Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H803_LEIBR

TriTrypDb:

LbrM.15.0330 , LBRM2903_150008500

Length:

794

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H803

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H803

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.710
CLV_C14_Caspase3-7	201	205	PF00656	0.551
CLV_C14_Caspase3-7	408	412	PF00656	0.313
CLV_C14_Caspase3-7	639	643	PF00656	0.674
CLV_C14_Caspase3-7	655	659	PF00656	0.544
CLV_NRD_NRD_1	117	119	PF00675	0.491
CLV_NRD_NRD_1	13	15	PF00675	0.504
CLV_NRD_NRD_1	307	309	PF00675	0.398
CLV_NRD_NRD_1	324	326	PF00675	0.360
CLV_NRD_NRD_1	334	336	PF00675	0.463
CLV_NRD_NRD_1	451	453	PF00675	0.457
CLV_NRD_NRD_1	496	498	PF00675	0.457
CLV_NRD_NRD_1	607	609	PF00675	0.616
CLV_NRD_NRD_1	616	618	PF00675	0.569
CLV_NRD_NRD_1	722	724	PF00675	0.655
CLV_NRD_NRD_1	725	727	PF00675	0.677
CLV_NRD_NRD_1	756	758	PF00675	0.584
CLV_NRD_NRD_1	766	768	PF00675	0.678
CLV_PCSK_FUR_1	11	15	PF00082	0.506
CLV_PCSK_FUR_1	332	336	PF00082	0.461
CLV_PCSK_FUR_1	608	612	PF00082	0.725
CLV_PCSK_FUR_1	614	618	PF00082	0.670
CLV_PCSK_FUR_1	723	727	PF00082	0.577
CLV_PCSK_KEX2_1	117	119	PF00082	0.491
CLV_PCSK_KEX2_1	13	15	PF00082	0.547
CLV_PCSK_KEX2_1	303	305	PF00082	0.445
CLV_PCSK_KEX2_1	307	309	PF00082	0.405
CLV_PCSK_KEX2_1	334	336	PF00082	0.463
CLV_PCSK_KEX2_1	451	453	PF00082	0.461
CLV_PCSK_KEX2_1	496	498	PF00082	0.457
CLV_PCSK_KEX2_1	610	612	PF00082	0.661
CLV_PCSK_KEX2_1	616	618	PF00082	0.571
CLV_PCSK_KEX2_1	722	724	PF00082	0.651
CLV_PCSK_KEX2_1	725	727	PF00082	0.673
CLV_PCSK_KEX2_1	756	758	PF00082	0.593
CLV_PCSK_KEX2_1	766	768	PF00082	0.678
CLV_PCSK_PC1ET2_1	303	305	PF00082	0.317
CLV_PCSK_PC1ET2_1	610	612	PF00082	0.649
CLV_PCSK_PC7_1	492	498	PF00082	0.411
CLV_PCSK_PC7_1	606	612	PF00082	0.605
CLV_PCSK_PC7_1	762	768	PF00082	0.537
CLV_PCSK_SKI1_1	155	159	PF00082	0.438
CLV_PCSK_SKI1_1	26	30	PF00082	0.516
CLV_PCSK_SKI1_1	285	289	PF00082	0.383
CLV_PCSK_SKI1_1	326	330	PF00082	0.439
CLV_PCSK_SKI1_1	37	41	PF00082	0.556
CLV_PCSK_SKI1_1	4	8	PF00082	0.601
CLV_PCSK_SKI1_1	551	555	PF00082	0.449
CLV_PCSK_SKI1_1	726	730	PF00082	0.693
DEG_APCC_DBOX_1	706	714	PF00400	0.570
DEG_APCC_KENBOX_2	502	506	PF00400	0.477
DEG_SCF_FBW7_1	591	598	PF00400	0.489
DEG_SPOP_SBC_1	168	172	PF00917	0.601
DEG_SPOP_SBC_1	193	197	PF00917	0.581
DEG_SPOP_SBC_1	651	655	PF00917	0.614
DOC_CKS1_1	592	597	PF01111	0.492
DOC_CYCLIN_RxL_1	152	161	PF00134	0.490
DOC_CYCLIN_yCln2_LP_2	28	34	PF00134	0.493
DOC_CYCLIN_yCln2_LP_2	426	432	PF00134	0.343
DOC_CYCLIN_yCln2_LP_2	485	491	PF00134	0.385
DOC_CYCLIN_yCln2_LP_2	585	591	PF00134	0.641
DOC_CYCLIN_yCln2_LP_2	80	86	PF00134	0.503
DOC_MAPK_DCC_7	155	164	PF00069	0.484
DOC_MAPK_DCC_7	467	475	PF00069	0.381
