ATP diphosphohydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP diphosphohydrolase

Species:

Leishmania braziliensis

UniProt:

A4H7X3_LEIBR

TriTrypDb:

LbrM.15.0030 , LBRM2903_150005300

Length:

425

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4H7X3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7X3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009132	nucleoside diphosphate metabolic process	5	1
GO:0009134	nucleoside diphosphate catabolic process	6	1
GO:0009987	cellular process	1	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0019637	organophosphate metabolic process	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046434	organophosphate catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901292	nucleoside phosphate catabolic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	9
GO:0005524	ATP binding	5	9
GO:0016787	hydrolase activity	2	10
GO:0017076	purine nucleotide binding	4	9
GO:0030554	adenyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032559	adenyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9
GO:0016462	pyrophosphatase activity	5	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0017110	nucleoside diphosphate phosphatase activity	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	270	272	PF00675	0.524
CLV_NRD_NRD_1	8	10	PF00675	0.422
CLV_PCSK_FUR_1	84	88	PF00082	0.517
CLV_PCSK_KEX2_1	230	232	PF00082	0.517
CLV_PCSK_KEX2_1	270	272	PF00082	0.551
CLV_PCSK_KEX2_1	8	10	PF00082	0.411
CLV_PCSK_KEX2_1	86	88	PF00082	0.521
CLV_PCSK_PC1ET2_1	230	232	PF00082	0.517
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.547
CLV_PCSK_PC7_1	82	88	PF00082	0.526
CLV_PCSK_SKI1_1	8	12	PF00082	0.460
DEG_SCF_FBW7_1	226	232	PF00400	0.293
DOC_ANK_TNKS_1	15	22	PF00023	0.373
DOC_CKS1_1	226	231	PF01111	0.293
DOC_MAPK_gen_1	16	25	PF00069	0.359
DOC_MAPK_gen_1	249	255	PF00069	0.315
DOC_MAPK_MEF2A_6	16	24	PF00069	0.263
DOC_PP2B_LxvP_1	399	402	PF13499	0.263
DOC_USP7_MATH_1	102	106	PF00917	0.290
DOC_USP7_MATH_1	158	162	PF00917	0.315
DOC_USP7_MATH_1	3	7	PF00917	0.675
DOC_USP7_MATH_1	320	324	PF00917	0.173
DOC_WW_Pin1_4	225	230	PF00397	0.173
DOC_WW_Pin1_4	260	265	PF00397	0.246
DOC_WW_Pin1_4	36	41	PF00397	0.405
DOC_WW_Pin1_4	368	373	PF00397	0.195
DOC_WW_Pin1_4	44	49	PF00397	0.321
LIG_14-3-3_CanoR_1	123	128	PF00244	0.223
LIG_14-3-3_CanoR_1	2	8	PF00244	0.662
LIG_14-3-3_CanoR_1	270	279	PF00244	0.231
LIG_14-3-3_CanoR_1	73	81	PF00244	0.195
LIG_14-3-3_CanoR_1	9	17	PF00244	0.610
LIG_Actin_WH2_2	3	20	PF00022	0.641
LIG_APCC_ABBA_1	293	298	PF00400	0.195
LIG_APCC_ABBA_1	33	38	PF00400	0.316
LIG_BIR_III_4	309	313	PF00653	0.315
LIG_BRCT_BRCA1_1	285	289	PF00533	0.173
LIG_BRCT_BRCA1_1	342	346	PF00533	0.173
LIG_BRCT_BRCA1_1	38	42	PF00533	0.480
LIG_BRCT_BRCA1_1	416	420	PF00533	0.315
LIG_deltaCOP1_diTrp_1	216	220	PF00928	0.317
LIG_FHA_1	130	136	PF00498	0.236
LIG_FHA_1	202	208	PF00498	0.254
LIG_FHA_1	271	277	PF00498	0.250
LIG_FHA_1	300	306	PF00498	0.173
LIG_FHA_1	386	392	PF00498	0.265
LIG_FHA_1	396	402	PF00498	0.236
LIG_FHA_1	74	80	PF00498	0.344
LIG_FHA_2	211	217	PF00498	0.372
LIG_FHA_2	285	291	PF00498	0.263
LIG_FHA_2	369	375	PF00498	0.308
LIG_FHA_2	95	101	PF00498	0.338
LIG_LIR_Apic_2	38	44	PF02991	0.262
LIG_LIR_Gen_1	254	264	PF02991	0.336
LIG_LIR_Gen_1	26	36	PF02991	0.325
LIG_LIR_Gen_1	332	341	PF02991	0.254
LIG_LIR_Gen_1	47	57	PF02991	0.283
LIG_LIR_Nem_3	172	178	PF02991	0.256
LIG_LIR_Nem_3	214	220	PF02991	0.322
LIG_LIR_Nem_3	239	243	PF02991	0.238
LIG_LIR_Nem_3	254	259	PF02991	0.243
LIG_LIR_Nem_3	26	31	PF02991	0.246
LIG_LIR_Nem_3	262	268	PF02991	0.232
LIG_LIR_Nem_3	332	338	PF02991	0.279
LIG_LIR_Nem_3	343	349	PF02991	0.279
LIG_LIR_Nem_3	351	356	PF02991	0.279
