Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7Y1_LEIBR

TriTrypDb:

LbrM.15.0110 , LBRM2903_150006100

Length:

797

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	1
GO:0016020	membrane	2	1

Expansion

Sequence features

A4H7Y1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7Y1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	146	150	PF00656	0.603
CLV_C14_Caspase3-7	283	287	PF00656	0.311
CLV_NRD_NRD_1	108	110	PF00675	0.794
CLV_NRD_NRD_1	234	236	PF00675	0.689
CLV_NRD_NRD_1	260	262	PF00675	0.459
CLV_NRD_NRD_1	387	389	PF00675	0.479
CLV_NRD_NRD_1	690	692	PF00675	0.638
CLV_NRD_NRD_1	717	719	PF00675	0.440
CLV_NRD_NRD_1	758	760	PF00675	0.500
CLV_PCSK_FUR_1	385	389	PF00082	0.552
CLV_PCSK_KEX2_1	108	110	PF00082	0.798
CLV_PCSK_KEX2_1	260	262	PF00082	0.457
CLV_PCSK_KEX2_1	387	389	PF00082	0.453
CLV_PCSK_KEX2_1	690	692	PF00082	0.719
CLV_PCSK_KEX2_1	717	719	PF00082	0.567
CLV_PCSK_KEX2_1	758	760	PF00082	0.500
CLV_PCSK_PC1ET2_1	690	692	PF00082	0.719
CLV_PCSK_SKI1_1	235	239	PF00082	0.738
CLV_PCSK_SKI1_1	273	277	PF00082	0.469
CLV_PCSK_SKI1_1	322	326	PF00082	0.414
CLV_PCSK_SKI1_1	388	392	PF00082	0.457
CLV_PCSK_SKI1_1	608	612	PF00082	0.419
CLV_PCSK_SKI1_1	616	620	PF00082	0.451
DEG_APCC_DBOX_1	615	623	PF00400	0.456
DEG_MDM2_SWIB_1	298	305	PF02201	0.512
DEG_Nend_UBRbox_1	1	4	PF02207	0.735
DEG_SCF_FBW7_1	160	166	PF00400	0.337
DEG_SCF_FBW7_1	555	562	PF00400	0.602
DEG_SCF_TRCP1_1	208	214	PF00400	0.661
DEG_SPOP_SBC_1	227	231	PF00917	0.746
DEG_SPOP_SBC_1	28	32	PF00917	0.509
DEG_SPOP_SBC_1	675	679	PF00917	0.503
DOC_ANK_TNKS_1	13	20	PF00023	0.514
DOC_CKS1_1	115	120	PF01111	0.501
DOC_CKS1_1	160	165	PF01111	0.329
DOC_CKS1_1	380	385	PF01111	0.573
DOC_CYCLIN_RxL_1	613	623	PF00134	0.580
DOC_MAPK_FxFP_2	393	396	PF00069	0.292
DOC_MAPK_gen_1	108	115	PF00069	0.539
DOC_MAPK_gen_1	179	188	PF00069	0.257
DOC_MAPK_HePTP_8	635	647	PF00069	0.554
DOC_MAPK_MEF2A_6	638	647	PF00069	0.531
DOC_PP1_RVXF_1	552	558	PF00149	0.538
DOC_PP2B_LxvP_1	511	514	PF13499	0.463
DOC_PP4_FxxP_1	164	167	PF00568	0.355
DOC_PP4_FxxP_1	393	396	PF00568	0.483
DOC_PP4_FxxP_1	734	737	PF00568	0.625
DOC_USP7_MATH_1	143	147	PF00917	0.567
DOC_USP7_MATH_1	227	231	PF00917	0.757
DOC_USP7_MATH_1	547	551	PF00917	0.485
