Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7Z9_LEIBR

TriTrypDb:

LbrM.15.0290 , LBRM2903_150007900

Length:

480

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0005930	axoneme	2	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4H7Z9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7Z9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	439	443	PF00656	0.647
CLV_NRD_NRD_1	115	117	PF00675	0.604
CLV_NRD_NRD_1	151	153	PF00675	0.549
CLV_NRD_NRD_1	202	204	PF00675	0.676
CLV_NRD_NRD_1	269	271	PF00675	0.567
CLV_NRD_NRD_1	358	360	PF00675	0.337
CLV_PCSK_FUR_1	113	117	PF00082	0.488
CLV_PCSK_KEX2_1	115	117	PF00082	0.458
CLV_PCSK_KEX2_1	151	153	PF00082	0.551
CLV_PCSK_KEX2_1	269	271	PF00082	0.567
CLV_PCSK_KEX2_1	37	39	PF00082	0.470
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.561
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.470
CLV_PCSK_PC7_1	147	153	PF00082	0.614
CLV_PCSK_SKI1_1	123	127	PF00082	0.426
CLV_PCSK_SKI1_1	223	227	PF00082	0.424
CLV_PCSK_SKI1_1	236	240	PF00082	0.478
CLV_PCSK_SKI1_1	269	273	PF00082	0.537
CLV_PCSK_SKI1_1	31	35	PF00082	0.534
CLV_PCSK_SKI1_1	311	315	PF00082	0.607
CLV_PCSK_SKI1_1	334	338	PF00082	0.442
CLV_PCSK_SKI1_1	373	377	PF00082	0.438
DEG_APCC_DBOX_1	363	371	PF00400	0.403
DEG_Nend_UBRbox_2	1	3	PF02207	0.543
DEG_SPOP_SBC_1	198	202	PF00917	0.448
DOC_CKS1_1	282	287	PF01111	0.527
DOC_USP7_MATH_1	140	144	PF00917	0.353
DOC_USP7_MATH_1	197	201	PF00917	0.510
DOC_USP7_MATH_1	354	358	PF00917	0.541
DOC_USP7_MATH_1	437	441	PF00917	0.710
DOC_USP7_MATH_1	445	449	PF00917	0.595
DOC_USP7_MATH_1	51	55	PF00917	0.625
DOC_WW_Pin1_4	281	286	PF00397	0.653
DOC_WW_Pin1_4	352	357	PF00397	0.539
DOC_WW_Pin1_4	407	412	PF00397	0.746
LIG_14-3-3_CanoR_1	103	111	PF00244	0.598
LIG_14-3-3_CanoR_1	115	125	PF00244	0.558
LIG_14-3-3_CanoR_1	269	279	PF00244	0.571
LIG_14-3-3_CanoR_1	364	368	PF00244	0.538
LIG_14-3-3_CanoR_1	58	66	PF00244	0.647
LIG_Actin_WH2_2	175	193	PF00022	0.533
LIG_Actin_WH2_2	344	361	PF00022	0.297
LIG_BIR_III_2	432	436	PF00653	0.656
LIG_FHA_1	185	191	PF00498	0.570
LIG_FHA_1	193	199	PF00498	0.678
LIG_FHA_1	466	472	PF00498	0.521
LIG_FHA_2	125	131	PF00498	0.333
LIG_FHA_2	208	214	PF00498	0.436
LIG_FHA_2	237	243	PF00498	0.334
LIG_FHA_2	270	276	PF00498	0.601
LIG_FHA_2	282	288	PF00498	0.520
LIG_FHA_2	86	92	PF00498	0.393
LIG_Integrin_isoDGR_2	330	332	PF01839	0.369
LIG_LIR_Gen_1	233	241	PF02991	0.443
LIG_LIR_LC3C_4	423	427	PF02991	0.656
LIG_LIR_Nem_3	2	7	PF02991	0.559
LIG_LIR_Nem_3	233	237	PF02991	0.481
LIG_LIR_Nem_3	28	33	PF02991	0.502
LIG_LIR_Nem_3	61	67	PF02991	0.460
LIG_Pex14_1	117	121	PF04695	0.406
LIG_Pex14_2	237	241	PF04695	0.555
LIG_SH2_CRK	30	34	PF00017	0.542
LIG_SH2_CRK	475	479	PF00017	0.470
LIG_SH2_NCK_1	438	442	PF00017	0.550
LIG_SH2_STAP1	21	25	PF00017	0.584
LIG_SH2_STAP1	234	238	PF00017	0.427
LIG_SH2_STAP1	392	396	PF00017	0.442
