Putative inositol 5'-phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

synaptojanin (N-terminal domain), putative

Species:

Leishmania braziliensis

UniProt:

A4H7W9_LEIBR

TriTrypDb:

LbrM.14.1680 , LBRM2903_140021900

Length:

847

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H7W9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7W9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0016791	phosphatase activity	5	11
GO:0042578	phosphoric ester hydrolase activity	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	258	262	PF00656	0.447
CLV_C14_Caspase3-7	566	570	PF00656	0.314
CLV_NRD_NRD_1	231	233	PF00675	0.349
CLV_NRD_NRD_1	472	474	PF00675	0.403
CLV_NRD_NRD_1	559	561	PF00675	0.494
CLV_NRD_NRD_1	628	630	PF00675	0.469
CLV_NRD_NRD_1	637	639	PF00675	0.427
CLV_NRD_NRD_1	696	698	PF00675	0.473
CLV_PCSK_KEX2_1	472	474	PF00082	0.403
CLV_PCSK_KEX2_1	696	698	PF00082	0.502
CLV_PCSK_KEX2_1	836	838	PF00082	0.663
CLV_PCSK_PC1ET2_1	836	838	PF00082	0.663
CLV_PCSK_SKI1_1	402	406	PF00082	0.348
CLV_PCSK_SKI1_1	479	483	PF00082	0.505
CLV_PCSK_SKI1_1	837	841	PF00082	0.635
CLV_Separin_Metazoa	349	353	PF03568	0.378
DEG_APCC_DBOX_1	401	409	PF00400	0.378
DEG_Nend_UBRbox_2	1	3	PF02207	0.539
DOC_CDC14_PxL_1	122	130	PF14671	0.511
DOC_CKS1_1	56	61	PF01111	0.704
DOC_CYCLIN_RxL_1	707	718	PF00134	0.324
DOC_CYCLIN_yCln2_LP_2	206	212	PF00134	0.223
DOC_CYCLIN_yCln2_LP_2	231	237	PF00134	0.368
DOC_CYCLIN_yCln2_LP_2	336	342	PF00134	0.383
DOC_CYCLIN_yCln2_LP_2	664	670	PF00134	0.377
DOC_MAPK_DCC_7	42	50	PF00069	0.587
DOC_MAPK_gen_1	133	141	PF00069	0.330
DOC_MAPK_gen_1	22	29	PF00069	0.405
DOC_MAPK_gen_1	42	50	PF00069	0.359
DOC_MAPK_gen_1	638	648	PF00069	0.391
DOC_MAPK_gen_1	770	779	PF00069	0.564
DOC_MAPK_HePTP_8	75	87	PF00069	0.322
DOC_MAPK_MEF2A_6	133	141	PF00069	0.330
DOC_MAPK_MEF2A_6	260	269	PF00069	0.408
DOC_MAPK_MEF2A_6	42	50	PF00069	0.636
DOC_MAPK_MEF2A_6	639	648	PF00069	0.388
DOC_MAPK_MEF2A_6	78	87	PF00069	0.429
DOC_PP1_RVXF_1	95	102	PF00149	0.512
DOC_PP1_SILK_1	317	322	PF00149	0.383
DOC_PP2B_LxvP_1	206	209	PF13499	0.349
DOC_PP2B_LxvP_1	71	74	PF13499	0.598
DOC_PP4_FxxP_1	168	171	PF00568	0.378
DOC_PP4_FxxP_1	212	215	PF00568	0.408
DOC_PP4_FxxP_1	56	59	PF00568	0.555
DOC_USP7_MATH_1	118	122	PF00917	0.434
DOC_USP7_MATH_1	420	424	PF00917	0.445
DOC_USP7_MATH_1	461	465	PF00917	0.542
DOC_USP7_MATH_1	562	566	PF00917	0.325
DOC_USP7_MATH_1	604	608	PF00917	0.319
DOC_USP7_MATH_1	818	822	PF00917	0.658
DOC_WW_Pin1_4	12	17	PF00397	0.636
DOC_WW_Pin1_4	176	181	PF00397	0.408
DOC_WW_Pin1_4	216	221	PF00397	0.397
DOC_WW_Pin1_4	457	462	PF00397	0.562
DOC_WW_Pin1_4	524	529	PF00397	0.612
