Lysine decarboxylase family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Possible lysine decarboxylase, putative

Species:

Leishmania braziliensis

UniProt:

A4H7X4_LEIBR

TriTrypDb:

LbrM.15.0040 , LBRM2903_150005400

Length:

332

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H7X4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7X4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	299	303	PF00656	0.535
CLV_MEL_PAP_1	168	174	PF00089	0.368
CLV_NRD_NRD_1	136	138	PF00675	0.439
CLV_NRD_NRD_1	231	233	PF00675	0.300
CLV_NRD_NRD_1	322	324	PF00675	0.522
CLV_PCSK_KEX2_1	170	172	PF00082	0.590
CLV_PCSK_KEX2_1	322	324	PF00082	0.384
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.590
CLV_PCSK_SKI1_1	75	79	PF00082	0.474
DOC_MAPK_DCC_7	263	273	PF00069	0.521
DOC_MAPK_gen_1	170	177	PF00069	0.543
DOC_MAPK_gen_1	263	273	PF00069	0.535
DOC_MAPK_MEF2A_6	266	275	PF00069	0.511
DOC_MIT_MIM_1	166	175	PF04212	0.580
DOC_PIKK_1	160	168	PF02985	0.445
DOC_PP4_FxxP_1	154	157	PF00568	0.404
DOC_PP4_FxxP_1	52	55	PF00568	0.465
DOC_USP7_MATH_1	101	105	PF00917	0.600
DOC_USP7_MATH_1	325	329	PF00917	0.416
DOC_USP7_MATH_2	157	163	PF00917	0.466
DOC_USP7_UBL2_3	263	267	PF12436	0.574
DOC_USP7_UBL2_3	278	282	PF12436	0.436
DOC_WW_Pin1_4	8	13	PF00397	0.623
LIG_14-3-3_CanoR_1	191	197	PF00244	0.488
LIG_14-3-3_CanoR_1	65	69	PF00244	0.396
LIG_14-3-3_CanoR_1	75	82	PF00244	0.416
LIG_Actin_WH2_2	249	265	PF00022	0.510
LIG_BIR_II_1	1	5	PF00653	0.688
LIG_BRCT_BRCA1_1	206	210	PF00533	0.510
LIG_BRCT_BRCA1_1	302	306	PF00533	0.547
LIG_BRCT_BRCA1_2	206	212	PF00533	0.472
LIG_FHA_1	217	223	PF00498	0.538
LIG_FHA_1	263	269	PF00498	0.510
LIG_FHA_2	108	114	PF00498	0.414
LIG_FHA_2	250	256	PF00498	0.500
LIG_FHA_2	76	82	PF00498	0.429
LIG_HP1_1	272	276	PF01393	0.521
LIG_LIR_Apic_2	152	157	PF02991	0.437
LIG_LIR_Apic_2	51	55	PF02991	0.442
LIG_LIR_Gen_1	225	234	PF02991	0.511
LIG_LIR_Gen_1	254	262	PF02991	0.500
LIG_LIR_Gen_1	3	14	PF02991	0.475
LIG_LIR_LC3C_4	174	177	PF02991	0.460
LIG_LIR_Nem_3	146	150	PF02991	0.476
LIG_LIR_Nem_3	152	156	PF02991	0.501
LIG_LIR_Nem_3	225	229	PF02991	0.504
LIG_LIR_Nem_3	254	260	PF02991	0.510
LIG_LIR_Nem_3	292	296	PF02991	0.501
LIG_LIR_Nem_3	3	9	PF02991	0.493
LIG_LIR_Nem_3	319	324	PF02991	0.553
LIG_MAD2	47	55	PF02301	0.444
LIG_PCNA_PIPBox_1	56	65	PF02747	0.328
LIG_PDZ_Class_1	327	332	PF00595	0.447
LIG_Pex14_2	226	230	PF04695	0.502
LIG_Pex14_2	320	324	PF04695	0.332
LIG_PTB_Apo_2	141	148	PF02174	0.380
LIG_PTB_Apo_2	31	38	PF02174	0.435
LIG_REV1ctd_RIR_1	227	237	PF16727	0.500
LIG_SH2_CRK	293	297	PF00017	0.602
