Putative delta-4 fatty acid desaturase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

delta-4 fatty acid desaturase, putative

Species:

Leishmania braziliensis

UniProt:

A4H7V4_LEIBR

TriTrypDb:

LbrM.14.1510 , LBRM2903_140019800

Length:

414

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4H7V4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7V4

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	11
GO:0008152	metabolic process	1	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016491	oxidoreductase activity	2	11
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	1
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	283	287	PF00656	0.228
CLV_NRD_NRD_1	50	52	PF00675	0.300
CLV_PCSK_KEX2_1	257	259	PF00082	0.292
CLV_PCSK_KEX2_1	49	51	PF00082	0.304
CLV_PCSK_PC1ET2_1	257	259	PF00082	0.292
CLV_PCSK_SKI1_1	254	258	PF00082	0.326
CLV_PCSK_SKI1_1	6	10	PF00082	0.369
DEG_MDM2_SWIB_1	337	345	PF02201	0.541
DOC_CYCLIN_RxL_1	159	172	PF00134	0.506
DOC_MAPK_gen_1	159	169	PF00069	0.495
DOC_MAPK_gen_1	254	264	PF00069	0.518
DOC_MAPK_gen_1	5	11	PF00069	0.571
DOC_MAPK_MEF2A_6	109	118	PF00069	0.371
DOC_MAPK_MEF2A_6	198	206	PF00069	0.292
DOC_MAPK_MEF2A_6	208	217	PF00069	0.292
DOC_MAPK_MEF2A_6	257	266	PF00069	0.522
DOC_MAPK_NFAT4_5	109	117	PF00069	0.362
DOC_PP1_RVXF_1	163	170	PF00149	0.492
DOC_PP2B_LxvP_1	202	205	PF13499	0.275
DOC_PP4_FxxP_1	232	235	PF00568	0.206
DOC_USP7_MATH_1	383	387	PF00917	0.501
LIG_14-3-3_CanoR_1	360	366	PF00244	0.405
LIG_APCC_ABBAyCdc20_2	64	70	PF00400	0.560
LIG_BRCT_BRCA1_1	308	312	PF00533	0.461
LIG_BRCT_BRCA1_1	333	337	PF00533	0.528
LIG_DLG_GKlike_1	80	87	PF00625	0.419
LIG_FHA_1	16	22	PF00498	0.524
LIG_FHA_2	387	393	PF00498	0.509
LIG_GBD_Chelix_1	114	122	PF00786	0.304
LIG_GBD_Chelix_1	288	296	PF00786	0.347
LIG_Integrin_isoDGR_2	36	38	PF01839	0.364
LIG_LIR_Apic_2	230	235	PF02991	0.206
LIG_LIR_Apic_2	58	63	PF02991	0.624
LIG_LIR_Gen_1	121	131	PF02991	0.375
LIG_LIR_Gen_1	364	373	PF02991	0.427
LIG_LIR_Gen_1	82	91	PF02991	0.507
LIG_LIR_Nem_3	121	126	PF02991	0.363
LIG_LIR_Nem_3	230	236	PF02991	0.261
LIG_LIR_Nem_3	364	369	PF02991	0.412
LIG_LIR_Nem_3	379	385	PF02991	0.483
LIG_LIR_Nem_3	386	390	PF02991	0.510
LIG_LIR_Nem_3	41	47	PF02991	0.488
LIG_LIR_Nem_3	82	87	PF02991	0.498
LIG_LYPXL_SIV_4	271	279	PF13949	0.206
LIG_PCNA_yPIPBox_3	159	167	PF02747	0.384
LIG_Pex14_2	337	341	PF04695	0.541
LIG_PTB_Apo_2	181	188	PF02174	0.341
LIG_PTB_Apo_2	238	245	PF02174	0.342
LIG_PTB_Phospho_1	181	187	PF10480	0.341
LIG_SH2_CRK	272	276	PF00017	0.426
LIG_SH2_CRK	366	370	PF00017	0.475
LIG_SH2_CRK	60	64	PF00017	0.600
LIG_SH2_GRB2like	192	195	PF00017	0.275
LIG_SH2_PTP2	225	228	PF00017	0.362
LIG_SH2_SRC	187	190	PF00017	0.341
LIG_SH2_STAP1	123	127	PF00017	0.486
LIG_SH2_STAP1	366	370	PF00017	0.565
LIG_SH2_STAP1	81	85	PF00017	0.571
LIG_SH2_STAT3	219	222	PF00017	0.240
LIG_SH2_STAT5	107	110	PF00017	0.333
LIG_SH2_STAT5	131	134	PF00017	0.337
LIG_SH2_STAT5	187	190	PF00017	0.276
LIG_SH2_STAT5	192	195	PF00017	0.254
LIG_SH2_STAT5	219	222	PF00017	0.292
LIG_SH2_STAT5	225	228	PF00017	0.260
LIG_SH2_STAT5	301	304	PF00017	0.304
LIG_SH2_STAT5	368	371	PF00017	0.477
LIG_SH2_STAT5	384	387	PF00017	0.483
LIG_SH2_STAT5	84	87	PF00017	0.488
LIG_SUMO_SIM_par_1	225	230	PF11976	0.206
LIG_SUMO_SIM_par_1	7	12	PF11976	0.567
LIG_SxIP_EBH_1	206	216	PF03271	0.341
LIG_SxIP_EBH_1	263	273	PF03271	0.374
LIG_TRAF2_1	389	392	PF00917	0.557
LIG_TYR_ITIM	270	275	PF00017	0.426
LIG_UBA3_1	242	247	PF00899	0.420
LIG_WRC_WIRS_1	136	141	PF05994	0.277
LIG_WRC_WIRS_1	387	392	PF05994	0.447
LIG_WRC_WIRS_1	395	400	PF05994	0.433
MOD_CK1_1	386	392	PF00069	0.275
MOD_CK2_1	386	392	PF00069	0.480
MOD_CK2_1	68	74	PF00069	0.496
MOD_CK2_1	80	86	PF00069	0.431
MOD_GlcNHglycan	210	213	PF01048	0.426
MOD_GSK3_1	131	138	PF00069	0.314
MOD_NEK2_1	135	140	PF00069	0.231
MOD_NEK2_1	174	179	PF00069	0.347
MOD_NEK2_1	279	284	PF00069	0.341
MOD_NEK2_1	306	311	PF00069	0.372
MOD_NEK2_1	394	399	PF00069	0.340
MOD_NEK2_2	175	180	PF00069	0.206
MOD_OFUCOSY	329	335	PF10250	0.426
MOD_PIKK_1	167	173	PF00454	0.357
MOD_Plk_1	38	44	PF00069	0.384
MOD_Plk_2-3	7	13	PF00069	0.468
MOD_Plk_4	121	127	PF00069	0.390
MOD_Plk_4	131	137	PF00069	0.129
MOD_Plk_4	265	271	PF00069	0.367
MOD_Plk_4	361	367	PF00069	0.236
MOD_Plk_4	68	74	PF00069	0.538
MOD_Plk_4	80	86	PF00069	0.353
TRG_DiLeu_BaEn_1	251	256	PF01217	0.426
TRG_DiLeu_BaLyEn_6	202	207	PF01217	0.334
TRG_DiLeu_LyEn_5	251	256	PF01217	0.459
TRG_ENDOCYTIC_2	105	108	PF00928	0.326
TRG_ENDOCYTIC_2	123	126	PF00928	0.348
TRG_ENDOCYTIC_2	225	228	PF00928	0.342
TRG_ENDOCYTIC_2	272	275	PF00928	0.426
TRG_ENDOCYTIC_2	366	369	PF00928	0.299
TRG_ENDOCYTIC_2	387	390	PF00928	0.376
TRG_ENDOCYTIC_2	84	87	PF00928	0.349
TRG_ER_diArg_1	49	51	PF00400	0.393
TRG_ER_diLys_1	410	414	PF00400	0.655
TRG_Pf-PMV_PEXEL_1	254	259	PF00026	0.236

