Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7Z0_LEIBR

TriTrypDb:

LbrM.15.0200 , LBRM2903_150007200

Length:

291

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4H7Z0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7Z0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	97	101	PF00656	0.640
CLV_NRD_NRD_1	120	122	PF00675	0.472
CLV_NRD_NRD_1	253	255	PF00675	0.593
CLV_NRD_NRD_1	54	56	PF00675	0.510
CLV_NRD_NRD_1	70	72	PF00675	0.347
CLV_NRD_NRD_1	87	89	PF00675	0.439
CLV_PCSK_KEX2_1	119	121	PF00082	0.474
CLV_PCSK_KEX2_1	54	56	PF00082	0.570
CLV_PCSK_KEX2_1	70	72	PF00082	0.339
CLV_PCSK_KEX2_1	87	89	PF00082	0.441
CLV_PCSK_SKI1_1	239	243	PF00082	0.636
DEG_APCC_DBOX_1	177	185	PF00400	0.475
DOC_MAPK_MEF2A_6	178	186	PF00069	0.526
DOC_PP4_FxxP_1	240	243	PF00568	0.340
DOC_USP7_MATH_1	33	37	PF00917	0.726
DOC_WW_Pin1_4	138	143	PF00397	0.692
DOC_WW_Pin1_4	20	25	PF00397	0.693
DOC_WW_Pin1_4	46	51	PF00397	0.779
LIG_14-3-3_CanoR_1	131	140	PF00244	0.625
LIG_14-3-3_CanoR_1	54	60	PF00244	0.606
LIG_BIR_II_1	1	5	PF00653	0.678
LIG_FHA_1	177	183	PF00498	0.495
LIG_FHA_1	272	278	PF00498	0.419
LIG_FHA_2	123	129	PF00498	0.705
LIG_FHA_2	41	47	PF00498	0.666
LIG_LIR_Gen_1	58	67	PF02991	0.613
LIG_LIR_Nem_3	270	275	PF02991	0.449
LIG_LIR_Nem_3	58	62	PF02991	0.573
LIG_NRBOX	180	186	PF00104	0.349
LIG_Pex14_2	267	271	PF04695	0.332
LIG_REV1ctd_RIR_1	238	242	PF16727	0.335
LIG_SH2_PTP2	192	195	PF00017	0.352
LIG_SH2_PTP2	209	212	PF00017	0.279
LIG_SH2_SRC	192	195	PF00017	0.216
LIG_SH2_STAT5	192	195	PF00017	0.411
LIG_SH2_STAT5	209	212	PF00017	0.295
LIG_SH2_STAT5	258	261	PF00017	0.390
LIG_SH2_STAT5	66	69	PF00017	0.610
LIG_SH2_STAT5	74	77	PF00017	0.660
LIG_SH3_3	12	18	PF00018	0.727
LIG_SH3_3	137	143	PF00018	0.673
LIG_SH3_3	146	152	PF00018	0.682
LIG_TRAF2_1	58	61	PF00917	0.574
LIG_TYR_ITIM	190	195	PF00017	0.352
LIG_TYR_ITIM	207	212	PF00017	0.325
LIG_UBA3_1	187	196	PF00899	0.306
LIG_UBA3_1	205	213	PF00899	0.457
LIG_WRC_WIRS_1	268	273	PF05994	0.343
MOD_CK1_1	38	44	PF00069	0.704
MOD_CK1_1	49	55	PF00069	0.751
MOD_CK1_1	69	75	PF00069	0.514
MOD_CK2_1	40	46	PF00069	0.719
MOD_CK2_1	55	61	PF00069	0.579
MOD_CMANNOS	166	169	PF00535	0.341
MOD_GlcNHglycan	1	4	PF01048	0.529
MOD_GlcNHglycan	126	131	PF01048	0.424
MOD_GlcNHglycan	198	201	PF01048	0.229
MOD_GlcNHglycan	37	40	PF01048	0.458
MOD_GlcNHglycan	43	46	PF01048	0.460
MOD_GSK3_1	122	129	PF00069	0.678
MOD_GSK3_1	267	274	PF00069	0.414
MOD_GSK3_1	33	40	PF00069	0.788
MOD_GSK3_1	69	76	PF00069	0.555
MOD_GSK3_1	9	16	PF00069	0.670
MOD_LATS_1	194	200	PF00433	0.216
MOD_N-GLC_1	176	181	PF02516	0.314
MOD_NEK2_1	1	6	PF00069	0.636
MOD_NEK2_1	267	272	PF00069	0.373
MOD_PIKK_1	74	80	PF00454	0.684
MOD_PKA_2	69	75	PF00069	0.565
MOD_PKA_2	9	15	PF00069	0.656
MOD_Plk_1	176	182	PF00069	0.548
MOD_Plk_4	165	171	PF00069	0.590
MOD_Plk_4	232	238	PF00069	0.432
MOD_Plk_4	267	273	PF00069	0.399
MOD_Plk_4	81	87	PF00069	0.613
MOD_Plk_4	9	15	PF00069	0.648
MOD_ProDKin_1	138	144	PF00069	0.692
MOD_ProDKin_1	20	26	PF00069	0.692
MOD_ProDKin_1	46	52	PF00069	0.776
MOD_SUMO_for_1	241	244	PF00179	0.439
TRG_ENDOCYTIC_2	192	195	PF00928	0.348
TRG_ENDOCYTIC_2	209	212	PF00928	0.387
TRG_ER_diArg_1	118	121	PF00400	0.675
TRG_ER_diArg_1	152	155	PF00400	0.614
TRG_ER_diArg_1	86	88	PF00400	0.750
TRG_Pf-PMV_PEXEL_1	282	287	PF00026	0.615

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDS0	Leptomonas seymouri	33%	97%
A0A3S5H6T8	Leishmania donovani	67%	100%
A4HWB8	Leishmania infantum	67%	80%
C9ZNV7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AQ18	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	80%
Q4QFG3	Leishmania major	66%	100%