Putative ecotin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Putative ecotin

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H805_LEIBR

TriTrypDb:

LbrM.15.0350 , LBRM2903_150008700

Length:

609

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H805

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H805

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	136	140	PF00656	0.613
CLV_C14_Caspase3-7	471	475	PF00656	0.568
CLV_NRD_NRD_1	151	153	PF00675	0.756
CLV_NRD_NRD_1	16	18	PF00675	0.566
CLV_NRD_NRD_1	354	356	PF00675	0.578
CLV_NRD_NRD_1	495	497	PF00675	0.646
CLV_NRD_NRD_1	500	502	PF00675	0.662
CLV_PCSK_FUR_1	149	153	PF00082	0.763
CLV_PCSK_KEX2_1	151	153	PF00082	0.756
CLV_PCSK_KEX2_1	16	18	PF00082	0.566
CLV_PCSK_KEX2_1	354	356	PF00082	0.578
CLV_PCSK_KEX2_1	499	501	PF00082	0.678
CLV_PCSK_PC1ET2_1	499	501	PF00082	0.678
CLV_PCSK_PC7_1	496	502	PF00082	0.669
CLV_PCSK_SKI1_1	178	182	PF00082	0.672
CLV_PCSK_SKI1_1	204	208	PF00082	0.588
CLV_PCSK_SKI1_1	555	559	PF00082	0.578
CLV_PCSK_SKI1_1	588	592	PF00082	0.606
DEG_APCC_DBOX_1	587	595	PF00400	0.717
DEG_Nend_Nbox_1	1	3	PF02207	0.527
DEG_SPOP_SBC_1	103	107	PF00917	0.567
DEG_SPOP_SBC_1	228	232	PF00917	0.706
DEG_SPOP_SBC_1	233	237	PF00917	0.660
DOC_CYCLIN_yCln2_LP_2	159	165	PF00134	0.532
DOC_CYCLIN_yCln2_LP_2	439	445	PF00134	0.553
DOC_MAPK_gen_1	149	158	PF00069	0.711
DOC_MAPK_MEF2A_6	149	158	PF00069	0.518
DOC_PP2B_LxvP_1	27	30	PF13499	0.616
DOC_PP2B_LxvP_1	574	577	PF13499	0.691
DOC_USP7_MATH_1	103	107	PF00917	0.711
DOC_USP7_MATH_1	154	158	PF00917	0.637
DOC_USP7_MATH_1	169	173	PF00917	0.774
DOC_USP7_MATH_1	228	232	PF00917	0.763
DOC_USP7_MATH_1	33	37	PF00917	0.588
DOC_USP7_MATH_1	337	341	PF00917	0.503
DOC_USP7_MATH_1	409	413	PF00917	0.600
DOC_USP7_MATH_1	420	424	PF00917	0.570
DOC_USP7_MATH_1	430	434	PF00917	0.497
DOC_USP7_MATH_1	48	52	PF00917	0.746
DOC_WW_Pin1_4	158	163	PF00397	0.530
DOC_WW_Pin1_4	317	322	PF00397	0.599
DOC_WW_Pin1_4	390	395	PF00397	0.833
DOC_WW_Pin1_4	521	526	PF00397	0.696
DOC_WW_Pin1_4	565	570	PF00397	0.667
LIG_14-3-3_CanoR_1	16	20	PF00244	0.716
LIG_14-3-3_CanoR_1	209	215	PF00244	0.676
LIG_14-3-3_CanoR_1	218	226	PF00244	0.651
LIG_14-3-3_CanoR_1	301	310	PF00244	0.837
LIG_14-3-3_CanoR_1	327	336	PF00244	0.723
LIG_14-3-3_CanoR_1	545	552	PF00244	0.603
LIG_14-3-3_CanoR_1	588	596	PF00244	0.460
LIG_Actin_WH2_2	119	135	PF00022	0.618
LIG_BRCT_BRCA1_1	156	160	PF00533	0.529
LIG_BRCT_BRCA1_1	196	200	PF00533	0.551
LIG_CSL_BTD_1	406	409	PF09270	0.541
LIG_FHA_1	205	211	PF00498	0.548
LIG_FHA_1	237	243	PF00498	0.576
LIG_FHA_1	265	271	PF00498	0.558