DOC_MAPK_gen_1	117	128	PF00069	0.419
DOC_MAPK_gen_1	303	313	PF00069	0.383
DOC_MAPK_gen_1	358	366	PF00069	0.336
DOC_MAPK_gen_1	756	763	PF00069	0.432
DOC_MAPK_MEF2A_6	155	164	PF00069	0.484
DOC_MAPK_MEF2A_6	467	475	PF00069	0.381
DOC_MAPK_MEF2A_6	756	763	PF00069	0.432
DOC_MAPK_NFAT4_5	756	764	PF00069	0.433
DOC_PP1_RVXF_1	549	556	PF00149	0.570
DOC_PP2B_LxvP_1	113	116	PF13499	0.664
DOC_PP2B_LxvP_1	157	160	PF13499	0.338
DOC_PP2B_LxvP_1	366	369	PF13499	0.379
DOC_PP2B_LxvP_1	713	716	PF13499	0.570
DOC_PP2B_LxvP_1	80	83	PF13499	0.501
DOC_PP4_FxxP_1	402	405	PF00568	0.356
DOC_USP7_MATH_1	168	172	PF00917	0.532
DOC_USP7_MATH_1	193	197	PF00917	0.579
DOC_USP7_MATH_1	245	249	PF00917	0.322
DOC_USP7_MATH_1	338	342	PF00917	0.433
DOC_USP7_MATH_1	474	478	PF00917	0.516
DOC_USP7_MATH_1	595	599	PF00917	0.604
DOC_USP7_MATH_1	601	605	PF00917	0.570
DOC_USP7_MATH_1	647	651	PF00917	0.710
DOC_USP7_MATH_1	728	732	PF00917	0.770
DOC_USP7_MATH_1	98	102	PF00917	0.635
DOC_USP7_UBL2_3	503	507	PF12436	0.483
DOC_WW_Pin1_4	12	17	PF00397	0.610
DOC_WW_Pin1_4	43	48	PF00397	0.559
DOC_WW_Pin1_4	465	470	PF00397	0.356
DOC_WW_Pin1_4	517	522	PF00397	0.379
DOC_WW_Pin1_4	591	596	PF00397	0.650
DOC_WW_Pin1_4	597	602	PF00397	0.598
DOC_WW_Pin1_4	739	744	PF00397	0.516
DOC_WW_Pin1_4	771	776	PF00397	0.737
LIG_14-3-3_CanoR_1	139	144	PF00244	0.418
LIG_14-3-3_CanoR_1	169	176	PF00244	0.667
LIG_14-3-3_CanoR_1	26	31	PF00244	0.480
LIG_14-3-3_CanoR_1	37	42	PF00244	0.632
LIG_Actin_WH2_2	413	430	PF00022	0.250
LIG_APCC_ABBA_1	288	293	PF00400	0.301
LIG_BIR_III_4	180	184	PF00653	0.519
LIG_BRCT_BRCA1_1	295	299	PF00533	0.282
LIG_CNOT1_NIM_1	206	215	PF04054	0.449
LIG_CtBP_PxDLS_1	665	669	PF00389	0.720
LIG_eIF4E_1	227	233	PF01652	0.476
LIG_FHA_1	121	127	PF00498	0.504
LIG_FHA_1	144	150	PF00498	0.380
LIG_FHA_1	189	195	PF00498	0.505
LIG_FHA_1	20	26	PF00498	0.449
LIG_FHA_1	215	221	PF00498	0.431
LIG_FHA_1	272	278	PF00498	0.324
LIG_FHA_1	292	298	PF00498	0.275
LIG_FHA_1	331	337	PF00498	0.575
LIG_FHA_1	38	44	PF00498	0.432
LIG_FHA_1	46	52	PF00498	0.537
LIG_FHA_1	5	11	PF00498	0.667
LIG_FHA_1	57	63	PF00498	0.507
LIG_FHA_2	214	220	PF00498	0.431
LIG_FHA_2	406	412	PF00498	0.302
LIG_FHA_2	439	445	PF00498	0.428
LIG_FHA_2	591	597	PF00498	0.595
LIG_FHA_2	786	792	PF00498	0.625
LIG_LIR_Apic_2	577	581	PF02991	0.398
LIG_LIR_Gen_1	204	212	PF02991	0.482
LIG_LIR_Gen_1	441	450	PF02991	0.343
LIG_LIR_Nem_3	151	157	PF02991	0.364
LIG_LIR_Nem_3	204	209	PF02991	0.507
LIG_LIR_Nem_3	211	215	PF02991	0.427
LIG_LIR_Nem_3	441	445	PF02991	0.399
LIG_LIR_Nem_3	457	462	PF02991	0.312
LIG_MYND_1	156	160	PF01753	0.343
LIG_PCNA_yPIPBox_3	223	233	PF02747	0.464
LIG_SH2_CRK	212	216	PF00017	0.398
LIG_SH2_CRK	727	731	PF00017	0.481
LIG_SH2_NCK_1	727	731	PF00017	0.589
