Serine hydroxymethyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine hydroxymethyltranferase (SHMT-S)

Species:

Leishmania braziliensis

UniProt:

A4H7V2_LEIBR

TriTrypDb:

LbrM.14.1490 , LBRM2903_140019600

Length:

465

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 2
Pissara et al.	no	yes: 6

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0005829	cytosol	2	1

Expansion

Sequence features

A4H7V2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7V2

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	19
GO:0006520	amino acid metabolic process	3	19
GO:0006544	glycine metabolic process	6	19
GO:0006545	glycine biosynthetic process	7	19
GO:0006563	L-serine metabolic process	6	19
GO:0006575	cellular modified amino acid metabolic process	3	19
GO:0006725	cellular aromatic compound metabolic process	3	19
GO:0006730	one-carbon metabolic process	3	19
GO:0006760	folic acid-containing compound metabolic process	4	19
GO:0006807	nitrogen compound metabolic process	2	19
GO:0008152	metabolic process	1	19
GO:0008652	amino acid biosynthetic process	4	19
GO:0009058	biosynthetic process	2	19
GO:0009069	serine family amino acid metabolic process	5	19
GO:0009070	serine family amino acid biosynthetic process	6	19
GO:0009987	cellular process	1	19
GO:0016053	organic acid biosynthetic process	4	19
GO:0019264	glycine biosynthetic process from serine	7	19
GO:0019752	carboxylic acid metabolic process	5	19
GO:0035999	tetrahydrofolate interconversion	4	19
GO:0042558	pteridine-containing compound metabolic process	4	19
GO:0043436	oxoacid metabolic process	4	19
GO:0044237	cellular metabolic process	2	19
GO:0044238	primary metabolic process	2	19
GO:0044249	cellular biosynthetic process	3	19
GO:0044281	small molecule metabolic process	2	19
GO:0044283	small molecule biosynthetic process	3	19
GO:0046394	carboxylic acid biosynthetic process	5	19
GO:0046483	heterocycle metabolic process	3	19
GO:0046653	tetrahydrofolate metabolic process	5	19
GO:0071704	organic substance metabolic process	2	19
GO:1901360	organic cyclic compound metabolic process	3	19
GO:1901564	organonitrogen compound metabolic process	3	19
GO:1901566	organonitrogen compound biosynthetic process	4	19
GO:1901576	organic substance biosynthetic process	3	19
GO:1901605	alpha-amino acid metabolic process	4	19
GO:1901607	alpha-amino acid biosynthetic process	5	19
GO:0032259	methylation	2	11
GO:0006565	L-serine catabolic process	5	2
GO:0006766	vitamin metabolic process	3	2
GO:0006767	water-soluble vitamin metabolic process	4	2
GO:0009056	catabolic process	2	2
GO:0009063	amino acid catabolic process	4	2
GO:0009071	serine family amino acid catabolic process	6	2
GO:0016054	organic acid catabolic process	4	2
GO:0043603	amide metabolic process	3	2
GO:0043648	dicarboxylic acid metabolic process	6	2
GO:0044248	cellular catabolic process	3	2
GO:0044282	small molecule catabolic process	3	2
GO:0046395	carboxylic acid catabolic process	5	2
GO:0046655	folic acid metabolic process	4	2
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2