DOC_USP7_MATH_1	580	584	PF00917	0.533
DOC_USP7_MATH_1	596	600	PF00917	0.368
DOC_USP7_MATH_1	675	679	PF00917	0.553
DOC_USP7_MATH_1	693	697	PF00917	0.621
DOC_USP7_UBL2_3	686	690	PF12436	0.719
DOC_USP7_UBL2_3	96	100	PF12436	0.524
DOC_WW_Pin1_4	100	105	PF00397	0.720
DOC_WW_Pin1_4	114	119	PF00397	0.711
DOC_WW_Pin1_4	159	164	PF00397	0.329
DOC_WW_Pin1_4	379	384	PF00397	0.526
DOC_WW_Pin1_4	426	431	PF00397	0.454
DOC_WW_Pin1_4	450	455	PF00397	0.435
DOC_WW_Pin1_4	543	548	PF00397	0.502
DOC_WW_Pin1_4	555	560	PF00397	0.465
DOC_WW_Pin1_4	568	573	PF00397	0.407
DOC_WW_Pin1_4	576	581	PF00397	0.427
DOC_WW_Pin1_4	583	588	PF00397	0.418
DOC_WW_Pin1_4	733	738	PF00397	0.632
DOC_WW_Pin1_4	8	13	PF00397	0.572
LIG_14-3-3_CanoR_1	170	178	PF00244	0.484
LIG_14-3-3_CanoR_1	228	233	PF00244	0.701
LIG_14-3-3_CanoR_1	273	280	PF00244	0.439
LIG_14-3-3_CanoR_1	589	593	PF00244	0.553
LIG_14-3-3_CanoR_1	674	681	PF00244	0.659
LIG_14-3-3_CanoR_1	701	709	PF00244	0.439
LIG_Actin_WH2_2	277	292	PF00022	0.481
LIG_Actin_WH2_2	313	328	PF00022	0.591
LIG_Actin_WH2_2	333	351	PF00022	0.649
LIG_BRCT_BRCA1_1	627	631	PF00533	0.406
LIG_CtBP_PxDLS_1	482	486	PF00389	0.523
LIG_deltaCOP1_diTrp_1	299	302	PF00928	0.440
LIG_deltaCOP1_diTrp_1	494	497	PF00928	0.590
LIG_FHA_1	191	197	PF00498	0.464
LIG_FHA_1	221	227	PF00498	0.649
LIG_FHA_1	23	29	PF00498	0.510
LIG_FHA_1	395	401	PF00498	0.538
LIG_FHA_1	486	492	PF00498	0.577
LIG_FHA_1	506	512	PF00498	0.422
LIG_FHA_1	589	595	PF00498	0.463
LIG_FHA_1	613	619	PF00498	0.549
LIG_FHA_1	762	768	PF00498	0.545
LIG_FHA_2	101	107	PF00498	0.553
LIG_FHA_2	153	159	PF00498	0.380
LIG_FHA_2	240	246	PF00498	0.718
LIG_FHA_2	478	484	PF00498	0.460
LIG_FHA_2	502	508	PF00498	0.524
LIG_FHA_2	701	707	PF00498	0.443
LIG_LIR_Apic_2	162	167	PF02991	0.358
LIG_LIR_Gen_1	151	161	PF02991	0.579
LIG_LIR_Gen_1	269	278	PF02991	0.542
LIG_LIR_Gen_1	299	307	PF02991	0.427
LIG_LIR_Gen_1	453	463	PF02991	0.428
LIG_LIR_Gen_1	531	540	PF02991	0.563
LIG_LIR_Gen_1	591	596	PF02991	0.407
LIG_LIR_Gen_1	620	629	PF02991	0.456
LIG_LIR_Gen_1	706	716	PF02991	0.620
LIG_LIR_Nem_3	116	122	PF02991	0.727
LIG_LIR_Nem_3	151	156	PF02991	0.545
LIG_LIR_Nem_3	299	305	PF02991	0.426
LIG_LIR_Nem_3	389	395	PF02991	0.415