LIG_SH2_PTP2	472	475	PF00017	0.372
LIG_SH2_PTP2	578	581	PF00017	0.398
LIG_SH2_SRC	567	570	PF00017	0.492
LIG_SH2_SRC	578	581	PF00017	0.452
LIG_SH2_SRC	683	686	PF00017	0.468
LIG_SH2_STAP1	206	210	PF00017	0.378
LIG_SH2_STAP1	346	350	PF00017	0.422
LIG_SH2_STAP1	362	366	PF00017	0.329
LIG_SH2_STAT3	346	349	PF00017	0.526
LIG_SH2_STAT3	398	401	PF00017	0.476
LIG_SH2_STAT5	143	146	PF00017	0.328
LIG_SH2_STAT5	240	243	PF00017	0.345
LIG_SH2_STAT5	260	263	PF00017	0.214
LIG_SH2_STAT5	472	475	PF00017	0.372
LIG_SH2_STAT5	542	545	PF00017	0.442
LIG_SH2_STAT5	567	570	PF00017	0.342
LIG_SH2_STAT5	578	581	PF00017	0.375
LIG_SH3_1	772	778	PF00018	0.503
LIG_SH3_3	468	474	PF00018	0.385
LIG_SH3_3	515	521	PF00018	0.442
LIG_SH3_3	585	591	PF00018	0.475
LIG_SH3_3	772	778	PF00018	0.611
LIG_SUMO_SIM_anti_2	216	222	PF11976	0.432
LIG_SUMO_SIM_anti_2	363	368	PF11976	0.309
LIG_SUMO_SIM_par_1	155	161	PF11976	0.389
LIG_SUMO_SIM_par_1	216	222	PF11976	0.305
LIG_SUMO_SIM_par_1	279	286	PF11976	0.387
LIG_SUMO_SIM_par_1	293	298	PF11976	0.367
LIG_SUMO_SIM_par_1	309	315	PF11976	0.285
LIG_SUMO_SIM_par_1	526	532	PF11976	0.331
LIG_TRAF2_1	669	672	PF00917	0.707
LIG_TRAF2_1	687	690	PF00917	0.662
LIG_TYR_ITIM	210	215	PF00017	0.430
LIG_WRC_WIRS_1	241	246	PF05994	0.355
LIG_WW_1	469	472	PF00397	0.402
MOD_CDK_SPK_2	12	17	PF00069	0.610
MOD_CDK_SPxK_1	597	603	PF00069	0.592
MOD_CDK_SPxxK_3	517	524	PF00069	0.387
MOD_CK1_1	195	201	PF00069	0.570
MOD_CK1_1	222	228	PF00069	0.248
MOD_CK1_1	463	469	PF00069	0.328
MOD_CK1_1	517	523	PF00069	0.303
MOD_CK1_1	650	656	PF00069	0.624
MOD_CK1_1	703	709	PF00069	0.452
MOD_CK1_1	741	747	PF00069	0.733
MOD_CK2_1	213	219	PF00069	0.420
MOD_CK2_1	311	317	PF00069	0.290
MOD_CK2_1	526	532	PF00069	0.448
MOD_CK2_1	590	596	PF00069	0.531
MOD_CK2_1	678	684	PF00069	0.605
MOD_CK2_1	773	779	PF00069	0.535
MOD_CK2_1	785	791	PF00069	0.565
MOD_GlcNHglycan	200	203	PF01048	0.548
MOD_GlcNHglycan	352	355	PF01048	0.411
MOD_GlcNHglycan	52	56	PF01048	0.585
MOD_GlcNHglycan	548	551	PF01048	0.447
MOD_GlcNHglycan	564	567	PF01048	0.330
MOD_GlcNHglycan	572	575	PF01048	0.336
MOD_GlcNHglycan	596	600	PF01048	0.722
MOD_GlcNHglycan	603	606	PF01048	0.679
MOD_GlcNHglycan	620	623	PF01048	0.606
MOD_GlcNHglycan	634	637	PF01048	0.554
MOD_GlcNHglycan	649	652	PF01048	0.561
MOD_GlcNHglycan	678	683	PF01048	0.501
MOD_GlcNHglycan	743	746	PF01048	0.737
MOD_GlcNHglycan	788	791	PF01048	0.518
MOD_GlcNHglycan	94	97	PF01048	0.781
MOD_GSK3_1	105	112	PF00069	0.636
MOD_GSK3_1	127	134	PF00069	0.379
MOD_GSK3_1	139	146	PF00069	0.326
MOD_GSK3_1	184	191	PF00069	0.622
MOD_GSK3_1	192	199	PF00069	0.541
MOD_GSK3_1	291	298	PF00069	0.502
MOD_GSK3_1	590	597	PF00069	0.716
MOD_GSK3_1	618	625	PF00069	0.706
MOD_GSK3_1	647	654	PF00069	0.806
