C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc finger (CCCH type) protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H7Y5_LEIBR

TriTrypDb:

LbrM.15.0150 , LBRM2903_150006700

Length:

803

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H7Y5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7Y5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0003729	mRNA binding	5	6
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	405	409	PF00656	0.589
CLV_C14_Caspase3-7	488	492	PF00656	0.537
CLV_NRD_NRD_1	115	117	PF00675	0.671
CLV_NRD_NRD_1	163	165	PF00675	0.677
CLV_NRD_NRD_1	24	26	PF00675	0.304
CLV_NRD_NRD_1	307	309	PF00675	0.541
CLV_NRD_NRD_1	415	417	PF00675	0.563
CLV_NRD_NRD_1	5	7	PF00675	0.532
CLV_NRD_NRD_1	653	655	PF00675	0.606
CLV_NRD_NRD_1	675	677	PF00675	0.607
CLV_NRD_NRD_1	726	728	PF00675	0.669
CLV_NRD_NRD_1	785	787	PF00675	0.585
CLV_PCSK_FUR_1	785	789	PF00082	0.652
CLV_PCSK_KEX2_1	115	117	PF00082	0.790
CLV_PCSK_KEX2_1	120	122	PF00082	0.632
CLV_PCSK_KEX2_1	162	164	PF00082	0.692
CLV_PCSK_KEX2_1	24	26	PF00082	0.304
CLV_PCSK_KEX2_1	306	308	PF00082	0.543
CLV_PCSK_KEX2_1	415	417	PF00082	0.563
CLV_PCSK_KEX2_1	5	7	PF00082	0.532
CLV_PCSK_KEX2_1	605	607	PF00082	0.529
CLV_PCSK_KEX2_1	652	654	PF00082	0.614
CLV_PCSK_KEX2_1	675	677	PF00082	0.612
CLV_PCSK_KEX2_1	725	727	PF00082	0.671
CLV_PCSK_KEX2_1	785	787	PF00082	0.634
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.790
CLV_PCSK_PC1ET2_1	120	122	PF00082	0.632
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.554
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.532
CLV_PCSK_PC1ET2_1	605	607	PF00082	0.529
CLV_PCSK_PC1ET2_1	725	727	PF00082	0.529
CLV_PCSK_PC1ET2_1	787	789	PF00082	0.658
CLV_PCSK_PC7_1	116	122	PF00082	0.544
CLV_PCSK_SKI1_1	116	120	PF00082	0.552
CLV_PCSK_SKI1_1	34	38	PF00082	0.346
CLV_PCSK_SKI1_1	620	624	PF00082	0.493
CLV_PCSK_SKI1_1	744	748	PF00082	0.521
CLV_PCSK_SKI1_1	788	792	PF00082	0.651
CLV_PCSK_SKI1_1	84	88	PF00082	0.610
DEG_APCC_DBOX_1	309	317	PF00400	0.540
DEG_APCC_DBOX_1	619	627	PF00400	0.499
DEG_APCC_DBOX_1	787	795	PF00400	0.592
DEG_SCF_FBW7_1	481	487	PF00400	0.542
DEG_SCF_TRCP1_1	408	414	PF00400	0.696
DEG_SPOP_SBC_1	278	282	PF00917	0.683
DEG_SPOP_SBC_1	317	321	PF00917	0.546
DEG_SPOP_SBC_1	599	603	PF00917	0.524
