Flavin-binding monooxygenase family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flavin-binding monooxygenase-like, putative

Species:

Leishmania braziliensis

UniProt:

A4H7Y0_LEIBR

TriTrypDb:

LbrM.15.0100 , LBRM2903_150006000

Length:

564

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H7Y0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7Y0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004497	monooxygenase activity	3	11
GO:0004499	N,N-dimethylaniline monooxygenase activity	5	11
GO:0005488	binding	1	11
GO:0016491	oxidoreductase activity	2	11
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	11
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0050660	flavin adenine dinucleotide binding	4	11
GO:0050661	NADP binding	4	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	364	368	PF00656	0.394
CLV_C14_Caspase3-7	408	412	PF00656	0.750
CLV_NRD_NRD_1	254	256	PF00675	0.644
CLV_NRD_NRD_1	296	298	PF00675	0.565
CLV_NRD_NRD_1	333	335	PF00675	0.593
CLV_NRD_NRD_1	377	379	PF00675	0.427
CLV_NRD_NRD_1	387	389	PF00675	0.471
CLV_NRD_NRD_1	552	554	PF00675	0.549
CLV_PCSK_KEX2_1	190	192	PF00082	0.299
CLV_PCSK_KEX2_1	209	211	PF00082	0.262
CLV_PCSK_KEX2_1	253	255	PF00082	0.759
CLV_PCSK_KEX2_1	333	335	PF00082	0.576
CLV_PCSK_KEX2_1	377	379	PF00082	0.427
CLV_PCSK_KEX2_1	387	389	PF00082	0.471
CLV_PCSK_KEX2_1	552	554	PF00082	0.549
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.313
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.313
CLV_PCSK_PC1ET2_1	552	554	PF00082	0.549
CLV_PCSK_SKI1_1	104	108	PF00082	0.381
CLV_PCSK_SKI1_1	266	270	PF00082	0.540
CLV_PCSK_SKI1_1	387	391	PF00082	0.467
CLV_PCSK_SKI1_1	443	447	PF00082	0.432
CLV_PCSK_SKI1_1	45	49	PF00082	0.381
CLV_PCSK_SKI1_1	531	535	PF00082	0.523
CLV_PCSK_SKI1_1	62	66	PF00082	0.194
DEG_APCC_DBOX_1	534	542	PF00400	0.514
DEG_Nend_UBRbox_3	1	3	PF02207	0.461
DEG_SPOP_SBC_1	354	358	PF00917	0.456
DEG_SPOP_SBC_1	404	408	PF00917	0.727
DOC_CYCLIN_RxL_1	525	537	PF00134	0.579
DOC_CYCLIN_yCln2_LP_2	445	448	PF00134	0.418
DOC_MAPK_DCC_7	306	315	PF00069	0.564
DOC_MAPK_DCC_7	443	452	PF00069	0.439
DOC_MAPK_gen_1	123	132	PF00069	0.413
DOC_MAPK_gen_1	257	267	PF00069	0.664
DOC_MAPK_gen_1	552	560	PF00069	0.544
DOC_MAPK_MEF2A_6	123	132	PF00069	0.410
DOC_MAPK_MEF2A_6	306	315	PF00069	0.562
DOC_MAPK_MEF2A_6	443	452	PF00069	0.439
DOC_PP1_RVXF_1	320	327	PF00149	0.469
DOC_PP2B_LxvP_1	445	448	PF13499	0.433
DOC_PP4_FxxP_1	381	384	PF00568	0.509
DOC_USP7_MATH_1	236	240	PF00917	0.721
DOC_USP7_MATH_1	309	313	PF00917	0.427
DOC_USP7_MATH_1	328	332	PF00917	0.609
DOC_USP7_MATH_1	354	358	PF00917	0.696
DOC_USP7_MATH_1	417	421	PF00917	0.682
DOC_USP7_MATH_1	432	436	PF00917	0.383
DOC_WW_Pin1_4	217	222	PF00397	0.320
DOC_WW_Pin1_4	350	355	PF00397	0.472
DOC_WW_Pin1_4	52	57	PF00397	0.321
LIG_14-3-3_CanoR_1	254	262	PF00244	0.740
LIG_14-3-3_CanoR_1	266	275	PF00244	0.478
LIG_14-3-3_CanoR_1	301	310	PF00244	0.468
LIG_14-3-3_CanoR_1	333	342	PF00244	0.598
LIG_14-3-3_CanoR_1	355	363	PF00244	0.386
LIG_14-3-3_CanoR_1	535	539	PF00244	0.613
LIG_BRCT_BRCA1_1	114	118	PF00533	0.407
LIG_deltaCOP1_diTrp_1	139	142	PF00928	0.313
LIG_FHA_1	150	156	PF00498	0.395
LIG_FHA_1	239	245	PF00498	0.704
LIG_FHA_1	267	273	PF00498	0.610
LIG_FHA_1	334	340	PF00498	0.610
LIG_FHA_1	462	468	PF00498	0.304
LIG_FHA_1	521	527	PF00498	0.480
LIG_FHA_2	109	115	PF00498	0.386
LIG_FHA_2	256	262	PF00498	0.650
LIG_FHA_2	26	32	PF00498	0.313
LIG_FHA_2	303	309	PF00498	0.594
LIG_FHA_2	406	412	PF00498	0.741
LIG_LIR_Gen_1	115	124	PF02991	0.420
LIG_LIR_Gen_1	139	147	PF02991	0.329
LIG_LIR_Gen_1	214	224	PF02991	0.458
LIG_LIR_Nem_3	115	121	PF02991	0.345
LIG_LIR_Nem_3	139	145	PF02991	0.321
LIG_LIR_Nem_3	183	187	PF02991	0.324
LIG_LIR_Nem_3	214	219	PF02991	0.451
LIG_LIR_Nem_3	456	461	PF02991	0.258
LIG_LIR_Nem_3	503	509	PF02991	0.401
LIG_LYPXL_S_1	57	61	PF13949	0.425
LIG_LYPXL_yS_3	379	382	PF13949	0.420
LIG_LYPXL_yS_3	58	61	PF13949	0.425
LIG_PCNA_PIPBox_1	162	171	PF02747	0.205
LIG_PCNA_yPIPBox_3	156	169	PF02747	0.321
LIG_SH2_CRK	216	220	PF00017	0.451
LIG_SH2_GRB2like	506	509	PF00017	0.388
LIG_SH2_NCK_1	79	83	PF00017	0.386
LIG_SH2_STAP1	202	206	PF00017	0.425
LIG_SH2_STAP1	375	379	PF00017	0.334
LIG_SH2_STAP1	522	526	PF00017	0.535
LIG_SH2_STAT3	97	100	PF00017	0.360
LIG_SH2_STAT5	168	171	PF00017	0.317
LIG_SH2_STAT5	204	207	PF00017	0.332
LIG_SH2_STAT5	375	378	PF00017	0.400
LIG_SH2_STAT5	425	428	PF00017	0.365
LIG_SH2_STAT5	506	509	PF00017	0.384
LIG_SH2_STAT5	522	525	PF00017	0.464
LIG_SH3_3	152	158	PF00018	0.332
LIG_SH3_3	310	316	PF00018	0.504
LIG_SH3_3	464	470	PF00018	0.392
LIG_SH3_3	53	59	PF00018	0.346
LIG_SUMO_SIM_anti_2	435	440	PF11976	0.444
MOD_CDK_SPK_2	350	355	PF00069	0.472
MOD_CK1_1	238	244	PF00069	0.686
MOD_CK1_1	353	359	PF00069	0.563
MOD_CK1_1	399	405	PF00069	0.746
MOD_CK1_1	406	412	PF00069	0.716
MOD_CK1_1	518	524	PF00069	0.524
MOD_CK2_1	108	114	PF00069	0.386
MOD_CK2_1	255	261	PF00069	0.611
MOD_CK2_1	302	308	PF00069	0.552
MOD_CK2_1	354	360	PF00069	0.521
MOD_Cter_Amidation	188	191	PF01082	0.267
MOD_GlcNHglycan	114	117	PF01048	0.436
MOD_GlcNHglycan	199	202	PF01048	0.389
MOD_GlcNHglycan	22	25	PF01048	0.346
MOD_GlcNHglycan	225	228	PF01048	0.712
MOD_GlcNHglycan	329	333	PF01048	0.522
MOD_GlcNHglycan	357	360	PF01048	0.542
MOD_GlcNHglycan	413	416	PF01048	0.662
MOD_GlcNHglycan	430	433	PF01048	0.386
MOD_GlcNHglycan	494	497	PF01048	0.496
MOD_GlcNHglycan	502	505	PF01048	0.398
MOD_GSK3_1	104	111	PF00069	0.324
MOD_GSK3_1	256	263	PF00069	0.715
MOD_GSK3_1	266	273	PF00069	0.548
MOD_GSK3_1	328	335	PF00069	0.584
MOD_GSK3_1	350	357	PF00069	0.590
MOD_GSK3_1	395	402	PF00069	0.666
MOD_GSK3_1	403	410	PF00069	0.648
MOD_GSK3_1	428	435	PF00069	0.329
MOD_GSK3_1	514	521	PF00069	0.580
MOD_NEK2_1	14	19	PF00069	0.335
MOD_NEK2_1	20	25	PF00069	0.298
MOD_NEK2_1	225	230	PF00069	0.644
MOD_NEK2_1	235	240	PF00069	0.643
MOD_NEK2_1	396	401	PF00069	0.657
MOD_NEK2_1	514	519	PF00069	0.584
MOD_NEK2_1	533	538	PF00069	0.287
MOD_NEK2_1	558	563	PF00069	0.620
MOD_PIKK_1	149	155	PF00454	0.386
MOD_PIKK_1	461	467	PF00454	0.469
MOD_PK_1	126	132	PF00069	0.393
MOD_PKA_1	333	339	PF00069	0.589
MOD_PKA_2	20	26	PF00069	0.332
MOD_PKA_2	256	262	PF00069	0.584
MOD_PKA_2	302	308	PF00069	0.562
MOD_PKA_2	332	338	PF00069	0.634
MOD_PKA_2	354	360	PF00069	0.434
MOD_PKA_2	518	524	PF00069	0.531
MOD_PKA_2	534	540	PF00069	0.527
MOD_PKB_1	253	261	PF00069	0.619
MOD_Plk_1	138	144	PF00069	0.386
MOD_Plk_4	15	21	PF00069	0.458
MOD_Plk_4	425	431	PF00069	0.359
MOD_Plk_4	534	540	PF00069	0.527
MOD_ProDKin_1	217	223	PF00069	0.341
MOD_ProDKin_1	350	356	PF00069	0.468
MOD_ProDKin_1	52	58	PF00069	0.321
MOD_SUMO_rev_2	203	211	PF00179	0.425
TRG_DiLeu_LyEn_5	392	397	PF01217	0.497
TRG_ENDOCYTIC_2	216	219	PF00928	0.458
TRG_ENDOCYTIC_2	379	382	PF00928	0.420
TRG_ENDOCYTIC_2	506	509	PF00928	0.446
TRG_ENDOCYTIC_2	58	61	PF00928	0.386
TRG_ER_diArg_1	253	255	PF00400	0.603
TRG_ER_diArg_1	377	379	PF00400	0.426
TRG_ER_diArg_1	386	388	PF00400	0.460
TRG_NES_CRM1_1	136	151	PF08389	0.373
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.292
TRG_Pf-PMV_PEXEL_1	388	392	PF00026	0.577

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJM8	Leptomonas seymouri	70%	99%
A0A0S4KJK2	Bodo saltans	40%	93%
A0A1X0NTN1	Trypanosomatidae	51%	100%
A0A3S7WTA1	Leishmania donovani	86%	100%
A4HWA7	Leishmania infantum	85%	100%
C9ZNU3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	90%
E9AQ07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
I1RF61	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	23%	100%
O60774	Homo sapiens	23%	100%
P31513	Homo sapiens	24%	100%
P49109	Cavia porcellus	24%	100%
P49326	Homo sapiens	24%	100%
P97872	Mus musculus	23%	100%
Q04799	Oryctolagus cuniculus	24%	100%
Q4QFH4	Leishmania major	87%	100%
Q5REK0	Pongo abelii	25%	100%
Q7YS44	Pan troglodytes	24%	100%
Q8K4C0	Rattus norvegicus	24%	100%
Q9EQ76	Rattus norvegicus	24%	100%
Q9FWW9	Arabidopsis thaliana	25%	100%
Q9SVQ1	Arabidopsis thaliana	22%	100%
V5BBZ3	Trypanosoma cruzi	50%	100%