C2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytoskeleton associated protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H7W4_LEIBR

TriTrypDb:

LbrM.14.1630 , LBRM2903_140021400

Length:

918

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	1
GO:0030863	cortical cytoskeleton	6	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H7W4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7W4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	240	244	PF00656	0.427
CLV_C14_Caspase3-7	631	635	PF00656	0.623
CLV_NRD_NRD_1	118	120	PF00675	0.591
CLV_NRD_NRD_1	20	22	PF00675	0.594
CLV_NRD_NRD_1	448	450	PF00675	0.370
CLV_NRD_NRD_1	648	650	PF00675	0.646
CLV_NRD_NRD_1	67	69	PF00675	0.538
CLV_NRD_NRD_1	836	838	PF00675	0.649
CLV_NRD_NRD_1	840	842	PF00675	0.676
CLV_NRD_NRD_1	88	90	PF00675	0.673
CLV_NRD_NRD_1	900	902	PF00675	0.813
CLV_NRD_NRD_1	906	908	PF00675	0.665
CLV_NRD_NRD_1	93	95	PF00675	0.618
CLV_PCSK_FUR_1	837	841	PF00082	0.688
CLV_PCSK_KEX2_1	118	120	PF00082	0.638
CLV_PCSK_KEX2_1	20	22	PF00082	0.594
CLV_PCSK_KEX2_1	448	450	PF00082	0.370
CLV_PCSK_KEX2_1	551	553	PF00082	0.503
CLV_PCSK_KEX2_1	648	650	PF00082	0.646
CLV_PCSK_KEX2_1	67	69	PF00082	0.520
CLV_PCSK_KEX2_1	836	838	PF00082	0.655
CLV_PCSK_KEX2_1	839	841	PF00082	0.679
CLV_PCSK_KEX2_1	900	902	PF00082	0.810
CLV_PCSK_KEX2_1	906	908	PF00082	0.662
CLV_PCSK_KEX2_1	93	95	PF00082	0.630
CLV_PCSK_PC1ET2_1	551	553	PF00082	0.503
CLV_PCSK_PC7_1	836	842	PF00082	0.579
CLV_PCSK_PC7_1	89	95	PF00082	0.662
CLV_PCSK_SKI1_1	59	63	PF00082	0.600
DEG_APCC_DBOX_1	906	914	PF00400	0.656
DEG_SCF_FBW7_2	169	175	PF00400	0.283
DOC_CKS1_1	169	174	PF01111	0.283
DOC_CKS1_1	315	320	PF01111	0.467
DOC_CYCLIN_RxL_1	439	450	PF00134	0.395
DOC_CYCLIN_RxL_1	498	509	PF00134	0.283
DOC_MAPK_DCC_7	121	131	PF00069	0.558
DOC_MAPK_FxFP_2	177	180	PF00069	0.344
DOC_MAPK_gen_1	268	275	PF00069	0.470
DOC_MAPK_gen_1	352	359	PF00069	0.487
DOC_MAPK_gen_1	67	74	PF00069	0.546
DOC_MAPK_gen_1	93	101	PF00069	0.549
DOC_MAPK_MEF2A_6	128	135	PF00069	0.470
DOC_MAPK_MEF2A_6	268	275	PF00069	0.470
DOC_MAPK_MEF2A_6	352	361	PF00069	0.483
DOC_MAPK_MEF2A_6	433	440	PF00069	0.283
DOC_MAPK_MEF2A_6	67	74	PF00069	0.546
DOC_MAPK_NFAT4_5	67	75	PF00069	0.551
DOC_PP2B_LxvP_1	208	211	PF13499	0.308
DOC_PP2B_LxvP_1	271	274	PF13499	0.570
DOC_PP2B_LxvP_1	553	556	PF13499	0.577
DOC_PP4_FxxP_1	177	180	PF00568	0.344
DOC_PP4_FxxP_1	4	7	PF00568	0.559
DOC_USP7_MATH_1	322	326	PF00917	0.574
DOC_USP7_MATH_1	40	44	PF00917	0.682
DOC_USP7_MATH_1	457	461	PF00917	0.291
DOC_USP7_MATH_1	537	541	PF00917	0.431
DOC_USP7_MATH_1	905	909	PF00917	0.714
DOC_WW_Pin1_4	168	173	PF00397	0.283
DOC_WW_Pin1_4	314	319	PF00397	0.539
DOC_WW_Pin1_4	449	454	PF00397	0.283
DOC_WW_Pin1_4	634	639	PF00397	0.694
