Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7V5_LEIBR

TriTrypDb:

LbrM.14.1520 , LBRM2903_140019900

Length:

748

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	4
GO:0005868	cytoplasmic dynein complex	4	4
GO:0005874	microtubule	6	4
GO:0005875	microtubule associated complex	2	4
GO:0030286	dynein complex	3	4
GO:0032991	protein-containing complex	1	4
GO:0099080	supramolecular complex	2	4
GO:0099081	supramolecular polymer	3	4
GO:0099512	supramolecular fiber	4	4
GO:0099513	polymeric cytoskeletal fiber	5	4
GO:0110165	cellular anatomical entity	1	4
GO:1902494	catalytic complex	2	4

Expansion

Sequence features

A4H7V5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7V5

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	4
GO:0007018	microtubule-based movement	3	4
GO:0009987	cellular process	1	4

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	4
GO:0005488	binding	1	4
GO:0005524	ATP binding	5	4
GO:0017076	purine nucleotide binding	4	4
GO:0030554	adenyl nucleotide binding	5	4
GO:0032553	ribonucleotide binding	3	4
GO:0032555	purine ribonucleotide binding	4	4
GO:0032559	adenyl ribonucleotide binding	5	4
GO:0035639	purine ribonucleoside triphosphate binding	4	4
GO:0036094	small molecule binding	2	4
GO:0043167	ion binding	2	4
GO:0043168	anion binding	3	4
GO:0097159	organic cyclic compound binding	2	4
GO:0097367	carbohydrate derivative binding	2	4
GO:1901265	nucleoside phosphate binding	3	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	151	155	PF00656	0.510
CLV_C14_Caspase3-7	490	494	PF00656	0.414
CLV_C14_Caspase3-7	525	529	PF00656	0.281
CLV_MEL_PAP_1	593	599	PF00089	0.612
CLV_NRD_NRD_1	218	220	PF00675	0.469
CLV_NRD_NRD_1	235	237	PF00675	0.454
CLV_NRD_NRD_1	370	372	PF00675	0.497
CLV_NRD_NRD_1	441	443	PF00675	0.497
CLV_PCSK_KEX2_1	218	220	PF00082	0.470
CLV_PCSK_KEX2_1	230	232	PF00082	0.444
CLV_PCSK_KEX2_1	235	237	PF00082	0.461
CLV_PCSK_KEX2_1	370	372	PF00082	0.497
CLV_PCSK_KEX2_1	441	443	PF00082	0.497
CLV_PCSK_PC1ET2_1	230	232	PF00082	0.456
CLV_PCSK_PC7_1	231	237	PF00082	0.535
CLV_PCSK_SKI1_1	100	104	PF00082	0.488
CLV_PCSK_SKI1_1	219	223	PF00082	0.540
CLV_PCSK_SKI1_1	587	591	PF00082	0.506
DEG_APCC_DBOX_1	564	572	PF00400	0.484
DEG_APCC_DBOX_1	586	594	PF00400	0.272
DEG_SPOP_SBC_1	475	479	PF00917	0.542
DOC_ANK_TNKS_1	695	702	PF00023	0.483
DOC_CDC14_PxL_1	115	123	PF14671	0.446
DOC_CKS1_1	301	306	PF01111	0.525
DOC_CKS1_1	702	707	PF01111	0.644
DOC_CYCLIN_RxL_1	120	130	PF00134	0.464
DOC_CYCLIN_yCln2_LP_2	11	17	PF00134	0.457
DOC_CYCLIN_yCln2_LP_2	116	122	PF00134	0.569
DOC_CYCLIN_yCln2_LP_2	506	512	PF00134	0.431
DOC_PP1_RVXF_1	233	240	PF00149	0.529
DOC_PP2B_LxvP_1	11	14	PF13499	0.458
DOC_PP2B_LxvP_1	116	119	PF13499	0.566
