J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H7V3_LEIBR

TriTrypDb:

LbrM.14.1500 , LBRM2903_140019700

Length:

515

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 9, no: 2
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H7V3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7V3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	148	150	PF00675	0.454
CLV_NRD_NRD_1	175	177	PF00675	0.367
CLV_NRD_NRD_1	228	230	PF00675	0.304
CLV_NRD_NRD_1	377	379	PF00675	0.443
CLV_NRD_NRD_1	397	399	PF00675	0.122
CLV_NRD_NRD_1	400	402	PF00675	0.241
CLV_PCSK_FUR_1	173	177	PF00082	0.391
CLV_PCSK_KEX2_1	175	177	PF00082	0.393
CLV_PCSK_KEX2_1	228	230	PF00082	0.286
CLV_PCSK_KEX2_1	373	375	PF00082	0.449
CLV_PCSK_KEX2_1	397	399	PF00082	0.241
CLV_PCSK_KEX2_1	444	446	PF00082	0.271
CLV_PCSK_PC1ET2_1	373	375	PF00082	0.411
CLV_PCSK_PC1ET2_1	444	446	PF00082	0.271
CLV_PCSK_SKI1_1	194	198	PF00082	0.481
CLV_PCSK_SKI1_1	252	256	PF00082	0.371
CLV_PCSK_SKI1_1	402	406	PF00082	0.389
CLV_PCSK_SKI1_1	415	419	PF00082	0.396
CLV_PCSK_SKI1_1	436	440	PF00082	0.241
DEG_APCC_DBOX_1	39	47	PF00400	0.317
DEG_Nend_Nbox_1	1	3	PF02207	0.314
DOC_CYCLIN_RxL_1	226	236	PF00134	0.341
DOC_CYCLIN_RxL_1	378	390	PF00134	0.302
DOC_MAPK_gen_1	149	157	PF00069	0.484
DOC_MAPK_gen_1	264	272	PF00069	0.458
DOC_MAPK_MEF2A_6	361	369	PF00069	0.348
DOC_MAPK_MEF2A_6	89	97	PF00069	0.313
DOC_PP1_RVXF_1	227	234	PF00149	0.234
DOC_USP7_MATH_1	180	184	PF00917	0.329
DOC_USP7_MATH_1	213	217	PF00917	0.274
DOC_USP7_MATH_1	404	408	PF00917	0.407
DOC_USP7_UBL2_3	255	259	PF12436	0.465
DOC_USP7_UBL2_3	379	383	PF12436	0.241
DOC_USP7_UBL2_3	99	103	PF12436	0.404
DOC_WW_Pin1_4	197	202	PF00397	0.461
DOC_WW_Pin1_4	319	324	PF00397	0.438
LIG_14-3-3_CanoR_1	106	114	PF00244	0.508
LIG_14-3-3_CanoR_1	119	127	PF00244	0.425
LIG_14-3-3_CanoR_1	228	234	PF00244	0.267
LIG_14-3-3_CanoR_1	301	309	PF00244	0.487
LIG_14-3-3_CanoR_1	74	78	PF00244	0.341
LIG_Actin_WH2_2	358	375	PF00022	0.466
LIG_FHA_1	188	194	PF00498	0.376
LIG_FHA_1	22	28	PF00498	0.318
LIG_FHA_2	322	328	PF00498	0.373
LIG_FHA_2	416	422	PF00498	0.302
LIG_IRF3_LxIS_1	57	64	PF10401	0.237
LIG_LIR_Apic_2	128	134	PF02991	0.412
LIG_LIR_Gen_1	121	130	PF02991	0.421
LIG_LIR_Gen_1	263	274	PF02991	0.415
LIG_LIR_Gen_1	42	52	PF02991	0.465
LIG_LIR_Nem_3	121	127	PF02991	0.326
LIG_LIR_Nem_3	21	26	PF02991	0.386
LIG_LIR_Nem_3	263	269	PF02991	0.377
LIG_LIR_Nem_3	380	385	PF02991	0.256
LIG_LIR_Nem_3	426	432	PF02991	0.241
LIG_NRBOX	80	86	PF00104	0.242
LIG_PCNA_yPIPBox_3	74	85	PF02747	0.360
LIG_Pex14_2	466	470	PF04695	0.651
LIG_Pex14_2	474	478	PF04695	0.607
LIG_Pex14_2	482	486	PF04695	0.607
LIG_Pex14_2	490	494	PF04695	0.444
LIG_SH2_CRK	138	142	PF00017	0.290
LIG_SH2_CRK	23	27	PF00017	0.379
LIG_SH2_CRK	382	386	PF00017	0.241
LIG_SH2_CRK	400	404	PF00017	0.241
LIG_SH2_CRK	98	102	PF00017	0.497
