Nucleotid_trans domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7X2_LEIBR

TriTrypDb:

LbrM.15.0020 , LBRM2903_150005200

Length:

574

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4H7X2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7X2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	452	456	PF00656	0.368
CLV_NRD_NRD_1	2	4	PF00675	0.401
CLV_NRD_NRD_1	360	362	PF00675	0.610
CLV_NRD_NRD_1	397	399	PF00675	0.537
CLV_NRD_NRD_1	431	433	PF00675	0.721
CLV_NRD_NRD_1	500	502	PF00675	0.585
CLV_PCSK_FUR_1	3	7	PF00082	0.403
CLV_PCSK_KEX2_1	2	4	PF00082	0.458
CLV_PCSK_KEX2_1	360	362	PF00082	0.643
CLV_PCSK_KEX2_1	430	432	PF00082	0.716
CLV_PCSK_KEX2_1	499	501	PF00082	0.733
CLV_PCSK_KEX2_1	5	7	PF00082	0.338
CLV_PCSK_KEX2_1	63	65	PF00082	0.693
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.289
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.631
CLV_PCSK_PC7_1	59	65	PF00082	0.601
CLV_PCSK_SKI1_1	2	6	PF00082	0.400
CLV_PCSK_SKI1_1	351	355	PF00082	0.554
CLV_PCSK_SKI1_1	47	51	PF00082	0.626
CLV_PCSK_SKI1_1	500	504	PF00082	0.701
CLV_PCSK_SKI1_1	536	540	PF00082	0.677
DEG_APCC_DBOX_1	431	439	PF00400	0.432
DEG_APCC_DBOX_1	5	13	PF00400	0.449
DEG_Nend_UBRbox_1	1	4	PF02207	0.542
DOC_CKS1_1	311	316	PF01111	0.365
DOC_CYCLIN_RxL_1	2	11	PF00134	0.485
DOC_CYCLIN_yCln2_LP_2	38	44	PF00134	0.421
DOC_MAPK_DCC_7	219	229	PF00069	0.366
DOC_MAPK_gen_1	444	451	PF00069	0.560
DOC_MAPK_MEF2A_6	150	158	PF00069	0.327
DOC_MAPK_MEF2A_6	405	414	PF00069	0.432
DOC_PP1_RVXF_1	92	98	PF00149	0.406
DOC_PP2B_LxvP_1	16	19	PF13499	0.264
DOC_PP4_FxxP_1	408	411	PF00568	0.345
DOC_PP4_FxxP_1	451	454	PF00568	0.455
DOC_PP4_FxxP_1	571	574	PF00568	0.404
DOC_USP7_MATH_1	111	115	PF00917	0.272
DOC_USP7_MATH_1	274	278	PF00917	0.410
DOC_USP7_MATH_1	416	420	PF00917	0.330
DOC_USP7_MATH_1	460	464	PF00917	0.515
DOC_USP7_MATH_1	510	514	PF00917	0.456
DOC_USP7_MATH_1	57	61	PF00917	0.421
DOC_WW_Pin1_4	167	172	PF00397	0.283
DOC_WW_Pin1_4	177	182	PF00397	0.401
DOC_WW_Pin1_4	310	315	PF00397	0.462
DOC_WW_Pin1_4	466	471	PF00397	0.519
DOC_WW_Pin1_4	566	571	PF00397	0.436
LIG_14-3-3_CanoR_1	262	268	PF00244	0.446
LIG_14-3-3_CanoR_1	275	281	PF00244	0.419
LIG_14-3-3_CanoR_1	479	484	PF00244	0.360
LIG_14-3-3_CanoR_1	493	502	PF00244	0.320
LIG_14-3-3_CanoR_1	532	539	PF00244	0.507
LIG_14-3-3_CanoR_1	59	65	PF00244	0.433
LIG_14-3-3_CanoR_1	6	16	PF00244	0.304
LIG_BRCT_BRCA1_1	288	292	PF00533	0.279
LIG_BRCT_BRCA1_1	381	385	PF00533	0.308
LIG_BRCT_BRCA1_1	462	466	PF00533	0.472
LIG_Clathr_ClatBox_1	414	418	PF01394	0.350
LIG_deltaCOP1_diTrp_1	105	108	PF00928	0.348
LIG_deltaCOP1_diTrp_1	523	529	PF00928	0.366
LIG_eIF4E_1	252	258	PF01652	0.325
LIG_EVH1_2	225	229	PF00568	0.350
LIG_FHA_1	168	174	PF00498	0.273
LIG_FHA_1	252	258	PF00498	0.462
LIG_FHA_1	424	430	PF00498	0.424
LIG_FHA_1	466	472	PF00498	0.501
LIG_FHA_1	83	89	PF00498	0.531
LIG_FHA_1	9	15	PF00498	0.389
LIG_FHA_2	163	169	PF00498	0.455
