Vac14_Fig4_bd domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vacuolar 14 Fab1-binding region/Vacuolar protein 14 C-terminal Fig4p binding, putative

Species:

Leishmania braziliensis

UniProt:

A4H7W5_LEIBR

TriTrypDb:

LbrM.14.1640 , LBRM2903_140021500

Length:

686

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005942	phosphatidylinositol 3-kinase complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0035032	phosphatidylinositol 3-kinase complex, class III	4	12
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	12
GO:0070772	PAS complex	5	12
GO:0098796	membrane protein complex	2	12
GO:1902494	catalytic complex	2	12
GO:1990234	transferase complex	3	12
GO:0005737	cytoplasm	2	1
GO:0010008	endosome membrane	5	1
GO:0012506	vesicle membrane	4	1
GO:0016020	membrane	2	1
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0031090	organelle membrane	3	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H7W5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7W5

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	12
GO:0006644	phospholipid metabolic process	4	12
GO:0006650	glycerophospholipid metabolic process	5	12
GO:0006661	phosphatidylinositol biosynthetic process	6	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0008152	metabolic process	1	12
GO:0008610	lipid biosynthetic process	4	12
GO:0008654	phospholipid biosynthetic process	5	12
GO:0009058	biosynthetic process	2	12
GO:0009987	cellular process	1	12
GO:0019637	organophosphate metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044255	cellular lipid metabolic process	3	12
GO:0045017	glycerolipid biosynthetic process	4	12
GO:0046474	glycerophospholipid biosynthetic process	5	12
GO:0046486	glycerolipid metabolic process	4	12
GO:0046488	phosphatidylinositol metabolic process	6	12
GO:0071704	organic substance metabolic process	2	12
GO:0090407	organophosphate biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12
GO:0009893	positive regulation of metabolic process	4	1
GO:0010562	positive regulation of phosphorus metabolic process	6	1
GO:0019220	regulation of phosphate metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0033674	positive regulation of kinase activity	6	1
GO:0042325	regulation of phosphorylation	7	1
GO:0042327	positive regulation of phosphorylation	8	1
GO:0043085	positive regulation of catalytic activity	4	1
GO:0043549	regulation of kinase activity	5	1
GO:0044093	positive regulation of molecular function	3	1
GO:0045937	positive regulation of phosphate metabolic process	7	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050790	regulation of catalytic activity	3	1
GO:0050794	regulation of cellular process	3	1
GO:0051174	regulation of phosphorus metabolic process	5	1
GO:0051338	regulation of transferase activity	4	1
GO:0051347	positive regulation of transferase activity	5	1
GO:0065007	biological regulation	1	1
GO:0065009	regulation of molecular function	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.346