MOD_GSK3_1	730	737	PF00069	0.687
MOD_GSK3_1	739	746	PF00069	0.716
MOD_GSK3_1	786	793	PF00069	0.705
MOD_NEK2_1	295	300	PF00069	0.281
MOD_NEK2_1	385	390	PF00069	0.481
MOD_NEK2_1	51	56	PF00069	0.549
MOD_NEK2_1	62	67	PF00069	0.707
MOD_NEK2_1	700	705	PF00069	0.462
MOD_NEK2_1	91	96	PF00069	0.587
MOD_NEK2_2	127	132	PF00069	0.396
MOD_NEK2_2	6	11	PF00069	0.702
MOD_PIKK_1	338	344	PF00454	0.427
MOD_PIKK_1	386	392	PF00454	0.371
MOD_PKA_1	616	622	PF00069	0.629
MOD_PKA_2	120	126	PF00069	0.438
MOD_PKA_2	168	174	PF00069	0.498
MOD_PKA_2	222	228	PF00069	0.461
MOD_PKA_2	616	622	PF00069	0.659
MOD_PKB_1	24	32	PF00069	0.416
MOD_PKB_1	614	622	PF00069	0.658
MOD_Plk_1	256	262	PF00069	0.308
MOD_Plk_1	362	368	PF00069	0.327
MOD_Plk_1	689	695	PF00069	0.507
MOD_Plk_1	700	706	PF00069	0.549
MOD_Plk_2-3	438	444	PF00069	0.402
MOD_Plk_4	139	145	PF00069	0.359
MOD_Plk_4	245	251	PF00069	0.288
MOD_Plk_4	256	262	PF00069	0.308
MOD_Plk_4	318	324	PF00069	0.375
MOD_Plk_4	362	368	PF00069	0.330
MOD_Plk_4	460	466	PF00069	0.385
MOD_Plk_4	526	532	PF00069	0.448
MOD_ProDKin_1	12	18	PF00069	0.608
MOD_ProDKin_1	43	49	PF00069	0.563
MOD_ProDKin_1	465	471	PF00069	0.363
MOD_ProDKin_1	517	523	PF00069	0.371
MOD_ProDKin_1	591	597	PF00069	0.652
MOD_ProDKin_1	739	745	PF00069	0.514
MOD_ProDKin_1	771	777	PF00069	0.739
TRG_DiLeu_BaEn_1	23	28	PF01217	0.537
TRG_DiLeu_BaLyEn_6	153	158	PF01217	0.353
TRG_DiLeu_BaLyEn_6	39	44	PF01217	0.529
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.513
TRG_DiLeu_LyEn_5	23	28	PF01217	0.459
TRG_ENDOCYTIC_2	206	209	PF00928	0.504
TRG_ENDOCYTIC_2	212	215	PF00928	0.397
TRG_ENDOCYTIC_2	472	475	PF00928	0.372
TRG_ER_diArg_1	10	13	PF00400	0.665
TRG_ER_diArg_1	116	118	PF00400	0.521
TRG_ER_diArg_1	24	27	PF00400	0.414
TRG_ER_diArg_1	306	308	PF00400	0.382
TRG_ER_diArg_1	332	335	PF00400	0.467
TRG_ER_diArg_1	358	361	PF00400	0.369
TRG_ER_diArg_1	450	452	PF00400	0.477
TRG_ER_diArg_1	495	497	PF00400	0.449
TRG_ER_diArg_1	614	617	PF00400	0.570
TRG_ER_diArg_1	722	725	PF00400	0.655
TRG_ER_diArg_1	755	757	PF00400	0.612
TRG_ER_diArg_1	759	762	PF00400	0.627
TRG_NLS_MonoCore_2	607	612	PF00514	0.603
TRG_NLS_MonoExtN_4	606	613	PF00514	0.689
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.368
TRG_Pf-PMV_PEXEL_1	253	257	PF00026	0.338
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.726

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU74	Leptomonas seymouri	64%	100%
A0A1X0NU60	Trypanosomatidae	46%	100%
A0A3S7WTA7	Leishmania donovani	80%	99%
A0A422N3L6	Trypanosoma rangeli	50%	100%
A4HWD1	Leishmania infantum	80%	99%
C9ZNX5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AQ31	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	99%
Q4QFF1	Leishmania major	80%	100%
V5BL46	Trypanosoma cruzi	47%	100%