LIG_FHA_1	276	282	PF00498	0.561
LIG_FHA_1	329	335	PF00498	0.630
LIG_FHA_1	426	432	PF00498	0.555
LIG_FHA_1	462	468	PF00498	0.824
LIG_FHA_1	556	562	PF00498	0.724
LIG_FHA_2	115	121	PF00498	0.500
LIG_FHA_2	387	393	PF00498	0.567
LIG_FHA_2	455	461	PF00498	0.576
LIG_FHA_2	493	499	PF00498	0.726
LIG_FHA_2	534	540	PF00498	0.600
LIG_GBD_Chelix_1	583	591	PF00786	0.560
LIG_LIR_Apic_2	190	195	PF02991	0.692
LIG_LIR_Gen_1	111	119	PF02991	0.617
LIG_LIR_Gen_1	121	132	PF02991	0.510
LIG_LIR_Gen_1	413	420	PF02991	0.563
LIG_LIR_Gen_1	478	485	PF02991	0.670
LIG_LIR_Nem_3	111	115	PF02991	0.629
LIG_LIR_Nem_3	121	127	PF02991	0.524
LIG_LIR_Nem_3	413	419	PF02991	0.563
LIG_LIR_Nem_3	478	484	PF02991	0.676
LIG_Pex14_2	596	600	PF04695	0.711
LIG_PTAP_UEV_1	41	46	PF05743	0.558
LIG_SH2_CRK	112	116	PF00017	0.620
LIG_SH2_CRK	124	128	PF00017	0.494
LIG_SH2_CRK	192	196	PF00017	0.689
LIG_SH2_NCK_1	192	196	PF00017	0.689
LIG_SH2_NCK_1	273	277	PF00017	0.486
LIG_SH2_SRC	128	131	PF00017	0.597
LIG_SH2_STAP1	124	128	PF00017	0.740
LIG_SH2_STAP1	273	277	PF00017	0.688
LIG_SH2_STAT5	192	195	PF00017	0.789
LIG_SH2_STAT5	595	598	PF00017	0.574
LIG_SH3_3	193	199	PF00018	0.774
LIG_SH3_3	23	29	PF00018	0.574
LIG_SH3_3	239	245	PF00018	0.615
LIG_SH3_3	39	45	PF00018	0.797
LIG_SH3_3	403	409	PF00018	0.712
LIG_SH3_3	439	445	PF00018	0.753
LIG_SH3_3	522	528	PF00018	0.716
LIG_SH3_3	558	564	PF00018	0.730
LIG_SH3_3	97	103	PF00018	0.778
LIG_SUMO_SIM_anti_2	155	161	PF11976	0.529
LIG_SUMO_SIM_par_1	334	341	PF11976	0.497
LIG_TRAF2_1	118	121	PF00917	0.631
LIG_TRFH_1	79	83	PF08558	0.598
LIG_TYR_ITIM	122	127	PF00017	0.485
LIG_WW_3	298	302	PF00397	0.810
LIG_WW_3	576	580	PF00397	0.549
MOD_CDK_SPxK_1	521	527	PF00069	0.563
MOD_CK1_1	161	167	PF00069	0.798
MOD_CK1_1	221	227	PF00069	0.710
MOD_CK1_1	232	238	PF00069	0.695
MOD_CK1_1	249	255	PF00069	0.626
MOD_CK1_1	260	266	PF00069	0.728
MOD_CK1_1	36	42	PF00069	0.652
MOD_CK1_1	410	416	PF00069	0.797
MOD_CK1_1	423	429	PF00069	0.607
MOD_CK1_1	454	460	PF00069	0.710
MOD_CK1_1	488	494	PF00069	0.639
MOD_CK1_1	51	57	PF00069	0.792
MOD_CK1_1	519	525	PF00069	0.831
MOD_CK2_1	114	120	PF00069	0.585
MOD_CK2_1	454	460	PF00069	0.586
MOD_CK2_1	492	498	PF00069	0.607
MOD_CK2_1	504	510	PF00069	0.790
MOD_CK2_1	533	539	PF00069	0.560
MOD_GlcNHglycan	210	213	PF01048	0.666
MOD_GlcNHglycan	226	229	PF01048	0.735
MOD_GlcNHglycan	231	234	PF01048	0.754
MOD_GlcNHglycan	262	265	PF01048	0.728
MOD_GlcNHglycan	292	295	PF01048	0.532
MOD_GlcNHglycan	305	308	PF01048	0.706
MOD_GlcNHglycan	400	403	PF01048	0.691
MOD_GlcNHglycan	432	435	PF01048	0.763