CLV_C14_Caspase3-7	370	374	PF00656	0.386
CLV_NRD_NRD_1	11	13	PF00675	0.524
CLV_NRD_NRD_1	460	462	PF00675	0.431
CLV_NRD_NRD_1	467	469	PF00675	0.389
CLV_NRD_NRD_1	527	529	PF00675	0.418
CLV_NRD_NRD_1	567	569	PF00675	0.351
CLV_NRD_NRD_1	637	639	PF00675	0.297
CLV_NRD_NRD_1	70	72	PF00675	0.289
CLV_PCSK_FUR_1	150	154	PF00082	0.413
CLV_PCSK_KEX2_1	152	154	PF00082	0.341
CLV_PCSK_KEX2_1	460	462	PF00082	0.431
CLV_PCSK_KEX2_1	467	469	PF00082	0.389
CLV_PCSK_KEX2_1	527	529	PF00082	0.428
CLV_PCSK_KEX2_1	567	569	PF00082	0.353
CLV_PCSK_KEX2_1	637	639	PF00082	0.297
CLV_PCSK_KEX2_1	70	72	PF00082	0.289
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.341
CLV_PCSK_PC7_1	523	529	PF00082	0.418
CLV_PCSK_SKI1_1	12	16	PF00082	0.461
CLV_PCSK_SKI1_1	152	156	PF00082	0.320
CLV_PCSK_SKI1_1	217	221	PF00082	0.470
CLV_PCSK_SKI1_1	236	240	PF00082	0.358
CLV_PCSK_SKI1_1	366	370	PF00082	0.462
CLV_PCSK_SKI1_1	504	508	PF00082	0.326
CLV_PCSK_SKI1_1	523	527	PF00082	0.149
CLV_PCSK_SKI1_1	528	532	PF00082	0.331
CLV_Separin_Metazoa	122	126	PF03568	0.413
DEG_APCC_DBOX_1	365	373	PF00400	0.450
DEG_APCC_DBOX_1	70	78	PF00400	0.317
DEG_MDM2_SWIB_1	294	302	PF02201	0.438
DEG_SPOP_SBC_1	395	399	PF00917	0.268
DOC_CYCLIN_RxL_1	233	243	PF00134	0.366
DOC_MAPK_gen_1	637	644	PF00069	0.413
DOC_MAPK_gen_1	70	77	PF00069	0.341
DOC_MAPK_MEF2A_6	482	489	PF00069	0.418
DOC_MAPK_MEF2A_6	500	509	PF00069	0.341
DOC_MAPK_MEF2A_6	637	646	PF00069	0.503
DOC_MAPK_RevD_3	554	568	PF00069	0.331
DOC_PP2B_LxvP_1	220	223	PF13499	0.393
DOC_PP2B_LxvP_1	623	626	PF13499	0.297
DOC_USP7_MATH_1	181	185	PF00917	0.340
DOC_USP7_MATH_1	196	200	PF00917	0.528
DOC_USP7_MATH_1	206	210	PF00917	0.417
DOC_USP7_MATH_1	241	245	PF00917	0.506
DOC_USP7_MATH_1	29	33	PF00917	0.483
DOC_USP7_MATH_1	396	400	PF00917	0.511
DOC_USP7_MATH_1	417	421	PF00917	0.245
DOC_USP7_MATH_1	88	92	PF00917	0.448
DOC_WW_Pin1_4	626	631	PF00397	0.307
LIG_14-3-3_CanoR_1	135	143	PF00244	0.403
LIG_14-3-3_CanoR_1	424	432	PF00244	0.291
LIG_14-3-3_CanoR_1	467	473	PF00244	0.467
LIG_14-3-3_CanoR_1	491	499	PF00244	0.418
LIG_14-3-3_CanoR_1	602	606	PF00244	0.341
LIG_14-3-3_CanoR_1	607	612	PF00244	0.341
LIG_14-3-3_CanoR_1	63	69	PF00244	0.439
LIG_Actin_WH2_2	201	219	PF00022	0.479
LIG_Actin_WH2_2	353	368	PF00022	0.424
LIG_Actin_WH2_2	409	426	PF00022	0.234
LIG_Actin_WH2_2	47	65	PF00022	0.450
LIG_Actin_WH2_2	486	502	PF00022	0.413
LIG_Actin_WH2_2	586	604	PF00022	0.413
LIG_AP2alpha_1	136	140	PF02296	0.413
LIG_APCC_ABBA_1	35	40	PF00400	0.420
LIG_BIR_III_2	107	111	PF00653	0.413
LIG_BRCT_BRCA1_1	594	598	PF00533	0.341
LIG_Clathr_ClatBox_1	645	649	PF01394	0.474
LIG_deltaCOP1_diTrp_1	130	136	PF00928	0.331
LIG_eIF4E_1	548	554	PF01652	0.413
LIG_eIF4E_1	619	625	PF01652	0.418
LIG_eIF4E_1	69	75	PF01652	0.413
LIG_FHA_1	32	38	PF00498	0.455
LIG_FHA_1	407	413	PF00498	0.374
LIG_FHA_1	564	570	PF00498	0.418
LIG_FHA_1	615	621	PF00498	0.413
LIG_FHA_1	63	69	PF00498	0.441
LIG_FHA_1	641	647	PF00498	0.509
LIG_FHA_2	162	168	PF00498	0.321