DOC_PP2B_LxvP_1	203	206	PF13499	0.685
DOC_PP2B_LxvP_1	361	364	PF13499	0.504
DOC_PP2B_LxvP_1	506	509	PF13499	0.452
DOC_PP2B_LxvP_1	554	557	PF13499	0.571
DOC_PP2B_LxvP_1	684	687	PF13499	0.711
DOC_PP4_FxxP_1	6	9	PF00568	0.453
DOC_USP7_MATH_1	109	113	PF00917	0.460
DOC_USP7_MATH_1	135	139	PF00917	0.762
DOC_USP7_MATH_1	143	147	PF00917	0.695
DOC_USP7_MATH_1	16	20	PF00917	0.454
DOC_USP7_MATH_1	176	180	PF00917	0.741
DOC_USP7_MATH_1	474	478	PF00917	0.538
DOC_USP7_MATH_1	589	593	PF00917	0.402
DOC_USP7_MATH_1	635	639	PF00917	0.603
DOC_USP7_MATH_1	64	68	PF00917	0.448
DOC_USP7_MATH_1	690	694	PF00917	0.717
DOC_USP7_MATH_1	736	740	PF00917	0.486
DOC_WW_Pin1_4	127	132	PF00397	0.680
DOC_WW_Pin1_4	164	169	PF00397	0.768
DOC_WW_Pin1_4	28	33	PF00397	0.463
DOC_WW_Pin1_4	300	305	PF00397	0.624
DOC_WW_Pin1_4	36	41	PF00397	0.443
DOC_WW_Pin1_4	501	506	PF00397	0.457
DOC_WW_Pin1_4	701	706	PF00397	0.582
DOC_WW_Pin1_4	95	100	PF00397	0.634
LIG_14-3-3_CanoR_1	105	114	PF00244	0.471
LIG_14-3-3_CanoR_1	175	179	PF00244	0.574
LIG_14-3-3_CanoR_1	355	362	PF00244	0.761
LIG_14-3-3_CanoR_1	370	376	PF00244	0.353
LIG_14-3-3_CanoR_1	41	46	PF00244	0.475
LIG_14-3-3_CanoR_1	507	515	PF00244	0.638
LIG_14-3-3_CanoR_1	565	569	PF00244	0.522
LIG_14-3-3_CanoR_1	596	600	PF00244	0.607
LIG_14-3-3_CanoR_1	645	653	PF00244	0.518
LIG_14-3-3_CanoR_1	696	703	PF00244	0.665
LIG_Actin_WH2_2	547	563	PF00022	0.577
LIG_BIR_II_1	1	5	PF00653	0.450
LIG_BRCT_BRCA1_1	280	284	PF00533	0.516
LIG_BRCT_BRCA1_1	356	360	PF00533	0.762
LIG_Clathr_ClatBox_1	400	404	PF01394	0.392
LIG_DLG_GKlike_1	43	50	PF00625	0.474
LIG_EH_1	614	618	PF12763	0.514
LIG_eIF4E_1	608	614	PF01652	0.631
LIG_EVH1_2	87	91	PF00568	0.457
LIG_FHA_1	3	9	PF00498	0.454
LIG_FHA_1	356	362	PF00498	0.669
LIG_FHA_1	42	48	PF00498	0.476
LIG_FHA_2	273	279	PF00498	0.674
LIG_FHA_2	523	529	PF00498	0.400
LIG_FHA_2	695	701	PF00498	0.674
LIG_LIR_Apic_2	5	9	PF02991	0.453
LIG_LIR_Apic_2	727	733	PF02991	0.471
LIG_LIR_Gen_1	416	427	PF02991	0.505
LIG_LIR_Gen_1	724	734	PF02991	0.717
LIG_LIR_Gen_1	742	748	PF02991	0.461
LIG_LIR_Gen_1	80	91	PF02991	0.457
LIG_LIR_Nem_3	416	422	PF02991	0.500
LIG_LIR_Nem_3	724	729	PF02991	0.616
LIG_LIR_Nem_3	742	748	PF02991	0.461
LIG_LIR_Nem_3	80	86	PF02991	0.690
LIG_NRBOX	567	573	PF00104	0.291
LIG_PDZ_Class_3	743	748	PF00595	0.524
LIG_Pex14_1	79	83	PF04695	0.456
LIG_Pex14_1	85	89	PF04695	0.440
LIG_Pex14_2	487	491	PF04695	0.415
LIG_Pex14_2	617	621	PF04695	0.273
LIG_PTB_Apo_2	612	619	PF02174	0.538
LIG_PTB_Phospho_1	612	618	PF10480	0.538
LIG_SH2_CRK	298	302	PF00017	0.685
LIG_SH2_GRB2like	608	611	PF00017	0.703
LIG_SH2_NCK_1	298	302	PF00017	0.646
LIG_SH2_SRC	608	611	PF00017	0.703
LIG_SH2_STAP1	608	612	PF00017	0.663
LIG_SH2_STAT3	329	332	PF00017	0.547
LIG_SH2_STAT3	715	718	PF00017	0.546
