Putative sterol carrier protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

sterol carrier protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H7Z7_LEIBR

TriTrypDb:

LbrM.15.0270 , LBRM2903_150007700

Length:

348

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H7Z7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7Z7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016740	transferase activity	2	11
GO:0016746	acyltransferase activity	3	11
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	126	128	PF00675	0.491
CLV_NRD_NRD_1	152	154	PF00675	0.387
CLV_NRD_NRD_1	180	182	PF00675	0.548
CLV_NRD_NRD_1	266	268	PF00675	0.491
CLV_NRD_NRD_1	324	326	PF00675	0.541
CLV_NRD_NRD_1	43	45	PF00675	0.483
CLV_PCSK_KEX2_1	103	105	PF00082	0.367
CLV_PCSK_KEX2_1	128	130	PF00082	0.497
CLV_PCSK_KEX2_1	152	154	PF00082	0.372
CLV_PCSK_KEX2_1	180	182	PF00082	0.559
CLV_PCSK_KEX2_1	266	268	PF00082	0.491
CLV_PCSK_KEX2_1	324	326	PF00082	0.396
CLV_PCSK_KEX2_1	43	45	PF00082	0.483
CLV_PCSK_KEX2_1	69	71	PF00082	0.505
CLV_PCSK_KEX2_1	98	100	PF00082	0.434
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.367
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.500
CLV_PCSK_PC1ET2_1	69	71	PF00082	0.532
CLV_PCSK_PC1ET2_1	98	100	PF00082	0.434
CLV_PCSK_PC7_1	99	105	PF00082	0.421
CLV_PCSK_SKI1_1	324	328	PF00082	0.441
DEG_APCC_DBOX_1	103	111	PF00400	0.354
DEG_APCC_DBOX_1	128	136	PF00400	0.505
DEG_Nend_UBRbox_3	1	3	PF02207	0.287
DOC_CDC14_PxL_1	107	115	PF14671	0.345
DOC_CYCLIN_yCln2_LP_2	194	200	PF00134	0.495
DOC_MAPK_gen_1	152	160	PF00069	0.362
DOC_MAPK_gen_1	180	187	PF00069	0.519
DOC_MAPK_gen_1	43	50	PF00069	0.487
DOC_MAPK_JIP1_4	181	187	PF00069	0.491
DOC_MAPK_MEF2A_6	153	162	PF00069	0.364
DOC_MAPK_MEF2A_6	43	52	PF00069	0.529
DOC_PP2B_LxvP_1	194	197	PF13499	0.418
DOC_PP2B_LxvP_1	60	63	PF13499	0.295
DOC_PP2B_LxvP_1	80	83	PF13499	0.222
DOC_PP4_FxxP_1	291	294	PF00568	0.336
DOC_USP7_MATH_1	143	147	PF00917	0.334
DOC_USP7_MATH_1	245	249	PF00917	0.220
DOC_USP7_MATH_1	31	35	PF00917	0.452
DOC_USP7_MATH_1	68	72	PF00917	0.437
DOC_WW_Pin1_4	201	206	PF00397	0.421
DOC_WW_Pin1_4	27	32	PF00397	0.453
DOC_WW_Pin1_4	319	324	PF00397	0.497
DOC_WW_Pin1_4	74	79	PF00397	0.509
LIG_14-3-3_CanoR_1	127	133	PF00244	0.451
LIG_BRCT_BRCA1_1	63	67	PF00533	0.436
LIG_BRCT_BRCA1_2	63	69	PF00533	0.532
LIG_FHA_1	143	149	PF00498	0.264
LIG_FHA_1	172	178	PF00498	0.566
LIG_FHA_2	129	135	PF00498	0.309
LIG_FHA_2	197	203	PF00498	0.570
LIG_LIR_Nem_3	228	234	PF02991	0.329
LIG_Pex14_2	238	242	PF04695	0.355
LIG_Pex14_2	291	295	PF04695	0.342
LIG_Pex14_2	91	95	PF04695	0.453
