Putative serine/threonine-protein kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine-protein kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4H7Y7_LEIBR

TriTrypDb:

LbrM.15.0170 , LBRM2903_150006900

Length:

796

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H7Y7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7Y7

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016310	phosphorylation	5	6
GO:0019538	protein metabolic process	3	6
GO:0036211	protein modification process	4	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0071704	organic substance metabolic process	2	6
GO:1901564	organonitrogen compound metabolic process	3	6

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0004672	protein kinase activity	3	6
GO:0004674	protein serine/threonine kinase activity	4	3
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	6
GO:0017076	purine nucleotide binding	4	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:0140096	catalytic activity, acting on a protein	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.579
CLV_C14_Caspase3-7	191	195	PF00656	0.514
CLV_C14_Caspase3-7	395	399	PF00656	0.595
CLV_C14_Caspase3-7	94	98	PF00656	0.827
CLV_NRD_NRD_1	16	18	PF00675	0.481
CLV_NRD_NRD_1	381	383	PF00675	0.582
CLV_NRD_NRD_1	445	447	PF00675	0.507
CLV_NRD_NRD_1	515	517	PF00675	0.408
CLV_NRD_NRD_1	666	668	PF00675	0.507
CLV_NRD_NRD_1	683	685	PF00675	0.416
CLV_PCSK_FUR_1	681	685	PF00082	0.507
CLV_PCSK_KEX2_1	16	18	PF00082	0.481
CLV_PCSK_KEX2_1	381	383	PF00082	0.582
CLV_PCSK_KEX2_1	434	436	PF00082	0.408
CLV_PCSK_KEX2_1	445	447	PF00082	0.408
CLV_PCSK_KEX2_1	46	48	PF00082	0.512
CLV_PCSK_KEX2_1	570	572	PF00082	0.507
CLV_PCSK_KEX2_1	666	668	PF00082	0.507
CLV_PCSK_KEX2_1	683	685	PF00082	0.416
CLV_PCSK_PC1ET2_1	434	436	PF00082	0.408
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.512
CLV_PCSK_PC1ET2_1	570	572	PF00082	0.507
CLV_PCSK_SKI1_1	476	480	PF00082	0.408
CLV_PCSK_SKI1_1	717	721	PF00082	0.462
CLV_PCSK_SKI1_1	76	80	PF00082	0.561
DEG_APCC_DBOX_1	597	605	PF00400	0.408
DEG_APCC_DBOX_1	665	673	PF00400	0.507
DEG_Nend_Nbox_1	1	3	PF02207	0.483
DEG_SCF_FBW7_1	206	212	PF00400	0.577
DEG_SPOP_SBC_1	239	243	PF00917	0.619
DEG_SPOP_SBC_1	244	248	PF00917	0.615
DEG_SPOP_SBC_1	262	266	PF00917	0.803
DEG_SPOP_SBC_1	317	321	PF00917	0.703
DOC_CKS1_1	206	211	PF01111	0.577
DOC_CKS1_1	592	597	PF01111	0.507
DOC_CKS1_1	685	690	PF01111	0.507
DOC_CYCLIN_yCln2_LP_2	720	726	PF00134	0.267
DOC_MAPK_FxFP_2	24	27	PF00069	0.478
DOC_MAPK_gen_1	503	512	PF00069	0.507
DOC_MAPK_gen_1	579	589	PF00069	0.408
DOC_MAPK_HePTP_8	576	588	PF00069	0.408
DOC_MAPK_MEF2A_6	357	366	PF00069	0.543
DOC_MAPK_MEF2A_6	451	460	PF00069	0.503
DOC_MAPK_MEF2A_6	506	514	PF00069	0.507
DOC_MAPK_MEF2A_6	579	588	PF00069	0.408