LIG_LIR_Nem_3	429	435	PF02991	0.399
LIG_LIR_Nem_3	453	459	PF02991	0.405
LIG_LIR_Nem_3	531	536	PF02991	0.612
LIG_LIR_Nem_3	542	548	PF02991	0.399
LIG_LIR_Nem_3	60	65	PF02991	0.620
LIG_LIR_Nem_3	620	624	PF02991	0.414
LIG_LIR_Nem_3	644	649	PF02991	0.411
LIG_LIR_Nem_3	706	712	PF02991	0.566
LIG_LIR_Nem_3	720	725	PF02991	0.379
LIG_MYND_1	426	430	PF01753	0.530
LIG_Pex14_2	298	302	PF04695	0.488
LIG_PTAP_UEV_1	326	331	PF05743	0.449
LIG_SH2_CRK	533	537	PF00017	0.609
LIG_SH2_NCK_1	119	123	PF00017	0.727
LIG_SH2_PTP2	519	522	PF00017	0.475
LIG_SH2_SRC	65	68	PF00017	0.464
LIG_SH2_STAP1	43	47	PF00017	0.604
LIG_SH2_STAP1	533	537	PF00017	0.615
LIG_SH2_STAP1	551	555	PF00017	0.503
LIG_SH2_STAP1	62	66	PF00017	0.649
LIG_SH2_STAT3	435	438	PF00017	0.537
LIG_SH2_STAT5	312	315	PF00017	0.379
LIG_SH2_STAT5	456	459	PF00017	0.394
LIG_SH2_STAT5	519	522	PF00017	0.411
LIG_SH2_STAT5	569	572	PF00017	0.540
LIG_SH2_STAT5	65	68	PF00017	0.582
LIG_SH2_STAT5	725	728	PF00017	0.508
LIG_SH2_STAT5	733	736	PF00017	0.482
LIG_SH2_STAT5	785	788	PF00017	0.562
LIG_SH3_1	377	383	PF00018	0.337
LIG_SH3_2	380	385	PF14604	0.573
LIG_SH3_2	405	410	PF14604	0.607
LIG_SH3_3	112	118	PF00018	0.706
LIG_SH3_3	193	199	PF00018	0.517
LIG_SH3_3	243	249	PF00018	0.594
LIG_SH3_3	321	327	PF00018	0.442
LIG_SH3_3	359	365	PF00018	0.523
LIG_SH3_3	377	383	PF00018	0.567
LIG_SH3_3	402	408	PF00018	0.563
LIG_SH3_3	52	58	PF00018	0.477
LIG_SH3_3	560	566	PF00018	0.486
LIG_SH3_4	96	103	PF00018	0.534
LIG_Sin3_3	409	416	PF02671	0.628
LIG_Sin3_3	88	95	PF02671	0.521
LIG_SUMO_SIM_anti_2	29	37	PF11976	0.697
LIG_SUMO_SIM_par_1	303	308	PF11976	0.542
LIG_SUMO_SIM_par_1	312	317	PF11976	0.227
LIG_TRAF2_1	104	107	PF00917	0.554
LIG_TRAF2_1	293	296	PF00917	0.519
LIG_TRAF2_1	367	370	PF00917	0.721
LIG_TYR_ITSM	115	122	PF00017	0.742
LIG_Vh1_VBS_1	595	613	PF01044	0.495
LIG_WRC_WIRS_1	456	461	PF05994	0.516
LIG_WRC_WIRS_1	618	623	PF05994	0.438
MOD_CDC14_SPxK_1	586	589	PF00782	0.312
MOD_CDK_SPxK_1	379	385	PF00069	0.577
MOD_CDK_SPxK_1	583	589	PF00069	0.302
MOD_CDK_SPxK_1	8	14	PF00069	0.507
MOD_CDK_SPxxK_3	163	170	PF00069	0.376
MOD_CK1_1	148	154	PF00069	0.626
MOD_CK1_1	190	196	PF00069	0.572
MOD_CK1_1	213	219	PF00069	0.697
MOD_CK1_1	220	226	PF00069	0.656
MOD_CK1_1	29	35	PF00069	0.705
