DUF667 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7Z2_LEIBR

TriTrypDb:

LbrM.15.0220 , LBRM2903_150007400

Length:

523

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H7Z2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7Z2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	175	179	PF00656	0.333
CLV_C14_Caspase3-7	318	322	PF00656	0.632
CLV_C14_Caspase3-7	374	378	PF00656	0.517
CLV_MEL_PAP_1	467	473	PF00089	0.489
CLV_NRD_NRD_1	35	37	PF00675	0.207
CLV_NRD_NRD_1	407	409	PF00675	0.542
CLV_NRD_NRD_1	432	434	PF00675	0.552
CLV_NRD_NRD_1	439	441	PF00675	0.532
CLV_PCSK_FUR_1	436	440	PF00082	0.531
CLV_PCSK_KEX2_1	380	382	PF00082	0.599
CLV_PCSK_KEX2_1	432	434	PF00082	0.552
CLV_PCSK_KEX2_1	438	440	PF00082	0.532
CLV_PCSK_PC1ET2_1	380	382	PF00082	0.599
CLV_PCSK_SKI1_1	14	18	PF00082	0.495
CLV_PCSK_SKI1_1	198	202	PF00082	0.575
CLV_PCSK_SKI1_1	274	278	PF00082	0.527
CLV_PCSK_SKI1_1	37	41	PF00082	0.256
DOC_CYCLIN_yCln2_LP_2	207	213	PF00134	0.498
DOC_MAPK_DCC_7	234	243	PF00069	0.484
DOC_MAPK_gen_1	127	135	PF00069	0.456
DOC_MAPK_gen_1	33	41	PF00069	0.445
DOC_MAPK_gen_1	432	443	PF00069	0.535
DOC_MAPK_HePTP_8	30	42	PF00069	0.407
DOC_MAPK_MEF2A_6	127	135	PF00069	0.456
DOC_MAPK_MEF2A_6	234	243	PF00069	0.484
DOC_MAPK_MEF2A_6	33	42	PF00069	0.531
DOC_MAPK_MEF2A_6	361	370	PF00069	0.526
DOC_PP2B_LxvP_1	123	126	PF13499	0.456
DOC_PP4_FxxP_1	145	148	PF00568	0.519
DOC_PP4_FxxP_1	187	190	PF00568	0.405
DOC_PP4_FxxP_1	192	195	PF00568	0.511
DOC_USP7_MATH_1	200	204	PF00917	0.639
DOC_USP7_MATH_1	269	273	PF00917	0.651
DOC_USP7_MATH_1	344	348	PF00917	0.570
DOC_USP7_MATH_1	393	397	PF00917	0.578
DOC_USP7_MATH_1	476	480	PF00917	0.489
DOC_USP7_MATH_1	59	63	PF00917	0.510
DOC_USP7_MATH_2	358	364	PF00917	0.527
DOC_USP7_UBL2_3	33	37	PF12436	0.510
DOC_WW_Pin1_4	206	211	PF00397	0.560
DOC_WW_Pin1_4	234	239	PF00397	0.579
DOC_WW_Pin1_4	262	267	PF00397	0.543
DOC_WW_Pin1_4	388	393	PF00397	0.528
DOC_WW_Pin1_4	410	415	PF00397	0.558
LIG_14-3-3_CanoR_1	361	365	PF00244	0.519
LIG_14-3-3_CanoR_1	470	474	PF00244	0.496
LIG_Actin_WH2_2	243	261	PF00022	0.494
LIG_BIR_II_1	1	5	PF00653	0.515
LIG_BIR_III_2	178	182	PF00653	0.341
LIG_BRCT_BRCA1_1	164	168	PF00533	0.369
LIG_FHA_1	116	122	PF00498	0.456
LIG_FHA_1	153	159	PF00498	0.267
LIG_FHA_1	220	226	PF00498	0.576
LIG_FHA_1	228	234	PF00498	0.535
LIG_FHA_1	259	265	PF00498	0.520
LIG_FHA_1	275	281	PF00498	0.484
LIG_FHA_1	396	402	PF00498	0.466
LIG_FHA_1	94	100	PF00498	0.465
LIG_FHA_2	110	116	PF00498	0.486
LIG_LIR_Apic_2	143	148	PF02991	0.456
LIG_LIR_Apic_2	352	357	PF02991	0.537
LIG_LIR_Gen_1	286	297	PF02991	0.561
LIG_LIR_Nem_3	117	123	PF02991	0.486
LIG_LIR_Nem_3	286	292	PF02991	0.533
LIG_LIR_Nem_3	296	300	PF02991	0.539
LIG_PCNA_TLS_4	97	105	PF02747	0.407
LIG_SH2_PTP2	297	300	PF00017	0.531
LIG_SH2_STAP1	109	113	PF00017	0.436
LIG_SH2_STAT5	103	106	PF00017	0.419
LIG_SH2_STAT5	120	123	PF00017	0.563
LIG_SH2_STAT5	297	300	PF00017	0.531
LIG_SH2_STAT5	492	495	PF00017	0.436
LIG_SH2_STAT5	91	94	PF00017	0.474
LIG_SH3_1	387	393	PF00018	0.603
LIG_SH3_2	336	341	PF14604	0.524
LIG_SH3_3	18	24	PF00018	0.373
LIG_SH3_3	232	238	PF00018	0.562
LIG_SH3_3	260	266	PF00018	0.528
LIG_SH3_3	333	339	PF00018	0.537
LIG_SH3_3	387	393	PF00018	0.603
LIG_SH3_3	48	54	PF00018	0.486
LIG_SH3_3	492	498	PF00018	0.491