LIG_SH2_NCK_1	6	10	PF00017	0.503
LIG_SH2_STAP1	238	242	PF00017	0.500
LIG_SH2_STAP1	82	86	PF00017	0.530
LIG_SH2_STAT5	13	16	PF00017	0.533
LIG_SH2_STAT5	149	152	PF00017	0.503
LIG_SH2_STAT5	153	156	PF00017	0.502
LIG_SH2_STAT5	228	231	PF00017	0.539
LIG_SH3_1	266	272	PF00018	0.521
LIG_SH3_3	241	247	PF00018	0.564
LIG_SH3_3	266	272	PF00018	0.500
LIG_SH3_3	6	12	PF00018	0.522
LIG_TRAF2_1	157	160	PF00917	0.593
LIG_TRAF2_1	96	99	PF00917	0.600
LIG_TRFH_1	154	158	PF08558	0.647
LIG_UBA3_1	25	33	PF00899	0.386
LIG_UBA3_1	256	263	PF00899	0.516
MOD_CK1_1	7	13	PF00069	0.642
MOD_CK1_1	73	79	PF00069	0.531
MOD_CK2_1	107	113	PF00069	0.435
MOD_CK2_1	249	255	PF00069	0.500
MOD_CK2_1	294	300	PF00069	0.500
MOD_CK2_1	306	312	PF00069	0.510
MOD_CK2_1	75	81	PF00069	0.378
MOD_GlcNHglycan	308	311	PF01048	0.400
MOD_GlcNHglycan	72	75	PF01048	0.417
MOD_GSK3_1	258	265	PF00069	0.510
MOD_GSK3_1	300	307	PF00069	0.602
MOD_GSK3_1	4	11	PF00069	0.714
MOD_N-GLC_1	143	148	PF02516	0.396
MOD_N-GLC_1	325	330	PF02516	0.579
MOD_NEK2_1	112	117	PF00069	0.495
MOD_NEK2_1	175	180	PF00069	0.407
MOD_NEK2_1	204	209	PF00069	0.510
MOD_NEK2_1	236	241	PF00069	0.517
MOD_NEK2_1	262	267	PF00069	0.510
MOD_NEK2_1	280	285	PF00069	0.522
MOD_NEK2_1	37	42	PF00069	0.524
MOD_NEK2_1	63	68	PF00069	0.492
MOD_NEK2_1	70	75	PF00069	0.379
MOD_NEK2_2	82	87	PF00069	0.487
MOD_PIKK_1	112	118	PF00454	0.486
MOD_PIKK_1	294	300	PF00454	0.563
MOD_PIKK_1	75	81	PF00454	0.553
MOD_PKA_2	64	70	PF00069	0.386
MOD_Plk_1	107	113	PF00069	0.480
MOD_Plk_1	143	149	PF00069	0.413
MOD_Plk_1	326	332	PF00069	0.438
MOD_Plk_1	82	88	PF00069	0.516
MOD_Plk_4	280	286	PF00069	0.497
MOD_Plk_4	300	306	PF00069	0.596
MOD_Plk_4	64	70	PF00069	0.372
MOD_ProDKin_1	8	14	PF00069	0.618
TRG_DiLeu_BaEn_1	255	260	PF01217	0.501
TRG_DiLeu_BaEn_1	300	305	PF01217	0.602
TRG_ENDOCYTIC_2	153	156	PF00928	0.592
TRG_ENDOCYTIC_2	293	296	PF00928	0.602
TRG_ENDOCYTIC_2	32	35	PF00928	0.560
TRG_ENDOCYTIC_2	321	324	PF00928	0.552
TRG_ENDOCYTIC_2	6	9	PF00928	0.529
TRG_ER_diArg_1	321	323	PF00400	0.348
TRG_Pf-PMV_PEXEL_1	47	51	PF00026	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2M2	Leptomonas seymouri	72%	100%
A0A0S4J0W4	Bodo saltans	39%	100%
A0A0S4KLV2	Bodo saltans	55%	98%
A0A1X0NU32	Trypanosomatidae	61%	100%
A0A3Q8IC52	Leishmania donovani	80%	100%
A0A422MT26	Trypanosoma rangeli	61%	100%
A4HWA1	Leishmania infantum	80%	100%
C9ZNT3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9AQ01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QFI0	Leishmania major	79%	100%
V5AWJ3	Trypanosoma cruzi	59%	88%