DEG_SPOP_SBC_1	641	645	PF00917	0.542
DOC_CKS1_1	126	131	PF01111	0.532
DOC_CKS1_1	341	346	PF01111	0.607
DOC_CKS1_1	481	486	PF01111	0.543
DOC_CYCLIN_yClb3_PxF_3	197	203	PF00134	0.508
DOC_MAPK_MEF2A_6	771	779	PF00069	0.481
DOC_PP2B_LxvP_1	167	170	PF13499	0.604
DOC_PP2B_LxvP_1	195	198	PF13499	0.593
DOC_PP2B_LxvP_1	267	270	PF13499	0.549
DOC_PP2B_LxvP_1	431	434	PF13499	0.486
DOC_PP4_FxxP_1	123	126	PF00568	0.530
DOC_PP4_FxxP_1	203	206	PF00568	0.511
DOC_USP7_MATH_1	219	223	PF00917	0.541
DOC_USP7_MATH_1	278	282	PF00917	0.675
DOC_USP7_MATH_1	299	303	PF00917	0.604
DOC_USP7_MATH_1	335	339	PF00917	0.534
DOC_USP7_MATH_1	392	396	PF00917	0.607
DOC_USP7_MATH_1	492	496	PF00917	0.715
DOC_USP7_MATH_1	597	601	PF00917	0.566
DOC_USP7_MATH_1	711	715	PF00917	0.474
DOC_USP7_MATH_1	734	738	PF00917	0.560
DOC_USP7_MATH_1	739	743	PF00917	0.597
DOC_USP7_MATH_1	745	749	PF00917	0.471
DOC_USP7_UBL2_3	115	119	PF12436	0.621
DOC_USP7_UBL2_3	681	685	PF12436	0.581
DOC_WW_Pin1_4	107	112	PF00397	0.741
DOC_WW_Pin1_4	125	130	PF00397	0.499
DOC_WW_Pin1_4	193	198	PF00397	0.675
DOC_WW_Pin1_4	340	345	PF00397	0.543
DOC_WW_Pin1_4	390	395	PF00397	0.621
DOC_WW_Pin1_4	414	419	PF00397	0.654
DOC_WW_Pin1_4	480	485	PF00397	0.565
DOC_WW_Pin1_4	575	580	PF00397	0.621
DOC_WW_Pin1_4	593	598	PF00397	0.624
DOC_WW_Pin1_4	61	66	PF00397	0.574
DOC_WW_Pin1_4	643	648	PF00397	0.530
DOC_WW_Pin1_4	719	724	PF00397	0.622
DOC_WW_Pin1_4	73	78	PF00397	0.627
LIG_14-3-3_CanoR_1	369	377	PF00244	0.540
LIG_14-3-3_CanoR_1	499	507	PF00244	0.461
LIG_14-3-3_CanoR_1	533	542	PF00244	0.511
LIG_14-3-3_CanoR_1	556	566	PF00244	0.508
LIG_14-3-3_CanoR_1	744	753	PF00244	0.500
LIG_14-3-3_CanoR_1	785	791	PF00244	0.585
LIG_Clathr_ClatBox_1	632	636	PF01394	0.525
LIG_Clathr_ClatBox_1	70	74	PF01394	0.545
LIG_deltaCOP1_diTrp_1	547	557	PF00928	0.479
LIG_EVH1_1	167	171	PF00568	0.659
LIG_EVH1_1	267	271	PF00568	0.601
LIG_EVH1_2	432	436	PF00568	0.613
LIG_FHA_1	131	137	PF00498	0.556
LIG_FHA_1	262	268	PF00498	0.640
LIG_FHA_1	391	397	PF00498	0.518
LIG_FHA_1	442	448	PF00498	0.521
LIG_FHA_1	481	487	PF00498	0.630
LIG_FHA_1	49	55	PF00498	0.664
LIG_FHA_1	521	527	PF00498	0.416
LIG_FHA_1	549	555	PF00498	0.464
LIG_FHA_1	576	582	PF00498	0.544
LIG_FHA_2	108	114	PF00498	0.541
LIG_FHA_2	534	540	PF00498	0.507
LIG_FHA_2	558	564	PF00498	0.497