MOD_CK1_1	332	338	PF00069	0.687
MOD_CK1_1	441	447	PF00069	0.520
MOD_CK1_1	455	461	PF00069	0.443
MOD_CK1_1	464	470	PF00069	0.548
MOD_CK1_1	503	509	PF00069	0.588
MOD_CK1_1	583	589	PF00069	0.302
MOD_CK1_1	620	626	PF00069	0.500
MOD_CK1_1	679	685	PF00069	0.632
MOD_CK2_1	100	106	PF00069	0.551
MOD_CK2_1	152	158	PF00069	0.364
MOD_CK2_1	239	245	PF00069	0.695
MOD_CK2_1	363	369	PF00069	0.592
MOD_CK2_1	38	44	PF00069	0.647
MOD_CK2_1	462	468	PF00069	0.560
MOD_CK2_1	477	483	PF00069	0.358
MOD_CK2_1	700	706	PF00069	0.674
MOD_GlcNHglycan	207	211	PF01048	0.718
MOD_GlcNHglycan	315	319	PF01048	0.420
MOD_GlcNHglycan	327	330	PF01048	0.540
MOD_GlcNHglycan	337	340	PF01048	0.718
MOD_GlcNHglycan	4	7	PF01048	0.627
MOD_GlcNHglycan	445	448	PF01048	0.514
MOD_GlcNHglycan	533	536	PF01048	0.625
MOD_GlcNHglycan	627	630	PF01048	0.491
MOD_GlcNHglycan	694	698	PF01048	0.716
MOD_GlcNHglycan	764	767	PF01048	0.426
MOD_GSK3_1	148	155	PF00069	0.496
MOD_GSK3_1	159	166	PF00069	0.406
MOD_GSK3_1	190	197	PF00069	0.568
MOD_GSK3_1	206	213	PF00069	0.516
MOD_GSK3_1	216	223	PF00069	0.689
MOD_GSK3_1	22	29	PF00069	0.775
MOD_GSK3_1	274	281	PF00069	0.444
MOD_GSK3_1	314	321	PF00069	0.535
MOD_GSK3_1	325	332	PF00069	0.590
MOD_GSK3_1	395	402	PF00069	0.485
MOD_GSK3_1	501	508	PF00069	0.487
MOD_GSK3_1	531	538	PF00069	0.541
MOD_GSK3_1	543	550	PF00069	0.411
MOD_GSK3_1	555	562	PF00069	0.616
MOD_GSK3_1	576	583	PF00069	0.510
MOD_GSK3_1	608	615	PF00069	0.393
MOD_GSK3_1	675	682	PF00069	0.681
MOD_GSK3_1	96	103	PF00069	0.637
MOD_LATS_1	498	504	PF00433	0.518
MOD_LATS_1	94	100	PF00433	0.525
MOD_N-GLC_1	372	377	PF02516	0.610
MOD_NEK2_1	1	6	PF00069	0.642
MOD_NEK2_1	194	199	PF00069	0.631
MOD_NEK2_1	226	231	PF00069	0.533
MOD_NEK2_1	274	279	PF00069	0.540
MOD_NEK2_1	298	303	PF00069	0.545
MOD_NEK2_1	399	404	PF00069	0.412
MOD_NEK2_1	412	417	PF00069	0.495
MOD_NEK2_1	485	490	PF00069	0.577
MOD_NEK2_1	509	514	PF00069	0.498
MOD_NEK2_2	372	377	PF00069	0.671
MOD_NEK2_2	38	43	PF00069	0.668
MOD_NEK2_2	474	479	PF00069	0.447
MOD_OFUCOSY	593	598	PF10250	0.547
MOD_PIKK_1	171	177	PF00454	0.449
MOD_PIKK_1	213	219	PF00454	0.549
MOD_PIKK_1	228	234	PF00454	0.517
MOD_PIKK_1	483	489	PF00454	0.596
MOD_PIKK_1	580	586	PF00454	0.490
