Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4H7Z5_LEIBR

TriTrypDb:

LbrM.15.0250 , LBRM2903_150007500

Length:

346

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	9
GO:0032991	protein-containing complex	1	9
GO:0043226	organelle	2	9
GO:0043228	non-membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043232	intracellular non-membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9
GO:1990904	ribonucleoprotein complex	2	9

Expansion

Sequence features

A4H7Z5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7Z5

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	296	300	PF00656	0.349
CLV_C14_Caspase3-7	49	53	PF00656	0.242
CLV_NRD_NRD_1	111	113	PF00675	0.251
CLV_NRD_NRD_1	292	294	PF00675	0.398
CLV_PCSK_KEX2_1	113	115	PF00082	0.236
CLV_PCSK_KEX2_1	292	294	PF00082	0.398
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.236
DOC_MAPK_gen_1	112	119	PF00069	0.233
DOC_MAPK_gen_1	332	338	PF00069	0.391
DOC_SPAK_OSR1_1	31	35	PF12202	0.317
DOC_USP7_MATH_1	53	57	PF00917	0.513
DOC_USP7_MATH_1	85	89	PF00917	0.388
DOC_WW_Pin1_4	190	195	PF00397	0.304
DOC_WW_Pin1_4	307	312	PF00397	0.427
DOC_WW_Pin1_4	72	77	PF00397	0.300
LIG_14-3-3_CanoR_1	112	118	PF00244	0.258
LIG_14-3-3_CanoR_1	235	245	PF00244	0.512
LIG_14-3-3_CanoR_1	96	102	PF00244	0.365
LIG_APCC_ABBA_1	62	67	PF00400	0.246
LIG_BIR_II_1	1	5	PF00653	0.525
LIG_BRCT_BRCA1_1	200	204	PF00533	0.445
LIG_BRCT_BRCA1_1	25	29	PF00533	0.351
LIG_FHA_1	137	143	PF00498	0.403
LIG_FHA_1	170	176	PF00498	0.308
LIG_FHA_1	274	280	PF00498	0.414
LIG_FHA_1	34	40	PF00498	0.478
LIG_FHA_1	52	58	PF00498	0.414
LIG_FHA_2	153	159	PF00498	0.264
LIG_FHA_2	206	212	PF00498	0.402
LIG_LIR_Gen_1	211	220	PF02991	0.511
LIG_LIR_Gen_1	225	236	PF02991	0.355
LIG_LIR_Gen_1	26	37	PF02991	0.323
LIG_LIR_Nem_3	127	132	PF02991	0.416
LIG_LIR_Nem_3	211	215	PF02991	0.502
LIG_LIR_Nem_3	225	231	PF02991	0.344
LIG_LIR_Nem_3	26	32	PF02991	0.343
LIG_PDZ_Class_1	341	346	PF00595	0.370
LIG_SH2_CRK	115	119	PF00017	0.368
LIG_SH2_PTP2	228	231	PF00017	0.431
LIG_SH2_SRC	228	231	PF00017	0.431
LIG_SH2_SRC	50	53	PF00017	0.246
LIG_SH2_STAP1	115	119	PF00017	0.368
LIG_SH2_STAP1	206	210	PF00017	0.450
LIG_SH2_STAT5	154	157	PF00017	0.415
LIG_SH2_STAT5	228	231	PF00017	0.431
LIG_SH3_3	165	171	PF00018	0.458
LIG_SUMO_SIM_par_1	138	145	PF11976	0.454
LIG_SUMO_SIM_par_1	183	189	PF11976	0.458
LIG_SUMO_SIM_par_1	81	88	PF11976	0.351
LIG_UBA3_1	184	191	PF00899	0.253
LIG_UBA3_1	244	249	PF00899	0.326
LIG_WRC_WIRS_1	260	265	PF05994	0.468
MOD_CK1_1	141	147	PF00069	0.350
MOD_CK1_1	153	159	PF00069	0.384
MOD_CK1_1	2	8	PF00069	0.400
MOD_CK1_1	222	228	PF00069	0.394