MOD_GlcNHglycan	454	457	PF01048	0.769
MOD_GlcNHglycan	50	53	PF01048	0.738
MOD_GlcNHglycan	506	509	PF01048	0.707
MOD_GlcNHglycan	528	531	PF01048	0.702
MOD_GlcNHglycan	59	62	PF01048	0.485
MOD_GlcNHglycan	71	74	PF01048	0.559
MOD_GSK3_1	104	111	PF00069	0.677
MOD_GSK3_1	139	146	PF00069	0.648
MOD_GSK3_1	154	161	PF00069	0.586
MOD_GSK3_1	190	197	PF00069	0.779
MOD_GSK3_1	204	211	PF00069	0.702
MOD_GSK3_1	214	221	PF00069	0.682
MOD_GSK3_1	224	231	PF00069	0.715
MOD_GSK3_1	232	239	PF00069	0.627
MOD_GSK3_1	260	267	PF00069	0.668
MOD_GSK3_1	36	43	PF00069	0.696
MOD_GSK3_1	386	393	PF00069	0.599
MOD_GSK3_1	420	427	PF00069	0.611
MOD_GSK3_1	446	453	PF00069	0.762
MOD_GSK3_1	488	495	PF00069	0.565
MOD_GSK3_1	5	12	PF00069	0.596
MOD_GSK3_1	500	507	PF00069	0.562
MOD_GSK3_1	53	60	PF00069	0.685
MOD_GSK3_1	535	542	PF00069	0.657
MOD_GSK3_1	565	572	PF00069	0.674
MOD_N-GLC_1	249	254	PF02516	0.560
MOD_N-GLC_1	317	322	PF02516	0.545
MOD_NEK2_1	144	149	PF00069	0.668
MOD_NEK2_1	163	168	PF00069	0.669
MOD_NEK2_1	214	219	PF00069	0.746
MOD_NEK2_1	302	307	PF00069	0.578
MOD_NEK2_1	346	351	PF00069	0.489
MOD_NEK2_1	504	509	PF00069	0.710
MOD_NEK2_1	57	62	PF00069	0.596
MOD_NEK2_1	583	588	PF00069	0.632
MOD_PIKK_1	218	224	PF00454	0.703
MOD_PK_1	152	158	PF00069	0.526
MOD_PKA_1	500	506	PF00069	0.557
MOD_PKA_2	15	21	PF00069	0.521
MOD_PKA_2	208	214	PF00069	0.695
MOD_PKA_2	252	258	PF00069	0.696
MOD_PKA_2	420	426	PF00069	0.564
MOD_PKA_2	485	491	PF00069	0.654
MOD_PKA_2	500	506	PF00069	0.699
MOD_PKA_2	526	532	PF00069	0.565
MOD_Plk_1	346	352	PF00069	0.497
MOD_Plk_1	36	42	PF00069	0.549
MOD_Plk_4	104	110	PF00069	0.485
MOD_Plk_4	154	160	PF00069	0.613
MOD_Plk_4	221	227	PF00069	0.728
MOD_ProDKin_1	158	164	PF00069	0.531
MOD_ProDKin_1	317	323	PF00069	0.594
MOD_ProDKin_1	390	396	PF00069	0.834
MOD_ProDKin_1	521	527	PF00069	0.694
MOD_ProDKin_1	565	571	PF00069	0.669
MOD_SUMO_for_1	20	23	PF00179	0.758
TRG_DiLeu_BaEn_4	22	28	PF01217	0.516
TRG_DiLeu_BaLyEn_6	176	181	PF01217	0.541
TRG_ENDOCYTIC_2	112	115	PF00928	0.623
TRG_ENDOCYTIC_2	124	127	PF00928	0.633
TRG_ER_diArg_1	148	151	PF00400	0.745
TRG_ER_diArg_1	15	17	PF00400	0.549
TRG_ER_diArg_1	353	355	PF00400	0.574
TRG_ER_diArg_1	493	496	PF00400	0.529
TRG_Pf-PMV_PEXEL_1	17	22	PF00026	0.738
TRG_Pf-PMV_PEXEL_1	348	352	PF00026	0.763
TRG_Pf-PMV_PEXEL_1	437	441	PF00026	0.555

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC10	Leptomonas seymouri	32%	97%
A0A3S7WTB9	Leishmania donovani	59%	94%
A4HWD3	Leishmania infantum	60%	93%
E9AQ33	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	93%
Q4QFE9	Leishmania major	58%	100%