DOC_WW_Pin1_4	55	60	PF00397	0.640
LIG_14-3-3_CanoR_1	232	238	PF00244	0.227
LIG_14-3-3_CanoR_1	255	260	PF00244	0.480
LIG_14-3-3_CanoR_1	479	487	PF00244	0.537
LIG_14-3-3_CanoR_1	837	843	PF00244	0.690
LIG_Actin_WH2_2	821	838	PF00022	0.698
LIG_BRCT_BRCA1_1	149	153	PF00533	0.257
LIG_BRCT_BRCA1_1	450	454	PF00533	0.455
LIG_BRCT_BRCA1_1	97	101	PF00533	0.511
LIG_Clathr_ClatBox_1	426	430	PF01394	0.319
LIG_Clathr_ClatBox_1	53	57	PF01394	0.596
LIG_CSL_BTD_1	164	167	PF09270	0.447
LIG_CtBP_PxDLS_1	220	224	PF00389	0.480
LIG_EH1_1	234	242	PF00400	0.227
LIG_FHA_1	144	150	PF00498	0.408
LIG_FHA_1	161	167	PF00498	0.335
LIG_FHA_1	321	327	PF00498	0.335
LIG_FHA_1	472	478	PF00498	0.491
LIG_FHA_1	514	520	PF00498	0.517
LIG_FHA_1	544	550	PF00498	0.658
LIG_FHA_1	66	72	PF00498	0.569
LIG_FHA_1	686	692	PF00498	0.545
LIG_FHA_1	702	708	PF00498	0.518
LIG_FHA_1	838	844	PF00498	0.478
LIG_FHA_2	211	217	PF00498	0.349
LIG_FHA_2	256	262	PF00498	0.417
LIG_FHA_2	333	339	PF00498	0.237
LIG_FHA_2	444	450	PF00498	0.418
LIG_FHA_2	564	570	PF00498	0.466
LIG_FHA_2	685	691	PF00498	0.495
LIG_FHA_2	723	729	PF00498	0.534
LIG_HCF-1_HBM_1	191	194	PF13415	0.227
LIG_HCF-1_HBM_1	296	299	PF13415	0.335
LIG_Integrin_isoDGR_2	374	376	PF01839	0.266
LIG_LIR_Apic_2	216	221	PF02991	0.391
LIG_LIR_Gen_1	104	112	PF02991	0.430
LIG_LIR_Gen_1	135	145	PF02991	0.372
LIG_LIR_Gen_1	296	306	PF02991	0.335
LIG_LIR_Gen_1	361	370	PF02991	0.347
LIG_LIR_Gen_1	430	438	PF02991	0.396
LIG_LIR_Gen_1	484	492	PF02991	0.443
LIG_LIR_Nem_3	104	109	PF02991	0.427
LIG_LIR_Nem_3	120	125	PF02991	0.414
LIG_LIR_Nem_3	135	141	PF02991	0.254
LIG_LIR_Nem_3	163	168	PF02991	0.337
LIG_LIR_Nem_3	296	302	PF02991	0.335
LIG_LIR_Nem_3	361	365	PF02991	0.329
LIG_LIR_Nem_3	430	434	PF02991	0.335
LIG_LIR_Nem_3	484	489	PF02991	0.437
LIG_LIR_Nem_3	654	659	PF02991	0.480
LIG_LIR_Nem_3	70	75	PF02991	0.518
LIG_LYPXL_yS_3	125	128	PF13949	0.425
LIG_Pex14_2	358	362	PF04695	0.355
LIG_Pex14_2	563	567	PF04695	0.438
LIG_Pex14_2	631	635	PF04695	0.469
LIG_PTB_Apo_2	356	363	PF02174	0.227
LIG_SH2_CRK	72	76	PF00017	0.580
LIG_SH2_CRK	811	815	PF00017	0.432
LIG_SH2_GRB2like	357	360	PF00017	0.227
LIG_SH2_GRB2like	521	524	PF00017	0.312
LIG_SH2_GRB2like	599	602	PF00017	0.430
LIG_SH2_NCK_1	218	222	PF00017	0.227
LIG_SH2_NCK_1	72	76	PF00017	0.396
LIG_SH2_PTP2	138	141	PF00017	0.408
LIG_SH2_SRC	299	302	PF00017	0.335
LIG_SH2_SRC	72	75	PF00017	0.384
LIG_SH2_SRC	811	814	PF00017	0.462
LIG_SH2_STAP1	200	204	PF00017	0.368
LIG_SH2_STAP1	299	303	PF00017	0.335
LIG_SH2_STAP1	545	549	PF00017	0.707
LIG_SH2_STAP1	599	603	PF00017	0.393
LIG_SH2_STAT3	813	816	PF00017	0.397
LIG_SH2_STAT5	138	141	PF00017	0.368