GO:1901606	alpha-amino acid catabolic process	5	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	19
GO:0004372	glycine hydroxymethyltransferase activity	5	19
GO:0005488	binding	1	19
GO:0016740	transferase activity	2	19
GO:0016741	transferase activity, transferring one-carbon groups	3	19
GO:0016742	hydroxymethyl-, formyl- and related transferase activity	4	19
GO:0019842	vitamin binding	3	19
GO:0030170	pyridoxal phosphate binding	4	19
GO:0036094	small molecule binding	2	19
GO:0043167	ion binding	2	19
GO:0043168	anion binding	3	19
GO:0070279	vitamin B6 binding	3	19
GO:0097159	organic cyclic compound binding	2	19
GO:1901363	heterocyclic compound binding	2	19
GO:0008168	methyltransferase activity	4	11
GO:0008270	zinc ion binding	6	2
GO:0016597	amino acid binding	4	2
GO:0031406	carboxylic acid binding	4	2
GO:0043169	cation binding	3	2
GO:0043177	organic acid binding	3	2
GO:0046872	metal ion binding	4	2
GO:0046914	transition metal ion binding	5	2
GO:0070905	serine binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	250	252	PF00675	0.186
CLV_NRD_NRD_1	435	437	PF00675	0.319
CLV_PCSK_KEX2_1	435	437	PF00082	0.241
CLV_PCSK_KEX2_1	80	82	PF00082	0.278
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.261
CLV_PCSK_SKI1_1	41	45	PF00082	0.278
CLV_PCSK_SKI1_1	80	84	PF00082	0.251
DEG_SPOP_SBC_1	231	235	PF00917	0.428
DOC_CKS1_1	135	140	PF01111	0.461
DOC_CKS1_1	293	298	PF01111	0.359
DOC_CYCLIN_yCln2_LP_2	222	228	PF00134	0.438
DOC_MAPK_gen_1	241	249	PF00069	0.426
DOC_MAPK_gen_1	346	356	PF00069	0.428
DOC_MAPK_MEF2A_6	349	358	PF00069	0.489
DOC_PP2B_LxvP_1	123	126	PF13499	0.413
DOC_PP4_FxxP_1	135	138	PF00568	0.461
DOC_PP4_FxxP_1	445	448	PF00568	0.335
DOC_USP7_MATH_1	181	185	PF00917	0.440
DOC_USP7_UBL2_3	299	303	PF12436	0.423
DOC_WW_Pin1_4	100	105	PF00397	0.418
DOC_WW_Pin1_4	134	139	PF00397	0.461
DOC_WW_Pin1_4	221	226	PF00397	0.416
DOC_WW_Pin1_4	292	297	PF00397	0.434
DOC_WW_Pin1_4	368	373	PF00397	0.431
LIG_BIR_II_1	1	5	PF00653	0.463
LIG_BRCT_BRCA1_1	145	149	PF00533	0.417
LIG_BRCT_BRCA1_1	23	27	PF00533	0.491
LIG_Clathr_ClatBox_1	205	209	PF01394	0.461
LIG_FHA_1	109	115	PF00498	0.461
LIG_FHA_1	211	217	PF00498	0.426
LIG_FHA_1	377	383	PF00498	0.418
LIG_FHA_1	442	448	PF00498	0.205
LIG_FHA_1	66	72	PF00498	0.426
LIG_FHA_2	258	264	PF00498	0.405
LIG_FHA_2	5	11	PF00498	0.240
LIG_GBD_Chelix_1	15	23	PF00786	0.296
LIG_LIR_Apic_2	132	138	PF02991	0.461
LIG_LIR_Apic_2	443	448	PF02991	0.391
LIG_LIR_Gen_1	115	125	PF02991	0.423
LIG_LIR_Gen_1	146	156	PF02991	0.418
LIG_LIR_Gen_1	163	172	PF02991	0.418
LIG_LIR_Gen_1	189	198	PF02991	0.418
LIG_LIR_Gen_1	68	78	PF02991	0.405
LIG_LIR_Nem_3	115	120	PF02991	0.489
LIG_LIR_Nem_3	146	152	PF02991	0.436
LIG_LIR_Nem_3	163	167	PF02991	0.436
LIG_LIR_Nem_3	189	195	PF02991	0.418
LIG_LIR_Nem_3	24	30	PF02991	0.426
LIG_LIR_Nem_3	295	301	PF02991	0.419
LIG_MLH1_MIPbox_1	145	149	PF16413	0.418
LIG_PCNA_PIPBox_1	392	401	PF02747	0.411
LIG_Pex14_2	441	445	PF04695	0.285
LIG_SH2_CRK	110	114	PF00017	0.454
LIG_SH2_CRK	117	121	PF00017	0.449
