Putative tyrosyl-tRNA synthetase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tyrosyl-tRNA synthetase, putative

Species:

Leishmania braziliensis

UniProt:

A4H7V7_LEIBR

TriTrypDb:

LbrM.14.1560 , LBRM2903_140020500

Length:

685

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H7V7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7V7

PDB structure(s): 3p0h_A , 3p0h_B , 3p0i_A , 3p0i_B , 3p0j_A , 3p0j_B , 3p0j_C , 3p0j_D , 5usf_A , 5usf_B

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006399	tRNA metabolic process	7	12
GO:0006418	tRNA aminoacylation for protein translation	6	12
GO:0006520	amino acid metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0019752	carboxylic acid metabolic process	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043038	amino acid activation	4	12
GO:0043039	tRNA aminoacylation	5	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043436	oxoacid metabolic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044281	small molecule metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004812	aminoacyl-tRNA ligase activity	4	12
GO:0004831	tyrosine-tRNA ligase activity	5	6
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016874	ligase activity	2	12
GO:0016875	ligase activity, forming carbon-oxygen bonds	3	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140101	catalytic activity, acting on a tRNA	4	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	226	230	PF00656	0.454
CLV_C14_Caspase3-7	519	523	PF00656	0.504
CLV_NRD_NRD_1	185	187	PF00675	0.254
CLV_NRD_NRD_1	200	202	PF00675	0.254
CLV_NRD_NRD_1	242	244	PF00675	0.254
CLV_NRD_NRD_1	28	30	PF00675	0.351
CLV_NRD_NRD_1	353	355	PF00675	0.436
CLV_NRD_NRD_1	476	478	PF00675	0.339
CLV_NRD_NRD_1	576	578	PF00675	0.380
CLV_NRD_NRD_1	680	682	PF00675	0.448
CLV_PCSK_KEX2_1	576	578	PF00082	0.383
CLV_PCSK_KEX2_1	679	681	PF00082	0.580
CLV_PCSK_PC1ET2_1	679	681	PF00082	0.580
CLV_PCSK_SKI1_1	109	113	PF00082	0.280
CLV_PCSK_SKI1_1	128	132	PF00082	0.267
CLV_PCSK_SKI1_1	201	205	PF00082	0.265
CLV_PCSK_SKI1_1	478	482	PF00082	0.401
CLV_PCSK_SKI1_1	504	508	PF00082	0.390
CLV_PCSK_SKI1_1	577	581	PF00082	0.395
CLV_PCSK_SKI1_1	657	661	PF00082	0.454
CLV_PCSK_SKI1_1	676	680	PF00082	0.352
CLV_Separin_Metazoa	8	12	PF03568	0.268
DEG_Nend_UBRbox_3	1	3	PF02207	0.519
DEG_SPOP_SBC_1	516	520	PF00917	0.429
DOC_CKS1_1	621	626	PF01111	0.486
DOC_CYCLIN_RxL_1	475	485	PF00134	0.399
DOC_CYCLIN_RxL_1	651	663	PF00134	0.432
DOC_MAPK_gen_1	201	208	PF00069	0.465
DOC_MAPK_gen_1	354	362	PF00069	0.601
DOC_PP1_RVXF_1	107	113	PF00149	0.454
DOC_PP2B_LxvP_1	329	332	PF13499	0.569
DOC_PP2B_LxvP_1	412	415	PF13499	0.305
DOC_PP2B_PxIxI_1	591	597	PF00149	0.490
DOC_USP7_MATH_1	221	225	PF00917	0.454
DOC_USP7_MATH_1	307	311	PF00917	0.520
DOC_USP7_MATH_1	317	321	PF00917	0.436