LIG_FHA_2	74	80	PF00498	0.539
LIG_Integrin_RGD_1	149	151	PF01839	0.684
LIG_LIR_Apic_2	202	206	PF02991	0.564
LIG_LIR_Gen_1	256	265	PF02991	0.505
LIG_LIR_Gen_1	331	342	PF02991	0.521
LIG_LIR_Gen_1	505	514	PF02991	0.495
LIG_LIR_Gen_1	519	529	PF02991	0.447
LIG_LIR_Gen_1	706	711	PF02991	0.405
LIG_LIR_Nem_3	208	212	PF02991	0.641
LIG_LIR_Nem_3	256	261	PF02991	0.630
LIG_LIR_Nem_3	331	337	PF02991	0.540
LIG_LIR_Nem_3	505	510	PF02991	0.491
LIG_LIR_Nem_3	519	524	PF02991	0.433
LIG_LIR_Nem_3	706	710	PF02991	0.394
LIG_MYND_1	193	197	PF01753	0.498
LIG_MYND_1	394	398	PF01753	0.517
LIG_PDZ_Class_2	798	803	PF00595	0.568
LIG_PROFILIN_1	268	274	PF00235	0.541
LIG_PTB_Apo_2	636	643	PF02174	0.517
LIG_Rb_LxCxE_1	694	717	PF01857	0.447
LIG_REV1ctd_RIR_1	20	29	PF16727	0.511
LIG_SH2_CRK	258	262	PF00017	0.506
LIG_SH2_CRK	507	511	PF00017	0.471
LIG_SH2_CRK	521	525	PF00017	0.430
LIG_SH2_NCK_1	521	525	PF00017	0.430
LIG_SH2_PTP2	227	230	PF00017	0.491
LIG_SH2_SRC	227	230	PF00017	0.652
LIG_SH2_SRC	346	349	PF00017	0.478
LIG_SH2_STAP1	507	511	PF00017	0.394
LIG_SH2_STAT3	614	617	PF00017	0.581
LIG_SH2_STAT5	227	230	PF00017	0.575
LIG_SH2_STAT5	346	349	PF00017	0.712
LIG_SH2_STAT5	521	524	PF00017	0.420
LIG_SH2_STAT5	700	703	PF00017	0.422
LIG_SH2_STAT5	709	712	PF00017	0.427
LIG_SH3_1	163	169	PF00018	0.530
LIG_SH3_2	194	199	PF14604	0.504
LIG_SH3_3	123	129	PF00018	0.530
LIG_SH3_3	163	169	PF00018	0.632
LIG_SH3_3	177	183	PF00018	0.623
LIG_SH3_3	187	193	PF00018	0.737
LIG_SH3_3	194	200	PF00018	0.594
LIG_SH3_3	265	271	PF00018	0.579
LIG_SH3_3	284	290	PF00018	0.574
LIG_SH3_3	309	315	PF00018	0.538
LIG_SH3_3	338	344	PF00018	0.560
LIG_SH3_3	375	381	PF00018	0.509
LIG_SH3_3	478	484	PF00018	0.536
LIG_SH3_3	52	58	PF00018	0.532
LIG_SUMO_SIM_par_1	249	254	PF11976	0.486
LIG_SxIP_EBH_1	517	528	PF03271	0.389
LIG_TRAF2_1	795	798	PF00917	0.621
LIG_WRC_WIRS_1	19	24	PF05994	0.304
LIG_WRC_WIRS_1	70	75	PF05994	0.542
LIG_WW_3	196	200	PF00397	0.501
MOD_CDC14_SPxK_1	196	199	PF00782	0.504
MOD_CDK_SPxK_1	193	199	PF00069	0.503
MOD_CDK_SPxK_1	719	725	PF00069	0.669
MOD_CDK_SPxxK_3	719	726	PF00069	0.669
MOD_CK1_1	104	110	PF00069	0.764
MOD_CK1_1	127	133	PF00069	0.639
MOD_CK1_1	18	24	PF00069	0.304
MOD_CK1_1	254	260	PF00069	0.611
MOD_CK1_1	406	412	PF00069	0.634
MOD_CK1_1	414	420	PF00069	0.642