LIG_SH2_CRK	428	432	PF00017	0.213
LIG_SH2_GRB2like	262	265	PF00017	0.335
LIG_SH2_SRC	228	231	PF00017	0.461
LIG_SH2_SRC	55	58	PF00017	0.418
LIG_SH2_STAP1	110	114	PF00017	0.457
LIG_SH2_STAP1	117	121	PF00017	0.457
LIG_SH2_STAP1	186	190	PF00017	0.436
LIG_SH2_STAP1	228	232	PF00017	0.447
LIG_SH2_STAP1	262	266	PF00017	0.415
LIG_SH2_STAP1	301	305	PF00017	0.407
LIG_SH2_STAT3	301	304	PF00017	0.418
LIG_SH2_STAT5	110	113	PF00017	0.426
LIG_SH2_STAT5	136	139	PF00017	0.411
LIG_SH2_STAT5	148	151	PF00017	0.411
LIG_SH2_STAT5	70	73	PF00017	0.350
LIG_SH3_3	170	176	PF00018	0.421
LIG_SH3_3	290	296	PF00018	0.412
LIG_SUMO_SIM_anti_2	168	174	PF11976	0.404
LIG_SUMO_SIM_anti_2	204	209	PF11976	0.335
LIG_SUMO_SIM_par_1	17	22	PF11976	0.499
LIG_SUMO_SIM_par_1	378	384	PF11976	0.404
LIG_TRFH_1	86	90	PF08558	0.436
LIG_TYR_ITIM	162	167	PF00017	0.447
LIG_WRC_WIRS_1	447	452	PF05994	0.437
MOD_CDK_SPK_2	134	139	PF00069	0.499
MOD_CDK_SPxK_1	134	140	PF00069	0.461
MOD_CDK_SPxxK_3	134	141	PF00069	0.461
MOD_CDK_SPxxK_3	292	299	PF00069	0.434
MOD_CK1_1	143	149	PF00069	0.418
MOD_CK1_1	325	331	PF00069	0.461
MOD_CK1_1	368	374	PF00069	0.438
MOD_CK1_1	381	387	PF00069	0.428
MOD_CK1_1	49	55	PF00069	0.418
MOD_CK2_1	257	263	PF00069	0.414
MOD_CK2_1	342	348	PF00069	0.461
MOD_CK2_1	4	10	PF00069	0.439
MOD_GlcNHglycan	100	103	PF01048	0.227
MOD_GlcNHglycan	126	129	PF01048	0.230
MOD_GlcNHglycan	142	145	PF01048	0.209
MOD_GlcNHglycan	183	186	PF01048	0.231
MOD_GlcNHglycan	316	319	PF01048	0.276
MOD_GlcNHglycan	324	327	PF01048	0.255
MOD_GlcNHglycan	366	370	PF01048	0.238
MOD_GlcNHglycan	414	417	PF01048	0.510
MOD_GlcNHglycan	428	431	PF01048	0.208
MOD_GlcNHglycan	48	51	PF01048	0.228
MOD_GSK3_1	232	239	PF00069	0.435
MOD_GSK3_1	304	311	PF00069	0.335
MOD_GSK3_1	32	39	PF00069	0.420
MOD_GSK3_1	376	383	PF00069	0.425
MOD_GSK3_1	408	415	PF00069	0.488
MOD_N-GLC_1	36	41	PF02516	0.218
MOD_NEK2_1	21	26	PF00069	0.548
MOD_NEK2_1	210	215	PF00069	0.447
MOD_NEK2_1	342	347	PF00069	0.440
MOD_NEK2_1	380	385	PF00069	0.506
MOD_NEK2_1	441	446	PF00069	0.378
MOD_NEK2_2	65	70	PF00069	0.493
MOD_PIKK_1	285	291	PF00454	0.418
MOD_PKA_1	140	146	PF00069	0.418
MOD_Plk_1	365	371	PF00069	0.420
MOD_Plk_2-3	163	169	PF00069	0.359
MOD_Plk_4	143	149	PF00069	0.418
MOD_Plk_4	201	207	PF00069	0.499
MOD_Plk_4	65	71	PF00069	0.493
MOD_ProDKin_1	100	106	PF00069	0.418
MOD_ProDKin_1	134	140	PF00069	0.461
MOD_ProDKin_1	221	227	PF00069	0.416
MOD_ProDKin_1	292	298	PF00069	0.434
MOD_ProDKin_1	368	374	PF00069	0.431
MOD_SUMO_rev_2	292	300	PF00179	0.461
TRG_DiLeu_BaEn_1	168	173	PF01217	0.499
TRG_DiLeu_BaEn_1	201	206	PF01217	0.404
TRG_ENDOCYTIC_2	110	113	PF00928	0.425
TRG_ENDOCYTIC_2	117	120	PF00928	0.420
TRG_ENDOCYTIC_2	164	167	PF00928	0.426
TRG_ENDOCYTIC_2	192	195	PF00928	0.417
TRG_ENDOCYTIC_2	228	231	PF00928	0.447
TRG_ENDOCYTIC_2	428	431	PF00928	0.508
TRG_ENDOCYTIC_2	70	73	PF00928	0.350
TRG_ER_diArg_1	434	436	PF00400	0.225
TRG_NES_CRM1_1	14	26	PF08389	0.483
TRG_NLS_MonoExtN_4	138	143	PF00514	0.499
TRG_Pf-PMV_PEXEL_1	196	200	PF00026	0.209
TRG_Pf-PMV_PEXEL_1	393	397	PF00026	0.233

