Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7Y8_LEIBR

TriTrypDb:

LbrM.15.0180 , LBRM2903_150007000

Length:

668

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H7Y8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7Y8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	363	367	PF00656	0.629
CLV_C14_Caspase3-7	555	559	PF00656	0.507
CLV_C14_Caspase3-7	90	94	PF00656	0.531
CLV_MEL_PAP_1	489	495	PF00089	0.553
CLV_NRD_NRD_1	358	360	PF00675	0.738
CLV_NRD_NRD_1	403	405	PF00675	0.651
CLV_NRD_NRD_1	45	47	PF00675	0.484
CLV_NRD_NRD_1	452	454	PF00675	0.666
CLV_NRD_NRD_1	477	479	PF00675	0.686
CLV_NRD_NRD_1	485	487	PF00675	0.511
CLV_NRD_NRD_1	620	622	PF00675	0.490
CLV_NRD_NRD_1	645	647	PF00675	0.556
CLV_NRD_NRD_1	665	667	PF00675	0.653
CLV_PCSK_FUR_1	43	47	PF00082	0.481
CLV_PCSK_KEX2_1	358	360	PF00082	0.738
CLV_PCSK_KEX2_1	403	405	PF00082	0.649
CLV_PCSK_KEX2_1	45	47	PF00082	0.484
CLV_PCSK_KEX2_1	452	454	PF00082	0.724
CLV_PCSK_KEX2_1	485	487	PF00082	0.511
CLV_PCSK_KEX2_1	522	524	PF00082	0.395
CLV_PCSK_KEX2_1	620	622	PF00082	0.490
CLV_PCSK_KEX2_1	665	667	PF00082	0.692
CLV_PCSK_PC1ET2_1	522	524	PF00082	0.395
CLV_PCSK_SKI1_1	201	205	PF00082	0.425
CLV_PCSK_SKI1_1	211	215	PF00082	0.417
CLV_PCSK_SKI1_1	384	388	PF00082	0.506
CLV_PCSK_SKI1_1	488	492	PF00082	0.547
CLV_PCSK_SKI1_1	583	587	PF00082	0.626
DEG_APCC_DBOX_1	534	542	PF00400	0.384
DEG_Nend_UBRbox_1	1	4	PF02207	0.552
DEG_ODPH_VHL_1	314	327	PF01847	0.571
DEG_SPOP_SBC_1	174	178	PF00917	0.709
DEG_SPOP_SBC_1	252	256	PF00917	0.497
DEG_SPOP_SBC_1	308	312	PF00917	0.531
DEG_SPOP_SBC_1	447	451	PF00917	0.515
DOC_CDC14_PxL_1	145	153	PF14671	0.528
DOC_CKS1_1	81	86	PF01111	0.620
DOC_CYCLIN_RxL_1	413	426	PF00134	0.455
DOC_CYCLIN_RxL_1	485	495	PF00134	0.544
DOC_MAPK_gen_1	485	493	PF00069	0.523
DOC_MAPK_MEF2A_6	485	493	PF00069	0.621
DOC_MAPK_NFAT4_5	486	494	PF00069	0.550
DOC_PP1_RVXF_1	95	101	PF00149	0.520
DOC_PP4_FxxP_1	21	24	PF00568	0.555
DOC_PP4_FxxP_1	313	316	PF00568	0.506
DOC_PP4_MxPP_1	57	60	PF00568	0.504
DOC_USP7_MATH_1	101	105	PF00917	0.657
DOC_USP7_MATH_1	137	141	PF00917	0.590
DOC_USP7_MATH_1	181	185	PF00917	0.629
DOC_USP7_MATH_1	212	216	PF00917	0.601
DOC_USP7_MATH_1	222	226	PF00917	0.519
DOC_USP7_MATH_1	245	249	PF00917	0.675
DOC_USP7_MATH_1	252	256	PF00917	0.664