MOD_CK1_1	461	467	PF00069	0.612
MOD_CK1_1	482	488	PF00069	0.636
MOD_CK1_1	519	525	PF00069	0.450
MOD_CK1_1	592	598	PF00069	0.571
MOD_CK1_1	600	606	PF00069	0.518
MOD_CK1_1	643	649	PF00069	0.615
MOD_CK1_1	712	718	PF00069	0.616
MOD_CK1_1	75	81	PF00069	0.645
MOD_CK2_1	107	113	PF00069	0.545
MOD_CK2_1	499	505	PF00069	0.571
MOD_CK2_1	50	56	PF00069	0.530
MOD_CK2_1	533	539	PF00069	0.595
MOD_CK2_1	557	563	PF00069	0.479
MOD_CK2_1	592	598	PF00069	0.618
MOD_CK2_1	73	79	PF00069	0.540
MOD_CK2_1	786	792	PF00069	0.651
MOD_Cter_Amidation	723	726	PF01082	0.671
MOD_Cter_Amidation	783	786	PF01082	0.565
MOD_GlcNHglycan	103	107	PF01048	0.629
MOD_GlcNHglycan	129	132	PF01048	0.609
MOD_GlcNHglycan	144	147	PF01048	0.634
MOD_GlcNHglycan	221	224	PF01048	0.517
MOD_GlcNHglycan	236	239	PF01048	0.707
MOD_GlcNHglycan	281	284	PF01048	0.670
MOD_GlcNHglycan	291	294	PF01048	0.563
MOD_GlcNHglycan	301	304	PF01048	0.476
MOD_GlcNHglycan	361	364	PF01048	0.544
MOD_GlcNHglycan	371	374	PF01048	0.643
MOD_GlcNHglycan	408	411	PF01048	0.744
MOD_GlcNHglycan	452	455	PF01048	0.646
MOD_GlcNHglycan	458	461	PF01048	0.598
MOD_GlcNHglycan	502	505	PF01048	0.660
MOD_GlcNHglycan	506	510	PF01048	0.421
MOD_GlcNHglycan	573	576	PF01048	0.602
MOD_GlcNHglycan	693	696	PF01048	0.463
MOD_GlcNHglycan	711	714	PF01048	0.501
MOD_GlcNHglycan	737	740	PF01048	0.588
MOD_GSK3_1	10	17	PF00069	0.482
MOD_GSK3_1	101	108	PF00069	0.735
MOD_GSK3_1	253	260	PF00069	0.654
MOD_GSK3_1	285	292	PF00069	0.612
MOD_GSK3_1	316	323	PF00069	0.659
MOD_GSK3_1	359	366	PF00069	0.541
MOD_GSK3_1	392	399	PF00069	0.618
MOD_GSK3_1	414	421	PF00069	0.773
MOD_GSK3_1	452	459	PF00069	0.606
MOD_GSK3_1	467	474	PF00069	0.498
MOD_GSK3_1	475	482	PF00069	0.607
MOD_GSK3_1	487	494	PF00069	0.598
MOD_GSK3_1	505	512	PF00069	0.430
MOD_GSK3_1	516	523	PF00069	0.429
MOD_GSK3_1	571	578	PF00069	0.647
MOD_GSK3_1	585	592	PF00069	0.613
MOD_GSK3_1	593	600	PF00069	0.605
MOD_GSK3_1	642	649	PF00069	0.530
MOD_GSK3_1	69	76	PF00069	0.629
MOD_GSK3_1	735	742	PF00069	0.572
MOD_N-GLC_1	317	322	PF02516	0.586
MOD_N-GLC_1	358	363	PF02516	0.644
MOD_N-GLC_1	406	411	PF02516	0.604
MOD_NEK2_1	141	146	PF00069	0.562
MOD_NEK2_1	186	191	PF00069	0.595
MOD_NEK2_1	253	258	PF00069	0.679
MOD_NEK2_1	279	284	PF00069	0.581
MOD_NEK2_1	322	327	PF00069	0.608
MOD_NEK2_1	357	362	PF00069	0.625