LIG_SUMO_SIM_par_1	154	159	PF11976	0.238
LIG_SUMO_SIM_par_1	208	215	PF11976	0.500
LIG_SUMO_SIM_par_1	260	265	PF11976	0.503
LIG_SUMO_SIM_par_1	363	369	PF11976	0.637
LIG_TRAF2_1	327	330	PF00917	0.800
LIG_TRAF2_1	357	360	PF00917	0.523
LIG_WRC_WIRS_1	289	294	PF05994	0.472
MOD_CDK_SPxxK_3	410	417	PF00069	0.508
MOD_CK1_1	237	243	PF00069	0.730
MOD_CK1_1	246	252	PF00069	0.513
MOD_CK1_1	272	278	PF00069	0.620
MOD_CK1_1	395	401	PF00069	0.467
MOD_CK1_1	407	413	PF00069	0.510
MOD_CK1_1	418	424	PF00069	0.645
MOD_CK1_1	89	95	PF00069	0.311
MOD_CK2_1	167	173	PF00069	0.411
MOD_CK2_1	349	355	PF00069	0.656
MOD_CK2_1	393	399	PF00069	0.589
MOD_CK2_1	517	523	PF00069	0.560
MOD_DYRK1A_RPxSP_1	234	238	PF00069	0.481
MOD_GlcNHglycan	216	219	PF01048	0.673
MOD_GlcNHglycan	274	277	PF01048	0.635
MOD_GlcNHglycan	346	349	PF01048	0.601
MOD_GlcNHglycan	351	354	PF01048	0.668
MOD_GlcNHglycan	362	365	PF01048	0.545
MOD_GlcNHglycan	421	424	PF01048	0.599
MOD_GSK3_1	10	17	PF00069	0.321
MOD_GSK3_1	148	155	PF00069	0.352
MOD_GSK3_1	168	175	PF00069	0.406
MOD_GSK3_1	196	203	PF00069	0.570
MOD_GSK3_1	212	219	PF00069	0.517
MOD_GSK3_1	237	244	PF00069	0.525
MOD_GSK3_1	258	265	PF00069	0.538
MOD_GSK3_1	270	277	PF00069	0.641
MOD_GSK3_1	325	332	PF00069	0.650
MOD_GSK3_1	340	347	PF00069	0.526
MOD_GSK3_1	376	383	PF00069	0.534
MOD_GSK3_1	388	395	PF00069	0.502
MOD_GSK3_1	415	422	PF00069	0.539
MOD_GSK3_1	465	472	PF00069	0.528
MOD_GSK3_1	89	96	PF00069	0.288
MOD_N-GLC_1	344	349	PF02516	0.619
MOD_N-GLC_1	428	433	PF02516	0.598
MOD_N-GLC_1	93	98	PF02516	0.231
MOD_NEK2_1	227	232	PF00069	0.490
MOD_NEK2_1	243	248	PF00069	0.476
MOD_NEK2_1	25	30	PF00069	0.319
MOD_NEK2_1	258	263	PF00069	0.583
MOD_NEK2_1	288	293	PF00069	0.474
MOD_NEK2_1	415	420	PF00069	0.524
MOD_NEK2_1	65	70	PF00069	0.285
MOD_NEK2_2	59	64	PF00069	0.361
MOD_PIKK_1	216	222	PF00454	0.487
MOD_PIKK_1	325	331	PF00454	0.605
MOD_PIKK_1	380	386	PF00454	0.538
MOD_PIKK_1	44	50	PF00454	0.328
MOD_PIKK_1	465	471	PF00454	0.552
MOD_PIKK_1	86	92	PF00454	0.285
MOD_PKA_1	380	386	PF00069	0.538
MOD_PKA_2	340	346	PF00069	0.523
MOD_PKA_2	360	366	PF00069	0.494
MOD_PKA_2	371	377	PF00069	0.520
MOD_PKA_2	380	386	PF00069	0.504
MOD_PKA_2	407	413	PF00069	0.492
MOD_PKA_2	469	475	PF00069	0.493
MOD_Plk_1	172	178	PF00069	0.449
MOD_Plk_1	476	482	PF00069	0.489
MOD_Plk_4	140	146	PF00069	0.323
MOD_Plk_4	246	252	PF00069	0.599
MOD_Plk_4	25	31	PF00069	0.217
MOD_Plk_4	258	264	PF00069	0.507
MOD_Plk_4	514	520	PF00069	0.581
MOD_Plk_4	65	71	PF00069	0.285
MOD_Plk_4	99	105	PF00069	0.217
MOD_ProDKin_1	206	212	PF00069	0.562
MOD_ProDKin_1	234	240	PF00069	0.579
MOD_ProDKin_1	262	268	PF00069	0.545
MOD_ProDKin_1	388	394	PF00069	0.523
MOD_ProDKin_1	410	416	PF00069	0.563
MOD_SUMO_for_1	308	311	PF00179	0.585
TRG_DiLeu_BaLyEn_6	119	124	PF01217	0.285
TRG_ENDOCYTIC_2	120	123	PF00928	0.328
TRG_ENDOCYTIC_2	297	300	PF00928	0.554
TRG_ENDOCYTIC_2	492	495	PF00928	0.436
TRG_ER_diArg_1	436	439	PF00400	0.603
TRG_ER_diArg_1	440	443	PF00400	0.648
TRG_NES_CRM1_1	77	90	PF08389	0.217

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P363	Leptomonas seymouri	52%	91%
A0A3Q8IIK6	Leishmania donovani	73%	100%
A4HWC0	Leishmania infantum	74%	100%
E9AQ20	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4QFG1	Leishmania major	74%	99%