LIG_SH2_STAT5	218	221	PF00017	0.292
LIG_SH2_STAT5	282	285	PF00017	0.335
LIG_SH2_STAT5	301	304	PF00017	0.335
LIG_SH2_STAT5	35	38	PF00017	0.466
LIG_SH2_STAT5	357	360	PF00017	0.335
LIG_SH2_STAT5	521	524	PF00017	0.548
LIG_SH2_STAT5	545	548	PF00017	0.628
LIG_SH2_STAT5	599	602	PF00017	0.435
LIG_SH2_STAT5	663	666	PF00017	0.414
LIG_SH3_3	13	19	PF00018	0.628
LIG_SH3_3	146	152	PF00018	0.447
LIG_SH3_3	35	41	PF00018	0.402
LIG_SH3_3	375	381	PF00018	0.227
LIG_SH3_3	525	531	PF00018	0.515
LIG_SH3_3	556	562	PF00018	0.599
LIG_SH3_3	677	683	PF00018	0.315
LIG_SH3_3	80	86	PF00018	0.326
LIG_SUMO_SIM_anti_2	422	428	PF11976	0.405
LIG_SUMO_SIM_anti_2	772	778	PF11976	0.409
LIG_SUMO_SIM_anti_2	80	85	PF11976	0.302
LIG_SUMO_SIM_par_1	145	150	PF11976	0.227
LIG_SUMO_SIM_par_1	722	728	PF11976	0.551
LIG_TRAF2_1	121	124	PF00917	0.479
LIG_TRAF2_1	535	538	PF00917	0.566
LIG_TRAF2_1	760	763	PF00917	0.632
LIG_TRFH_1	663	667	PF08558	0.484
LIG_TYR_ITIM	33	38	PF00017	0.486
LIG_WRC_WIRS_1	119	124	PF05994	0.479
MOD_CDK_SPxxK_3	176	183	PF00069	0.408
MOD_CK1_1	236	242	PF00069	0.474
MOD_CK1_1	464	470	PF00069	0.496
MOD_CK1_1	701	707	PF00069	0.484
MOD_CK1_1	727	733	PF00069	0.620
MOD_CK1_1	822	828	PF00069	0.581
MOD_CK2_1	118	124	PF00069	0.433
MOD_CK2_1	210	216	PF00069	0.265
MOD_CK2_1	236	242	PF00069	0.227
MOD_CK2_1	332	338	PF00069	0.335
MOD_CK2_1	443	449	PF00069	0.389
MOD_CK2_1	456	462	PF00069	0.439
MOD_CK2_1	684	690	PF00069	0.506
MOD_CK2_1	722	728	PF00069	0.395
MOD_GlcNHglycan	288	291	PF01048	0.349
MOD_GlcNHglycan	353	356	PF01048	0.466
MOD_GlcNHglycan	394	397	PF01048	0.436
MOD_GlcNHglycan	552	555	PF01048	0.615
MOD_GlcNHglycan	601	604	PF01048	0.398
MOD_GlcNHglycan	700	703	PF01048	0.428
MOD_GlcNHglycan	716	720	PF01048	0.412
MOD_GlcNHglycan	745	749	PF01048	0.689
MOD_GlcNHglycan	824	827	PF01048	0.579
MOD_GlcNHglycan	91	94	PF01048	0.513
MOD_GSK3_1	101	108	PF00069	0.478
MOD_GSK3_1	143	150	PF00069	0.363
MOD_GSK3_1	210	217	PF00069	0.411
MOD_GSK3_1	308	315	PF00069	0.439
MOD_GSK3_1	326	333	PF00069	0.246
MOD_GSK3_1	370	377	PF00069	0.341
MOD_GSK3_1	457	464	PF00069	0.547
MOD_GSK3_1	491	498	PF00069	0.427
MOD_GSK3_1	651	658	PF00069	0.516
MOD_GSK3_1	818	825	PF00069	0.643
MOD_N-GLC_1	358	363	PF02516	0.227
MOD_N-GLC_1	818	823	PF02516	0.656
MOD_N-GLC_1	89	94	PF02516	0.535
MOD_N-GLC_2	23	25	PF02516	0.419
MOD_N-GLC_2	782	784	PF02516	0.477
MOD_NEK2_1	140	145	PF00069	0.348
MOD_NEK2_1	320	325	PF00069	0.335
MOD_NEK2_1	332	337	PF00069	0.335
MOD_NEK2_1	351	356	PF00069	0.193
MOD_NEK2_1	358	363	PF00069	0.427
MOD_NEK2_1	370	375	PF00069	0.269
MOD_NEK2_1	454	459	PF00069	0.480
MOD_NEK2_1	495	500	PF00069	0.372