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSI5	Leptomonas seymouri	83%	100%
A0A0N1I2Y4	Leptomonas seymouri	60%	97%
A0A0S4IKW4	Bodo saltans	66%	87%
A0A0S4IVF6	Bodo saltans	59%	99%
A0A0S4JPH2	Bodo saltans	67%	100%
A0A1X0NNF7	Trypanosomatidae	69%	100%
A0A1X0NSD5	Trypanosomatidae	59%	99%
A0A3Q8IA22	Leishmania donovani	89%	100%
A0A3Q8IF07	Leishmania donovani	59%	98%
A0ALM4	Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / CIP 8149 / NCTC 11857 / SLCC 5334 / V8)	46%	100%
A0B8J6	Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)	45%	100%
A0KNH4	Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049)	47%	100%
A0KU60	Shewanella sp. (strain ANA-3)	45%	100%
A0L403	Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1)	45%	100%
A0LI16	Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB)	45%	100%
A0LV49	Acidothermus cellulolyticus (strain ATCC 43068 / DSM 8971 / 11B)	46%	100%
A0M3N2	Gramella forsetii (strain KT0803)	45%	100%
A0PZX4	Clostridium novyi (strain NT)	49%	100%
A0Q7C5	Francisella tularensis subsp. novicida (strain U112)	42%	100%
A0RLA3	Bacillus thuringiensis (strain Al Hakam)	45%	100%
A0RQ16	Campylobacter fetus subsp. fetus (strain 82-40)	46%	100%
A1APU0	Pelobacter propionicus (strain DSM 2379 / NBRC 103807 / OttBd1)	46%	100%
A1B0I7	Paracoccus denitrificans (strain Pd 1222)	47%	100%
A1BE30	Chlorobium phaeobacteroides (strain DSM 266)	46%	100%
A1K9B2	Azoarcus sp. (strain BH72)	46%	100%
A1R032	Borrelia turicatae (strain 91E135)	45%	100%
A1RHD0	Shewanella sp. (strain W3-18-1)	45%	100%
A1S4B5	Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)	46%	100%
A1SUU0	Psychromonas ingrahamii (strain 37)	46%	100%
A1TRH1	Acidovorax citrulli (strain AAC00-1)	46%	100%
A1USI0	Bartonella bacilliformis (strain ATCC 35685 / NCTC 12138 / KC583)	47%	100%
A1VRC8	Polaromonas naphthalenivorans (strain CJ2)	42%	100%
A1VYC2	Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176)	46%	100%
A1W6H6	Acidovorax sp. (strain JS42)	44%	100%
A1WQP4	Verminephrobacter eiseniae (strain EF01-2)	45%	100%
A1WVG6	Halorhodospira halophila (strain DSM 244 / SL1)	46%	100%
A2BP57	Prochlorococcus marinus (strain AS9601)	43%	100%
A2BUN9	Prochlorococcus marinus (strain MIT 9515)	45%	100%
A2C090	Prochlorococcus marinus (strain NATL1A)	45%	100%
A2CCJ3	Prochlorococcus marinus (strain MIT 9303)	48%	100%
A2RIS0	Lactococcus lactis subsp. cremoris (strain MG1363)	47%	100%
A3D7D0	Shewanella baltica (strain OS155 / ATCC BAA-1091)	45%	100%
A3DEB1	Acetivibrio thermocellus (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372)	50%	100%
