Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7W2_LEIBR

TriTrypDb:

LbrM.14.1610 , LBRM2903_140021200

Length:

670

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H7W2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7W2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	64	68	PF00656	0.493
CLV_NRD_NRD_1	118	120	PF00675	0.373
CLV_NRD_NRD_1	348	350	PF00675	0.415
CLV_NRD_NRD_1	473	475	PF00675	0.509
CLV_NRD_NRD_1	564	566	PF00675	0.503
CLV_NRD_NRD_1	60	62	PF00675	0.522
CLV_NRD_NRD_1	665	667	PF00675	0.519
CLV_PCSK_FUR_1	58	62	PF00082	0.644
CLV_PCSK_KEX2_1	348	350	PF00082	0.415
CLV_PCSK_KEX2_1	473	475	PF00082	0.509
CLV_PCSK_KEX2_1	58	60	PF00082	0.537
CLV_PCSK_KEX2_1	634	636	PF00082	0.291
CLV_PCSK_KEX2_1	665	667	PF00082	0.464
CLV_PCSK_PC1ET2_1	634	636	PF00082	0.384
CLV_PCSK_PC7_1	630	636	PF00082	0.271
CLV_PCSK_SKI1_1	181	185	PF00082	0.397
CLV_PCSK_SKI1_1	250	254	PF00082	0.421
CLV_PCSK_SKI1_1	325	329	PF00082	0.496
CLV_PCSK_SKI1_1	451	455	PF00082	0.412
CLV_PCSK_SKI1_1	635	639	PF00082	0.315
DEG_APCC_DBOX_1	386	394	PF00400	0.483
DEG_APCC_DBOX_1	58	66	PF00400	0.450
DEG_Nend_UBRbox_2	1	3	PF02207	0.587
DEG_ODPH_VHL_1	334	345	PF01847	0.435
DOC_CDC14_PxL_1	121	129	PF14671	0.484
DOC_CDC14_PxL_1	406	414	PF14671	0.410
DOC_CKS1_1	304	309	PF01111	0.420
DOC_CKS1_1	365	370	PF01111	0.333
DOC_CYCLIN_RxL_1	247	256	PF00134	0.424
DOC_MAPK_DCC_7	650	659	PF00069	0.436
DOC_MAPK_gen_1	178	186	PF00069	0.476
DOC_MAPK_gen_1	348	357	PF00069	0.395
DOC_MAPK_gen_1	565	572	PF00069	0.465
DOC_MAPK_gen_1	650	659	PF00069	0.294
DOC_MAPK_MEF2A_6	178	186	PF00069	0.476
DOC_MAPK_MEF2A_6	23	31	PF00069	0.615
DOC_MAPK_MEF2A_6	239	248	PF00069	0.388
DOC_MAPK_MEF2A_6	325	334	PF00069	0.400
DOC_MAPK_MEF2A_6	350	359	PF00069	0.383
DOC_MAPK_MEF2A_6	516	524	PF00069	0.329
DOC_MAPK_MEF2A_6	652	660	PF00069	0.283
DOC_PP2B_LxvP_1	212	215	PF13499	0.539
DOC_PP2B_LxvP_1	386	389	PF13499	0.306
DOC_PP2B_LxvP_1	502	505	PF13499	0.426
DOC_PP4_FxxP_1	36	39	PF00568	0.603
DOC_PP4_FxxP_1	582	585	PF00568	0.410
DOC_SPAK_OSR1_1	114	118	PF12202	0.481
DOC_USP7_MATH_1	208	212	PF00917	0.529
DOC_USP7_MATH_1	22	26	PF00917	0.561
DOC_USP7_MATH_1	231	235	PF00917	0.413
DOC_USP7_MATH_1	416	420	PF00917	0.593
DOC_USP7_MATH_1	47	51	PF00917	0.597