MOD_CK1_1	23	29	PF00069	0.442
MOD_CK1_1	270	276	PF00069	0.427
MOD_CK1_1	307	313	PF00069	0.379
MOD_CK1_1	79	85	PF00069	0.345
MOD_CK2_1	152	158	PF00069	0.264
MOD_GlcNHglycan	2	5	PF01048	0.452
MOD_GlcNHglycan	221	224	PF01048	0.313
MOD_GlcNHglycan	39	42	PF01048	0.377
MOD_GlcNHglycan	78	81	PF01048	0.505
MOD_GSK3_1	136	143	PF00069	0.371
MOD_GSK3_1	148	155	PF00069	0.557
MOD_GSK3_1	186	193	PF00069	0.402
MOD_GSK3_1	269	276	PF00069	0.456
MOD_GSK3_1	33	40	PF00069	0.477
MOD_GSK3_1	72	79	PF00069	0.367
MOD_N-GLC_1	236	241	PF02516	0.483
MOD_N-GLC_1	37	42	PF02516	0.420
MOD_NEK2_1	142	147	PF00069	0.485
MOD_NEK2_1	195	200	PF00069	0.438
MOD_NEK2_1	204	209	PF00069	0.377
MOD_NEK2_1	267	272	PF00069	0.406
MOD_NEK2_1	304	309	PF00069	0.308
MOD_NEK2_1	324	329	PF00069	0.160
MOD_NEK2_1	33	38	PF00069	0.390
MOD_NEK2_1	84	89	PF00069	0.336
MOD_NEK2_2	107	112	PF00069	0.246
MOD_PIKK_1	23	29	PF00454	0.506
MOD_PK_1	332	338	PF00069	0.493
MOD_PKA_1	113	119	PF00069	0.224
MOD_PKA_1	332	338	PF00069	0.493
MOD_PKA_2	113	119	PF00069	0.176
MOD_PKA_2	95	101	PF00069	0.317
MOD_Plk_1	251	257	PF00069	0.416
MOD_Plk_1	273	279	PF00069	0.424
MOD_Plk_4	113	119	PF00069	0.224
MOD_Plk_4	297	303	PF00069	0.313
MOD_Plk_4	332	338	PF00069	0.498
MOD_Plk_4	79	85	PF00069	0.359
MOD_ProDKin_1	190	196	PF00069	0.311
MOD_ProDKin_1	307	313	PF00069	0.424
MOD_ProDKin_1	72	78	PF00069	0.315
MOD_SUMO_rev_2	123	132	PF00179	0.310
MOD_SUMO_rev_2	281	291	PF00179	0.514
MOD_SUMO_rev_2	326	335	PF00179	0.333
MOD_SUMO_rev_2	339	344	PF00179	0.425
MOD_SUMO_rev_2	40	45	PF00179	0.458
TRG_DiLeu_BaEn_2	27	33	PF01217	0.392
TRG_ENDOCYTIC_2	115	118	PF00928	0.368
TRG_ENDOCYTIC_2	228	231	PF00928	0.431
TRG_ER_diArg_1	111	114	PF00400	0.254
TRG_ER_diArg_1	291	293	PF00400	0.408
TRG_Pf-PMV_PEXEL_1	292	296	PF00026	0.426

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZX3	Leptomonas seymouri	73%	100%
A0A0S4JKW8	Bodo saltans	30%	87%
A0A1X0NTY1	Trypanosomatidae	47%	99%
A0A3Q8IA26	Leishmania donovani	87%	100%
A0A422NSA5	Trypanosoma rangeli	47%	99%
A4HWC3	Leishmania infantum	87%	100%
C9ZNW6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	99%
E9AQ23	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q3KPT3	Xenopus laevis	24%	89%
Q4QFF8	Leishmania major	86%	100%
Q4R571	Macaca fascicularis	26%	89%
Q53HC9	Homo sapiens	26%	89%
Q5M8I4	Xenopus tropicalis	24%	89%
Q5PPK9	Rattus norvegicus	25%	90%
Q5RE10	Pongo abelii	27%	84%
Q5XJP1	Danio rerio	24%	89%
Q6DUZ9	Gekko japonicus	26%	89%
Q6NPN9	Arabidopsis thaliana	25%	99%
Q8K0G5	Mus musculus	24%	90%
Q9U1Q0	Caenorhabditis elegans	26%	96%
V5BGM5	Trypanosoma cruzi	44%	100%