DOC_USP7_MATH_1	302	306	PF00917	0.594
DOC_USP7_MATH_1	309	313	PF00917	0.592
DOC_USP7_MATH_1	317	321	PF00917	0.492
DOC_USP7_MATH_1	369	373	PF00917	0.624
DOC_USP7_MATH_1	429	433	PF00917	0.664
DOC_USP7_MATH_1	443	447	PF00917	0.540
DOC_USP7_MATH_1	540	544	PF00917	0.542
DOC_USP7_MATH_1	550	554	PF00917	0.610
DOC_USP7_MATH_1	569	573	PF00917	0.487
DOC_USP7_MATH_1	575	579	PF00917	0.457
DOC_USP7_MATH_1	62	66	PF00917	0.539
DOC_USP7_MATH_2	301	307	PF00917	0.542
DOC_USP7_MATH_2	575	581	PF00917	0.458
DOC_WW_Pin1_4	138	143	PF00397	0.680
DOC_WW_Pin1_4	20	25	PF00397	0.555
DOC_WW_Pin1_4	277	282	PF00397	0.692
DOC_WW_Pin1_4	296	301	PF00397	0.521
DOC_WW_Pin1_4	349	354	PF00397	0.653
DOC_WW_Pin1_4	55	60	PF00397	0.505
DOC_WW_Pin1_4	606	611	PF00397	0.688
DOC_WW_Pin1_4	613	618	PF00397	0.576
DOC_WW_Pin1_4	72	77	PF00397	0.535
DOC_WW_Pin1_4	80	85	PF00397	0.581
LIG_14-3-3_CanoR_1	12	17	PF00244	0.565
LIG_14-3-3_CanoR_1	201	206	PF00244	0.467
LIG_14-3-3_CanoR_1	238	243	PF00244	0.601
LIG_14-3-3_CanoR_1	403	412	PF00244	0.515
LIG_14-3-3_CanoR_1	45	50	PF00244	0.489
LIG_14-3-3_CanoR_1	539	549	PF00244	0.523
LIG_14-3-3_CanoR_1	587	594	PF00244	0.526
LIG_14-3-3_CanoR_1	627	636	PF00244	0.553
LIG_14-3-3_CanoR_1	64	74	PF00244	0.497
LIG_14-3-3_CanoR_1	646	651	PF00244	0.670
LIG_Actin_WH2_2	477	494	PF00022	0.561
LIG_BRCT_BRCA1_1	309	313	PF00533	0.530
LIG_BRCT_BRCA1_1	34	38	PF00533	0.534
LIG_CaM_NSCaTE_8	273	280	PF13499	0.523
LIG_Clathr_ClatBox_1	150	154	PF01394	0.532
LIG_FHA_1	103	109	PF00498	0.791
LIG_FHA_1	234	240	PF00498	0.695
LIG_FHA_1	272	278	PF00498	0.625
LIG_FHA_1	316	322	PF00498	0.492
LIG_FHA_1	336	342	PF00498	0.479
LIG_FHA_1	363	369	PF00498	0.721
LIG_FHA_1	385	391	PF00498	0.635
LIG_FHA_1	588	594	PF00498	0.466
LIG_FHA_1	598	604	PF00498	0.573
LIG_FHA_2	361	367	PF00498	0.704
LIG_FHA_2	372	378	PF00498	0.629
LIG_FHA_2	387	393	PF00498	0.501
LIG_GBD_Chelix_1	390	398	PF00786	0.509
LIG_GBD_Chelix_1	541	549	PF00786	0.439
LIG_LIR_Apic_2	20	24	PF02991	0.556
LIG_LIR_Apic_2	310	316	PF02991	0.627
LIG_LIR_Apic_2	649	653	PF02991	0.533
LIG_LIR_Nem_3	48	52	PF02991	0.489
LIG_LIR_Nem_3	99	103	PF02991	0.513
LIG_NRBOX	486	492	PF00104	0.667
LIG_NRP_CendR_1	665	668	PF00754	0.531
LIG_PCNA_APIM_2	581	587	PF02747	0.397
LIG_SH2_STAT5	471	474	PF00017	0.467
LIG_SH2_STAT5	584	587	PF00017	0.566
