LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
protein kinase, putative
Species:
Leishmania braziliensis
UniProt:
A4H7W1_LEIBR
TriTrypDb:
LbrM.14.1600 , LBRM2903_140021100 *
Length:
549

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 8
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 23
NetGPI no yes: 0, no: 23
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H7W1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7W1

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 24
GO:0006793 phosphorus metabolic process 3 24
GO:0006796 phosphate-containing compound metabolic process 4 24
GO:0006807 nitrogen compound metabolic process 2 24
GO:0008152 metabolic process 1 24
GO:0009987 cellular process 1 24
GO:0016310 phosphorylation 5 24
GO:0019538 protein metabolic process 3 24
GO:0036211 protein modification process 4 24
GO:0043170 macromolecule metabolic process 3 24
GO:0043412 macromolecule modification 4 24
GO:0044237 cellular metabolic process 2 24
GO:0044238 primary metabolic process 2 24
GO:0071704 organic substance metabolic process 2 24
GO:1901564 organonitrogen compound metabolic process 3 24
GO:0007165 signal transduction 2 1
GO:0035556 intracellular signal transduction 3 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 24
GO:0003824 catalytic activity 1 24
GO:0004672 protein kinase activity 3 24
GO:0005488 binding 1 24
GO:0005524 ATP binding 5 24
GO:0016301 kinase activity 4 24
GO:0016740 transferase activity 2 24
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 24
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 24
GO:0017076 purine nucleotide binding 4 24
GO:0030554 adenyl nucleotide binding 5 24
GO:0032553 ribonucleotide binding 3 24
GO:0032555 purine ribonucleotide binding 4 24
GO:0032559 adenyl ribonucleotide binding 5 24
GO:0035639 purine ribonucleoside triphosphate binding 4 24
GO:0036094 small molecule binding 2 24
GO:0043167 ion binding 2 24
GO:0043168 anion binding 3 24
GO:0097159 organic cyclic compound binding 2 24
GO:0097367 carbohydrate derivative binding 2 24
GO:0140096 catalytic activity, acting on a protein 2 24
GO:1901265 nucleoside phosphate binding 3 24
GO:1901363 heterocyclic compound binding 2 24
GO:0004674 protein serine/threonine kinase activity 4 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 361 365 PF00656 0.540
CLV_NRD_NRD_1 123 125 PF00675 0.321
CLV_NRD_NRD_1 346 348 PF00675 0.482
CLV_NRD_NRD_1 484 486 PF00675 0.542
CLV_NRD_NRD_1 544 546 PF00675 0.419
CLV_NRD_NRD_1 72 74 PF00675 0.239
CLV_PCSK_KEX2_1 346 348 PF00082 0.522
CLV_PCSK_KEX2_1 484 486 PF00082 0.526
CLV_PCSK_KEX2_1 543 545 PF00082 0.415
CLV_PCSK_SKI1_1 105 109 PF00082 0.317
CLV_PCSK_SKI1_1 124 128 PF00082 0.359
CLV_PCSK_SKI1_1 129 133 PF00082 0.348
CLV_PCSK_SKI1_1 208 212 PF00082 0.419
CLV_PCSK_SKI1_1 518 522 PF00082 0.513
CLV_PCSK_SKI1_1 531 535 PF00082 0.448