DOC_USP7_MATH_1	403	407	PF00917	0.492
DOC_USP7_MATH_1	419	423	PF00917	0.519
DOC_USP7_MATH_1	629	633	PF00917	0.429
DOC_USP7_MATH_1	643	647	PF00917	0.295
DOC_USP7_UBL2_3	351	355	PF12436	0.447
DOC_WW_Pin1_4	620	625	PF00397	0.493
LIG_14-3-3_CanoR_1	252	260	PF00244	0.571
LIG_14-3-3_CanoR_1	504	510	PF00244	0.459
LIG_Actin_WH2_1	477	495	PF00022	0.341
LIG_Actin_WH2_2	480	495	PF00022	0.471
LIG_BRCT_BRCA1_1	229	233	PF00533	0.454
LIG_CSL_BTD_1	378	381	PF09270	0.323
LIG_FHA_1	240	246	PF00498	0.391
LIG_FHA_1	407	413	PF00498	0.484
LIG_FHA_1	506	512	PF00498	0.277
LIG_FHA_2	127	133	PF00498	0.410
LIG_FHA_2	235	241	PF00498	0.465
LIG_FHA_2	298	304	PF00498	0.460
LIG_FHA_2	424	430	PF00498	0.426
LIG_FHA_2	517	523	PF00498	0.410
LIG_KLC1_Yacidic_2	564	569	PF13176	0.485
LIG_LIR_Apic_2	618	624	PF02991	0.555
LIG_LIR_Gen_1	194	203	PF02991	0.454
LIG_LIR_Gen_1	277	287	PF02991	0.479
LIG_LIR_Gen_1	300	309	PF02991	0.465
LIG_LIR_Gen_1	4	13	PF02991	0.277
LIG_LIR_Gen_1	416	425	PF02991	0.343
LIG_LIR_Gen_1	467	476	PF02991	0.400
LIG_LIR_Gen_1	73	82	PF02991	0.454
LIG_LIR_Nem_3	125	130	PF02991	0.477
LIG_LIR_Nem_3	194	198	PF02991	0.454
LIG_LIR_Nem_3	277	282	PF02991	0.465
LIG_LIR_Nem_3	297	301	PF02991	0.359
LIG_LIR_Nem_3	4	10	PF02991	0.348
LIG_LIR_Nem_3	416	420	PF02991	0.344
LIG_LIR_Nem_3	467	472	PF02991	0.471
LIG_LIR_Nem_3	73	77	PF02991	0.454
LIG_LYPXL_S_1	162	166	PF13949	0.254
LIG_LYPXL_yS_3	163	166	PF13949	0.454
LIG_REV1ctd_RIR_1	170	179	PF16727	0.454
LIG_RPA_C_Fungi	647	659	PF08784	0.279
LIG_SH2_CRK	284	288	PF00017	0.332
LIG_SH2_CRK	583	587	PF00017	0.392
LIG_SH2_NCK_1	284	288	PF00017	0.326
LIG_SH2_NCK_1	583	587	PF00017	0.535
LIG_SH2_NCK_1	621	625	PF00017	0.550
LIG_SH2_STAT5	195	198	PF00017	0.292
LIG_SH2_STAT5	249	252	PF00017	0.307
LIG_SH2_STAT5	278	281	PF00017	0.363
LIG_SH2_STAT5	532	535	PF00017	0.515
LIG_SH2_STAT5	567	570	PF00017	0.430
LIG_SH2_STAT5	95	98	PF00017	0.300
LIG_SH3_2	368	373	PF14604	0.555
LIG_SH3_3	158	164	PF00018	0.385
LIG_SH3_3	365	371	PF00018	0.479
LIG_SH3_3	381	387	PF00018	0.301
LIG_SH3_5	274	278	PF00018	0.292
LIG_SUMO_SIM_anti_2	409	414	PF11976	0.329
LIG_SUMO_SIM_par_1	204	209	PF11976	0.292
LIG_SUMO_SIM_par_1	386	392	PF11976	0.460
LIG_SUMO_SIM_par_1	409	416	PF11976	0.354
LIG_SUMO_SIM_par_1	507	512	PF11976	0.398
LIG_SUMO_SIM_par_1	605	610	PF11976	0.384
LIG_TRAF2_1	115	118	PF00917	0.373
LIG_TRAF2_1	586	589	PF00917	0.489
LIG_UBA3_1	171	175	PF00899	0.292
LIG_UBA3_1	212	217	PF00899	0.262
LIG_WRC_WIRS_1	525	530	PF05994	0.269
MOD_CK1_1	406	412	PF00069	0.303
MOD_CK1_1	667	673	PF00069	0.305
MOD_CK2_1	112	118	PF00069	0.292
MOD_CK2_1	22	28	PF00069	0.353
MOD_CK2_1	336	342	PF00069	0.487
MOD_CK2_1	423	429	PF00069	0.447
MOD_CK2_1	479	485	PF00069	0.513
MOD_CK2_1	9	15	PF00069	0.369
MOD_Cter_Amidation	199	202	PF01082	0.292