LIG_SH3_1	637	643	PF00018	0.744
LIG_SH3_2	230	235	PF14604	0.519
LIG_SH3_2	59	64	PF14604	0.521
LIG_SH3_3	110	116	PF00018	0.565
LIG_SH3_3	227	233	PF00018	0.688
LIG_SH3_3	27	33	PF00018	0.540
LIG_SH3_3	437	443	PF00018	0.512
LIG_SH3_3	48	54	PF00018	0.487
LIG_SH3_3	56	62	PF00018	0.492
LIG_SH3_3	632	638	PF00018	0.717
LIG_SH3_3	95	101	PF00018	0.536
LIG_SUMO_SIM_anti_2	576	583	PF11976	0.438
LIG_SUMO_SIM_par_1	115	120	PF11976	0.525
LIG_SUMO_SIM_par_1	322	328	PF11976	0.659
LIG_UBA3_1	419	424	PF00899	0.452
MOD_CDK_SPxxK_3	282	289	PF00069	0.540
MOD_CDK_SPxxK_3	613	620	PF00069	0.499
MOD_CK1_1	140	146	PF00069	0.671
MOD_CK1_1	162	168	PF00069	0.779
MOD_CK1_1	169	175	PF00069	0.658
MOD_CK1_1	184	190	PF00069	0.595
MOD_CK1_1	253	259	PF00069	0.578
MOD_CK1_1	285	291	PF00069	0.751
MOD_CK1_1	331	337	PF00069	0.671
MOD_CK1_1	367	373	PF00069	0.600
MOD_CK1_1	411	417	PF00069	0.470
MOD_CK1_1	433	439	PF00069	0.558
MOD_CK1_1	446	452	PF00069	0.713
MOD_CK1_1	552	558	PF00069	0.641
MOD_CK1_1	561	567	PF00069	0.617
MOD_CK1_1	65	71	PF00069	0.531
MOD_CK1_1	99	105	PF00069	0.612
MOD_CK2_1	256	262	PF00069	0.654
MOD_CK2_1	288	294	PF00069	0.716
MOD_CK2_1	429	435	PF00069	0.665
MOD_CK2_1	460	466	PF00069	0.499
MOD_CK2_1	540	546	PF00069	0.540
MOD_DYRK1A_RPxSP_1	72	76	PF00069	0.527
MOD_GlcNHglycan	214	217	PF01048	0.668
MOD_GlcNHglycan	282	285	PF01048	0.631
MOD_GlcNHglycan	39	42	PF01048	0.496
MOD_GlcNHglycan	435	438	PF01048	0.585
MOD_GlcNHglycan	444	448	PF01048	0.630
MOD_GlcNHglycan	512	516	PF01048	0.537
MOD_GlcNHglycan	571	574	PF01048	0.499
MOD_GlcNHglycan	595	598	PF01048	0.615
MOD_GlcNHglycan	652	656	PF01048	0.709
MOD_GSK3_1	137	144	PF00069	0.533
MOD_GSK3_1	159	166	PF00069	0.761
MOD_GSK3_1	169	176	PF00069	0.586
MOD_GSK3_1	20	27	PF00069	0.620
MOD_GSK3_1	201	208	PF00069	0.504
MOD_GSK3_1	212	219	PF00069	0.622
MOD_GSK3_1	252	259	PF00069	0.569
MOD_GSK3_1	267	274	PF00069	0.645
MOD_GSK3_1	28	35	PF00069	0.639
MOD_GSK3_1	303	310	PF00069	0.709
MOD_GSK3_1	327	334	PF00069	0.594
MOD_GSK3_1	349	356	PF00069	0.700
MOD_GSK3_1	358	365	PF00069	0.625
MOD_GSK3_1	367	374	PF00069	0.540
MOD_GSK3_1	380	387	PF00069	0.559
MOD_GSK3_1	404	411	PF00069	0.628
MOD_GSK3_1	429	436	PF00069	0.549
MOD_GSK3_1	443	450	PF00069	0.496
MOD_GSK3_1	545	552	PF00069	0.527
MOD_GSK3_1	554	561	PF00069	0.617