LIG_SH2_GRB2like	448	451	PF00017	0.417
LIG_SH2_NCK_1	138	142	PF00017	0.512
LIG_SH2_NCK_1	38	42	PF00017	0.300
LIG_SH2_SRC	16	19	PF00017	0.247
LIG_SH2_SRC	448	451	PF00017	0.417
LIG_SH2_STAP1	120	124	PF00017	0.375
LIG_SH2_STAP1	285	289	PF00017	0.459
LIG_SH2_STAT3	195	198	PF00017	0.357
LIG_SH2_STAT3	285	288	PF00017	0.355
LIG_SH2_STAT5	120	123	PF00017	0.357
LIG_SH2_STAT5	138	141	PF00017	0.409
LIG_SH2_STAT5	195	198	PF00017	0.384
LIG_SH2_STAT5	23	26	PF00017	0.307
LIG_SH3_3	278	284	PF00018	0.423
LIG_SH3_3	451	457	PF00018	0.487
LIG_SUMO_SIM_anti_2	153	159	PF11976	0.315
LIG_SUMO_SIM_par_1	59	64	PF11976	0.289
LIG_TRAF2_1	189	192	PF00917	0.326
LIG_TRAF2_1	284	287	PF00917	0.496
LIG_UBA3_1	253	259	PF00899	0.338
LIG_UBA3_1	384	389	PF00899	0.386
LIG_UBA3_1	59	65	PF00899	0.311
MOD_CK1_1	166	172	PF00069	0.411
MOD_CK1_1	21	27	PF00069	0.378
MOD_CK1_1	321	327	PF00069	0.308
MOD_CK1_1	465	471	PF00069	0.471
MOD_CK2_1	220	226	PF00069	0.431
MOD_CK2_1	321	327	PF00069	0.484
MOD_CK2_1	357	363	PF00069	0.414
MOD_CK2_1	36	42	PF00069	0.292
MOD_CK2_1	415	421	PF00069	0.256
MOD_GlcNHglycan	182	185	PF01048	0.270
MOD_GlcNHglycan	374	377	PF01048	0.528
MOD_GlcNHglycan	391	394	PF01048	0.315
MOD_GlcNHglycan	457	460	PF01048	0.594
MOD_GSK3_1	118	125	PF00069	0.513
MOD_GSK3_1	21	28	PF00069	0.327
MOD_GSK3_1	411	418	PF00069	0.241
MOD_GSK3_1	462	469	PF00069	0.473
MOD_NEK2_1	220	225	PF00069	0.361
MOD_NEK2_1	372	377	PF00069	0.544
MOD_NEK2_1	387	392	PF00069	0.312
MOD_NEK2_1	403	408	PF00069	0.181
MOD_NEK2_1	466	471	PF00069	0.600
MOD_NEK2_1	59	64	PF00069	0.436
MOD_NEK2_1	73	78	PF00069	0.316
MOD_PIKK_1	129	135	PF00454	0.540
MOD_PIKK_1	187	193	PF00454	0.453
MOD_PIKK_1	194	200	PF00454	0.482
MOD_PKA_2	118	124	PF00069	0.425
MOD_PKA_2	300	306	PF00069	0.355
MOD_PKA_2	73	79	PF00069	0.321
MOD_PKB_1	413	421	PF00069	0.269
MOD_Plk_1	220	226	PF00069	0.448
MOD_Plk_4	136	142	PF00069	0.299
MOD_Plk_4	265	271	PF00069	0.237
MOD_Plk_4	321	327	PF00069	0.456
MOD_Plk_4	42	48	PF00069	0.341
MOD_ProDKin_1	197	203	PF00069	0.459
MOD_ProDKin_1	319	325	PF00069	0.428
MOD_SUMO_for_1	31	34	PF00179	0.400
MOD_SUMO_for_1	367	370	PF00179	0.420
MOD_SUMO_rev_2	354	362	PF00179	0.546
MOD_SUMO_rev_2	431	438	PF00179	0.261
MOD_SUMO_rev_2	441	446	PF00179	0.246
TRG_DiLeu_BaEn_1	153	158	PF01217	0.394
TRG_ENDOCYTIC_2	138	141	PF00928	0.564
TRG_ENDOCYTIC_2	23	26	PF00928	0.406
TRG_ENDOCYTIC_2	381	384	PF00928	0.241
TRG_ENDOCYTIC_2	400	403	PF00928	0.241
TRG_ENDOCYTIC_2	44	47	PF00928	0.483
TRG_ENDOCYTIC_2	98	101	PF00928	0.404
TRG_ER_diArg_1	172	175	PF00400	0.392
TRG_ER_diArg_1	227	229	PF00400	0.298
TRG_ER_diArg_1	396	398	PF00400	0.241
TRG_ER_diArg_1	412	415	PF00400	0.241
TRG_ER_diArg_1	445	448	PF00400	0.299
TRG_ER_diArg_1	47	50	PF00400	0.348
TRG_Golgi_diPhe_1	501	515	PF00400	0.467
TRG_Pf-PMV_PEXEL_1	229	234	PF00026	0.328