LIG_SH2_STAT5	329	332	PF00017	0.531
LIG_SH2_STAT5	417	420	PF00017	0.411
LIG_SH2_STAT5	425	428	PF00017	0.378
LIG_SH2_STAT5	624	627	PF00017	0.362
LIG_SH2_STAT5	715	718	PF00017	0.520
LIG_SH3_3	165	171	PF00018	0.763
LIG_SH3_3	298	304	PF00018	0.641
LIG_SH3_3	673	679	PF00018	0.594
LIG_SH3_3	684	690	PF00018	0.737
LIG_SH3_3	699	705	PF00018	0.663
LIG_SH3_3	84	90	PF00018	0.455
LIG_SUMO_SIM_anti_2	395	402	PF11976	0.382
LIG_SUMO_SIM_anti_2	662	668	PF11976	0.418
LIG_SUMO_SIM_par_1	146	154	PF11976	0.517
LIG_SUMO_SIM_par_1	398	404	PF11976	0.391
LIG_SUMO_SIM_par_1	43	49	PF11976	0.475
LIG_TRAF2_1	138	141	PF00917	0.521
LIG_TRAF2_1	448	451	PF00917	0.530
MOD_CDC14_SPxK_1	31	34	PF00782	0.460
MOD_CDK_SPK_2	167	172	PF00069	0.525
MOD_CDK_SPK_2	300	305	PF00069	0.524
MOD_CDK_SPK_2	36	41	PF00069	0.467
MOD_CDK_SPK_2	95	100	PF00069	0.486
MOD_CDK_SPxK_1	28	34	PF00069	0.465
MOD_CDK_SPxK_1	501	507	PF00069	0.496
MOD_CDK_SPxxK_3	36	43	PF00069	0.468
MOD_CK1_1	108	114	PF00069	0.504
MOD_CK1_1	139	145	PF00069	0.673
MOD_CK1_1	164	170	PF00069	0.768
MOD_CK1_1	179	185	PF00069	0.660
MOD_CK1_1	2	8	PF00069	0.454
MOD_CK1_1	210	216	PF00069	0.634
MOD_CK1_1	320	326	PF00069	0.631
MOD_CK1_1	406	412	PF00069	0.507
MOD_CK1_1	46	52	PF00069	0.471
MOD_CK1_1	469	475	PF00069	0.645
MOD_CK1_1	477	483	PF00069	0.602
MOD_CK1_1	511	517	PF00069	0.565
MOD_CK1_1	567	573	PF00069	0.448
MOD_CK1_1	598	604	PF00069	0.594
MOD_CK1_1	638	644	PF00069	0.572
MOD_CK1_1	95	101	PF00069	0.654
MOD_CK2_1	135	141	PF00069	0.522
MOD_CK2_1	417	423	PF00069	0.516
MOD_CK2_1	433	439	PF00069	0.481
MOD_CK2_1	694	700	PF00069	0.663
MOD_CK2_1	95	101	PF00069	0.486
MOD_Cter_Amidation	228	231	PF01082	0.428
MOD_GlcNHglycan	1	4	PF01048	0.450
MOD_GlcNHglycan	107	110	PF01048	0.474
MOD_GlcNHglycan	141	144	PF01048	0.695
MOD_GlcNHglycan	227	230	PF01048	0.471
MOD_GlcNHglycan	257	260	PF01048	0.818
MOD_GlcNHglycan	277	283	PF01048	0.439
MOD_GlcNHglycan	322	325	PF01048	0.632
MOD_GlcNHglycan	350	353	PF01048	0.652
MOD_GlcNHglycan	395	398	PF01048	0.546
MOD_GlcNHglycan	468	471	PF01048	0.644
MOD_GlcNHglycan	493	496	PF01048	0.580
MOD_GlcNHglycan	510	513	PF01048	0.620
MOD_GlcNHglycan	541	544	PF01048	0.574
MOD_GlcNHglycan	610	613	PF01048	0.616
MOD_GlcNHglycan	647	650	PF01048	0.426
MOD_GlcNHglycan	692	695	PF01048	0.562
MOD_GlcNHglycan	738	741	PF01048	0.743
MOD_GSK3_1	105	112	PF00069	0.473
MOD_GSK3_1	135	142	PF00069	0.723
MOD_GSK3_1	144	151	PF00069	0.739
MOD_GSK3_1	158	165	PF00069	0.786
MOD_GSK3_1	210	217	PF00069	0.660
MOD_GSK3_1	225	232	PF00069	0.379
MOD_GSK3_1	245	252	PF00069	0.411
MOD_GSK3_1	296	303	PF00069	0.722
MOD_GSK3_1	365	372	PF00069	0.489
MOD_GSK3_1	403	410	PF00069	0.491
MOD_GSK3_1	417	424	PF00069	0.468
MOD_GSK3_1	429	436	PF00069	0.519