MOD_GSK3_1	593	600	PF00069	0.543
MOD_GSK3_1	62	69	PF00069	0.538
MOD_GSK3_1	642	649	PF00069	0.804
MOD_N-GLC_1	558	563	PF02516	0.548
MOD_NEK2_1	327	332	PF00069	0.665
MOD_NEK2_1	386	391	PF00069	0.491
MOD_NEK2_1	39	44	PF00069	0.490
MOD_NEK2_1	510	515	PF00069	0.617
MOD_NEK2_1	549	554	PF00069	0.599
MOD_NEK2_1	605	610	PF00069	0.546
MOD_NEK2_2	222	227	PF00069	0.475
MOD_OFUCOSY	251	257	PF10250	0.491
MOD_OFUCOSY	427	434	PF10250	0.491
MOD_OFUCOSY	457	464	PF10250	0.511
MOD_OFUCOSY	537	544	PF10250	0.547
MOD_PIKK_1	143	149	PF00454	0.523
MOD_PIKK_1	360	366	PF00454	0.720
MOD_PK_1	32	38	PF00069	0.535
MOD_PKA_1	358	364	PF00069	0.719
MOD_PKA_1	45	51	PF00069	0.483
MOD_PKA_1	497	503	PF00069	0.555
MOD_PKA_1	646	652	PF00069	0.541
MOD_PKA_2	129	135	PF00069	0.525
MOD_PKA_2	181	187	PF00069	0.681
MOD_PKA_2	271	277	PF00069	0.518
MOD_PKA_2	288	294	PF00069	0.515
MOD_PKA_2	335	341	PF00069	0.618
MOD_PKA_2	358	364	PF00069	0.711
MOD_PKA_2	45	51	PF00069	0.483
MOD_PKA_2	491	497	PF00069	0.566
MOD_PKA_2	65	71	PF00069	0.492
MOD_PKB_1	43	51	PF00069	0.482
MOD_PKB_1	64	72	PF00069	0.533
MOD_Plk_1	327	333	PF00069	0.666
MOD_Plk_1	545	551	PF00069	0.558
MOD_Plk_1	575	581	PF00069	0.444
MOD_Plk_2-3	558	564	PF00069	0.546
MOD_Plk_4	309	315	PF00069	0.531
MOD_Plk_4	317	323	PF00069	0.551
MOD_Plk_4	328	334	PF00069	0.630
MOD_Plk_4	386	392	PF00069	0.490
MOD_Plk_4	577	583	PF00069	0.570
MOD_ProDKin_1	138	144	PF00069	0.680
MOD_ProDKin_1	20	26	PF00069	0.551
MOD_ProDKin_1	277	283	PF00069	0.693
MOD_ProDKin_1	296	302	PF00069	0.519
MOD_ProDKin_1	349	355	PF00069	0.649
MOD_ProDKin_1	55	61	PF00069	0.507
MOD_ProDKin_1	606	612	PF00069	0.713
MOD_ProDKin_1	613	619	PF00069	0.599
MOD_ProDKin_1	72	78	PF00069	0.537
MOD_ProDKin_1	80	86	PF00069	0.581
TRG_DiLeu_BaEn_4	482	488	PF01217	0.489
TRG_DiLeu_BaLyEn_6	146	151	PF01217	0.528
TRG_DiLeu_BaLyEn_6	485	490	PF01217	0.566
TRG_DiLeu_BaLyEn_6	601	606	PF01217	0.530
TRG_ER_diArg_1	403	405	PF00400	0.649
TRG_ER_diArg_1	43	46	PF00400	0.482
TRG_ER_diArg_1	484	486	PF00400	0.541
TRG_ER_diArg_1	665	668	PF00400	0.531
TRG_Pf-PMV_PEXEL_1	418	423	PF00026	0.557

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IC62	Leishmania donovani	64%	100%
A4HWB6	Leishmania infantum	64%	100%
E9AQ16	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
Q4QFG5	Leishmania major	62%	100%