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0C5PRW9	Tachysurus fulvidraco	22%	93%
A0A0N1HZP4	Leptomonas seymouri	80%	100%
A0A0N1PAQ6	Leptomonas seymouri	24%	99%
A0A0S4IVF3	Bodo saltans	51%	97%
A0A0S4KLP1	Bodo saltans	23%	100%
A0A1X0NMZ1	Trypanosomatidae	22%	100%
A0A1X0NPK3	Trypanosomatidae	22%	99%
A0A1X0P7J5	Trypanosomatidae	58%	97%
A0A3Q8I9Z6	Leishmania donovani	85%	100%
A0A3Q8IK71	Leishmania donovani	22%	100%
A0A3S5H618	Leishmania donovani	22%	99%
A0A422NCE1	Trypanosoma rangeli	54%	97%
A0PJ29	Rebecca salina	36%	93%
A4H558	Leishmania braziliensis	22%	100%
A4HQL7	Leishmania braziliensis	23%	100%
A4HTD5	Leishmania infantum	22%	99%
A4HW80	Leishmania infantum	85%	100%
A4IFP3	Bos taurus	25%	93%
A4KDP0	Rebecca salina	24%	97%
A4UVI1	Papio anubis	22%	93%
A8MWK0	Homo sapiens	25%	86%
A9SIZ6	Physcomitrium patens	27%	86%
B2KKL4	Siganus canaliculatus	22%	93%
D0A3D4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
D8X2C5	Siganus canaliculatus	23%	93%
E9AI08	Leishmania infantum	21%	100%
E9ALC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	99%
E9APY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
E9AUD2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
G5EG11	Caenorhabditis elegans	23%	93%
I2CYZ4	Chlamydomonas reinhardtii	28%	80%
O04353	Borago officinalis	25%	92%
O60427	Homo sapiens	21%	93%
O74212	Mortierella alpina	25%	93%
O96099	Dictyostelium discoideum	24%	89%
Q08871	Synechocystis sp. (strain PCC 6803 / Kazusa)	31%	100%
Q0VAX3	Mus musculus	23%	85%
Q1ZXQ5	Dictyostelium discoideum	25%	90%
Q23221	Caenorhabditis elegans	23%	93%
Q2HWK7	Chlamydomonas reinhardtii	22%	87%
Q3EBF7	Arabidopsis thaliana	23%	92%
Q43469	Helianthus annuus	23%	90%
Q4Q058	Leishmania major	22%	100%
Q4QFK0	Leishmania major	85%	100%
Q4QIH7	Leishmania major	23%	100%
Q5AEK8	Candida albicans (strain SC5314 / ATCC MYA-2876)	25%	71%
Q6CMK7	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	24%	72%
Q6DDK2	Xenopus laevis	22%	93%
Q6VPV2	Diacronema lutheri	36%	93%
Q6WNG7	Euglena gracilis	31%	77%
Q8K1P9	Rattus norvegicus	25%	92%
Q8S3C0	Thraustochytrium sp.	24%	80%
Q920L1	Mus musculus	22%	93%
Q9FR82	Borago officinalis	23%	93%
Q9JJE7	Mus musculus	25%	92%
Q9LEM9	Ceratodon purpureus	24%	80%
Q9LEN0	Ceratodon purpureus	27%	86%
Q9SWQ9	Euglena gracilis	24%	99%
Q9Y1W0	Dictyostelium discoideum	24%	89%
Q9Y5Q0	Homo sapiens	26%	93%