LIG_FHA_2	210	216	PF00498	0.330
LIG_FHA_2	301	307	PF00498	0.447
LIG_FHA_2	311	317	PF00498	0.441
LIG_FHA_2	450	456	PF00498	0.569
LIG_FHA_2	541	547	PF00498	0.394
LIG_LIR_Apic_2	234	240	PF02991	0.362
LIG_LIR_Apic_2	406	411	PF02991	0.398
LIG_LIR_Apic_2	448	454	PF02991	0.450
LIG_LIR_Apic_2	569	574	PF02991	0.383
LIG_LIR_Gen_1	128	137	PF02991	0.380
LIG_LIR_Gen_1	242	253	PF02991	0.397
LIG_LIR_Gen_1	286	293	PF02991	0.298
LIG_LIR_Gen_1	504	511	PF02991	0.377
LIG_LIR_Nem_3	128	134	PF02991	0.365
LIG_LIR_Nem_3	138	143	PF02991	0.335
LIG_LIR_Nem_3	242	248	PF02991	0.383
LIG_LIR_Nem_3	279	284	PF02991	0.434
LIG_LIR_Nem_3	286	291	PF02991	0.352
LIG_LIR_Nem_3	406	410	PF02991	0.340
LIG_LIR_Nem_3	447	453	PF02991	0.578
LIG_LIR_Nem_3	504	509	PF02991	0.486
LIG_LIR_Nem_3	523	528	PF02991	0.326
LIG_MLH1_MIPbox_1	288	292	PF16413	0.279
LIG_PCNA_PIPBox_1	72	81	PF02747	0.359
LIG_Pex14_1	524	528	PF04695	0.379
LIG_Pex14_2	172	176	PF04695	0.465
LIG_Pex14_2	525	529	PF04695	0.435
LIG_PTB_Apo_2	326	333	PF02174	0.301
LIG_SH2_CRK	237	241	PF00017	0.354
LIG_SH2_CRK	284	288	PF00017	0.387
LIG_SH2_GRB2like	333	336	PF00017	0.337
LIG_SH2_NCK_1	179	183	PF00017	0.320
LIG_SH2_SRC	333	336	PF00017	0.360
LIG_SH2_STAP1	131	135	PF00017	0.339
LIG_SH2_STAP1	288	292	PF00017	0.279
LIG_SH2_STAP1	381	385	PF00017	0.308
LIG_SH2_STAT3	78	81	PF00017	0.360
LIG_SH2_STAT5	140	143	PF00017	0.373
LIG_SH2_STAT5	252	255	PF00017	0.450
LIG_SH2_STAT5	333	336	PF00017	0.340
LIG_SH2_STAT5	37	40	PF00017	0.554
LIG_SH2_STAT5	407	410	PF00017	0.244
LIG_SH2_STAT5	442	445	PF00017	0.479
LIG_SH2_STAT5	528	531	PF00017	0.379
LIG_SH2_STAT5	78	81	PF00017	0.434
LIG_SH3_3	38	44	PF00018	0.368
LIG_SH3_3	85	91	PF00018	0.315
LIG_SUMO_SIM_anti_2	121	130	PF11976	0.261
LIG_SUMO_SIM_par_1	151	161	PF11976	0.400
LIG_SUMO_SIM_par_1	413	419	PF11976	0.432
LIG_TRAF2_1	364	367	PF00917	0.324
LIG_TYR_ITSM	127	134	PF00017	0.272
LIG_UBA3_1	538	547	PF00899	0.279
LIG_WRC_WIRS_1	288	293	PF05994	0.286
LIG_WRC_WIRS_1	503	508	PF05994	0.380
MOD_CK1_1	101	107	PF00069	0.382
MOD_CK1_1	167	173	PF00069	0.366
MOD_CK1_1	180	186	PF00069	0.451
MOD_CK1_1	266	272	PF00069	0.421
MOD_CK1_1	286	292	PF00069	0.443
MOD_CK1_1	373	379	PF00069	0.259
MOD_CK1_1	540	546	PF00069	0.355
MOD_CK1_1	554	560	PF00069	0.302
MOD_CK2_1	115	121	PF00069	0.330
MOD_CK2_1	209	215	PF00069	0.328
MOD_CK2_1	300	306	PF00069	0.437
MOD_CK2_1	416	422	PF00069	0.263
MOD_CK2_1	540	546	PF00069	0.271
MOD_CMANNOS	524	527	PF00535	0.592
MOD_GlcNHglycan	117	120	PF01048	0.545
MOD_GlcNHglycan	203	206	PF01048	0.542
MOD_GlcNHglycan	21	24	PF01048	0.693
MOD_GlcNHglycan	276	279	PF01048	0.713
MOD_GlcNHglycan	30	33	PF01048	0.567
MOD_GlcNHglycan	462	465	PF01048	0.752
MOD_GlcNHglycan	495	498	PF01048	0.607
MOD_GlcNHglycan	539	542	PF01048	0.621
MOD_GSK3_1	111	118	PF00069	0.332
MOD_GSK3_1	120	127	PF00069	0.274
MOD_GSK3_1	247	254	PF00069	0.352
MOD_GSK3_1	283	290	PF00069	0.294
MOD_GSK3_1	306	313	PF00069	0.455
MOD_GSK3_1	370	377	PF00069	0.266