DOC_WW_Pin1_4	901	906	PF00397	0.684
DOC_WW_Pin1_4	911	916	PF00397	0.573
LIG_14-3-3_CanoR_1	146	150	PF00244	0.630
LIG_14-3-3_CanoR_1	268	274	PF00244	0.481
LIG_14-3-3_CanoR_1	839	845	PF00244	0.585
LIG_14-3-3_CanoR_1	900	905	PF00244	0.727
LIG_14-3-3_CanoR_1	906	911	PF00244	0.777
LIG_APCC_ABBA_1	1	6	PF00400	0.583
LIG_APCC_ABBA_1	72	77	PF00400	0.568
LIG_BIR_II_1	1	5	PF00653	0.571
LIG_BIR_III_2	195	199	PF00653	0.344
LIG_BIR_III_4	478	482	PF00653	0.283
LIG_Clathr_ClatBox_1	69	73	PF01394	0.550
LIG_CtBP_PxDLS_1	453	457	PF00389	0.283
LIG_deltaCOP1_diTrp_1	403	414	PF00928	0.493
LIG_DLG_GKlike_1	906	913	PF00625	0.608
LIG_eIF4E_1	508	514	PF01652	0.345
LIG_FHA_1	14	20	PF00498	0.592
LIG_FHA_1	158	164	PF00498	0.344
LIG_FHA_1	276	282	PF00498	0.467
LIG_FHA_1	461	467	PF00498	0.283
LIG_FHA_1	516	522	PF00498	0.554
LIG_FHA_2	111	117	PF00498	0.618
LIG_FHA_2	169	175	PF00498	0.312
LIG_FHA_2	238	244	PF00498	0.430
LIG_FHA_2	366	372	PF00498	0.664
LIG_FHA_2	497	503	PF00498	0.283
LIG_Integrin_isoDGR_2	646	648	PF01839	0.572
LIG_LIR_Apic_2	174	180	PF02991	0.344
LIG_LIR_Apic_2	2	7	PF02991	0.558
LIG_LIR_Apic_2	35	40	PF02991	0.649
LIG_LIR_Apic_2	851	856	PF02991	0.617
LIG_LIR_Gen_1	171	181	PF02991	0.312
LIG_LIR_Gen_1	27	38	PF02991	0.560
LIG_LIR_Gen_1	333	342	PF02991	0.440
LIG_LIR_Gen_1	383	388	PF02991	0.499
LIG_LIR_Gen_1	434	444	PF02991	0.341
LIG_LIR_Gen_1	455	466	PF02991	0.283
LIG_LIR_Gen_1	490	498	PF02991	0.344
LIG_LIR_LC3C_4	189	193	PF02991	0.395
LIG_LIR_Nem_3	171	176	PF02991	0.335
LIG_LIR_Nem_3	252	257	PF02991	0.384
LIG_LIR_Nem_3	333	338	PF02991	0.482
LIG_LIR_Nem_3	383	387	PF02991	0.505
LIG_LIR_Nem_3	404	410	PF02991	0.483
LIG_LIR_Nem_3	434	440	PF02991	0.344
LIG_LIR_Nem_3	455	461	PF02991	0.391
LIG_LIR_Nem_3	490	496	PF02991	0.355
LIG_LIR_Nem_3	549	553	PF02991	0.441
LIG_LIR_Nem_3	63	69	PF02991	0.519
LIG_Pex14_1	173	177	PF04695	0.344
LIG_Pex14_1	253	257	PF04695	0.391
LIG_SH2_CRK	550	554	PF00017	0.467
LIG_SH2_CRK	66	70	PF00017	0.479
LIG_SH2_CRK	92	96	PF00017	0.658
LIG_SH2_GRB2like	181	184	PF00017	0.395
LIG_SH2_PTP2	458	461	PF00017	0.432
LIG_SH2_PTP2	853	856	PF00017	0.602
LIG_SH2_PTP2	98	101	PF00017	0.557
LIG_SH2_SRC	651	654	PF00017	0.579
LIG_SH2_SRC	669	672	PF00017	0.577
LIG_SH2_SRC	678	681	PF00017	0.586
LIG_SH2_SRC	696	699	PF00017	0.567
LIG_SH2_SRC	714	717	PF00017	0.595
LIG_SH2_SRC	732	735	PF00017	0.596
LIG_SH2_SRC	750	753	PF00017	0.606
LIG_SH2_SRC	768	771	PF00017	0.565
LIG_SH2_STAP1	483	487	PF00017	0.283
LIG_SH2_STAT3	337	340	PF00017	0.437
LIG_SH2_STAT3	595	598	PF00017	0.621
LIG_SH2_STAT5	254	257	PF00017	0.463
LIG_SH2_STAT5	287	290	PF00017	0.501
LIG_SH2_STAT5	316	319	PF00017	0.441
LIG_SH2_STAT5	330	333	PF00017	0.598
LIG_SH2_STAT5	337	340	PF00017	0.523
