GOLD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

emp24/gp25L/p24 family/GOLD, putative

Species:

Leishmania braziliensis

UniProt:

A4H7V9_LEIBR

TriTrypDb:

LbrM.14.1580 , LBRM2903_140020700

Length:

204

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 9, no: 1
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005783	endoplasmic reticulum	5	1
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	5	1
GO:0005794	Golgi apparatus	5	1
GO:0030134	COPII-coated ER to Golgi transport vesicle	8	1
GO:0030135	coated vesicle	7	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1

Expansion

Sequence features

A4H7V9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7V9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	1
GO:0006996	organelle organization	4	1
GO:0007030	Golgi organization	5	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0016192	vesicle-mediated transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0048193	Golgi vesicle transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	128	132	PF00656	0.313
CLV_NRD_NRD_1	123	125	PF00675	0.541
CLV_NRD_NRD_1	189	191	PF00675	0.438
CLV_NRD_NRD_1	202	204	PF00675	0.381
CLV_PCSK_KEX2_1	114	116	PF00082	0.475
CLV_PCSK_KEX2_1	189	191	PF00082	0.444
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.475
CLV_PCSK_SKI1_1	102	106	PF00082	0.483
CLV_PCSK_SKI1_1	125	129	PF00082	0.452
CLV_PCSK_SKI1_1	157	161	PF00082	0.454
CLV_PCSK_SKI1_1	165	169	PF00082	0.439
DOC_MAPK_gen_1	102	110	PF00069	0.266
DOC_MAPK_MEF2A_6	102	110	PF00069	0.251
DOC_MAPK_MEF2A_6	157	166	PF00069	0.313
DOC_PP1_RVXF_1	75	81	PF00149	0.248
LIG_14-3-3_CanoR_1	165	173	PF00244	0.222
LIG_14-3-3_CanoR_1	189	194	PF00244	0.663
LIG_APCC_ABBA_1	135	140	PF00400	0.248
LIG_deltaCOP1_diTrp_1	153	159	PF00928	0.341
LIG_DLG_GKlike_1	189	197	PF00625	0.539
LIG_FHA_1	16	22	PF00498	0.284
LIG_FHA_1	161	167	PF00498	0.267
LIG_FHA_2	126	132	PF00498	0.313
LIG_HCF-1_HBM_1	87	90	PF13415	0.341
LIG_LIR_Gen_1	156	167	PF02991	0.326
LIG_LIR_Gen_1	49	59	PF02991	0.348
LIG_LIR_Nem_3	156	162	PF02991	0.326
LIG_LIR_Nem_3	34	39	PF02991	0.321
LIG_LIR_Nem_3	49	55	PF02991	0.216
LIG_NRBOX	174	180	PF00104	0.234
LIG_PTB_Apo_2	91	98	PF02174	0.248
LIG_PTB_Phospho_1	91	97	PF10480	0.248
LIG_SH2_STAP1	65	69	PF00017	0.341
LIG_SH2_STAT5	186	189	PF00017	0.514
LIG_SH2_STAT5	79	82	PF00017	0.306
LIG_SH2_STAT5	90	93	PF00017	0.279
LIG_SUMO_SIM_anti_2	174	180	PF11976	0.256
LIG_UBA3_1	142	147	PF00899	0.341
MOD_GlcNHglycan	96	100	PF01048	0.478
MOD_GSK3_1	189	196	PF00069	0.602
MOD_NEK2_1	171	176	PF00069	0.269
MOD_NEK2_1	182	187	PF00069	0.343
MOD_NEK2_1	193	198	PF00069	0.653
MOD_NEK2_2	109	114	PF00069	0.273
MOD_PKA_1	189	195	PF00069	0.692
MOD_PKA_2	189	195	PF00069	0.668
MOD_Plk_4	171	177	PF00069	0.229
MOD_SUMO_for_1	104	107	PF00179	0.341
MOD_SUMO_rev_2	96	104	PF00179	0.321
TRG_ENDOCYTIC_2	36	39	PF00928	0.268
TRG_ENDOCYTIC_2	43	46	PF00928	0.228
TRG_ER_diArg_1	188	190	PF00400	0.513
TRG_NES_CRM1_1	156	169	PF08389	0.313

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSZ0	Leptomonas seymouri	79%	97%
A0A1X0NPX7	Trypanosomatidae	48%	93%
A0A3Q8IC43	Leishmania donovani	90%	92%
A0A422NFM3	Trypanosoma rangeli	48%	91%
A4HW85	Leishmania infantum	90%	92%
C9ZST1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	91%
E9APY7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	92%
Q4QFJ5	Leishmania major	91%	100%
V5BKG3	Trypanosoma cruzi	48%	90%