A3M736	Acinetobacter baumannii (strain ATCC 17978 / CIP 53.77 / LMG 1025 / NCDC KC755 / 5377)	46%	100%
A3PAX9	Prochlorococcus marinus (strain MIT 9301)	46%	100%
A3QC57	Shewanella loihica (strain ATCC BAA-1088 / PV-4)	45%	100%
A4G7M4	Herminiimonas arsenicoxydans	45%	100%
A4HGU0	Leishmania braziliensis	59%	100%
A4HW78	Leishmania infantum	89%	100%
A4I3W7	Leishmania infantum	59%	98%
A4ITJ9	Geobacillus thermodenitrificans (strain NG80-2)	47%	100%
A4IXD7	Francisella tularensis subsp. tularensis (strain WY96-3418)	42%	100%
A4J9B1	Desulforamulus reducens (strain ATCC BAA-1160 / DSM 100696 / MI-1)	48%	100%
A4SFY3	Chlorobium phaeovibrioides (strain DSM 265 / 1930)	44%	100%
A4SJN4	Aeromonas salmonicida (strain A449)	47%	100%
A4SVI6	Polynucleobacter asymbioticus (strain DSM 18221 / CIP 109841 / QLW-P1DMWA-1)	45%	100%
A4TMW4	Yersinia pestis (strain Pestoides F)	44%	100%
A4VI36	Pseudomonas stutzeri (strain A1501)	44%	100%
A4VUM9	Streptococcus suis (strain 05ZYH33)	45%	100%
A4W0W9	Streptococcus suis (strain 98HAH33)	45%	100%
A4XL61	Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903 / Tp8T 6331)	47%	100%
A4Y966	Shewanella putrefaciens (strain CN-32 / ATCC BAA-453)	45%	100%
A4YW97	Bradyrhizobium sp. (strain ORS 278)	49%	100%
A5CWI3	Vesicomyosocius okutanii subsp. Calyptogena okutanii (strain HA)	48%	100%
A5CYB7	Pelotomaculum thermopropionicum (strain DSM 13744 / JCM 10971 / SI)	49%	100%
A5EKI3	Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)	50%	100%
A5EVR7	Dichelobacter nodosus (strain VCS1703A)	47%	100%
A5FEF4	Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / JCM 8514 / NBRC 14942 / NCIMB 11054 / UW101)	45%	100%
A5GF66	Geotalea uraniireducens (strain Rf4)	46%	100%
A5GIG4	Synechococcus sp. (strain WH7803)	48%	100%
A5I526	Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)	45%	100%
A5IGI2	Legionella pneumophila (strain Corby)	48%	100%
A5IJ65	Thermotoga petrophila (strain ATCC BAA-488 / DSM 13995 / JCM 10881 / RKU-1)	45%	100%
A5IUQ8	Staphylococcus aureus (strain JH9)	46%	100%
A5N7P5	Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)	45%	100%
A5UQB7	Roseiflexus sp. (strain RS-1)	47%	100%
A5VIP9	Limosilactobacillus reuteri (strain DSM 20016)	46%	100%
A5VPU7	Brucella ovis (strain ATCC 25840 / 63/290 / NCTC 10512)	47%	100%
A5WH82	Psychrobacter sp. (strain PRwf-1)	46%	100%
A6GXG2	Flavobacterium psychrophilum (strain ATCC 49511 / DSM 21280 / CIP 103535 / JIP02/86)	45%	100%
A6L5K3	Phocaeicola vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 / NBRC 14291 / NCTC 11154)	44%	100%