DEG_APCC_DBOX_1 104 112 PF00400 0.209
DEG_APCC_DBOX_1 247 255 PF00400 0.415
DEG_Nend_UBRbox_2 1 3 PF02207 0.413
DEG_SCF_FBW7_1 520 525 PF00400 0.482
DEG_SPOP_SBC_1 358 362 PF00917 0.786
DOC_CKS1_1 166 171 PF01111 0.321
DOC_CKS1_1 349 354 PF01111 0.528
DOC_CKS1_1 416 421 PF01111 0.523
DOC_CKS1_1 507 512 PF01111 0.466
DOC_CKS1_1 519 524 PF01111 0.479
DOC_CYCLIN_yCln2_LP_2 178 184 PF00134 0.393
DOC_CYCLIN_yCln2_LP_2 201 207 PF00134 0.230
DOC_CYCLIN_yCln2_LP_2 520 526 PF00134 0.532
DOC_MAPK_DCC_7 379 389 PF00069 0.498
DOC_MAPK_gen_1 129 138 PF00069 0.387
DOC_MAPK_gen_1 248 257 PF00069 0.404
DOC_MAPK_gen_1 73 80 PF00069 0.236
DOC_MAPK_gen_1 95 102 PF00069 0.362
DOC_MAPK_MEF2A_6 250 259 PF00069 0.393
DOC_MAPK_MEF2A_6 73 82 PF00069 0.355
DOC_MAPK_RevD_3 112 125 PF00069 0.316
DOC_PP2B_LxvP_1 255 258 PF13499 0.317
DOC_PP2B_LxvP_1 342 345 PF13499 0.481
DOC_PP2B_LxvP_1 520 523 PF13499 0.541
DOC_PP2B_LxvP_1 524 527 PF13499 0.498
DOC_PP4_FxxP_1 374 377 PF00568 0.468
DOC_PP4_FxxP_1 416 419 PF00568 0.576
DOC_USP7_MATH_1 358 362 PF00917 0.678
DOC_USP7_MATH_1 72 76 PF00917 0.347
DOC_USP7_UBL2_3 8 12 PF12436 0.230
DOC_WW_Pin1_4 165 170 PF00397 0.329
DOC_WW_Pin1_4 297 302 PF00397 0.484
DOC_WW_Pin1_4 348 353 PF00397 0.596
DOC_WW_Pin1_4 364 369 PF00397 0.471
DOC_WW_Pin1_4 404 409 PF00397 0.548
DOC_WW_Pin1_4 415 420 PF00397 0.486
DOC_WW_Pin1_4 438 443 PF00397 0.532
DOC_WW_Pin1_4 506 511 PF00397 0.468
DOC_WW_Pin1_4 518 523 PF00397 0.485
LIG_14-3-3_CanoR_1 346 352 PF00244 0.581
LIG_14-3-3_CanoR_1 431 436 PF00244 0.546
LIG_14-3-3_CanoR_1 45 50 PF00244 0.339
LIG_14-3-3_CanoR_1 491 501 PF00244 0.513
LIG_14-3-3_CanoR_1 53 59 PF00244 0.321
LIG_14-3-3_CanoR_1 73 81 PF00244 0.454
LIG_APCC_ABBAyCdc20_2 124 130 PF00400 0.373
LIG_BRCT_BRCA1_1 412 416 PF00533 0.740
LIG_eIF4E_1 171 177 PF01652 0.230
LIG_FHA_1 131 137 PF00498 0.368
LIG_FHA_1 15 21 PF00498 0.302
LIG_FHA_1 519 525 PF00498 0.485
LIG_LIR_Apic_2 168 174 PF02991 0.353
LIG_LIR_Apic_2 413 419 PF02991 0.516
LIG_LIR_Apic_2 458 464 PF02991 0.535
LIG_LIR_Apic_2 499 505 PF02991 0.486
LIG_LIR_Gen_1 2 10 PF02991 0.397
LIG_LIR_Gen_1 474 483 PF02991 0.465
LIG_LIR_Nem_3 2 7 PF02991 0.397
LIG_LIR_Nem_3 26 32 PF02991 0.312
LIG_MAD2 216 224 PF02301 0.316
LIG_MAD2 53 61 PF02301 0.230
LIG_MYND_1 501 505 PF01753 0.477
LIG_MYND_1 522 526 PF01753 0.516
LIG_PDZ_Class_3 544 549 PF00595 0.435
LIG_PTB_Apo_2 501 508 PF02174 0.487
LIG_PTB_Phospho_1 501 507 PF10480 0.428
LIG_RPA_C_Fungi 531 543 PF08784 0.400
LIG_SH2_CRK 222 226 PF00017 0.260
LIG_SH2_CRK 349 353 PF00017 0.465
LIG_SH2_CRK 381 385 PF00017 0.693
LIG_SH2_CRK 4 8 PF00017 0.345
LIG_SH2_CRK 461 465 PF00017 0.536
LIG_SH2_CRK 507 511 PF00017 0.478
LIG_SH2_CRK 517 521 PF00017 0.519
LIG_SH2_GRB2like 381 384 PF00017 0.495
LIG_SH2_GRB2like 502 505 PF00017 0.470
LIG_SH2_NCK_1 159 163 PF00017 0.335
LIG_SH2_NCK_1 349 353 PF00017 0.465