DOC_PP1_RVXF_1	556	563	PF00149	0.408
DOC_PP2B_LxvP_1	36	39	PF13499	0.487
DOC_PP2B_LxvP_1	402	405	PF13499	0.539
DOC_PP4_FxxP_1	24	27	PF00568	0.478
DOC_PP4_FxxP_1	724	727	PF00568	0.495
DOC_USP7_MATH_1	121	125	PF00917	0.617
DOC_USP7_MATH_1	168	172	PF00917	0.587
DOC_USP7_MATH_1	240	244	PF00917	0.695
DOC_USP7_MATH_1	317	321	PF00917	0.769
DOC_USP7_MATH_1	344	348	PF00917	0.808
DOC_USP7_MATH_1	53	57	PF00917	0.809
DOC_USP7_MATH_1	760	764	PF00917	0.631
DOC_WW_Pin1_4	173	178	PF00397	0.612
DOC_WW_Pin1_4	205	210	PF00397	0.576
DOC_WW_Pin1_4	30	35	PF00397	0.478
DOC_WW_Pin1_4	323	328	PF00397	0.565
DOC_WW_Pin1_4	382	387	PF00397	0.660
DOC_WW_Pin1_4	580	585	PF00397	0.408
DOC_WW_Pin1_4	591	596	PF00397	0.408
DOC_WW_Pin1_4	639	644	PF00397	0.408
DOC_WW_Pin1_4	684	689	PF00397	0.462
LIG_14-3-3_CanoR_1	152	158	PF00244	0.661
LIG_14-3-3_CanoR_1	16	22	PF00244	0.481
LIG_14-3-3_CanoR_1	169	177	PF00244	0.688
LIG_14-3-3_CanoR_1	263	272	PF00244	0.691
LIG_14-3-3_CanoR_1	445	451	PF00244	0.408
LIG_14-3-3_CanoR_1	598	602	PF00244	0.408
LIG_14-3-3_CanoR_1	666	670	PF00244	0.507
LIG_APCC_ABBA_1	586	591	PF00400	0.408
LIG_BIR_III_2	145	149	PF00653	0.579
LIG_BIR_III_2	741	745	PF00653	0.507
LIG_BRCT_BRCA1_1	8	12	PF00533	0.471
LIG_Clathr_ClatBox_1	526	530	PF01394	0.507
LIG_EH1_1	471	479	PF00400	0.507
LIG_EVH1_2	39	43	PF00568	0.488
LIG_FHA_1	206	212	PF00498	0.577
LIG_FHA_1	521	527	PF00498	0.507
LIG_FHA_1	63	69	PF00498	0.532
LIG_FHA_1	728	734	PF00498	0.636
LIG_FHA_2	177	183	PF00498	0.814
LIG_FHA_2	592	598	PF00498	0.408
LIG_FHA_2	75	81	PF00498	0.554
LIG_FHA_2	92	98	PF00498	0.754
LIG_HCF-1_HBM_1	785	788	PF13415	0.578
LIG_LIR_Apic_2	352	358	PF02991	0.671
LIG_LIR_Apic_2	578	584	PF02991	0.408
LIG_LIR_Apic_2	591	595	PF02991	0.408
LIG_LIR_Gen_1	20	30	PF02991	0.478
LIG_LIR_Gen_1	398	409	PF02991	0.463
LIG_LIR_Gen_1	697	706	PF02991	0.520
LIG_LIR_Nem_3	20	25	PF02991	0.480
LIG_LIR_Nem_3	368	373	PF02991	0.495
LIG_LIR_Nem_3	398	404	PF02991	0.469
LIG_LIR_Nem_3	407	413	PF02991	0.455
LIG_LIR_Nem_3	423	427	PF02991	0.353
LIG_LIR_Nem_3	495	499	PF02991	0.356
LIG_LIR_Nem_3	505	510	PF02991	0.363
LIG_LIR_Nem_3	692	698	PF02991	0.474
LIG_MYND_1	34	38	PF01753	0.478
LIG_MYND_1	723	727	PF01753	0.408
LIG_NRBOX	457	463	PF00104	0.408
LIG_PCNA_yPIPBox_3	463	474	PF02747	0.424
LIG_Pex14_2	22	26	PF04695	0.481
LIG_Pex14_2	701	705	PF04695	0.507
LIG_PTAP_UEV_1	198	203	PF05743	0.571
LIG_PTB_Apo_2	371	378	PF02174	0.609
LIG_PTB_Phospho_1	371	377	PF10480	0.614
LIG_RPA_C_Fungi	371	383	PF08784	0.576
LIG_SH2_CRK	355	359	PF00017	0.666
LIG_SH2_CRK	370	374	PF00017	0.355
LIG_SH2_CRK	499	503	PF00017	0.408
LIG_SH2_CRK	592	596	PF00017	0.507
LIG_SH2_CRK	650	654	PF00017	0.267
LIG_SH2_SRC	788	791	PF00017	0.568
LIG_SH2_STAP1	116	120	PF00017	0.515
LIG_SH2_STAP1	729	733	PF00017	0.637
LIG_SH2_STAP1	87	91	PF00017	0.789
LIG_SH2_STAT3	377	380	PF00017	0.621
LIG_SH2_STAT3	413	416	PF00017	0.542
LIG_SH2_STAT5	377	380	PF00017	0.621
LIG_SH2_STAT5	401	404	PF00017	0.463
LIG_SH2_STAT5	41	44	PF00017	0.508
LIG_SH2_STAT5	413	416	PF00017	0.442
LIG_SH2_STAT5	575	578	PF00017	0.420
LIG_SH2_STAT5	729	732	PF00017	0.633
LIG_SH3_1	269	275	PF00018	0.583
LIG_SH3_3	128	134	PF00018	0.601
LIG_SH3_3	196	202	PF00018	0.772
LIG_SH3_3	2	8	PF00018	0.477
LIG_SH3_3	203	209	PF00018	0.746
LIG_SH3_3	269	275	PF00018	0.600
LIG_SH3_3	287	293	PF00018	0.678
LIG_SH3_3	304	310	PF00018	0.815
LIG_SH3_3	742	748	PF00018	0.729
LIG_SUMO_SIM_anti_2	457	462	PF11976	0.408
LIG_SUMO_SIM_anti_2	511	516	PF11976	0.507
LIG_SUMO_SIM_par_1	486	492	PF11976	0.408
LIG_SUMO_SIM_par_1	604	610	PF11976	0.296
LIG_TRAF2_1	348	351	PF00917	0.552
LIG_TRAF2_1	78	81	PF00917	0.524
LIG_TRFH_1	30	34	PF08558	0.476
LIG_UBA3_1	366	371	PF00899	0.605
LIG_UBA3_1	526	533	PF00899	0.507
LIG_WRC_WIRS_1	493	498	PF05994	0.507
LIG_WW_1	38	41	PF00397	0.478
MOD_CDK_SPK_2	639	644	PF00069	0.408
MOD_CDK_SPxxK_3	382	389	PF00069	0.666
MOD_CDK_SPxxK_3	591	598	PF00069	0.507
MOD_CK1_1	114	120	PF00069	0.632
MOD_CK1_1	126	132	PF00069	0.765
MOD_CK1_1	153	159	PF00069	0.718
MOD_CK1_1	161	167	PF00069	0.746
MOD_CK1_1	173	179	PF00069	0.648
MOD_CK1_1	185	191	PF00069	0.717
MOD_CK1_1	215	221	PF00069	0.584
MOD_CK1_1	242	248	PF00069	0.821
MOD_CK1_1	315	321	PF00069	0.769
MOD_CK1_1	349	355	PF00069	0.493
MOD_CK1_1	423	429	PF00069	0.408
MOD_CK1_1	449	455	PF00069	0.408
MOD_CK1_1	56	62	PF00069	0.757
MOD_CK1_1	64	70	PF00069	0.733
MOD_CK1_1	762	768	PF00069	0.816
MOD_CK2_1	121	127	PF00069	0.569
MOD_CK2_1	282	288	PF00069	0.723
MOD_CK2_1	344	350	PF00069	0.561
MOD_CK2_1	74	80	PF00069	0.513
MOD_CK2_1	779	785	PF00069	0.809
MOD_Cter_Amidation	681	684	PF01082	0.507
MOD_GlcNHglycan	127	131	PF01048	0.840
MOD_GlcNHglycan	160	163	PF01048	0.758
MOD_GlcNHglycan	216	220	PF01048	0.808
MOD_GlcNHglycan	242	245	PF01048	0.765
MOD_GlcNHglycan	320	323	PF01048	0.783
MOD_GlcNHglycan	331	334	PF01048	0.687
MOD_GlcNHglycan	338	342	PF01048	0.691
MOD_GlcNHglycan	346	349	PF01048	0.518
MOD_GlcNHglycan	391	394	PF01048	0.624
MOD_GlcNHglycan	554	557	PF01048	0.450
MOD_GlcNHglycan	563	566	PF01048	0.357
MOD_GlcNHglycan	654	657	PF01048	0.507
MOD_GSK3_1	111	118	PF00069	0.590
MOD_GSK3_1	121	128	PF00069	0.558
MOD_GSK3_1	169	176	PF00069	0.772
MOD_GSK3_1	184	191	PF00069	0.562
MOD_GSK3_1	205	212	PF00069	0.578
MOD_GSK3_1	238	245	PF00069	0.755
MOD_GSK3_1	275	282	PF00069	0.755
MOD_GSK3_1	311	318	PF00069	0.804
MOD_GSK3_1	322	329	PF00069	0.646
MOD_GSK3_1	441	448	PF00069	0.507
MOD_GSK3_1	52	59	PF00069	0.811
MOD_GSK3_1	548	555	PF00069	0.437
MOD_GSK3_1	759	766	PF00069	0.730
MOD_GSK3_1	771	778	PF00069	0.719
MOD_GSK3_1	780	787	PF00069	0.745
MOD_GSK3_1	91	98	PF00069	0.827
MOD_LATS_1	150	156	PF00433	0.578
MOD_N-GLC_1	552	557	PF02516	0.408
MOD_N-GLC_1	651	656	PF02516	0.507
MOD_NEK2_1	12	17	PF00069	0.526
MOD_NEK2_1	184	189	PF00069	0.648
MOD_NEK2_1	295	300	PF00069	0.599
MOD_NEK2_1	311	316	PF00069	0.625
MOD_NEK2_1	441	446	PF00069	0.408
MOD_NEK2_1	52	57	PF00069	0.807
MOD_NEK2_1	522	527	PF00069	0.507
MOD_NEK2_1	548	553	PF00069	0.267
MOD_OFUCOSY	4	10	PF10250	0.476
MOD_PIKK_1	155	161	PF00454	0.599
MOD_PIKK_1	170	176	PF00454	0.541
MOD_PIKK_1	296	302	PF00454	0.626
MOD_PIKK_1	449	455	PF00454	0.408
MOD_PIKK_1	528	534	PF00454	0.267
MOD_PIKK_1	548	554	PF00454	0.180
MOD_PIKK_1	58	64	PF00454	0.551
MOD_PIKK_1	748	754	PF00454	0.749
MOD_PIKK_1	760	766	PF00454	0.722
MOD_PIKK_1	91	97	PF00454	0.828
MOD_PKA_1	445	451	PF00069	0.507
MOD_PKA_2	168	174	PF00069	0.784
MOD_PKA_2	226	232	PF00069	0.578
MOD_PKA_2	262	268	PF00069	0.597
MOD_PKA_2	445	451	PF00069	0.507
MOD_PKA_2	597	603	PF00069	0.408
MOD_PKA_2	665	671	PF00069	0.507
MOD_PKB_1	167	175	PF00069	0.783
MOD_Plk_1	215	221	PF00069	0.584
MOD_Plk_1	627	633	PF00069	0.507
MOD_Plk_1	784	790	PF00069	0.689
MOD_Plk_1	91	97	PF00069	0.588
MOD_Plk_2-3	665	671	PF00069	0.507
MOD_Plk_2-3	780	786	PF00069	0.566
MOD_Plk_4	111	117	PF00069	0.530
MOD_Plk_4	17	23	PF00069	0.480
MOD_Plk_4	423	429	PF00069	0.408
MOD_Plk_4	522	528	PF00069	0.507
MOD_Plk_4	64	70	PF00069	0.499
MOD_Plk_4	668	674	PF00069	0.507
MOD_ProDKin_1	173	179	PF00069	0.610
MOD_ProDKin_1	205	211	PF00069	0.578
MOD_ProDKin_1	30	36	PF00069	0.480
MOD_ProDKin_1	323	329	PF00069	0.563
MOD_ProDKin_1	382	388	PF00069	0.665
MOD_ProDKin_1	580	586	PF00069	0.408
MOD_ProDKin_1	591	597	PF00069	0.408
MOD_ProDKin_1	639	645	PF00069	0.408
MOD_ProDKin_1	684	690	PF00069	0.462
MOD_SUMO_for_1	454	457	PF00179	0.408
MOD_SUMO_for_1	542	545	PF00179	0.408
MOD_SUMO_for_1	625	628	PF00179	0.507
TRG_DiLeu_BaEn_1	457	462	PF01217	0.408
TRG_DiLeu_BaEn_2	584	590	PF01217	0.507
TRG_DiLeu_BaLyEn_6	307	312	PF01217	0.587
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.477
TRG_DiLeu_BaLyEn_6	473	478	PF01217	0.507
TRG_DiLeu_BaLyEn_6	555	560	PF01217	0.408
TRG_ENDOCYTIC_2	370	373	PF00928	0.510
TRG_ENDOCYTIC_2	401	404	PF00928	0.463
TRG_ENDOCYTIC_2	499	502	PF00928	0.408
TRG_ENDOCYTIC_2	650	653	PF00928	0.300
TRG_ENDOCYTIC_2	695	698	PF00928	0.424
TRG_ER_diArg_1	167	170	PF00400	0.808
TRG_ER_diArg_1	381	383	PF00400	0.588
TRG_ER_diArg_1	680	683	PF00400	0.429
TRG_Pf-PMV_PEXEL_1	190	194	PF00026	0.570
TRG_Pf-PMV_PEXEL_1	412	416	PF00026	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WTA3	Leishmania donovani	76%	100%
A4HWB5	Leishmania infantum	76%	100%
C9ZNW1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AQ15	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%