A6LBG7	Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152)	45%	100%
A6LKU9	Thermosipho melanesiensis (strain DSM 12029 / CIP 104789 / BI429)	46%	100%
A6LUK9	Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052)	48%	100%
A6Q478	Nitratiruptor sp. (strain SB155-2)	50%	100%
A6Q7H8	Sulfurovum sp. (strain NBC37-1)	48%	100%
A6QIV7	Staphylococcus aureus (strain Newman)	46%	100%
A6T0T6	Janthinobacterium sp. (strain Marseille)	44%	100%
A6TQQ1	Alkaliphilus metalliredigens (strain QYMF)	45%	100%
A6U3J8	Staphylococcus aureus (strain JH1)	46%	100%
A6WR52	Shewanella baltica (strain OS185)	45%	100%
A6X1Y9	Brucella anthropi (strain ATCC 49188 / DSM 6882 / CCUG 24695 / JCM 21032 / LMG 3331 / NBRC 15819 / NCTC 12168 / Alc 37)	46%	100%
A7FFW1	Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)	44%	100%
A7FWM6	Clostridium botulinum (strain ATCC 19397 / Type A)	45%	100%
A7GGI2	Clostridium botulinum (strain Langeland / NCTC 10281 / Type F)	46%	100%
A7GV66	Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98)	46%	100%
A7GX48	Campylobacter curvus (strain 525.92)	48%	100%
A7H4X6	Campylobacter jejuni subsp. doylei (strain ATCC BAA-1458 / RM4099 / 269.97)	46%	100%
A7HDY8	Anaeromyxobacter sp. (strain Fw109-5)	47%	100%
A7HJ69	Fervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)	45%	100%
A7I3S9	Campylobacter hominis (strain ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A)	46%	100%
A7NB66	Francisella tularensis subsp. holarctica (strain FTNF002-00 / FTA)	42%	100%
A7NIF2	Roseiflexus castenholzii (strain DSM 13941 / HLO8)	48%	100%
A7X4V7	Staphylococcus aureus (strain Mu3 / ATCC 700698)	46%	100%
A7Z9Q9	Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / LMG 26770 / FZB42)	47%	100%
A7ZFA4	Campylobacter concisus (strain 13826)	47%	100%
A8F595	Pseudothermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / NBRC 107922 / TMO)	46%	100%
A8FIC1	Bacillus pumilus (strain SAFR-032)	43%	100%
A8FKI9	Campylobacter jejuni subsp. jejuni serotype O:6 (strain 81116 / NCTC 11828)	46%	100%
A8G2R8	Prochlorococcus marinus (strain MIT 9215)	43%	100%
A8GHZ4	Serratia proteamaculans (strain 568)	44%	100%
A8MGL7	Alkaliphilus oremlandii (strain OhILAs)	47%	100%
A8YY80	Staphylococcus aureus (strain USA300 / TCH1516)	45%	100%
A8ZTV3	Desulfococcus oleovorans (strain DSM 6200 / JCM 39069 / Hxd3)	46%	100%
A9BDM9	Prochlorococcus marinus (strain MIT 9211)	45%	100%
A9BIK8	Petrotoga mobilis (strain DSM 10674 / SJ95)	46%	100%
A9GPH2	Sorangium cellulosum (strain So ce56)	46%	100%
A9I292	Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)	43%	100%