MOD_NEK2_1	548	553	PF00069	0.475
MOD_NEK2_1	642	647	PF00069	0.529
MOD_NEK2_1	684	689	PF00069	0.535
MOD_PIKK_1	130	136	PF00454	0.563
MOD_PIKK_1	668	674	PF00454	0.662
MOD_PIKK_1	739	745	PF00454	0.507
MOD_PK_1	786	792	PF00069	0.586
MOD_PKA_1	786	792	PF00069	0.586
MOD_PKA_2	368	374	PF00069	0.622
MOD_PKA_2	411	417	PF00069	0.596
MOD_PKA_2	532	538	PF00069	0.503
MOD_PKA_2	568	574	PF00069	0.553
MOD_Plk_1	317	323	PF00069	0.544
MOD_Plk_1	475	481	PF00069	0.525
MOD_Plk_1	505	511	PF00069	0.406
MOD_Plk_1	540	546	PF00069	0.513
MOD_Plk_2-3	50	56	PF00069	0.530
MOD_Plk_2-3	540	546	PF00069	0.513
MOD_Plk_4	18	24	PF00069	0.304
MOD_Plk_4	462	468	PF00069	0.590
MOD_Plk_4	703	709	PF00069	0.470
MOD_ProDKin_1	107	113	PF00069	0.743
MOD_ProDKin_1	125	131	PF00069	0.502
MOD_ProDKin_1	193	199	PF00069	0.681
MOD_ProDKin_1	340	346	PF00069	0.546
MOD_ProDKin_1	390	396	PF00069	0.625
MOD_ProDKin_1	414	420	PF00069	0.655
MOD_ProDKin_1	480	486	PF00069	0.569
MOD_ProDKin_1	575	581	PF00069	0.622
MOD_ProDKin_1	593	599	PF00069	0.622
MOD_ProDKin_1	61	67	PF00069	0.575
MOD_ProDKin_1	643	649	PF00069	0.530
MOD_ProDKin_1	719	725	PF00069	0.623
MOD_ProDKin_1	73	79	PF00069	0.627
MOD_SUMO_rev_2	41	51	PF00179	0.721
TRG_DiLeu_BaEn_2	702	708	PF01217	0.429
TRG_DiLeu_BaLyEn_6	66	71	PF01217	0.531
TRG_ENDOCYTIC_2	214	217	PF00928	0.628
TRG_ENDOCYTIC_2	227	230	PF00928	0.573
TRG_ENDOCYTIC_2	258	261	PF00928	0.646
TRG_ENDOCYTIC_2	348	351	PF00928	0.564
TRG_ENDOCYTIC_2	507	510	PF00928	0.478
TRG_ENDOCYTIC_2	521	524	PF00928	0.420
TRG_ER_diArg_1	23	25	PF00400	0.227
TRG_ER_diArg_1	307	310	PF00400	0.537
TRG_ER_diArg_1	652	654	PF00400	0.667
TRG_ER_diArg_1	674	676	PF00400	0.529
TRG_ER_diArg_1	785	788	PF00400	0.510
TRG_NLS_MonoExtC_3	114	119	PF00514	0.632
TRG_NLS_MonoExtC_3	161	166	PF00514	0.538
TRG_NLS_MonoExtC_3	305	310	PF00514	0.533
TRG_NLS_MonoExtN_4	115	120	PF00514	0.598
TRG_NLS_MonoExtN_4	161	166	PF00514	0.538
TRG_NLS_MonoExtN_4	723	729	PF00514	0.528
TRG_NLS_MonoExtN_4	783	790	PF00514	0.577
TRG_Pf-PMV_PEXEL_1	528	532	PF00026	0.445

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Y8	Leptomonas seymouri	38%	100%
A0A3Q8I906	Leishmania donovani	61%	96%
A4HWB3	Leishmania infantum	61%	95%
E9AQ13	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	97%
Q4QFG8	Leishmania major	61%	99%