MOD_PIKK_1	657	663	PF00454	0.699
MOD_PIKK_1	710	716	PF00454	0.624
MOD_PK_1	349	355	PF00069	0.518
MOD_PKA_2	169	175	PF00069	0.491
MOD_PKA_2	227	233	PF00069	0.699
MOD_PKA_2	325	331	PF00069	0.631
MOD_PKA_2	588	594	PF00069	0.552
MOD_PKA_2	700	706	PF00069	0.700
MOD_Plk_1	151	157	PF00069	0.560
MOD_Plk_1	298	304	PF00069	0.508
MOD_Plk_1	332	338	PF00069	0.503
MOD_Plk_1	751	757	PF00069	0.659
MOD_Plk_2-3	152	158	PF00069	0.502
MOD_Plk_2-3	239	245	PF00069	0.497
MOD_Plk_4	239	245	PF00069	0.617
MOD_Plk_4	31	37	PF00069	0.666
MOD_Plk_4	38	44	PF00069	0.558
MOD_Plk_4	395	401	PF00069	0.498
MOD_Plk_4	452	458	PF00069	0.539
MOD_Plk_4	617	623	PF00069	0.500
MOD_Plk_4	738	744	PF00069	0.576
MOD_ProDKin_1	100	106	PF00069	0.721
MOD_ProDKin_1	114	120	PF00069	0.711
MOD_ProDKin_1	159	165	PF00069	0.333
MOD_ProDKin_1	379	385	PF00069	0.530
MOD_ProDKin_1	426	432	PF00069	0.454
MOD_ProDKin_1	450	456	PF00069	0.432
MOD_ProDKin_1	543	549	PF00069	0.497
MOD_ProDKin_1	555	561	PF00069	0.474
MOD_ProDKin_1	568	574	PF00069	0.404
MOD_ProDKin_1	576	582	PF00069	0.432
MOD_ProDKin_1	583	589	PF00069	0.424
MOD_ProDKin_1	733	739	PF00069	0.635
MOD_ProDKin_1	8	14	PF00069	0.574
MOD_SUMO_for_1	749	752	PF00179	0.608
MOD_SUMO_rev_2	72	80	PF00179	0.599
TRG_DiLeu_BaEn_2	616	622	PF01217	0.383
TRG_DiLeu_BaEn_2	729	735	PF01217	0.560
TRG_DiLeu_BaLyEn_6	374	379	PF01217	0.481
TRG_DiLeu_BaLyEn_6	573	578	PF01217	0.564
TRG_ENDOCYTIC_2	119	122	PF00928	0.721
TRG_ENDOCYTIC_2	185	188	PF00928	0.360
TRG_ENDOCYTIC_2	271	274	PF00928	0.423
TRG_ENDOCYTIC_2	456	459	PF00928	0.394
TRG_ENDOCYTIC_2	518	521	PF00928	0.385
TRG_ENDOCYTIC_2	533	536	PF00928	0.522
TRG_ER_diArg_1	385	388	PF00400	0.493
TRG_ER_diArg_1	716	718	PF00400	0.431
TRG_ER_diArg_1	757	759	PF00400	0.502
TRG_Pf-PMV_PEXEL_1	479	483	PF00026	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCR8	Leptomonas seymouri	48%	98%
A0A0S4KHH2	Bodo saltans	29%	92%
A0A1X0NTL8	Trypanosomatidae	38%	100%
A0A3Q8IA12	Leishmania donovani	74%	100%
A0A422NS84	Trypanosoma rangeli	35%	100%
A4HWA8	Leishmania infantum	74%	100%
C9ZNU4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AQ08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4QFH3	Leishmania major	72%	100%
V5AWK1	Trypanosoma cruzi	34%	96%