LIG_LIR_Nem_3	47	52	PF02991	0.346
LIG_LIR_Nem_3	83	88	PF02991	0.291
LIG_NRBOX	105	111	PF00104	0.317
LIG_Pex14_2	208	212	PF04695	0.173
LIG_SH2_CRK	335	339	PF00017	0.312
LIG_SH2_CRK	384	388	PF00017	0.236
LIG_SH2_CRK	4	8	PF00017	0.676
LIG_SH2_CRK	49	53	PF00017	0.242
LIG_SH2_GRB2like	49	52	PF00017	0.317
LIG_SH2_NCK_1	49	53	PF00017	0.317
LIG_SH2_SRC	236	239	PF00017	0.279
LIG_SH2_SRC	382	385	PF00017	0.216
LIG_SH2_SRC	53	56	PF00017	0.275
LIG_SH2_STAP1	222	226	PF00017	0.271
LIG_SH2_STAP1	329	333	PF00017	0.254
LIG_SH2_STAP1	335	339	PF00017	0.254
LIG_SH2_STAP1	49	53	PF00017	0.246
LIG_SH2_STAT3	222	225	PF00017	0.317
LIG_SH2_STAT5	182	185	PF00017	0.254
LIG_SH2_STAT5	240	243	PF00017	0.256
LIG_SH2_STAT5	333	336	PF00017	0.279
LIG_SH2_STAT5	349	352	PF00017	0.279
LIG_SH2_STAT5	382	385	PF00017	0.195
LIG_SH3_1	314	320	PF00018	0.233
LIG_SH3_2	319	324	PF14604	0.315
LIG_SH3_3	313	319	PF00018	0.279
LIG_SUMO_SIM_anti_2	74	83	PF11976	0.301
LIG_SUMO_SIM_par_1	21	26	PF11976	0.376
LIG_SUMO_SIM_par_1	74	83	PF11976	0.301
LIG_TRAF2_1	97	100	PF00917	0.173
LIG_UBA3_1	183	189	PF00899	0.233
LIG_UBA3_1	252	258	PF00899	0.173
LIG_WRC_WIRS_1	383	388	PF05994	0.279
LIG_WRC_WIRS_1	92	97	PF05994	0.315
LIG_WW_2	319	322	PF00397	0.173
MOD_CDK_SPK_2	225	230	PF00069	0.293
MOD_CDK_SPK_2	368	373	PF00069	0.173
MOD_CDK_SPxK_1	225	231	PF00069	0.293
MOD_CK1_1	165	171	PF00069	0.317
MOD_CK1_1	263	269	PF00069	0.173
MOD_CK1_1	385	391	PF00069	0.257
MOD_CK1_1	47	53	PF00069	0.281
MOD_CK1_1	61	67	PF00069	0.225
MOD_CK1_1	94	100	PF00069	0.324
MOD_CK2_1	210	216	PF00069	0.315
MOD_CK2_1	349	355	PF00069	0.344
MOD_CK2_1	368	374	PF00069	0.239
MOD_CK2_1	94	100	PF00069	0.173
MOD_GlcNHglycan	167	170	PF01048	0.517
MOD_GlcNHglycan	213	216	PF01048	0.547
MOD_GlcNHglycan	25	28	PF01048	0.358
MOD_GlcNHglycan	364	367	PF01048	0.487
MOD_GSK3_1	125	132	PF00069	0.254
MOD_GSK3_1	158	165	PF00069	0.332
MOD_GSK3_1	207	214	PF00069	0.319
MOD_GSK3_1	225	232	PF00069	0.293
MOD_GSK3_1	259	266	PF00069	0.173
MOD_GSK3_1	36	43	PF00069	0.424
MOD_GSK3_1	362	369	PF00069	0.343
MOD_GSK3_1	391	398	PF00069	0.265
MOD_GSK3_1	410	417	PF00069	0.260
MOD_GSK3_1	90	97	PF00069	0.294
MOD_N-GLC_1	259	264	PF02516	0.479
MOD_NEK2_1	129	134	PF00069	0.261
MOD_NEK2_1	23	28	PF00069	0.321
MOD_NEK2_1	414	419	PF00069	0.221
MOD_NEK2_2	150	155	PF00069	0.173
MOD_NEK2_2	3	8	PF00069	0.732
MOD_PIKK_1	201	207	PF00454	0.254
MOD_PIKK_1	8	14	PF00454	0.650
MOD_PK_1	123	129	PF00069	0.294
MOD_PK_1	162	168	PF00069	0.317
MOD_PKA_1	270	276	PF00069	0.173
MOD_PKA_1	8	14	PF00069	0.673
MOD_PKA_2	122	128	PF00069	0.268
MOD_PKA_2	270	276	PF00069	0.250
MOD_PKA_2	362	368	PF00069	0.317
MOD_PKA_2	72	78	PF00069	0.317
MOD_PKA_2	8	14	PF00069	0.655
MOD_Plk_1	373	379	PF00069	0.209
MOD_Plk_1	395	401	PF00069	0.356
MOD_Plk_2-3	395	401	PF00069	0.173
MOD_Plk_4	162	168	PF00069	0.254
MOD_Plk_4	236	242	PF00069	0.240
MOD_Plk_4	248	254	PF00069	0.247
MOD_Plk_4	382	388	PF00069	0.258
MOD_Plk_4	416	422	PF00069	0.261
MOD_ProDKin_1	225	231	PF00069	0.173
MOD_ProDKin_1	260	266	PF00069	0.246
MOD_ProDKin_1	36	42	PF00069	0.406
MOD_ProDKin_1	368	374	PF00069	0.195
MOD_ProDKin_1	44	50	PF00069	0.317
MOD_SUMO_for_1	422	425	PF00179	0.380
MOD_SUMO_rev_2	203	213	PF00179	0.173
TRG_DiLeu_BaLyEn_6	133	138	PF01217	0.236
TRG_ENDOCYTIC_2	175	178	PF00928	0.317
TRG_ENDOCYTIC_2	240	243	PF00928	0.239
TRG_ENDOCYTIC_2	335	338	PF00928	0.273
TRG_ENDOCYTIC_2	353	356	PF00928	0.160
TRG_ENDOCYTIC_2	384	387	PF00928	0.236
TRG_ENDOCYTIC_2	4	7	PF00928	0.681
TRG_ENDOCYTIC_2	49	52	PF00928	0.246
TRG_ENDOCYTIC_2	53	56	PF00928	0.226
TRG_ER_diArg_1	16	19	PF00400	0.270
TRG_ER_diArg_1	269	271	PF00400	0.230
TRG_ER_diArg_1	7	9	PF00400	0.634
TRG_Pf-PMV_PEXEL_1	136	140	PF00026	0.454