LIG_SH2_NCK_1 461 465 PF00017 0.536
LIG_SH2_SRC 502 505 PF00017 0.470
LIG_SH2_SRC 66 69 PF00017 0.230
LIG_SH2_SRC 84 87 PF00017 0.297
LIG_SH2_STAP1 229 233 PF00017 0.404
LIG_SH2_STAT3 120 123 PF00017 0.404
LIG_SH2_STAT3 388 391 PF00017 0.526
LIG_SH2_STAT3 465 468 PF00017 0.516
LIG_SH2_STAT5 120 123 PF00017 0.309
LIG_SH2_STAT5 171 174 PF00017 0.333
LIG_SH2_STAT5 278 281 PF00017 0.383
LIG_SH2_STAT5 30 33 PF00017 0.247
LIG_SH2_STAT5 388 391 PF00017 0.548
LIG_SH2_STAT5 4 7 PF00017 0.322
LIG_SH2_STAT5 477 480 PF00017 0.501
LIG_SH2_STAT5 502 505 PF00017 0.470
LIG_SH2_STAT5 66 69 PF00017 0.320
LIG_SH3_3 163 169 PF00018 0.373
LIG_SH3_3 239 245 PF00018 0.230
LIG_SH3_3 374 380 PF00018 0.514
LIG_SH3_3 384 390 PF00018 0.470
LIG_SH3_3 444 450 PF00018 0.511
LIG_SH3_3 454 460 PF00018 0.524
LIG_SH3_3 520 526 PF00018 0.523
LIG_SH3_3 97 103 PF00018 0.268
LIG_SUMO_SIM_par_1 114 119 PF11976 0.282
LIG_TRFH_1 170 174 PF08558 0.313
LIG_TYR_ITIM 194 199 PF00017 0.277
LIG_TYR_ITIM 220 225 PF00017 0.230
LIG_WRC_WIRS_1 67 72 PF05994 0.335
MOD_CDK_SPK_2 297 302 PF00069 0.399
MOD_CDK_SPK_2 506 511 PF00069 0.460
MOD_CK1_1 300 306 PF00069 0.540
MOD_CK1_1 320 326 PF00069 0.516
MOD_CK1_1 350 356 PF00069 0.717
MOD_CK1_1 406 412 PF00069 0.690
MOD_CK1_1 414 420 PF00069 0.509
MOD_CK1_1 441 447 PF00069 0.574
MOD_CK1_1 496 502 PF00069 0.516
MOD_CK1_1 525 531 PF00069 0.427
MOD_CK2_1 45 51 PF00069 0.334
MOD_GlcNHglycan 205 208 PF01048 0.311
MOD_GlcNHglycan 302 305 PF01048 0.677
MOD_GlcNHglycan 323 326 PF01048 0.650
MOD_GlcNHglycan 352 355 PF01048 0.697
MOD_GlcNHglycan 361 364 PF01048 0.541
MOD_GlcNHglycan 423 426 PF01048 0.641
MOD_GlcNHglycan 473 476 PF01048 0.455
MOD_GlcNHglycan 498 501 PF01048 0.505
MOD_GlcNHglycan 86 89 PF01048 0.230
MOD_GSK3_1 151 158 PF00069 0.302
MOD_GSK3_1 161 168 PF00069 0.340
MOD_GSK3_1 2 9 PF00069 0.292
MOD_GSK3_1 224 231 PF00069 0.282
MOD_GSK3_1 293 300 PF00069 0.622
MOD_GSK3_1 316 323 PF00069 0.636
MOD_GSK3_1 406 413 PF00069 0.610
MOD_GSK3_1 427 434 PF00069 0.499
MOD_GSK3_1 437 444 PF00069 0.475
MOD_GSK3_1 451 458 PF00069 0.475
MOD_GSK3_1 492 499 PF00069 0.512
MOD_GSK3_1 518 525 PF00069 0.487
MOD_LATS_1 396 402 PF00433 0.528
MOD_N-GLC_1 364 369 PF02516 0.565
MOD_N-GLC_2 77 79 PF02516 0.230
MOD_NEK2_1 427 432 PF00069 0.703
MOD_NEK2_1 471 476 PF00069 0.456
MOD_PIKK_1 130 136 PF00454 0.230
MOD_PKA_2 38 44 PF00069 0.271
MOD_PKA_2 427 433 PF00069 0.487
MOD_PKA_2 448 454 PF00069 0.517
MOD_PKA_2 72 78 PF00069 0.234
MOD_Plk_1 35 41 PF00069 0.439
MOD_Plk_4 161 167 PF00069 0.260
MOD_Plk_4 224 230 PF00069 0.358
MOD_Plk_4 293 299 PF00069 0.481
MOD_Plk_4 411 417 PF00069 0.593
MOD_Plk_4 66 72 PF00069 0.308
MOD_ProDKin_1 165 171 PF00069 0.329
MOD_ProDKin_1 297 303 PF00069 0.484
MOD_ProDKin_1 348 354 PF00069 0.597
MOD_ProDKin_1 364 370 PF00069 0.471
MOD_ProDKin_1 404 410 PF00069 0.542
MOD_ProDKin_1 415 421 PF00069 0.486