LIG_SH2_STAT5	21	24	PF00017	0.626
LIG_SH2_STAT5	473	476	PF00017	0.495
LIG_SH3_3	279	285	PF00018	0.612
LIG_SH3_3	413	419	PF00018	0.742
LIG_SH3_3	6	12	PF00018	0.649
LIG_SH3_3	63	69	PF00018	0.581
LIG_TRAF2_1	210	213	PF00917	0.585
LIG_TRAF2_1	90	93	PF00917	0.521
LIG_UBA3_1	457	465	PF00899	0.525
LIG_ULM_U2AF65_1	203	208	PF00076	0.513
LIG_WRC_WIRS_1	118	123	PF05994	0.429
MOD_CDK_SPxxK_3	352	359	PF00069	0.311
MOD_CK1_1	19	25	PF00069	0.637
MOD_CK1_1	281	287	PF00069	0.607
MOD_CK1_1	407	413	PF00069	0.629
MOD_CK1_1	60	66	PF00069	0.581
MOD_CK1_1	70	76	PF00069	0.564
MOD_CK1_1	82	88	PF00069	0.606
MOD_CK2_1	207	213	PF00069	0.446
MOD_CK2_1	236	242	PF00069	0.466
MOD_CK2_1	269	275	PF00069	0.510
MOD_CK2_1	281	287	PF00069	0.601
MOD_CK2_1	85	91	PF00069	0.463
MOD_GlcNHglycan	142	145	PF01048	0.358
MOD_GlcNHglycan	18	21	PF01048	0.615
MOD_GlcNHglycan	404	407	PF01048	0.705
MOD_GlcNHglycan	429	432	PF01048	0.589
MOD_GlcNHglycan	43	46	PF01048	0.660
MOD_GlcNHglycan	439	442	PF01048	0.635
MOD_GlcNHglycan	446	450	PF01048	0.620
MOD_GSK3_1	105	112	PF00069	0.531
MOD_GSK3_1	16	23	PF00069	0.687
MOD_GSK3_1	186	193	PF00069	0.593
MOD_GSK3_1	37	44	PF00069	0.641
MOD_GSK3_1	461	468	PF00069	0.511
MOD_GSK3_1	53	60	PF00069	0.481
MOD_LATS_1	114	120	PF00433	0.335
MOD_N-GLC_1	261	266	PF02516	0.480
MOD_N-GLC_1	380	385	PF02516	0.413
MOD_NEK2_1	190	195	PF00069	0.725
MOD_PIKK_1	105	111	PF00454	0.611
MOD_PIKK_1	465	471	PF00454	0.535
MOD_PKA_1	269	275	PF00069	0.505
MOD_PKA_1	37	43	PF00069	0.435
MOD_PKA_2	102	108	PF00069	0.624
MOD_PKA_2	269	275	PF00069	0.577
MOD_PKA_2	363	369	PF00069	0.550
MOD_PKA_2	37	43	PF00069	0.648
MOD_PKA_2	57	63	PF00069	0.468
MOD_PKA_2	85	91	PF00069	0.529
MOD_Plk_1	261	267	PF00069	0.537
MOD_Plk_1	383	389	PF00069	0.606
MOD_Plk_1	60	66	PF00069	0.483
MOD_Plk_4	159	165	PF00069	0.567
MOD_Plk_4	278	284	PF00069	0.654
MOD_Plk_4	383	389	PF00069	0.604
MOD_ProDKin_1	281	287	PF00069	0.650
MOD_ProDKin_1	352	358	PF00069	0.536
MOD_ProDKin_1	407	413	PF00069	0.742
TRG_DiLeu_BaLyEn_6	331	336	PF01217	0.549
TRG_ENDOCYTIC_2	234	237	PF00928	0.430
TRG_ENDOCYTIC_2	30	33	PF00928	0.541
TRG_ENDOCYTIC_2	4	7	PF00928	0.541
TRG_ER_diArg_1	113	116	PF00400	0.548
TRG_ER_diArg_1	268	270	PF00400	0.573
TRG_ER_diArg_1	332	335	PF00400	0.484
TRG_NLS_MonoCore_2	202	207	PF00514	0.514
TRG_NLS_MonoExtN_4	151	156	PF00514	0.383
TRG_Pf-PMV_PEXEL_1	133	138	PF00026	0.592
TRG_Pf-PMV_PEXEL_1	223	227	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	456	460	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P362	Leptomonas seymouri	62%	100%
A0A0S4JPG7	Bodo saltans	35%	98%
A0A1X0NUB6	Trypanosomatidae	39%	100%
A0A3R7NLS4	Trypanosoma rangeli	38%	100%
A0A3S7WTC2	Leishmania donovani	80%	100%
A4HWC7	Leishmania infantum	80%	100%
C9ZNW9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AQ27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QFF4	Leishmania major	80%	99%