DOC_USP7_MATH_1	515	519	PF00917	0.624
DOC_USP7_MATH_1	529	533	PF00917	0.540
DOC_USP7_MATH_1	574	578	PF00917	0.302
DOC_USP7_MATH_2	416	422	PF00917	0.488
DOC_USP7_UBL2_3	441	445	PF12436	0.286
DOC_WW_Pin1_4	303	308	PF00397	0.417
DOC_WW_Pin1_4	364	369	PF00397	0.341
DOC_WW_Pin1_4	412	417	PF00397	0.536
LIG_14-3-3_CanoR_1	105	112	PF00244	0.507
LIG_14-3-3_CanoR_1	132	137	PF00244	0.436
LIG_14-3-3_CanoR_1	181	187	PF00244	0.373
LIG_14-3-3_CanoR_1	23	31	PF00244	0.565
LIG_14-3-3_CanoR_1	239	246	PF00244	0.478
LIG_14-3-3_CanoR_1	250	258	PF00244	0.510
LIG_14-3-3_CanoR_1	308	317	PF00244	0.451
LIG_14-3-3_CanoR_1	32	37	PF00244	0.525
LIG_14-3-3_CanoR_1	451	459	PF00244	0.293
LIG_14-3-3_CanoR_1	46	52	PF00244	0.653
LIG_14-3-3_CanoR_1	516	521	PF00244	0.526
LIG_14-3-3_CanoR_1	94	100	PF00244	0.468
LIG_Clathr_ClatBox_1	572	576	PF01394	0.364
LIG_eIF4E_1	353	359	PF01652	0.375
LIG_FHA_1	12	18	PF00498	0.577
LIG_FHA_1	155	161	PF00498	0.481
LIG_FHA_1	235	241	PF00498	0.497
LIG_FHA_1	312	318	PF00498	0.502
LIG_FHA_1	365	371	PF00498	0.327
LIG_FHA_1	424	430	PF00498	0.456
LIG_FHA_1	433	439	PF00498	0.369
LIG_FHA_1	517	523	PF00498	0.496
LIG_FHA_1	627	633	PF00498	0.397
LIG_FHA_2	105	111	PF00498	0.440
LIG_FHA_2	615	621	PF00498	0.385
LIG_FHA_2	646	652	PF00498	0.433
LIG_LIR_Apic_2	35	39	PF02991	0.589
LIG_LIR_Apic_2	580	585	PF02991	0.393
LIG_LIR_Gen_1	219	230	PF02991	0.472
LIG_LIR_Gen_1	531	542	PF02991	0.448
LIG_LIR_Gen_1	553	563	PF02991	0.354
LIG_LIR_Gen_1	598	609	PF02991	0.396
LIG_LIR_Gen_1	98	103	PF02991	0.499
LIG_LIR_Nem_3	19	24	PF02991	0.525
LIG_LIR_Nem_3	198	203	PF02991	0.351
LIG_LIR_Nem_3	219	225	PF02991	0.367
LIG_LIR_Nem_3	53	57	PF02991	0.623
LIG_LIR_Nem_3	531	537	PF02991	0.462
LIG_LIR_Nem_3	598	604	PF02991	0.412
LIG_LIR_Nem_3	98	102	PF02991	0.493
LIG_LYPXL_yS_3	21	24	PF13949	0.420
LIG_LYPXL_yS_3	409	412	PF13949	0.401
LIG_NRBOX	289	295	PF00104	0.433
LIG_NRBOX	369	375	PF00104	0.375
LIG_Pex14_1	595	599	PF04695	0.353
LIG_Pex14_2	222	226	PF04695	0.369
LIG_SH2_CRK	413	417	PF00017	0.560
LIG_SH2_CRK	534	538	PF00017	0.303
LIG_SH2_STAP1	326	330	PF00017	0.418
LIG_SH2_STAP1	599	603	PF00017	0.427
LIG_SH2_STAT5	16	19	PF00017	0.603
LIG_SH2_STAT5	534	537	PF00017	0.385
LIG_SH2_STAT5	55	58	PF00017	0.661
