PPM-type phosphatase domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein phosphatase 2C, putative

Species:

Leishmania braziliensis

UniProt:

A4H7Y6_LEIBR

TriTrypDb:

LbrM.15.0160 , LBRM2903_150006800

Length:

404

Annotations

LeishMANIAdb annotations

This large family encompasses many diverse protein phosphatases. Some appear to have evolved transmembrane segments. Very tentatively they might regulate transmembrane receptor kinases.. The TM and non-TM groups diverged early in Eukaryota and appear to be distinct enough that they probably should not be part of the same cluster. This latter group has not expanded.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H7Y6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7Y6

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	17
GO:0006793	phosphorus metabolic process	3	17
GO:0006796	phosphate-containing compound metabolic process	4	17
GO:0006807	nitrogen compound metabolic process	2	17
GO:0008152	metabolic process	1	17
GO:0009987	cellular process	1	17
GO:0016311	dephosphorylation	5	17
GO:0019538	protein metabolic process	3	17
GO:0036211	protein modification process	4	17
GO:0043170	macromolecule metabolic process	3	17
GO:0043412	macromolecule modification	4	17
GO:0044237	cellular metabolic process	2	17
GO:0044238	primary metabolic process	2	17
GO:0071704	organic substance metabolic process	2	17
GO:1901564	organonitrogen compound metabolic process	3	17