MOD_ProDKin_1 438 444 PF00069 0.532
MOD_ProDKin_1 506 512 PF00069 0.470
MOD_ProDKin_1 518 524 PF00069 0.484
MOD_SUMO_for_1 249 252 PF00179 0.261
MOD_SUMO_rev_2 206 213 PF00179 0.175
MOD_SUMO_rev_2 525 533 PF00179 0.417
TRG_ENDOCYTIC_2 196 199 PF00928 0.319
TRG_ENDOCYTIC_2 222 225 PF00928 0.306
TRG_ENDOCYTIC_2 29 32 PF00928 0.316
TRG_ENDOCYTIC_2 381 384 PF00928 0.495
TRG_ENDOCYTIC_2 4 7 PF00928 0.355
TRG_ENDOCYTIC_2 477 480 PF00928 0.474
TRG_ENDOCYTIC_2 517 520 PF00928 0.531
TRG_ER_diArg_1 329 332 PF00400 0.533
TRG_ER_diArg_1 345 347 PF00400 0.469
TRG_ER_diArg_1 483 485 PF00400 0.492
TRG_ER_diArg_1 543 545 PF00400 0.464
TRG_NES_CRM1_1 106 119 PF08389 0.276
TRG_NES_CRM1_1 209 223 PF08389 0.230
TRG_NES_CRM1_1 232 244 PF08389 0.321
TRG_Pf-PMV_PEXEL_1 216 221 PF00026 0.244
TRG_Pf-PMV_PEXEL_1 332 336 PF00026 0.581

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I9A0 Leptomonas seymouri 28% 84%
A0A0S4IQ75 Bodo saltans 31% 100%
A0A0S4JIJ6 Bodo saltans 29% 97%
A0A3Q8IB74 Leishmania donovani 24% 100%
A0A3Q8IC87 Leishmania donovani 30% 100%
A0A3Q8IFK8 Leishmania donovani 36% 100%
A0A3Q8IIG1 Leishmania donovani 30% 100%
A0A3Q8IIH5 Leishmania donovani 77% 99%
A0A3Q8INQ4 Leishmania donovani 27% 100%
A0A3S5H789 Leishmania donovani 25% 100%
A0A3S7X2W3 Leishmania donovani 27% 100%
A0A3S7X7Y2 Leishmania donovani 28% 100%
A4H9X5 Leishmania braziliensis 23% 100%
A4HAS1 Leishmania braziliensis 29% 100%
A4HED7 Leishmania braziliensis 27% 100%
A4HFC9 Leishmania braziliensis 25% 83%
A4HH03 Leishmania braziliensis 31% 100%
A4HHN1 Leishmania braziliensis 27% 100%
A4HJT5 Leishmania braziliensis 36% 100%
A4HW88 Leishmania infantum 77% 99%
A4HYX6 Leishmania infantum 25% 100%
A4HZV1 Leishmania infantum 30% 100%
A4I1T4 Leishmania infantum 27% 100%
A4I435 Leishmania infantum 30% 100%
A4I4U6 Leishmania infantum 27% 100%
A4I7A1 Leishmania infantum 36% 100%
A4I9Y5 Leishmania infantum 28% 100%
E9AGS0 Leishmania infantum 24% 100%
E9ALJ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9APY9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 77% 99%
E9ARW9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9AUS3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9AVR5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9AXW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9B296 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9B4Z4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
Q4Q2Z2 Leishmania major 28% 100%
Q4Q3K6 Leishmania major 24% 100%
Q4Q5W2 Leishmania major 36% 100%
Q4Q7W2 Leishmania major 30% 100%
Q4Q9K2 Leishmania major 27% 100%
Q4QBR6 Leishmania major 30% 100%
Q4QCR3 Leishmania major 24% 100%
Q4QDK3 Leishmania major 24% 100%
Q4QFJ2 Leishmania major 77% 100%
Q7KZI7 Homo sapiens 28% 70%
Q9Y077 Leishmania major 27% 100%
V5BAZ8 Trypanosoma cruzi 26% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS