Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7X7_LEIBR

TriTrypDb:

LbrM.15.0070 , LBRM2903_150005700

Length:

467

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H7X7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7X7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	120	124	PF00656	0.495
CLV_C14_Caspase3-7	240	244	PF00656	0.559
CLV_C14_Caspase3-7	53	57	PF00656	0.484
CLV_C14_Caspase3-7	93	97	PF00656	0.452
CLV_NRD_NRD_1	183	185	PF00675	0.678
CLV_NRD_NRD_1	284	286	PF00675	0.502
CLV_NRD_NRD_1	355	357	PF00675	0.492
CLV_PCSK_KEX2_1	183	185	PF00082	0.640
CLV_PCSK_KEX2_1	284	286	PF00082	0.497
CLV_PCSK_KEX2_1	355	357	PF00082	0.492
CLV_PCSK_PC7_1	351	357	PF00082	0.462
CLV_PCSK_SKI1_1	427	431	PF00082	0.355
DEG_ODPH_VHL_1	362	374	PF01847	0.436
DEG_ODPH_VHL_1	68	81	PF01847	0.423
DEG_SCF_FBW7_1	170	175	PF00400	0.584
DOC_CKS1_1	416	421	PF01111	0.556
DOC_CYCLIN_RxL_1	391	402	PF00134	0.497
DOC_MAPK_gen_1	355	362	PF00069	0.513
DOC_MAPK_JIP1_4	229	235	PF00069	0.514
DOC_USP7_MATH_1	161	165	PF00917	0.734
DOC_USP7_MATH_1	172	176	PF00917	0.660
DOC_USP7_MATH_1	185	189	PF00917	0.530
DOC_USP7_MATH_1	212	216	PF00917	0.671
DOC_USP7_MATH_1	217	221	PF00917	0.600
DOC_USP7_MATH_1	237	241	PF00917	0.651
DOC_USP7_MATH_1	260	264	PF00917	0.409
DOC_USP7_MATH_1	462	466	PF00917	0.724
DOC_WW_Pin1_4	168	173	PF00397	0.604
DOC_WW_Pin1_4	208	213	PF00397	0.665
DOC_WW_Pin1_4	261	266	PF00397	0.449
DOC_WW_Pin1_4	415	420	PF00397	0.582
LIG_14-3-3_CanoR_1	165	172	PF00244	0.567
LIG_14-3-3_CanoR_1	229	234	PF00244	0.663
LIG_14-3-3_CanoR_1	236	242	PF00244	0.686
LIG_14-3-3_CanoR_1	321	329	PF00244	0.412
LIG_14-3-3_CanoR_1	35	42	PF00244	0.435
LIG_APCC_ABBA_1	77	82	PF00400	0.389
LIG_EVH1_1	415	419	PF00568	0.555
LIG_FHA_1	14	20	PF00498	0.541
LIG_FHA_1	230	236	PF00498	0.645
LIG_FHA_1	304	310	PF00498	0.623
LIG_FHA_1	381	387	PF00498	0.409
LIG_FHA_1	59	65	PF00498	0.588
LIG_FHA_2	240	246	PF00498	0.563
LIG_FHA_2	27	33	PF00498	0.434
LIG_FHA_2	35	41	PF00498	0.436
LIG_FHA_2	407	413	PF00498	0.464
LIG_FHA_2	416	422	PF00498	0.426
LIG_FHA_2	51	57	PF00498	0.582
LIG_FHA_2	91	97	PF00498	0.313
LIG_LIR_Apic_2	378	382	PF02991	0.398
LIG_LIR_Gen_1	283	294	PF02991	0.388
LIG_LIR_Gen_1	89	95	PF02991	0.475
LIG_LIR_Nem_3	283	289	PF02991	0.365
LIG_LIR_Nem_3	89	94	PF02991	0.476
LIG_NRBOX	425	431	PF00104	0.362
LIG_PTAP_UEV_1	381	386	PF05743	0.413
LIG_PTB_Apo_2	304	311	PF02174	0.429
LIG_RPA_C_Fungi	351	363	PF08784	0.591
LIG_SH2_CRK	286	290	PF00017	0.377
LIG_SH2_NCK_1	444	448	PF00017	0.465
LIG_SH2_SRC	121	124	PF00017	0.531
LIG_SH2_STAP1	102	106	PF00017	0.452
LIG_SH2_STAT5	266	269	PF00017	0.482
LIG_SH2_STAT5	44	47	PF00017	0.519
LIG_SH3_1	184	190	PF00018	0.514
LIG_SH3_2	187	192	PF14604	0.530
LIG_SH3_3	109	115	PF00018	0.496
LIG_SH3_3	160	166	PF00018	0.684
LIG_SH3_3	179	185	PF00018	0.763
LIG_SH3_3	187	193	PF00018	0.654
LIG_SH3_3	231	237	PF00018	0.549
LIG_SH3_3	371	377	PF00018	0.503
LIG_SH3_3	379	385	PF00018	0.432
LIG_SH3_3	413	419	PF00018	0.611
LIG_SUMO_SIM_anti_2	370	376	PF11976	0.407
LIG_SUMO_SIM_anti_2	89	96	PF11976	0.466
LIG_TRAF2_1	399	402	PF00917	0.456
LIG_TRAF2_1	83	86	PF00917	0.648
LIG_WRC_WIRS_1	88	93	PF05994	0.440
MOD_CK1_1	152	158	PF00069	0.696
MOD_CK1_1	164	170	PF00069	0.719
MOD_CK1_1	211	217	PF00069	0.756
MOD_CK1_1	220	226	PF00069	0.654
MOD_CK1_1	228	234	PF00069	0.648
MOD_CK1_1	46	52	PF00069	0.509
MOD_CK2_1	123	129	PF00069	0.648
MOD_CK2_1	239	245	PF00069	0.580
MOD_CK2_1	406	412	PF00069	0.445
MOD_CK2_1	415	421	PF00069	0.434
MOD_GlcNHglycan	147	150	PF01048	0.655
MOD_GlcNHglycan	151	154	PF01048	0.698
MOD_GlcNHglycan	159	162	PF01048	0.643
MOD_GlcNHglycan	200	203	PF01048	0.593
MOD_GlcNHglycan	254	258	PF01048	0.552
MOD_GlcNHglycan	423	426	PF01048	0.521
MOD_GlcNHglycan	432	436	PF01048	0.381
MOD_GlcNHglycan	445	448	PF01048	0.494
MOD_GlcNHglycan	464	467	PF01048	0.473
MOD_GSK3_1	13	20	PF00069	0.464
MOD_GSK3_1	145	152	PF00069	0.747
MOD_GSK3_1	157	164	PF00069	0.684
MOD_GSK3_1	168	175	PF00069	0.534
MOD_GSK3_1	208	215	PF00069	0.606
MOD_GSK3_1	220	227	PF00069	0.768
MOD_GSK3_1	456	463	PF00069	0.550
MOD_GSK3_1	46	53	PF00069	0.500
MOD_GSK3_1	86	93	PF00069	0.436
MOD_N-GLC_1	303	308	PF02516	0.473
MOD_NEK2_1	13	18	PF00069	0.459
MOD_NEK2_1	225	230	PF00069	0.522
MOD_PIKK_1	217	223	PF00454	0.634
MOD_PKA_2	164	170	PF00069	0.568
MOD_PKA_2	217	223	PF00069	0.737
MOD_PKA_2	228	234	PF00069	0.694
MOD_PKA_2	320	326	PF00069	0.445
MOD_PKA_2	34	40	PF00069	0.454
MOD_PKA_2	375	381	PF00069	0.531
MOD_Plk_1	117	123	PF00069	0.466
MOD_Plk_1	149	155	PF00069	0.519
MOD_Plk_1	64	70	PF00069	0.483
MOD_Plk_2-3	117	123	PF00069	0.565
MOD_Plk_4	87	93	PF00069	0.443
MOD_ProDKin_1	168	174	PF00069	0.603
MOD_ProDKin_1	208	214	PF00069	0.666
MOD_ProDKin_1	261	267	PF00069	0.448
MOD_ProDKin_1	415	421	PF00069	0.575
MOD_SUMO_for_1	442	445	PF00179	0.371
MOD_SUMO_for_1	7	10	PF00179	0.439
TRG_DiLeu_BaEn_1	391	396	PF01217	0.486
TRG_DiLeu_LyEn_5	391	396	PF01217	0.350
TRG_ENDOCYTIC_2	286	289	PF00928	0.393
TRG_ER_diArg_1	182	184	PF00400	0.679
TRG_ER_diArg_1	284	286	PF00400	0.457
TRG_NES_CRM1_1	421	432	PF08389	0.371
TRG_Pf-PMV_PEXEL_1	427	432	PF00026	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5C4	Leptomonas seymouri	41%	87%
A0A3Q8IIJ0	Leishmania donovani	64%	100%
A0A422NS55	Trypanosoma rangeli	28%	78%
A4HWA4	Leishmania infantum	64%	100%
E9AQ04	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
Q4QFH7	Leishmania major	65%	100%