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	17
GO:0004721	phosphoprotein phosphatase activity	3	17
GO:0004722	protein serine/threonine phosphatase activity	4	17
GO:0016787	hydrolase activity	2	17
GO:0016788	hydrolase activity, acting on ester bonds	3	17
GO:0016791	phosphatase activity	5	17
GO:0042578	phosphoric ester hydrolase activity	4	17
GO:0140096	catalytic activity, acting on a protein	2	17
GO:0017018	myosin phosphatase activity	5	3
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	126	130	PF00656	0.543
CLV_C14_Caspase3-7	330	334	PF00656	0.431
CLV_C14_Caspase3-7	391	395	PF00656	0.393
CLV_NRD_NRD_1	163	165	PF00675	0.197
CLV_NRD_NRD_1	56	58	PF00675	0.512
CLV_NRD_NRD_1	71	73	PF00675	0.543
CLV_PCSK_FUR_1	94	98	PF00082	0.393
CLV_PCSK_KEX2_1	328	330	PF00082	0.490
CLV_PCSK_KEX2_1	96	98	PF00082	0.448
CLV_PCSK_PC1ET2_1	328	330	PF00082	0.490
CLV_PCSK_PC1ET2_1	96	98	PF00082	0.391
CLV_PCSK_SKI1_1	117	121	PF00082	0.458
CLV_PCSK_SKI1_1	194	198	PF00082	0.341
CLV_PCSK_SKI1_1	251	255	PF00082	0.319
CLV_PCSK_SKI1_1	60	64	PF00082	0.526
CLV_Separin_Metazoa	65	69	PF03568	0.382
DEG_APCC_DBOX_1	96	104	PF00400	0.391
DEG_Nend_UBRbox_1	1	4	PF02207	0.601
DOC_USP7_MATH_1	113	117	PF00917	0.625
DOC_WW_Pin1_4	235	240	PF00397	0.357
DOC_WW_Pin1_4	379	384	PF00397	0.296
LIG_14-3-3_CanoR_1	194	199	PF00244	0.201
LIG_BRCT_BRCA1_1	184	188	PF00533	0.514
LIG_BRCT_BRCA1_2	184	190	PF00533	0.201
LIG_FHA_1	229	235	PF00498	0.284
LIG_FHA_1	395	401	PF00498	0.355
LIG_FHA_1	48	54	PF00498	0.596
LIG_FHA_1	82	88	PF00498	0.551
LIG_FHA_2	124	130	PF00498	0.522
LIG_FHA_2	209	215	PF00498	0.301
LIG_Integrin_isoDGR_2	13	15	PF01839	0.542
LIG_LIR_Gen_1	193	199	PF02991	0.317
LIG_LIR_Gen_1	211	219	PF02991	0.330
LIG_LIR_Gen_1	332	343	PF02991	0.314
LIG_LIR_Gen_1	36	46	PF02991	0.521
LIG_LIR_Nem_3	166	172	PF02991	0.347
LIG_LIR_Nem_3	193	198	PF02991	0.291
LIG_LIR_Nem_3	211	215	PF02991	0.313
LIG_LIR_Nem_3	332	338	PF02991	0.313
LIG_LIR_Nem_3	36	42	PF02991	0.527
LIG_NRBOX	99	105	PF00104	0.540
LIG_PCNA_yPIPBox_3	349	360	PF02747	0.244
LIG_PCNA_yPIPBox_3	94	108	PF02747	0.512
LIG_Pex14_2	208	212	PF04695	0.384
LIG_PTB_Apo_2	127	134	PF02174	0.431
LIG_PTB_Apo_2	151	158	PF02174	0.305
LIG_SH2_CRK	195	199	PF00017	0.305
LIG_SH2_PTP2	236	239	PF00017	0.441
LIG_SH2_PTP2	335	338	PF00017	0.441
LIG_SH2_STAP1	195	199	PF00017	0.288
LIG_SH2_STAT5	236	239	PF00017	0.471
LIG_SH2_STAT5	335	338	PF00017	0.441
LIG_SH3_3	316	322	PF00018	0.393
LIG_SH3_3	377	383	PF00018	0.305
LIG_SUMO_SIM_anti_2	397	402	PF11976	0.373
LIG_SUMO_SIM_par_1	317	323	PF11976	0.229
LIG_SUMO_SIM_par_1	396	402	PF11976	0.402
LIG_TRAF2_1	34	37	PF00917	0.449
LIG_TRAF2_1	348	351	PF00917	0.384
LIG_UBA3_1	352	360	PF00899	0.441
LIG_UBA3_1	399	404	PF00899	0.352
MOD_CK1_1	228	234	PF00069	0.351
MOD_CK1_1	362	368	PF00069	0.201
MOD_CK1_1	44	50	PF00069	0.548
MOD_CK2_1	208	214	PF00069	0.423
MOD_CK2_1	345	351	PF00069	0.330
MOD_CK2_1	378	384	PF00069	0.429
MOD_CK2_1	80	86	PF00069	0.618
MOD_GlcNHglycan	108	111	PF01048	0.592
MOD_GlcNHglycan	160	163	PF01048	0.349
MOD_GlcNHglycan	175	178	PF01048	0.277
MOD_GlcNHglycan	179	182	PF01048	0.316
MOD_GlcNHglycan	227	230	PF01048	0.357
MOD_GlcNHglycan	256	259	PF01048	0.253
MOD_GlcNHglycan	361	364	PF01048	0.201
MOD_GSK3_1	113	120	PF00069	0.534
MOD_GSK3_1	173	180	PF00069	0.506
MOD_GSK3_1	182	189	PF00069	0.456
MOD_GSK3_1	323	330	PF00069	0.471
MOD_GSK3_1	362	369	PF00069	0.336
MOD_GSK3_1	390	397	PF00069	0.447
MOD_N-GLC_1	394	399	PF02516	0.354
MOD_N-GLC_2	375	377	PF02516	0.441
MOD_NEK2_1	157	162	PF00069	0.193
MOD_NEK2_1	208	213	PF00069	0.436
MOD_NEK2_1	254	259	PF00069	0.467
MOD_NEK2_1	294	299	PF00069	0.314
MOD_NEK2_1	46	51	PF00069	0.643
MOD_PIKK_1	47	53	PF00454	0.550
MOD_PKA_1	359	365	PF00069	0.281
MOD_PKA_1	7	13	PF00069	0.628
MOD_PKA_2	14	20	PF00069	0.571
MOD_PKA_2	81	87	PF00069	0.646
MOD_Plk_1	394	400	PF00069	0.353
MOD_Plk_4	194	200	PF00069	0.358
MOD_Plk_4	208	214	PF00069	0.206
MOD_Plk_4	331	337	PF00069	0.332
MOD_Plk_4	394	400	PF00069	0.353
MOD_ProDKin_1	235	241	PF00069	0.357
MOD_ProDKin_1	379	385	PF00069	0.296
MOD_SUMO_for_1	62	65	PF00179	0.515
MOD_SUMO_rev_2	262	269	PF00179	0.318
TRG_DiLeu_BaEn_1	148	153	PF01217	0.357
TRG_DiLeu_BaEn_3	350	356	PF01217	0.433
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.388
TRG_ENDOCYTIC_2	195	198	PF00928	0.450
TRG_ENDOCYTIC_2	335	338	PF00928	0.441
TRG_NLS_Bipartite_1	57	76	PF00514	0.525
TRG_NLS_MonoExtC_3	71	77	PF00514	0.596
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.692