MOD_GSK3_1	475	482	PF00069	0.707
MOD_GSK3_1	487	494	PF00069	0.582
MOD_GSK3_1	522	529	PF00069	0.378
MOD_GSK3_1	690	697	PF00069	0.678
MOD_N-GLC_1	158	163	PF02516	0.524
MOD_N-GLC_1	179	184	PF02516	0.522
MOD_N-GLC_1	501	506	PF02516	0.651
MOD_N-GLC_1	635	640	PF02516	0.626
MOD_NEK2_1	114	119	PF00069	0.588
MOD_NEK2_1	17	22	PF00069	0.457
MOD_NEK2_1	365	370	PF00069	0.587
MOD_NEK2_1	429	434	PF00069	0.542
MOD_NEK2_1	487	492	PF00069	0.418
MOD_NEK2_1	539	544	PF00069	0.595
MOD_NEK2_1	564	569	PF00069	0.467
MOD_NEK2_1	595	600	PF00069	0.490
MOD_NEK2_1	670	675	PF00069	0.626
MOD_NEK2_2	64	69	PF00069	0.451
MOD_PIKK_1	100	106	PF00454	0.490
MOD_PIKK_1	109	115	PF00454	0.431
MOD_PIKK_1	129	135	PF00454	0.585
MOD_PIKK_1	136	142	PF00454	0.640
MOD_PIKK_1	210	216	PF00454	0.665
MOD_PIKK_1	429	435	PF00454	0.342
MOD_PIKK_1	49	55	PF00454	0.466
MOD_PIKK_1	573	579	PF00454	0.479
MOD_PKA_1	370	376	PF00069	0.524
MOD_PKA_2	174	180	PF00069	0.734
MOD_PKA_2	354	360	PF00069	0.762
MOD_PKA_2	369	375	PF00069	0.362
MOD_PKA_2	531	537	PF00069	0.504
MOD_PKA_2	564	570	PF00069	0.429
MOD_PKA_2	595	601	PF00069	0.608
MOD_PKA_2	695	701	PF00069	0.679
MOD_PKB_1	41	49	PF00069	0.474
MOD_Plk_1	179	185	PF00069	0.520
MOD_Plk_1	278	284	PF00069	0.669
MOD_Plk_1	406	412	PF00069	0.484
MOD_Plk_1	487	493	PF00069	0.491
MOD_Plk_1	635	641	PF00069	0.627
MOD_Plk_1	721	727	PF00069	0.408
MOD_Plk_2-3	541	547	PF00069	0.389
MOD_Plk_4	421	427	PF00069	0.444
MOD_Plk_4	43	49	PF00069	0.475
MOD_Plk_4	567	573	PF00069	0.399
MOD_Plk_4	64	70	PF00069	0.452
MOD_Plk_4	680	686	PF00069	0.517
MOD_ProDKin_1	127	133	PF00069	0.683
MOD_ProDKin_1	164	170	PF00069	0.768
MOD_ProDKin_1	28	34	PF00069	0.465
MOD_ProDKin_1	300	306	PF00069	0.624
MOD_ProDKin_1	36	42	PF00069	0.443
MOD_ProDKin_1	501	507	PF00069	0.467
MOD_ProDKin_1	701	707	PF00069	0.574
MOD_ProDKin_1	95	101	PF00069	0.634
MOD_SUMO_rev_2	451	460	PF00179	0.539
TRG_DiLeu_BaEn_1	546	551	PF01217	0.588
TRG_DiLeu_BaEn_1	680	685	PF01217	0.479
TRG_DiLeu_BaLyEn_6	116	121	PF01217	0.443
TRG_ENDOCYTIC_2	298	301	PF00928	0.685
TRG_ENDOCYTIC_2	419	422	PF00928	0.366
TRG_ENDOCYTIC_2	618	621	PF00928	0.372
TRG_ENDOCYTIC_2	83	86	PF00928	0.578
TRG_ER_diArg_1	218	220	PF00400	0.469
TRG_ER_diArg_1	235	237	PF00400	0.454
TRG_ER_diArg_1	369	371	PF00400	0.500
TRG_ER_diArg_1	40	43	PF00400	0.461
TRG_ER_diArg_1	440	442	PF00400	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAQ5	Leptomonas seymouri	58%	100%
A0A1X0NMR8	Trypanosomatidae	29%	100%
A0A3Q8I9X0	Leishmania donovani	77%	100%
A0A422NDE3	Trypanosoma rangeli	27%	100%
A4HW81	Leishmania infantum	76%	100%
D0A9A0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9APY3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4QFJ9	Leishmania major	75%	100%
V5BID0	Trypanosoma cruzi	28%	100%