C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc finger (CCCH type) protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H7Y4_LEIBR

TriTrypDb:

LbrM.15.0140 , LBRM2903_150006500

Length:

214

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H7Y4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7Y4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0003729	mRNA binding	5	5
GO:0005488	binding	1	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.596
CLV_PCSK_FUR_1	106	110	PF00082	0.684
CLV_PCSK_KEX2_1	108	110	PF00082	0.581
CLV_PCSK_SKI1_1	21	25	PF00082	0.352
CLV_PCSK_SKI1_1	34	38	PF00082	0.398
DOC_CKS1_1	97	102	PF01111	0.739
DOC_MAPK_gen_1	106	116	PF00069	0.597
DOC_MAPK_MEF2A_6	108	116	PF00069	0.615
DOC_USP7_MATH_1	189	193	PF00917	0.562
DOC_USP7_MATH_1	88	92	PF00917	0.688
DOC_WW_Pin1_4	125	130	PF00397	0.663
DOC_WW_Pin1_4	74	79	PF00397	0.737
DOC_WW_Pin1_4	96	101	PF00397	0.686
LIG_14-3-3_CanoR_1	108	113	PF00244	0.686
LIG_14-3-3_CanoR_1	186	196	PF00244	0.596
LIG_FHA_1	109	115	PF00498	0.672
LIG_FHA_1	205	211	PF00498	0.654
LIG_FHA_1	65	71	PF00498	0.681
LIG_FHA_1	75	81	PF00498	0.595
LIG_FHA_1	99	105	PF00498	0.662
LIG_FHA_2	119	125	PF00498	0.689
LIG_FHA_2	131	137	PF00498	0.729
LIG_IBAR_NPY_1	202	204	PF08397	0.583
LIG_LIR_Apic_2	123	129	PF02991	0.692
LIG_LIR_Gen_1	141	150	PF02991	0.472
LIG_LIR_Nem_3	136	142	PF02991	0.727
LIG_LIR_Nem_3	146	150	PF02991	0.498
LIG_REV1ctd_RIR_1	20	29	PF16727	0.444
LIG_SH2_CRK	126	130	PF00017	0.697
LIG_SH2_CRK	147	151	PF00017	0.676
LIG_SH2_NCK_1	142	146	PF00017	0.606
LIG_SH2_STAT3	149	152	PF00017	0.701
LIG_SH2_STAT3	159	162	PF00017	0.692
LIG_SH2_STAT5	149	152	PF00017	0.490
LIG_SH2_STAT5	182	185	PF00017	0.692
LIG_SH3_3	111	117	PF00018	0.649
LIG_SH3_3	94	100	PF00018	0.717
LIG_SUMO_SIM_anti_2	69	75	PF11976	0.488
LIG_SUMO_SIM_par_1	110	115	PF11976	0.614
LIG_TYR_ITIM	145	150	PF00017	0.474
MOD_CDK_SPxxK_3	99	106	PF00069	0.658
MOD_CK1_1	174	180	PF00069	0.558
MOD_CK1_1	79	85	PF00069	0.695
MOD_CK1_1	86	92	PF00069	0.681
MOD_CK2_1	118	124	PF00069	0.693
MOD_CK2_1	140	146	PF00069	0.621
MOD_CK2_1	92	98	PF00069	0.520
MOD_GlcNHglycan	187	190	PF01048	0.607
MOD_GlcNHglycan	85	88	PF01048	0.746
MOD_GSK3_1	10	17	PF00069	0.541
MOD_GSK3_1	108	115	PF00069	0.736
MOD_GSK3_1	160	167	PF00069	0.563
MOD_GSK3_1	185	192	PF00069	0.611
MOD_GSK3_1	72	79	PF00069	0.606
MOD_GSK3_1	88	95	PF00069	0.744
MOD_N-GLC_1	118	123	PF02516	0.609
MOD_N-GLC_1	130	135	PF02516	0.482
MOD_NEK2_1	171	176	PF00069	0.587
MOD_NEK2_1	187	192	PF00069	0.552
MOD_NEK2_1	54	59	PF00069	0.563
MOD_OFUCOSY	185	191	PF10250	0.613
MOD_PIKK_1	130	136	PF00454	0.481
MOD_PIKK_1	148	154	PF00454	0.694
MOD_PIKK_1	189	195	PF00454	0.654
MOD_PIKK_1	64	70	PF00454	0.605
MOD_PKA_1	108	114	PF00069	0.690
MOD_PKA_2	108	114	PF00069	0.690
MOD_PKA_2	185	191	PF00069	0.618
MOD_PKB_1	106	114	PF00069	0.690
MOD_Plk_1	130	136	PF00069	0.481
MOD_Plk_1	140	146	PF00069	0.607
MOD_Plk_4	88	94	PF00069	0.532
MOD_ProDKin_1	125	131	PF00069	0.662
MOD_ProDKin_1	74	80	PF00069	0.736
MOD_ProDKin_1	96	102	PF00069	0.713
MOD_SUMO_rev_2	41	51	PF00179	0.655
TRG_ENDOCYTIC_2	142	145	PF00928	0.695
TRG_ENDOCYTIC_2	147	150	PF00928	0.639
TRG_ER_diArg_1	105	108	PF00400	0.597

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3Y1	Leptomonas seymouri	68%	99%
A0A1X0NV29	Trypanosomatidae	43%	100%
A0A3S7WT90	Leishmania donovani	82%	100%
A0A422NSB0	Trypanosoma rangeli	39%	100%
A4HWB1	Leishmania infantum	82%	100%
C9ZNU9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AQ11	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QFH0	Leishmania major	81%	100%