LIG_SH2_NCK_1	218	222	PF00017	0.423
LIG_SH2_NCK_1	301	305	PF00017	0.464
LIG_SH2_STAP1	89	93	PF00017	0.329
LIG_SH2_STAT5	130	133	PF00017	0.295
LIG_SH2_STAT5	183	186	PF00017	0.471
LIG_SH2_STAT5	5	8	PF00017	0.429
LIG_SH3_3	190	196	PF00018	0.430
LIG_SH3_3	72	78	PF00018	0.452
LIG_SH3_3	80	86	PF00018	0.326
LIG_SUMO_SIM_anti_2	338	346	PF11976	0.352
LIG_SUMO_SIM_par_1	55	66	PF11976	0.320
LIG_TRAF2_1	131	134	PF00917	0.506
LIG_TRAF2_1	199	202	PF00917	0.578
LIG_UBA3_1	41	49	PF00899	0.274
MOD_CDK_SPK_2	319	324	PF00069	0.529
MOD_CDK_SPxK_1	319	325	PF00069	0.527
MOD_CK1_1	115	121	PF00069	0.471
MOD_CK1_1	30	36	PF00069	0.446
MOD_CK1_1	71	77	PF00069	0.430
MOD_CK2_1	128	134	PF00069	0.444
MOD_CK2_1	143	149	PF00069	0.405
MOD_CK2_1	196	202	PF00069	0.521
MOD_Cter_Amidation	178	181	PF01082	0.550
MOD_GlcNHglycan	114	117	PF01048	0.460
MOD_GlcNHglycan	189	193	PF01048	0.424
MOD_GlcNHglycan	224	227	PF01048	0.344
MOD_GlcNHglycan	335	338	PF01048	0.336
MOD_GSK3_1	23	30	PF00069	0.430
MOD_GSK3_1	58	65	PF00069	0.461
MOD_N-GLC_1	71	76	PF02516	0.457
MOD_NEK2_1	10	15	PF00069	0.530
MOD_NEK2_1	246	251	PF00069	0.452
MOD_NEK2_1	335	340	PF00069	0.330
MOD_PKA_1	128	134	PF00069	0.513
MOD_PKA_2	128	134	PF00069	0.513
MOD_Plk_1	71	77	PF00069	0.430
MOD_Plk_4	143	149	PF00069	0.376
MOD_ProDKin_1	201	207	PF00069	0.412
MOD_ProDKin_1	27	33	PF00069	0.452
MOD_ProDKin_1	319	325	PF00069	0.494
MOD_ProDKin_1	74	80	PF00069	0.503
MOD_SUMO_for_1	102	105	PF00179	0.390
TRG_ENDOCYTIC_2	235	238	PF00928	0.319
TRG_ENDOCYTIC_2	89	92	PF00928	0.222
TRG_ER_diArg_1	127	130	PF00400	0.481
TRG_ER_diArg_1	180	182	PF00400	0.551
TRG_ER_diArg_1	265	267	PF00400	0.520
TRG_ER_diArg_1	323	325	PF00400	0.544
TRG_ER_diArg_1	42	44	PF00400	0.426

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUB7	Leptomonas seymouri	79%	86%
A0A0S4IUN8	Bodo saltans	27%	82%
A0A0S4JDZ8	Bodo saltans	62%	95%
A0A1X0NX18	Trypanosomatidae	25%	79%
A0A3S5H6U0	Leishmania donovani	92%	86%
A0A422NT95	Trypanosoma rangeli	59%	86%
A4HCU5	Leishmania braziliensis	25%	79%
A4HWC5	Leishmania infantum	93%	86%
C9ZUV7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	85%
D1AB74	Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / KCTC 9072 / NBRC 15933 / NCIMB 10081 / Henssen B9)	27%	89%
E9AQ25	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	86%
I6Y3T7	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	30%	90%
O26884	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	33%	91%
Q4QFF6	Leishmania major	91%	100%
Q58944	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	26%	89%
V5BHW0	Trypanosoma cruzi	62%	75%