LIG_FHA_2	321	327	PF00498	0.384
LIG_FHA_2	42	48	PF00498	0.429
LIG_FHA_2	513	519	PF00498	0.297
LIG_GBD_Chelix_1	505	513	PF00786	0.418
LIG_GBD_Chelix_1	614	622	PF00786	0.413
LIG_LIR_Gen_1	118	129	PF02991	0.418
LIG_LIR_Gen_1	137	147	PF02991	0.312
LIG_LIR_Gen_1	247	255	PF02991	0.478
LIG_LIR_Gen_1	386	395	PF02991	0.330
LIG_LIR_Gen_1	537	543	PF02991	0.466
LIG_LIR_Gen_1	582	590	PF02991	0.377
LIG_LIR_Gen_1	595	606	PF02991	0.247
LIG_LIR_Gen_1	617	626	PF02991	0.418
LIG_LIR_Gen_1	629	639	PF02991	0.341
LIG_LIR_LC3C_4	197	202	PF02991	0.620
LIG_LIR_Nem_3	118	124	PF02991	0.413
LIG_LIR_Nem_3	137	143	PF02991	0.303
LIG_LIR_Nem_3	247	253	PF02991	0.476
LIG_LIR_Nem_3	386	390	PF02991	0.326
LIG_LIR_Nem_3	515	519	PF02991	0.323
LIG_LIR_Nem_3	537	542	PF02991	0.345
LIG_LIR_Nem_3	582	586	PF02991	0.365
LIG_LIR_Nem_3	595	601	PF02991	0.226
LIG_LIR_Nem_3	617	622	PF02991	0.418
LIG_LIR_Nem_3	629	635	PF02991	0.304
LIG_LIR_Nem_3	667	672	PF02991	0.428
LIG_NRBOX	234	240	PF00104	0.374
LIG_NRBOX	384	390	PF00104	0.442
LIG_NRBOX	445	451	PF00104	0.471
LIG_NRBOX	617	623	PF00104	0.413
LIG_NRBOX	93	99	PF00104	0.418
LIG_PCNA_yPIPBox_3	443	454	PF02747	0.265
LIG_Pex14_1	132	136	PF04695	0.358
LIG_Pex14_2	136	140	PF04695	0.279
LIG_Pex14_2	294	298	PF04695	0.435
LIG_SH2_CRK	548	552	PF00017	0.302
LIG_SH2_CRK	632	636	PF00017	0.326
LIG_SH2_NCK_1	548	552	PF00017	0.297
LIG_SH2_PTP2	583	586	PF00017	0.406
LIG_SH2_PTP2	619	622	PF00017	0.418
LIG_SH2_STAP1	682	686	PF00017	0.551
LIG_SH2_STAT5	583	586	PF00017	0.411
LIG_SH2_STAT5	619	622	PF00017	0.418
LIG_SH2_STAT5	672	675	PF00017	0.518
LIG_SH3_3	82	88	PF00018	0.417
LIG_SUMO_SIM_anti_2	274	282	PF11976	0.329
LIG_SUMO_SIM_anti_2	367	374	PF11976	0.438
LIG_SUMO_SIM_anti_2	386	392	PF11976	0.335
LIG_SUMO_SIM_anti_2	408	415	PF11976	0.226
LIG_SUMO_SIM_anti_2	47	53	PF11976	0.517
LIG_SUMO_SIM_par_1	367	374	PF11976	0.438
LIG_SUMO_SIM_par_1	408	415	PF11976	0.265
LIG_SUMO_SIM_par_1	47	53	PF11976	0.484
LIG_SUMO_SIM_par_1	505	511	PF11976	0.198
LIG_TRAF2_1	341	344	PF00917	0.476
LIG_TRAF2_1	376	379	PF00917	0.492
LIG_TRAF2_1	674	677	PF00917	0.529
LIG_WRC_WIRS_1	182	187	PF05994	0.339
MOD_CK1_1	192	198	PF00069	0.430
MOD_CK1_1	230	236	PF00069	0.373
MOD_CK1_1	244	250	PF00069	0.350
MOD_CK1_1	265	271	PF00069	0.513
MOD_CK1_1	288	294	PF00069	0.399
MOD_CK1_1	31	37	PF00069	0.485
MOD_CK1_1	494	500	PF00069	0.406
MOD_CK1_1	508	514	PF00069	0.320
MOD_CK1_1	579	585	PF00069	0.317
MOD_CK1_1	596	602	PF00069	0.317
MOD_CK2_1	161	167	PF00069	0.341
MOD_CK2_1	320	326	PF00069	0.381
MOD_CK2_1	364	370	PF00069	0.401
MOD_CK2_1	394	400	PF00069	0.435
MOD_CK2_1	41	47	PF00069	0.402
MOD_CK2_1	471	477	PF00069	0.428
MOD_CK2_1	512	518	PF00069	0.297
MOD_GlcNHglycan	171	174	PF01048	0.490
MOD_GlcNHglycan	194	197	PF01048	0.582
MOD_GlcNHglycan	264	267	PF01048	0.534
MOD_GlcNHglycan	287	290	PF01048	0.502
MOD_GlcNHglycan	356	359	PF01048	0.501
MOD_GlcNHglycan	373	376	PF01048	0.379
MOD_GlcNHglycan	539	542	PF01048	0.316
MOD_GSK3_1	134	141	PF00069	0.399
MOD_GSK3_1	161	168	PF00069	0.368
