Mitochondrial pyruvate carrier

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mitochondrial pyruvate carrier 2

Species:

Leishmania braziliensis

UniProt:

A4H7W6_LEIBR

TriTrypDb:

LbrM.14.1650 , LBRM2903_140021600

Length:

140

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005743	mitochondrial inner membrane	5	11
GO:0016020	membrane	2	11
GO:0019866	organelle inner membrane	4	11
GO:0031090	organelle membrane	3	11
GO:0031966	mitochondrial membrane	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4H7W6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7W6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006811	monoatomic ion transport	4	11
GO:0006820	monoatomic anion transport	5	11
GO:0006848	pyruvate transport	6	11
GO:0006850	mitochondrial pyruvate transmembrane transport	4	11
GO:0009987	cellular process	1	11
GO:0015711	organic anion transport	5	11
GO:0015718	monocarboxylic acid transport	7	11
GO:0015849	organic acid transport	5	11
GO:0034220	monoatomic ion transmembrane transport	3	11
GO:0046942	carboxylic acid transport	6	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0055085	transmembrane transport	2	11
GO:0071702	organic substance transport	4	11
GO:0098656	monoatomic anion transmembrane transport	4	11
GO:1901475	pyruvate transmembrane transport	5	11
GO:1903825	organic acid transmembrane transport	3	11
GO:1905039	carboxylic acid transmembrane transport	4	11
GO:1990542	mitochondrial transmembrane transport	3	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DOC_MAPK_gen_1	124	133	PF00069	0.359
DOC_MAPK_MEF2A_6	105	114	PF00069	0.439
DOC_PP1_RVXF_1	72	78	PF00149	0.221
DOC_PP4_FxxP_1	14	17	PF00568	0.347
DOC_PP4_FxxP_1	30	33	PF00568	0.368
DOC_USP7_MATH_1	17	21	PF00917	0.451
DOC_USP7_MATH_1	99	103	PF00917	0.421
DOC_WW_Pin1_4	29	34	PF00397	0.240
LIG_14-3-3_CanoR_1	127	132	PF00244	0.407
LIG_14-3-3_CanoR_1	16	22	PF00244	0.262
LIG_BIR_II_1	1	5	PF00653	0.380
LIG_EH_1	36	40	PF12763	0.240
LIG_eIF4E_1	47	53	PF01652	0.264
LIG_FHA_1	22	28	PF00498	0.439
LIG_FHA_1	47	53	PF00498	0.302
LIG_FHA_1	84	90	PF00498	0.246
LIG_LIR_Nem_3	125	131	PF02991	0.350
LIG_NRBOX	91	97	PF00104	0.164
LIG_Pex14_2	14	18	PF04695	0.411
LIG_PTB_Apo_2	41	48	PF02174	0.277
LIG_PTB_Phospho_1	41	47	PF10480	0.279
LIG_SH2_CRK	128	132	PF00017	0.490
LIG_SH2_CRK	63	67	PF00017	0.302
LIG_SH2_CRK	93	97	PF00017	0.264
LIG_SH2_GRB2like	42	45	PF00017	0.271
LIG_SH2_NCK_1	47	51	PF00017	0.264
LIG_SH2_SRC	42	45	PF00017	0.278
LIG_SH2_STAP1	93	97	PF00017	0.264
LIG_SH2_STAT5	42	45	PF00017	0.271
LIG_SUMO_SIM_anti_2	106	111	PF11976	0.464
LIG_SUMO_SIM_anti_2	56	61	PF11976	0.239
MOD_CDK_SPxxK_3	29	36	PF00069	0.241
MOD_CK2_1	29	35	PF00069	0.237
MOD_GlcNHglycan	101	104	PF01048	0.221
MOD_GlcNHglycan	124	127	PF01048	0.317
MOD_GlcNHglycan	66	69	PF01048	0.493
MOD_GlcNHglycan	79	82	PF01048	0.139
MOD_GSK3_1	17	24	PF00069	0.408
MOD_GSK3_1	42	49	PF00069	0.288
MOD_GSK3_1	99	106	PF00069	0.423
MOD_N-GLC_1	77	82	PF02516	0.245
MOD_N-GLC_2	111	113	PF02516	0.221
MOD_NEK2_1	1	6	PF00069	0.433
MOD_NEK2_1	53	58	PF00069	0.239
MOD_NEK2_1	77	82	PF00069	0.250
MOD_NEK2_1	83	88	PF00069	0.238
MOD_NEK2_2	42	47	PF00069	0.292
MOD_Plk_4	17	23	PF00069	0.383
MOD_Plk_4	42	48	PF00069	0.237
MOD_Plk_4	55	61	PF00069	0.286
MOD_ProDKin_1	29	35	PF00069	0.237
TRG_DiLeu_BaEn_2	34	40	PF01217	0.306
TRG_ENDOCYTIC_2	128	131	PF00928	0.449
TRG_ENDOCYTIC_2	63	66	PF00928	0.221
TRG_ENDOCYTIC_2	93	96	PF00928	0.281

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2T5	Leptomonas seymouri	79%	100%
A0A0S4IYK9	Bodo saltans	57%	100%
A0A1X0NNE8	Trypanosomatidae	70%	100%
A0A3S7WT79	Leishmania donovani	82%	100%
A0A422N3T5	Trypanosoma rangeli	56%	100%
A4HW93	Leishmania infantum	82%	100%
C9ZSR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	100%
E9APZ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
O95563	Homo sapiens	34%	100%
Q4QFI7	Leishmania major	83%	100%
Q55GU3	Dictyostelium discoideum	47%	100%