LIG_SH2_STAT5	599	602	PF00017	0.335
LIG_SH3_1	170	176	PF00018	0.493
LIG_SH3_2	173	178	PF14604	0.496
LIG_SH3_2	511	516	PF14604	0.446
LIG_SH3_3	170	176	PF00018	0.493
LIG_SH3_3	502	508	PF00018	0.559
LIG_SH3_3	74	80	PF00018	0.476
LIG_SUMO_SIM_anti_2	133	138	PF11976	0.404
LIG_SUMO_SIM_anti_2	369	375	PF11976	0.375
LIG_SUMO_SIM_anti_2	600	606	PF11976	0.377
LIG_SUMO_SIM_anti_2	655	662	PF11976	0.424
LIG_SUMO_SIM_par_1	144	152	PF11976	0.434
LIG_SUMO_SIM_par_1	340	347	PF11976	0.440
LIG_SUMO_SIM_par_1	375	381	PF11976	0.424
LIG_SUMO_SIM_par_1	434	440	PF11976	0.325
LIG_SUMO_SIM_par_1	518	523	PF11976	0.490
LIG_SUMO_SIM_par_1	655	662	PF11976	0.382
LIG_TRAF2_1	437	440	PF00917	0.377
LIG_UBA3_1	165	170	PF00899	0.381
LIG_UBA3_1	432	441	PF00899	0.253
LIG_UBA3_1	449	457	PF00899	0.315
LIG_WRC_WIRS_1	33	38	PF05994	0.586
LIG_WW_3	513	517	PF00397	0.434
MOD_CDK_SPK_2	303	308	PF00069	0.417
MOD_CK1_1	189	195	PF00069	0.446
MOD_CK1_1	234	240	PF00069	0.428
MOD_CK1_1	272	278	PF00069	0.552
MOD_CK1_1	311	317	PF00069	0.427
MOD_CK1_1	366	372	PF00069	0.316
MOD_CK1_1	518	524	PF00069	0.419
MOD_CK1_1	577	583	PF00069	0.369
MOD_CK2_1	104	110	PF00069	0.521
MOD_CK2_1	412	418	PF00069	0.550
MOD_CK2_1	614	620	PF00069	0.399
MOD_CK2_1	645	651	PF00069	0.406
MOD_GlcNHglycan	203	206	PF01048	0.382
MOD_GlcNHglycan	233	236	PF01048	0.511
MOD_GlcNHglycan	24	27	PF01048	0.526
MOD_GlcNHglycan	271	274	PF01048	0.364
MOD_GlcNHglycan	280	283	PF01048	0.393
MOD_GlcNHglycan	468	471	PF01048	0.409
MOD_GlcNHglycan	538	541	PF01048	0.283
MOD_GlcNHglycan	667	670	PF01048	0.568
MOD_GSK3_1	182	189	PF00069	0.400
MOD_GSK3_1	191	198	PF00069	0.397
MOD_GSK3_1	234	241	PF00069	0.495
MOD_GSK3_1	253	260	PF00069	0.258
MOD_GSK3_1	309	316	PF00069	0.518
MOD_GSK3_1	412	419	PF00069	0.511
MOD_GSK3_1	529	536	PF00069	0.424
MOD_GSK3_1	538	545	PF00069	0.345
MOD_GSK3_1	574	581	PF00069	0.346
MOD_N-GLC_1	130	135	PF02516	0.515
MOD_N-GLC_1	201	206	PF02516	0.330
MOD_N-GLC_1	423	428	PF02516	0.466
MOD_NEK2_1	154	159	PF00069	0.492
MOD_NEK2_1	186	191	PF00069	0.425
MOD_NEK2_1	240	245	PF00069	0.372
MOD_NEK2_1	252	257	PF00069	0.290
MOD_NEK2_1	358	363	PF00069	0.386
MOD_NEK2_1	432	437	PF00069	0.337
MOD_NEK2_1	538	543	PF00069	0.233
MOD_NEK2_1	559	564	PF00069	0.461