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5C7	Leptomonas seymouri	69%	100%
A0A0N0P8F8	Leptomonas seymouri	38%	100%
A0A0N1I0H9	Leptomonas seymouri	39%	100%
A0A0N1IHU6	Leptomonas seymouri	31%	99%
A0A0N1PAL8	Leptomonas seymouri	33%	100%
A0A0N1PET0	Leptomonas seymouri	36%	69%
A0A0S4ILP4	Bodo saltans	26%	77%
A0A0S4IY95	Bodo saltans	37%	100%
A0A0S4J0A6	Bodo saltans	32%	99%
A0A0S4J8Y7	Bodo saltans	29%	78%
A0A0S4JHB4	Bodo saltans	35%	100%
A0A0S4JPC3	Bodo saltans	44%	100%
A0A0S4JPM8	Bodo saltans	48%	100%
A0A0S4KIS4	Bodo saltans	36%	89%
A0A0S4KJV9	Bodo saltans	39%	93%
A0A1X0NRG3	Trypanosomatidae	35%	100%
A0A1X0NVC4	Trypanosomatidae	54%	98%
A0A1X0P568	Trypanosomatidae	33%	99%
A0A1X0P991	Trypanosomatidae	42%	100%
A0A1X0PAN4	Trypanosomatidae	28%	100%
A0A3Q8IEK6	Leishmania donovani	39%	100%
A0A3Q8IFG7	Leishmania donovani	33%	100%
A0A3Q8IGS1	Leishmania donovani	36%	72%
A0A3Q8IK65	Leishmania donovani	40%	100%
A0A3Q8IL63	Leishmania donovani	26%	100%
A0A3S7WTA2	Leishmania donovani	80%	100%
A0A3S7WZ14	Leishmania donovani	31%	100%
A0A3S7X808	Leishmania donovani	32%	90%
A0A422N8D7	Trypanosoma rangeli	28%	100%
A0A422NAJ1	Trypanosoma rangeli	36%	100%
A0A422NL94	Trypanosoma rangeli	37%	92%
A0A422NS77	Trypanosoma rangeli	50%	98%
A0A422P293	Trypanosoma rangeli	39%	100%
A0BLX0	Paramecium tetraurelia	34%	100%
A0BQL0	Paramecium tetraurelia	36%	100%
A0CUB5	Paramecium tetraurelia	34%	100%
A0DSB3	Paramecium tetraurelia	35%	100%
A0DTY1	Paramecium tetraurelia	35%	100%
A3A8W2	Oryza sativa subsp. japonica	31%	100%
A3A8W6	Oryza sativa subsp. japonica	27%	70%
A4HAW6	Leishmania braziliensis	30%	90%
A4HE10	Leishmania braziliensis	29%	100%
A4HG10	Leishmania braziliensis	39%	100%
A4HHY5	Leishmania braziliensis	34%	100%
A4HKF6	Leishmania braziliensis	35%	71%
A4HNR1	Leishmania braziliensis	40%	100%
A4HWB4	Leishmania infantum	80%	100%
A4I1B7	Leishmania infantum	31%	100%
A4I329	Leishmania infantum	39%	100%
A4I565	Leishmania infantum	33%	100%
A4I7Y4	Leishmania infantum	36%	72%
A4IA25	Leishmania infantum	26%	100%
A4IA26	Leishmania infantum	31%	90%
A4ICT4	Leishmania infantum	41%	100%
A5PJZ2	Bos taurus	33%	100%
C9ZJK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
C9ZMJ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZNW4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	95%
D0A2L9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
D0A5L0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	99%
E9ACV0	Leishmania major	39%	100%
E9AQ14	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
E9ASH0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AXF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AZD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9B0G2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9B2U5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	72%
E9B540	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B541	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
O62829	Bos taurus	35%	100%
O62830	Bos taurus	36%	83%