LIG_SH2_STAT5	37	40	PF00017	0.649
LIG_SH2_STAT5	458	461	PF00017	0.450
LIG_SH2_STAT5	483	486	PF00017	0.334
LIG_SH2_STAT5	651	654	PF00017	0.607
LIG_SH2_STAT5	669	672	PF00017	0.852
LIG_SH2_STAT5	678	681	PF00017	0.737
LIG_SH2_STAT5	696	699	PF00017	0.567
LIG_SH2_STAT5	714	717	PF00017	0.595
LIG_SH2_STAT5	732	735	PF00017	0.596
LIG_SH2_STAT5	741	744	PF00017	0.582
LIG_SH2_STAT5	750	753	PF00017	0.606
LIG_SH2_STAT5	768	771	PF00017	0.565
LIG_SH2_STAT5	777	780	PF00017	0.594
LIG_SH2_STAT5	786	789	PF00017	0.540
LIG_SH2_STAT5	795	798	PF00017	0.498
LIG_SH2_STAT5	812	815	PF00017	0.674
LIG_SH2_STAT5	853	856	PF00017	0.724
LIG_SH2_STAT5	98	101	PF00017	0.557
LIG_SH3_1	853	859	PF00018	0.718
LIG_SH3_3	103	109	PF00018	0.636
LIG_SH3_3	166	172	PF00018	0.386
LIG_SH3_3	224	230	PF00018	0.603
LIG_SH3_3	356	362	PF00018	0.419
LIG_SH3_3	468	474	PF00018	0.395
LIG_SH3_3	821	827	PF00018	0.593
LIG_SH3_3	843	849	PF00018	0.588
LIG_SH3_3	853	859	PF00018	0.722
LIG_SH3_5	849	853	PF00018	0.575
LIG_SUMO_SIM_anti_2	144	151	PF11976	0.439
LIG_SUMO_SIM_anti_2	186	192	PF11976	0.352
LIG_SUMO_SIM_anti_2	365	378	PF11976	0.668
LIG_SUMO_SIM_anti_2	392	399	PF11976	0.462
LIG_SUMO_SIM_anti_2	522	532	PF11976	0.524
LIG_SUMO_SIM_par_1	189	195	PF11976	0.344
LIG_SUMO_SIM_par_1	392	399	PF11976	0.526
LIG_SUMO_SIM_par_1	512	518	PF11976	0.537
LIG_TRAF2_1	172	175	PF00917	0.344
LIG_TRAF2_1	362	365	PF00917	0.546
LIG_TRAF2_1	368	371	PF00917	0.685
LIG_TRAF2_1	628	631	PF00917	0.852
LIG_TYR_ITIM	548	553	PF00017	0.369
LIG_TYR_ITIM	96	101	PF00017	0.551
LIG_UBA3_1	345	353	PF00899	0.445
MOD_CDC14_SPxK_1	637	640	PF00782	0.598
MOD_CDK_SPK_2	901	906	PF00069	0.684
MOD_CDK_SPxK_1	634	640	PF00069	0.606
MOD_CDK_SPxK_1	901	907	PF00069	0.690
MOD_CK1_1	325	331	PF00069	0.504
MOD_CK1_1	389	395	PF00069	0.459
MOD_CK1_1	43	49	PF00069	0.565
MOD_CK1_1	460	466	PF00069	0.395
MOD_CK1_1	515	521	PF00069	0.542
MOD_CK2_1	110	116	PF00069	0.589
MOD_CK2_1	168	174	PF00069	0.312
MOD_CK2_1	364	370	PF00069	0.775
MOD_CK2_1	449	455	PF00069	0.286
MOD_CK2_1	461	467	PF00069	0.271
MOD_CK2_1	496	502	PF00069	0.283
MOD_CK2_1	619	625	PF00069	0.720
MOD_CK2_1	889	895	PF00069	0.601
MOD_Cter_Amidation	646	649	PF01082	0.573
MOD_DYRK1A_RPxSP_1	901	905	PF00069	0.676
MOD_GlcNHglycan	139	142	PF01048	0.507
MOD_GlcNHglycan	21	24	PF01048	0.578
MOD_GlcNHglycan	391	394	PF01048	0.461
MOD_GlcNHglycan	625	630	PF01048	0.622
MOD_GlcNHglycan	859	862	PF01048	0.769
MOD_GSK3_1	245	252	PF00069	0.406
MOD_GSK3_1	269	276	PF00069	0.648
MOD_GSK3_1	310	317	PF00069	0.495
MOD_GSK3_1	324	331	PF00069	0.503
MOD_GSK3_1	432	439	PF00069	0.428
MOD_GSK3_1	457	464	PF00069	0.270
MOD_GSK3_1	657	664	PF00069	0.599
MOD_GSK3_1	895	902	PF00069	0.635
MOD_N-GLC_1	308	313	PF02516	0.541
MOD_N-GLC_1	340	345	PF02516	0.498