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBE5	Leptomonas seymouri	60%	100%
A0A0S4IR76	Bodo saltans	41%	74%
A0A1X0NQR7	Trypanosomatidae	31%	68%
A0A1X0NTJ7	Trypanosomatidae	38%	98%
A0A3Q8I8Z5	Leishmania donovani	79%	100%
A0A3R7NV38	Trypanosoma rangeli	32%	67%
A0JND9	Bos taurus	27%	86%
A4HWA0	Leishmania infantum	79%	100%
C9ZS87	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	96%
C9ZVG6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	70%
D2GZV9	Ailuropoda melanoleuca	32%	98%
E1BPW0	Bos taurus	32%	98%
E1C1L6	Gallus gallus	32%	99%
E9AQ00	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
O18956	Bos taurus	26%	83%
O35795	Rattus norvegicus	29%	86%
O55026	Mus musculus	29%	86%
O75354	Homo sapiens	29%	88%
O75355	Homo sapiens	27%	80%
O75356	Homo sapiens	33%	99%
O80612	Arabidopsis thaliana	30%	77%
O93295	Gallus gallus	26%	86%
P32621	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	82%
P49961	Homo sapiens	26%	83%
P52914	Pisum sativum	28%	93%
P55772	Mus musculus	28%	83%
P79784	Gallus gallus	28%	86%
P80595	Solanum tuberosum	30%	94%
P97687	Rattus norvegicus	27%	83%
Q18411	Caenorhabditis elegans	31%	78%
Q21815	Caenorhabditis elegans	25%	77%
Q2QYE1	Oryza sativa subsp. japonica	27%	94%
Q3TCT4	Mus musculus	27%	70%
Q3U0P5	Mus musculus	32%	93%
Q4QFI1	Leishmania major	78%	100%
Q5DRK1	Rattus norvegicus	25%	86%
Q5MY95	Homo sapiens	27%	86%
Q5REF6	Pongo abelii	26%	70%
Q617Y0	Caenorhabditis briggsae	26%	77%
Q6NQA8	Arabidopsis thaliana	26%	87%
Q6P6S9	Rattus norvegicus	32%	100%
Q6Z4P2	Oryza sativa subsp. japonica	28%	91%
Q8BFW6	Mus musculus	27%	80%
Q8H1D8	Arabidopsis thaliana	28%	84%
Q8H7L6	Oryza sativa subsp. japonica	30%	87%
Q8K0L2	Mus musculus	26%	86%
Q8TGG8	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	30%	84%
Q8TGH6	Candida albicans (strain SC5314 / ATCC MYA-2876)	33%	71%
Q9DBT4	Mus musculus	25%	69%
Q9ER31	Rattus norvegicus	32%	93%
Q9HEM6	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	32%	81%
Q9MYU4	Sus scrofa	28%	83%
Q9QYC8	Mesocricetus auratus	33%	91%
Q9SPM5	Arabidopsis thaliana	28%	90%
Q9SQG2	Arabidopsis thaliana	27%	90%
Q9USP2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	74%
Q9UT35	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	76%
Q9WUZ9	Mus musculus	33%	100%
Q9XI62	Arabidopsis thaliana	28%	88%
Q9XU84	Caenorhabditis elegans	30%	89%
Q9Y227	Homo sapiens	25%	69%
Q9Y5L3	Homo sapiens	29%	86%