MOD_NEK2_1	578	583	PF00069	0.318
MOD_NEK2_1	591	596	PF00069	0.402
MOD_NEK2_1	607	612	PF00069	0.196
MOD_NEK2_1	626	631	PF00069	0.473
MOD_NEK2_1	85	90	PF00069	0.503
MOD_NEK2_2	47	52	PF00069	0.581
MOD_NEK2_2	529	534	PF00069	0.430
MOD_PIKK_1	189	195	PF00454	0.441
MOD_PIKK_1	37	43	PF00454	0.445
MOD_PIKK_1	378	384	PF00454	0.389
MOD_PIKK_1	416	422	PF00454	0.606
MOD_PIKK_1	451	457	PF00454	0.288
MOD_PK_1	132	138	PF00069	0.407
MOD_PK_1	257	263	PF00069	0.267
MOD_PK_1	61	67	PF00069	0.391
MOD_PKA_2	104	110	PF00069	0.453
MOD_PKA_2	22	28	PF00069	0.611
MOD_PKA_2	238	244	PF00069	0.496
MOD_PKA_2	506	512	PF00069	0.637
MOD_PKA_2	515	521	PF00069	0.571
MOD_PKB_1	30	38	PF00069	0.456
MOD_PKB_1	59	67	PF00069	0.612
MOD_Plk_1	130	136	PF00069	0.407
MOD_Plk_1	597	603	PF00069	0.400
MOD_Plk_4	132	138	PF00069	0.407
MOD_Plk_4	161	167	PF00069	0.359
MOD_Plk_4	195	201	PF00069	0.415
MOD_Plk_4	240	246	PF00069	0.361
MOD_Plk_4	366	372	PF00069	0.386
MOD_Plk_4	529	535	PF00069	0.421
MOD_Plk_4	597	603	PF00069	0.522
MOD_Plk_4	61	67	PF00069	0.686
MOD_ProDKin_1	303	309	PF00069	0.420
MOD_ProDKin_1	364	370	PF00069	0.339
MOD_ProDKin_1	412	418	PF00069	0.545
MOD_SUMO_rev_2	300	304	PF00179	0.452
MOD_SUMO_rev_2	645	654	PF00179	0.368
TRG_DiLeu_BaEn_1	523	528	PF01217	0.488
TRG_DiLeu_BaLyEn_6	389	394	PF01217	0.388
TRG_ENDOCYTIC_2	21	24	PF00928	0.650
TRG_ENDOCYTIC_2	33	36	PF00928	0.644
TRG_ENDOCYTIC_2	352	355	PF00928	0.327
TRG_ENDOCYTIC_2	409	412	PF00928	0.405
TRG_ENDOCYTIC_2	487	490	PF00928	0.275
TRG_ENDOCYTIC_2	534	537	PF00928	0.307
TRG_ENDOCYTIC_2	599	602	PF00928	0.416
TRG_ENDOCYTIC_2	99	102	PF00928	0.502
TRG_ER_diArg_1	29	32	PF00400	0.414
TRG_ER_diArg_1	472	474	PF00400	0.508
TRG_ER_diArg_1	57	60	PF00400	0.544
TRG_ER_diArg_1	665	667	PF00400	0.468
TRG_Pf-PMV_PEXEL_1	451	455	PF00026	0.270

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAI6	Leptomonas seymouri	61%	100%
A0A1X0NND4	Trypanosomatidae	32%	85%
A0A3R7NL73	Trypanosoma rangeli	31%	95%
A0A3S7WT73	Leishmania donovani	85%	100%
A4HW89	Leishmania infantum	85%	100%
C9ZSS6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9APZ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QFJ1	Leishmania major	86%	100%
V5AW01	Trypanosoma cruzi	31%	95%