MOD_GlcNHglycan	229	232	PF01048	0.318
MOD_GlcNHglycan	255	258	PF01048	0.444
MOD_GlcNHglycan	40	44	PF01048	0.292
MOD_GlcNHglycan	416	420	PF01048	0.415
MOD_GlcNHglycan	431	435	PF01048	0.343
MOD_GlcNHglycan	511	514	PF01048	0.294
MOD_GlcNHglycan	583	586	PF01048	0.529
MOD_GlcNHglycan	632	635	PF01048	0.416
MOD_GlcNHglycan	652	655	PF01048	0.231
MOD_GlcNHglycan	660	663	PF01048	0.379
MOD_GSK3_1	113	120	PF00069	0.307
MOD_GSK3_1	122	129	PF00069	0.309
MOD_GSK3_1	223	230	PF00069	0.292
MOD_GSK3_1	307	314	PF00069	0.386
MOD_GSK3_1	415	422	PF00069	0.454
MOD_GSK3_1	505	512	PF00069	0.349
MOD_N-GLC_1	438	443	PF02516	0.490
MOD_N-GLC_2	58	60	PF02516	0.292
MOD_NEK2_1	346	351	PF00069	0.478
MOD_NEK2_1	468	473	PF00069	0.508
MOD_NEK2_1	509	514	PF00069	0.354
MOD_NEK2_1	641	646	PF00069	0.442
MOD_NEK2_1	650	655	PF00069	0.462
MOD_NEK2_1	664	669	PF00069	0.350
MOD_NEK2_1	9	14	PF00069	0.352
MOD_PIKK_1	643	649	PF00454	0.278
MOD_PKA_1	679	685	PF00069	0.521
MOD_PKA_2	679	685	PF00069	0.470
MOD_Plk_1	415	421	PF00069	0.326
MOD_Plk_1	438	444	PF00069	0.233
MOD_Plk_2-3	22	28	PF00069	0.397
MOD_Plk_4	122	128	PF00069	0.331
MOD_Plk_4	144	150	PF00069	0.305
MOD_Plk_4	408	414	PF00069	0.472
MOD_Plk_4	438	444	PF00069	0.423
MOD_Plk_4	468	474	PF00069	0.474
MOD_Plk_4	505	511	PF00069	0.231
MOD_ProDKin_1	620	626	PF00069	0.490
MOD_SUMO_rev_2	22	32	PF00179	0.433
MOD_SUMO_rev_2	661	667	PF00179	0.339
TRG_DiLeu_BaEn_1	22	27	PF01217	0.369
TRG_DiLeu_BaEn_1	325	330	PF01217	0.347
TRG_DiLeu_BaEn_1	342	347	PF01217	0.346
TRG_DiLeu_BaEn_1	450	455	PF01217	0.276
TRG_DiLeu_BaEn_1	5	10	PF01217	0.336
TRG_DiLeu_BaEn_2	193	199	PF01217	0.204
TRG_DiLeu_BaEn_3	588	594	PF01217	0.284
TRG_ENDOCYTIC_2	163	166	PF00928	0.292
TRG_ENDOCYTIC_2	195	198	PF00928	0.292
TRG_ENDOCYTIC_2	301	304	PF00928	0.292
TRG_ENDOCYTIC_2	36	39	PF00928	0.292
TRG_ENDOCYTIC_2	7	10	PF00928	0.377
TRG_ER_diArg_1	575	577	PF00400	0.434
TRG_NLS_Bipartite_1	186	205	PF00514	0.292
TRG_NLS_Bipartite_1	665	683	PF00514	0.360
TRG_NLS_MonoExtC_3	200	205	PF00514	0.292
TRG_NLS_MonoExtC_3	576	581	PF00514	0.397
TRG_NLS_MonoExtN_4	576	581	PF00514	0.412
TRG_NLS_MonoExtN_4	676	683	PF00514	0.423
TRG_Pf-PMV_PEXEL_1	24	28	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	243	247	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	94	98	PF00026	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3B3	Leptomonas seymouri	80%	100%
A0A0S4JQB1	Bodo saltans	60%	76%
A0A1X0NNR8	Trypanosomatidae	61%	98%
A0A3Q8ID88	Leishmania donovani	89%	100%
A0A422NFL4	Trypanosoma rangeli	61%	100%
A4HW83	Leishmania infantum	88%	100%
C9ZST4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	98%
E9APY5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
F4HWL4	Arabidopsis thaliana	36%	92%
Q4QFJ7	Leishmania major	89%	100%
V5AW05	Trypanosoma cruzi	61%	99%