O75688	Homo sapiens	36%	84%
O81716	Arabidopsis thaliana	34%	100%
P20650	Rattus norvegicus	35%	100%
P34221	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	86%
P35182	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
P35813	Homo sapiens	35%	100%
P35814	Oryctolagus cuniculus	35%	100%
P35815	Rattus norvegicus	37%	100%
P36982	Leishmania chagasi	31%	100%
P36993	Mus musculus	36%	100%
P38089	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
P39966	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	87%
P49443	Mus musculus	35%	100%
P49444	Paramecium tetraurelia	34%	100%
P49593	Homo sapiens	30%	89%
P49594	Caenorhabditis elegans	24%	90%
P49596	Caenorhabditis elegans	40%	100%
P49599	Arabidopsis thaliana	25%	100%
Q09172	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	100%
Q09173	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	98%
Q0IIF0	Bos taurus	31%	100%
Q0J2L7	Oryza sativa subsp. japonica	32%	100%
Q0JL75	Oryza sativa subsp. japonica	30%	100%
Q0JLP9	Oryza sativa subsp. japonica	32%	87%
Q10MX1	Oryza sativa subsp. japonica	31%	100%
Q19775	Caenorhabditis elegans	34%	86%
Q2QWE3	Oryza sativa subsp. japonica	27%	96%
Q2R637	Oryza sativa subsp. japonica	29%	94%
Q4Q225	Leishmania major	39%	100%
Q4Q2U5	Leishmania major	31%	90%
Q4Q2U6	Leishmania major	26%	100%
Q4Q5B1	Leishmania major	36%	72%
Q4Q7S1	Leishmania major	32%	100%
Q4QA19	Leishmania major	31%	100%
Q4QFG7	Leishmania major	79%	100%
Q53Q11	Oryza sativa subsp. japonica	27%	100%
Q5SGD2	Homo sapiens	34%	100%
Q5SMK6	Oryza sativa subsp. japonica	28%	100%
Q5SN75	Oryza sativa subsp. japonica	33%	100%
Q653S3	Oryza sativa subsp. japonica	34%	100%
Q65XG6	Oryza sativa subsp. japonica	33%	97%
Q67UP9	Oryza sativa subsp. japonica	34%	100%
Q67UX7	Oryza sativa subsp. japonica	31%	100%
Q69QZ0	Oryza sativa subsp. japonica	28%	100%
Q69VD9	Oryza sativa subsp. japonica	31%	100%
Q6AUQ4	Oryza sativa subsp. japonica	30%	100%
Q6ETK3	Oryza sativa subsp. japonica	35%	100%
Q6K1U4	Oryza sativa subsp. japonica	27%	78%
Q6K5I0	Oryza sativa subsp. japonica	24%	78%
Q6L4R7	Oryza sativa subsp. japonica	33%	91%
Q6L5H6	Oryza sativa subsp. japonica	32%	100%
Q7XJ53	Arabidopsis thaliana	26%	100%
Q7XU84	Oryza sativa subsp. japonica	31%	100%
Q84JI0	Oryza sativa subsp. japonica	32%	100%
Q8BHN0	Mus musculus	33%	100%
Q8CGA0	Mus musculus	32%	89%
Q8GY60	Arabidopsis thaliana	29%	86%
Q8N819	Homo sapiens	33%	94%
Q8R0F6	Mus musculus	31%	100%
Q9CAJ0	Arabidopsis thaliana	32%	79%
Q9FXE4	Arabidopsis thaliana	31%	91%
Q9H0C8	Homo sapiens	31%	100%
Q9LMT1	Arabidopsis thaliana	27%	100%
Q9LNF4	Arabidopsis thaliana	29%	100%
Q9LNP9	Arabidopsis thaliana	32%	79%
Q9M1V8	Arabidopsis thaliana	26%	96%
Q9SA22	Arabidopsis thaliana	27%	82%
Q9SZ53	Arabidopsis thaliana	34%	100%
Q9WVR7	Rattus norvegicus	33%	90%
Q9XEE8	Arabidopsis thaliana	28%	100%
Q9Z1Z6	Rattus norvegicus	31%	100%
V5BA03	Trypanosoma cruzi	41%	100%
V5BCX6	Trypanosoma cruzi	35%	100%
V5BH00	Trypanosoma cruzi	35%	100%
V5DCR6	Trypanosoma cruzi	52%	98%