MOD_GSK3_1	449	456	PF00069	0.483
MOD_GSK3_1	488	495	PF00069	0.412
MOD_GSK3_1	528	535	PF00069	0.429
MOD_GSK3_1	566	573	PF00069	0.392
MOD_N-GLC_1	101	106	PF02516	0.548
MOD_N-GLC_1	301	306	PF02516	0.623
MOD_N-GLC_1	554	559	PF02516	0.612
MOD_N-GLC_1	82	87	PF02516	0.588
MOD_NEK2_1	206	211	PF00069	0.496
MOD_NEK2_1	30	35	PF00069	0.403
MOD_NEK2_1	338	343	PF00069	0.358
MOD_NEK2_1	392	397	PF00069	0.338
MOD_NEK2_1	423	428	PF00069	0.421
MOD_NEK2_1	449	454	PF00069	0.443
MOD_NEK2_1	465	470	PF00069	0.476
MOD_NEK2_1	486	491	PF00069	0.533
MOD_NEK2_1	7	12	PF00069	0.328
MOD_NEK2_1	71	76	PF00069	0.343
MOD_OFUCOSY	109	115	PF10250	0.530
MOD_PK_1	479	485	PF00069	0.359
MOD_PKA_2	274	280	PF00069	0.446
MOD_PKA_2	492	498	PF00069	0.397
MOD_PKA_2	531	537	PF00069	0.508
MOD_PKA_2	58	64	PF00069	0.432
MOD_PKB_1	499	507	PF00069	0.321
MOD_Plk_1	104	110	PF00069	0.343
MOD_Plk_1	120	126	PF00069	0.352
MOD_Plk_1	127	133	PF00069	0.416
MOD_Plk_1	301	307	PF00069	0.372
MOD_Plk_1	370	376	PF00069	0.348
MOD_Plk_1	436	442	PF00069	0.467
MOD_Plk_1	486	492	PF00069	0.385
MOD_Plk_1	554	560	PF00069	0.430
MOD_Plk_4	120	126	PF00069	0.374
MOD_Plk_4	263	269	PF00069	0.395
MOD_Plk_4	283	289	PF00069	0.296
MOD_Plk_4	306	312	PF00069	0.413
MOD_Plk_4	328	334	PF00069	0.399
MOD_Plk_4	370	376	PF00069	0.348
MOD_Plk_4	502	508	PF00069	0.382
MOD_Plk_4	540	546	PF00069	0.362
MOD_Plk_4	8	14	PF00069	0.504
MOD_ProDKin_1	167	173	PF00069	0.277
MOD_ProDKin_1	177	183	PF00069	0.402
MOD_ProDKin_1	310	316	PF00069	0.461
MOD_ProDKin_1	466	472	PF00069	0.517
MOD_ProDKin_1	566	572	PF00069	0.424
MOD_SUMO_for_1	364	367	PF00179	0.403
MOD_SUMO_for_1	548	551	PF00179	0.295
TRG_DiLeu_BaEn_2	305	311	PF01217	0.400
TRG_DiLeu_BaLyEn_6	481	486	PF01217	0.335
TRG_ENDOCYTIC_2	131	134	PF00928	0.375
TRG_ENDOCYTIC_2	252	255	PF00928	0.325
TRG_ENDOCYTIC_2	284	287	PF00928	0.402
TRG_ENDOCYTIC_2	288	291	PF00928	0.369
TRG_ENDOCYTIC_2	381	384	PF00928	0.349
TRG_ENDOCYTIC_2	407	410	PF00928	0.244
TRG_ENDOCYTIC_2	517	520	PF00928	0.422
TRG_ER_diArg_1	1	3	PF00400	0.583
TRG_ER_diArg_1	360	363	PF00400	0.420
TRG_ER_diArg_1	429	432	PF00400	0.465
TRG_ER_diArg_1	443	446	PF00400	0.380
TRG_ER_diArg_1	498	501	PF00400	0.404
TRG_NLS_MonoExtC_3	431	437	PF00514	0.354
TRG_NLS_MonoExtN_4	430	436	PF00514	0.357
TRG_Pf-PMV_PEXEL_1	219	223	PF00026	0.681
TRG_Pf-PMV_PEXEL_1	433	437	PF00026	0.600

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGZ4	Leptomonas seymouri	32%	89%
A0A0N1PDD7	Leptomonas seymouri	23%	94%
A0A3Q8ID98	Leishmania donovani	77%	93%
A0A3Q8IM92	Leishmania donovani	33%	86%
A4HLI8	Leishmania braziliensis	34%	89%
A4HLJ0	Leishmania braziliensis	32%	89%
A4HLJ2	Leishmania braziliensis	31%	100%
A4HW99	Leishmania infantum	78%	93%
A4I8Z8	Leishmania infantum	32%	86%
E9APZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	93%
E9B3W7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	86%
Q4Q457	Leishmania major	32%	100%
Q4QFI2	Leishmania major	75%	100%