MOD_N-GLC_1	481	486	PF02516	0.283
MOD_N-GLC_1	634	639	PF02516	0.604
MOD_N-GLC_2	617	619	PF02516	0.590
MOD_NEK2_1	129	134	PF00069	0.441
MOD_NEK2_1	135	140	PF00069	0.455
MOD_NEK2_1	396	401	PF00069	0.541
MOD_NEK2_1	436	441	PF00069	0.344
MOD_NEK2_1	871	876	PF00069	0.661
MOD_OFUCOSY	512	519	PF10250	0.379
MOD_PIKK_1	340	346	PF00454	0.599
MOD_PIKK_1	496	502	PF00454	0.283
MOD_PKA_1	839	845	PF00069	0.692
MOD_PKA_1	900	906	PF00069	0.678
MOD_PKA_2	145	151	PF00069	0.478
MOD_PKA_2	19	25	PF00069	0.577
MOD_PKA_2	303	309	PF00069	0.515
MOD_PKA_2	839	845	PF00069	0.847
MOD_PKA_2	874	880	PF00069	0.514
MOD_PKA_2	899	905	PF00069	0.722
MOD_PKA_2	906	912	PF00069	0.761
MOD_PKB_1	837	845	PF00069	0.727
MOD_Plk_1	340	346	PF00069	0.487
MOD_Plk_1	408	414	PF00069	0.434
MOD_Plk_1	895	901	PF00069	0.630
MOD_Plk_2-3	366	372	PF00069	0.599
MOD_Plk_2-3	467	473	PF00069	0.395
MOD_Plk_4	14	20	PF00069	0.592
MOD_Plk_4	245	251	PF00069	0.427
MOD_Plk_4	275	281	PF00069	0.515
MOD_Plk_4	310	316	PF00069	0.581
MOD_Plk_4	325	331	PF00069	0.495
MOD_Plk_4	432	438	PF00069	0.432
MOD_ProDKin_1	168	174	PF00069	0.283
MOD_ProDKin_1	314	320	PF00069	0.548
MOD_ProDKin_1	449	455	PF00069	0.283
MOD_ProDKin_1	634	640	PF00069	0.696
MOD_ProDKin_1	901	907	PF00069	0.690
MOD_ProDKin_1	911	917	PF00069	0.571
MOD_SUMO_rev_2	392	401	PF00179	0.467
MOD_SUMO_rev_2	57	64	PF00179	0.577
TRG_DiLeu_BaEn_1	370	375	PF01217	0.593
TRG_DiLeu_BaEn_1	50	55	PF01217	0.546
TRG_DiLeu_BaEn_1	509	514	PF01217	0.505
TRG_DiLeu_BaEn_1	65	70	PF01217	0.538
TRG_DiLeu_LyEn_5	50	55	PF01217	0.598
TRG_ENDOCYTIC_2	30	33	PF00928	0.633
TRG_ENDOCYTIC_2	335	338	PF00928	0.517
TRG_ENDOCYTIC_2	458	461	PF00928	0.395
TRG_ENDOCYTIC_2	550	553	PF00928	0.441
TRG_ENDOCYTIC_2	608	611	PF00928	0.621
TRG_ENDOCYTIC_2	66	69	PF00928	0.476
TRG_ENDOCYTIC_2	92	95	PF00928	0.657
TRG_ENDOCYTIC_2	98	101	PF00928	0.621
TRG_ER_diArg_1	117	119	PF00400	0.695
TRG_ER_diArg_1	19	21	PF00400	0.597
TRG_ER_diArg_1	447	449	PF00400	0.376
TRG_ER_diArg_1	66	68	PF00400	0.560
TRG_ER_diArg_1	78	81	PF00400	0.603
TRG_ER_diArg_1	836	839	PF00400	0.668
TRG_ER_diArg_1	899	901	PF00400	0.646
TRG_ER_diArg_1	905	907	PF00400	0.620
TRG_ER_diArg_1	92	94	PF00400	0.518
TRG_NES_CRM1_1	372	385	PF08389	0.516
TRG_NES_CRM1_1	434	450	PF08389	0.332
TRG_Pf-PMV_PEXEL_1	417	421	PF00026	0.558
TRG_Pf-PMV_PEXEL_1	425	430	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	53	57	PF00026	0.639
TRG_Pf-PMV_PEXEL_1	567	571	PF00026	0.613
TRG_Pf-PMV_PEXEL_1	67	71	PF00026	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NNE4	Trypanosomatidae	48%	100%
A0A3S5H6T3	Leishmania donovani	67%	98%
A4HW91	Leishmania infantum	70%	91%
E9APZ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	95%
Q4QFI9	Leishmania major	60%	100%