Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7Z4_LEIBR

TriTrypDb:

LbrM.15.0240

Length:

269

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H7Z4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7Z4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	129	131	PF00675	0.478
CLV_NRD_NRD_1	232	234	PF00675	0.671
CLV_NRD_NRD_1	63	65	PF00675	0.759
CLV_PCSK_KEX2_1	234	236	PF00082	0.683
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.708
CLV_PCSK_SKI1_1	175	179	PF00082	0.440
CLV_PCSK_SKI1_1	68	72	PF00082	0.522
DOC_CDC14_PxL_1	77	85	PF14671	0.471
DOC_CYCLIN_yCln2_LP_2	103	109	PF00134	0.514
DOC_MAPK_DCC_7	144	154	PF00069	0.633
DOC_MAPK_MEF2A_6	144	152	PF00069	0.545
DOC_MAPK_MEF2A_6	46	54	PF00069	0.481
DOC_MAPK_RevD_3	50	65	PF00069	0.480
DOC_PP2B_LxvP_1	103	106	PF13499	0.489
DOC_PP4_FxxP_1	160	163	PF00568	0.633
DOC_PP4_FxxP_1	36	39	PF00568	0.480
DOC_PP4_FxxP_1	84	87	PF00568	0.298
DOC_USP7_MATH_1	124	128	PF00917	0.595
DOC_USP7_MATH_1	212	216	PF00917	0.555
DOC_USP7_MATH_1	26	30	PF00917	0.471
DOC_WW_Pin1_4	214	219	PF00397	0.489
DOC_WW_Pin1_4	235	240	PF00397	0.578
DOC_WW_Pin1_4	46	51	PF00397	0.484
LIG_14-3-3_CanoR_1	64	68	PF00244	0.676
LIG_Actin_WH2_2	31	48	PF00022	0.480
LIG_Actin_WH2_2	79	97	PF00022	0.616
LIG_BRCT_BRCA1_1	117	121	PF00533	0.468
LIG_BRCT_BRCA1_1	23	27	PF00533	0.466
LIG_CtBP_PxDLS_1	39	43	PF00389	0.481
LIG_FHA_1	153	159	PF00498	0.376
LIG_FHA_1	35	41	PF00498	0.479
LIG_LIR_Apic_2	157	163	PF02991	0.652
LIG_LIR_Gen_1	12	21	PF02991	0.443
LIG_LIR_Nem_3	219	224	PF02991	0.617
LIG_LIR_Nem_3	256	262	PF02991	0.601
LIG_MYND_2	254	258	PF01753	0.486
LIG_SH2_CRK	259	263	PF00017	0.655
LIG_SH2_NCK_1	259	263	PF00017	0.644
LIG_SH2_SRC	259	262	PF00017	0.599
LIG_SH2_STAT5	133	136	PF00017	0.281
LIG_SH2_STAT5	203	206	PF00017	0.584
LIG_SH3_3	103	109	PF00018	0.615
LIG_SH3_3	145	151	PF00018	0.548
LIG_SUMO_SIM_anti_2	29	35	PF11976	0.471
LIG_SUMO_SIM_par_1	150	155	PF11976	0.518
LIG_TYR_ITIM	257	262	PF00017	0.651
LIG_UBA3_1	52	58	PF00899	0.483
MOD_CK1_1	206	212	PF00069	0.601
MOD_CK1_1	214	220	PF00069	0.588
MOD_CK1_1	227	233	PF00069	0.542
MOD_CK1_1	29	35	PF00069	0.471
MOD_CK1_1	66	72	PF00069	0.608
MOD_CK2_1	247	253	PF00069	0.503
MOD_CK2_1	66	72	PF00069	0.650
MOD_DYRK1A_RPxSP_1	235	239	PF00069	0.577
MOD_GlcNHglycan	180	183	PF01048	0.413
MOD_GlcNHglycan	192	195	PF01048	0.342
MOD_GlcNHglycan	198	201	PF01048	0.547
MOD_GlcNHglycan	205	208	PF01048	0.512
MOD_GlcNHglycan	229	232	PF01048	0.690
MOD_GlcNHglycan	68	71	PF01048	0.484
MOD_GSK3_1	110	117	PF00069	0.587
MOD_GSK3_1	120	127	PF00069	0.523
MOD_GSK3_1	154	161	PF00069	0.649
MOD_GSK3_1	225	232	PF00069	0.565
MOD_GSK3_1	34	41	PF00069	0.478
MOD_GSK3_1	89	96	PF00069	0.499
MOD_N-GLC_1	21	26	PF02516	0.455
MOD_N-GLC_1	29	34	PF02516	0.446
MOD_NEK2_1	152	157	PF00069	0.354
MOD_NEK2_1	178	183	PF00069	0.314
MOD_NEK2_1	229	234	PF00069	0.519
MOD_NEK2_1	45	50	PF00069	0.567
MOD_NEK2_1	63	68	PF00069	0.592
MOD_NEK2_1	82	87	PF00069	0.467
MOD_NEK2_1	94	99	PF00069	0.378
MOD_PKA_1	233	239	PF00069	0.751
MOD_PKA_2	224	230	PF00069	0.512
MOD_PKA_2	45	51	PF00069	0.502
MOD_PKA_2	63	69	PF00069	0.658
MOD_Plk_1	114	120	PF00069	0.466
MOD_Plk_1	225	231	PF00069	0.493
MOD_Plk_1	29	35	PF00069	0.471
MOD_Plk_4	253	259	PF00069	0.554
MOD_Plk_4	29	35	PF00069	0.471
MOD_ProDKin_1	214	220	PF00069	0.481
MOD_ProDKin_1	235	241	PF00069	0.575
MOD_ProDKin_1	46	52	PF00069	0.486
MOD_SUMO_rev_2	140	146	PF00179	0.625
TRG_DiLeu_BaEn_1	253	258	PF01217	0.634
TRG_DiLeu_BaEn_2	218	224	PF01217	0.342
TRG_DiLeu_BaLyEn_6	78	83	PF01217	0.369
TRG_ENDOCYTIC_2	133	136	PF00928	0.281
TRG_ENDOCYTIC_2	259	262	PF00928	0.610
TRG_ER_diArg_1	173	176	PF00400	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCF0	Leptomonas seymouri	46%	100%
A0A3Q8IA55	Leishmania donovani	70%	100%
A4HWC2	Leishmania infantum	70%	100%
E9AQ22	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4QFF9	Leishmania major	71%	100%