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0D1E2P6	Ustilago maydis (strain 521 / FGSC 9021)	26%	89%
A0A0D2XVZ5	Fusarium oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 / FGSC 9935 / NRRL 34936)	30%	99%
A0A0N1PCC0	Leptomonas seymouri	65%	91%
A0A0N1PF59	Leptomonas seymouri	26%	98%
A0A0S4JQ76	Bodo saltans	45%	96%
A0A1X0NP19	Trypanosomatidae	44%	91%
A0A1X0P9Z7	Trypanosomatidae	27%	75%
A0A3S7WTD0	Leishmania donovani	85%	90%
A0A3S7XAC9	Leishmania donovani	26%	100%
A0A422NFP3	Trypanosoma rangeli	48%	98%
A0A422P0G2	Trypanosoma rangeli	26%	73%
A4HNQ8	Leishmania braziliensis	26%	100%
A4HW79	Leishmania infantum	85%	90%
A4ICT7	Leishmania infantum	26%	100%
C9ZML0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	73%
C9ZST7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	98%
E9APY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	91%
E9ASG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
J9VKM5	Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487)	25%	99%
Q13217	Homo sapiens	26%	100%
Q27968	Bos taurus	26%	100%
Q4Q228	Leishmania major	26%	100%
Q4QFK1	Leishmania major	83%	100%
Q54M21	Dictyostelium discoideum	24%	100%
Q5R8D8	Pongo abelii	23%	100%
Q5ZI13	Gallus gallus	27%	100%
Q91YW3	Mus musculus	26%	100%
Q99615	Homo sapiens	23%	100%
Q9QYI3	Mus musculus	23%	100%
Q9R0T3	Rattus norvegicus	26%	100%
V5BKG1	Trypanosoma cruzi	27%	74%
V5BKH0	Trypanosoma cruzi	48%	98%