MOD_GSK3_1	192	199	PF00069	0.548
MOD_GSK3_1	258	265	PF00069	0.468
MOD_GSK3_1	284	291	PF00069	0.415
MOD_GSK3_1	508	515	PF00069	0.188
MOD_GSK3_1	528	535	PF00069	0.156
MOD_GSK3_1	592	599	PF00069	0.413
MOD_GSK3_1	650	657	PF00069	0.470
MOD_N-GLC_1	244	249	PF02516	0.508
MOD_N-GLC_2	271	273	PF02516	0.234
MOD_NEK2_1	165	170	PF00069	0.454
MOD_NEK2_1	227	232	PF00069	0.447
MOD_NEK2_1	279	284	PF00069	0.277
MOD_NEK2_1	320	325	PF00069	0.430
MOD_NEK2_1	364	369	PF00069	0.450
MOD_NEK2_1	371	376	PF00069	0.498
MOD_NEK2_1	512	517	PF00069	0.310
MOD_NEK2_1	530	535	PF00069	0.297
MOD_NEK2_1	563	568	PF00069	0.418
MOD_NEK2_1	593	598	PF00069	0.440
MOD_NEK2_1	601	606	PF00069	0.266
MOD_NEK2_1	614	619	PF00069	0.201
MOD_NEK2_1	62	67	PF00069	0.392
MOD_NEK2_1	8	13	PF00069	0.472
MOD_PIKK_1	206	212	PF00454	0.460
MOD_PIKK_1	258	264	PF00454	0.499
MOD_PKA_2	134	140	PF00069	0.413
MOD_PKA_2	423	429	PF00069	0.289
MOD_PKA_2	481	487	PF00069	0.191
MOD_PKA_2	601	607	PF00069	0.341
MOD_PKA_2	62	68	PF00069	0.392
MOD_Plk_1	377	383	PF00069	0.343
MOD_Plk_1	576	582	PF00069	0.413
MOD_Plk_1	593	599	PF00069	0.413
MOD_Plk_2-3	53	59	PF00069	0.256
MOD_Plk_4	181	187	PF00069	0.356
MOD_Plk_4	230	236	PF00069	0.374
MOD_Plk_4	377	383	PF00069	0.495
MOD_Plk_4	481	487	PF00069	0.347
MOD_Plk_4	508	514	PF00069	0.188
MOD_Plk_4	579	585	PF00069	0.320
MOD_Plk_4	601	607	PF00069	0.324
MOD_Plk_4	614	620	PF00069	0.268
MOD_Plk_4	640	646	PF00069	0.481
MOD_ProDKin_1	626	632	PF00069	0.307
TRG_DiLeu_BaEn_1	440	445	PF01217	0.429
TRG_DiLeu_BaEn_4	47	53	PF01217	0.388
TRG_DiLeu_BaLyEn_6	445	450	PF01217	0.462
TRG_DiLeu_BaLyEn_6	520	525	PF01217	0.191
TRG_ENDOCYTIC_2	121	124	PF00928	0.387
TRG_ENDOCYTIC_2	38	41	PF00928	0.475
TRG_ENDOCYTIC_2	548	551	PF00928	0.306
TRG_ENDOCYTIC_2	583	586	PF00928	0.387
TRG_ENDOCYTIC_2	619	622	PF00928	0.418
TRG_ENDOCYTIC_2	632	635	PF00928	0.304
TRG_ER_diArg_1	290	293	PF00400	0.458
TRG_ER_diArg_1	459	461	PF00400	0.431
TRG_ER_diArg_1	466	468	PF00400	0.389
TRG_ER_diArg_1	472	475	PF00400	0.372
TRG_ER_diArg_1	526	528	PF00400	0.418
TRG_ER_diArg_1	567	569	PF00400	0.331
TRG_ER_diArg_1	637	639	PF00400	0.301
TRG_ER_diArg_1	69	71	PF00400	0.300
TRG_NES_CRM1_1	297	310	PF08389	0.476
TRG_NES_CRM1_1	498	510	PF08389	0.421
TRG_Pf-PMV_PEXEL_1	13	17	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	198	203	PF00026	0.356
TRG_Pf-PMV_PEXEL_1	491	495	PF00026	0.226
TRG_Pf-PMV_PEXEL_1	567	571	PF00026	0.418

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC70	Leptomonas seymouri	61%	99%
A0A0S4IRF4	Bodo saltans	28%	100%
A0A1X0NNZ5	Trypanosomatidae	28%	99%
A0A3Q8IA32	Leishmania donovani	84%	100%
A0A422N3V6	Trypanosoma rangeli	31%	99%
A4HW92	Leishmania infantum	84%	100%
C9ZSR9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	99%
E9APZ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
P87145	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	85%
Q4QFI8	Leishmania major	84%	100%
Q66L58	Danio rerio	24%	89%
Q9ZU97	Arabidopsis thaliana	27%	92%
V5AVZ7	Trypanosoma cruzi	29%	99%