNHglycan	420	423	PF01048	0.510
MOD_GlcNHglycan	460	463	PF01048	0.483
MOD_GlcNHglycan	534	538	PF01048	0.536
MOD_GlcNHglycan	541	544	PF01048	0.516
MOD_GlcNHglycan	653	656	PF01048	0.816
MOD_GlcNHglycan	683	686	PF01048	0.598
MOD_GlcNHglycan	95	98	PF01048	0.445
MOD_GlcNHglycan	99	102	PF01048	0.484
MOD_GSK3_1	165	172	PF00069	0.693
MOD_GSK3_1	174	181	PF00069	0.696
MOD_GSK3_1	185	192	PF00069	0.606
MOD_GSK3_1	215	222	PF00069	0.686
MOD_GSK3_1	234	241	PF00069	0.699
MOD_GSK3_1	371	378	PF00069	0.339
MOD_GSK3_1	533	540	PF00069	0.353
MOD_GSK3_1	583	590	PF00069	0.398
MOD_GSK3_1	642	649	PF00069	0.585
MOD_GSK3_1	657	664	PF00069	0.498
MOD_GSK3_1	66	73	PF00069	0.550
MOD_GSK3_1	673	680	PF00069	0.496
MOD_GSK3_1	705	712	PF00069	0.406
MOD_GSK3_1	93	100	PF00069	0.667
MOD_LATS_1	644	650	PF00433	0.546
MOD_N-GLC_1	165	170	PF02516	0.411
MOD_N-GLC_1	185	190	PF02516	0.490
MOD_N-GLC_1	234	239	PF02516	0.540
MOD_N-GLC_1	280	285	PF02516	0.392
MOD_N-GLC_1	396	401	PF02516	0.521
MOD_NEK2_1	16	21	PF00069	0.364
MOD_NEK2_1	189	194	PF00069	0.588
MOD_NEK2_1	215	220	PF00069	0.668
MOD_NEK2_1	34	39	PF00069	0.405
MOD_NEK2_1	539	544	PF00069	0.294
MOD_NEK2_2	266	271	PF00069	0.645
MOD_NEK2_2	450	455	PF00069	0.331
MOD_PIKK_1	201	207	PF00454	0.727
MOD_PIKK_1	222	228	PF00454	0.815
MOD_PIKK_1	413	419	PF00454	0.254
MOD_PK_1	646	652	PF00069	0.461
MOD_PKA_1	66	72	PF00069	0.550
MOD_PKA_2	119	125	PF00069	0.613
MOD_PKA_2	141	147	PF00069	0.686
MOD_PKA_2	255	261	PF00069	0.533
MOD_PKA_2	277	283	PF00069	0.714
MOD_PKA_2	450	456	PF00069	0.313
MOD_PKA_2	494	500	PF00069	0.321
MOD_PKA_2	645	651	PF00069	0.545
MOD_PKA_2	66	72	PF00069	0.529
MOD_PKA_2	73	79	PF00069	0.570
MOD_Plk_1	185	191	PF00069	0.725
MOD_Plk_1	220	226	PF00069	0.638
MOD_Plk_1	234	240	PF00069	0.759
MOD_Plk_1	396	402	PF00069	0.254
MOD_Plk_2-3	141	147	PF00069	0.670
MOD_Plk_2-3	236	242	PF00069	0.741
MOD_Plk_2-3	371	377	PF00069	0.321
MOD_Plk_2-3	428	434	PF00069	0.330
MOD_Plk_2-3	604	610	PF00069	0.277
MOD_Plk_4	155	161	PF00069	0.674
MOD_Plk_4	266	272	PF00069	0.655
MOD_Plk_4	396	402	PF00069	0.266
MOD_Plk_4	407	413	PF00069	0.236
MOD_Plk_4	587	593	PF00069	0.432
MOD_Plk_4	604	610	PF00069	0.306
MOD_Plk_4	720	726	PF00069	0.379
MOD_ProDKin_1	126	132	PF00069	0.731
MOD_ProDKin_1	169	175	PF00069	0.669
MOD_ProDKin_1	58	64	PF00069	0.369
MOD_ProDKin_1	677	683	PF00069	0.502
MOD_ProDKin_1	684	690	PF00069	0.504
MOD_ProDKin_1	705	711	PF00069	0.400
MOD_SUMO_rev_2	275	280	PF00179	0.585
TRG_DiLeu_BaLyEn_6	315	320	PF01217	0.587
TRG_ENDOCYTIC_2	262	265	PF00928	0.512
TRG_ENDOCYTIC_2	355	358	PF00928	0.254
TRG_ENDOCYTIC_2	362	365	PF00928	0.254
TRG_ENDOCYTIC_2	432	435	PF00928	0.439
TRG_ENDOCYTIC_2	457	460	PF00928	0.292
TRG_ENDOCYTIC_2	479	482	PF00928	0.323
TRG_ENDOCYTIC_2	579	582	PF00928	0.329
TRG_ENDOCYTIC_2	608	611	PF00928	0.435
TRG_ER_diArg_1	200	203	PF00400	0.751
TRG_ER_diArg_1	315	318	PF00400	0.693
TRG_ER_diArg_1	320	323	PF00400	0.643
TRG_ER_diArg_1	65	67	PF00400	0.525
TRG_NLS_Bipartite_1	296	318	PF00514	0.783
TRG_NLS_MonoExtC_3	313	318	PF00514	0.779
TRG_NLS_MonoExtC_3	320	325	PF00514	0.391
TRG_NLS_MonoExtN_4	311	318	PF00514	0.769
TRG_Pf-PMV_PEXEL_1	476	481	PF00026	0.651

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ74	Leptomonas seymouri	63%	100%
A0A1X0NTZ0	Trypanosomatidae	43%	100%
A0A3Q8IC72	Leishmania donovani	79%	96%
A0A3R7K197	Trypanosoma rangeli	49%	100%
A4HWD4	Leishmania infantum	79%	96%
E9AQ34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QFE8	Leishmania major	78%	100%