MOD_NEK2_1	507	512	PF00069	0.345
MOD_NEK2_1	513	518	PF00069	0.393
MOD_NEK2_1	563	568	PF00069	0.449
MOD_NEK2_1	597	602	PF00069	0.437
MOD_NEK2_1	671	676	PF00069	0.441
MOD_NEK2_1	714	719	PF00069	0.464
MOD_NEK2_1	722	727	PF00069	0.456
MOD_NEK2_1	801	806	PF00069	0.452
MOD_NEK2_1	95	100	PF00069	0.542
MOD_NEK2_2	225	230	PF00069	0.227
MOD_PIKK_1	327	333	PF00454	0.370
MOD_PIKK_1	479	485	PF00454	0.513
MOD_PIKK_1	513	519	PF00454	0.475
MOD_PIKK_1	624	630	PF00454	0.450
MOD_PK_1	233	239	PF00069	0.227
MOD_PKA_2	315	321	PF00069	0.344
MOD_PKA_2	351	357	PF00069	0.408
MOD_PKA_2	471	477	PF00069	0.402
MOD_PKA_2	822	828	PF00069	0.655
MOD_Plk_1	181	187	PF00069	0.256
MOD_Plk_1	190	196	PF00069	0.212
MOD_Plk_1	358	364	PF00069	0.454
MOD_Plk_1	448	454	PF00069	0.425
MOD_Plk_1	461	467	PF00069	0.480
MOD_Plk_1	691	697	PF00069	0.436
MOD_Plk_1	715	721	PF00069	0.367
MOD_Plk_1	727	733	PF00069	0.468
MOD_Plk_1	819	825	PF00069	0.718
MOD_Plk_2-3	105	111	PF00069	0.426
MOD_Plk_4	236	242	PF00069	0.380
MOD_Plk_4	315	321	PF00069	0.335
MOD_Plk_4	443	449	PF00069	0.392
MOD_Plk_4	461	467	PF00069	0.457
MOD_Plk_4	788	794	PF00069	0.449
MOD_Plk_4	79	85	PF00069	0.393
MOD_Plk_4	838	844	PF00069	0.692
MOD_ProDKin_1	12	18	PF00069	0.626
MOD_ProDKin_1	176	182	PF00069	0.408
MOD_ProDKin_1	216	222	PF00069	0.397
MOD_ProDKin_1	457	463	PF00069	0.552
MOD_ProDKin_1	524	530	PF00069	0.604
MOD_ProDKin_1	55	61	PF00069	0.641
MOD_SUMO_for_1	46	49	PF00179	0.655
MOD_SUMO_for_1	731	734	PF00179	0.464
TRG_DiLeu_BaEn_1	242	247	PF01217	0.419
TRG_DiLeu_BaLyEn_6	476	481	PF01217	0.482
TRG_DiLeu_BaLyEn_6	710	715	PF01217	0.328
TRG_ENDOCYTIC_2	125	128	PF00928	0.372
TRG_ENDOCYTIC_2	138	141	PF00928	0.271
TRG_ENDOCYTIC_2	299	302	PF00928	0.335
TRG_ENDOCYTIC_2	35	38	PF00928	0.469
TRG_ENDOCYTIC_2	521	524	PF00928	0.571
TRG_ENDOCYTIC_2	72	75	PF00928	0.384
TRG_ER_diArg_1	183	186	PF00400	0.335
TRG_ER_diArg_1	21	24	PF00400	0.333
TRG_ER_diArg_1	471	473	PF00400	0.384
TRG_ER_diArg_1	695	697	PF00400	0.482
TRG_NES_CRM1_1	398	412	PF08389	0.227
TRG_NES_CRM1_1	425	437	PF08389	0.335
TRG_NLS_Bipartite_1	629	643	PF00514	0.533
TRG_NLS_MonoExtN_4	638	643	PF00514	0.509
TRG_Pf-PMV_PEXEL_1	479	483	PF00026	0.559
TRG_Pf-PMV_PEXEL_1	582	586	PF00026	0.367

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2T7	Leptomonas seymouri	71%	99%
A0A1X0NNZ9	Trypanosomatidae	50%	100%
A0A3Q8I9X9	Leishmania donovani	76%	100%
A0A3R7LN11	Trypanosoma rangeli	47%	100%
A4HW96	Leishmania infantum	76%	100%
C9ZSR4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9APZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4QFI4	Leishmania major	75%	100%
V5AVZ2	Trypanosoma cruzi	48%	100%