A9IVC5	Bartonella tribocorum (strain CIP 105476 / IBS 506)	46%	100%
A9KSH6	Lachnoclostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg)	47%	100%
A9KYJ6	Shewanella baltica (strain OS195)	45%	100%
A9LYX4	Neisseria meningitidis serogroup C (strain 053442)	45%	100%
A9MAE5	Brucella canis (strain ATCC 23365 / NCTC 10854)	47%	100%
A9NEA9	Acholeplasma laidlawii (strain PG-8A)	46%	100%
A9R8C1	Yersinia pestis bv. Antiqua (strain Angola)	44%	100%
A9VSB4	Bacillus mycoides (strain KBAB4)	45%	100%
A9VYW6	Methylorubrum extorquens (strain PA1)	46%	100%
A9WI58	Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)	48%	100%
B0CEI9	Acaryochloris marina (strain MBIC 11017)	44%	100%
B0CL90	Brucella suis (strain ATCC 23445 / NCTC 10510)	47%	100%
B0JPX8	Microcystis aeruginosa (strain NIES-843 / IAM M-2473)	44%	100%
B0K631	Thermoanaerobacter sp. (strain X514)	48%	100%
B0K742	Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E)	48%	100%
B0RVE1	Xanthomonas campestris pv. campestris (strain B100)	47%	100%
B0S1N3	Finegoldia magna (strain ATCC 29328 / DSM 20472 / WAL 2508)	44%	100%
B0T1I5	Caulobacter sp. (strain K31)	47%	100%
B0TI64	Heliobacterium modesticaldum (strain ATCC 51547 / Ice1)	47%	100%
B0TYH3	Francisella philomiragia subsp. philomiragia (strain ATCC 25017 / FSC 153 / O#319-036)	43%	100%
B0U4K9	Xylella fastidiosa (strain M12)	47%	100%
B0VBB3	Acinetobacter baumannii (strain AYE)	46%	100%
B0VLF5	Acinetobacter baumannii (strain SDF)	46%	100%
B1HM45	Lysinibacillus sphaericus (strain C3-41)	48%	100%
B1I6M4	Desulforudis audaxviator (strain MP104C)	53%	100%
B1IJJ8	Clostridium botulinum (strain Okra / Type B1)	48%	100%
B1JRX7	Yersinia pseudotuberculosis serotype O:3 (strain YPIII)	44%	100%
B1KXQ5	Clostridium botulinum (strain Loch Maree / Type A3)	47%	100%
B1L7Y6	Thermotoga sp. (strain RQ2)	44%	100%
B1LZ88	Methylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831 / NBRC 15690 / NCIMB 10815 / 0-1)	46%	100%
B1MYF5	Leuconostoc citreum (strain KM20)	48%	100%
B1WPY4	Crocosphaera subtropica (strain ATCC 51142 / BH68)	47%	100%
B1XTC3	Polynucleobacter necessarius subsp. necessarius (strain STIR1)	45%	100%
B1XYE7	Leptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6)	46%	100%
B1YEH3	Exiguobacterium sibiricum (strain DSM 17290 / CIP 109462 / JCM 13490 / 255-15)	47%	100%
B1ZJN1	Methylorubrum populi (strain ATCC BAA-705 / NCIMB 13946 / BJ001)	45%	100%
B2A3H6	Natranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF)	44%	100%
B2FNK2	Stenotrophomonas maltophilia (strain K279a)	48%	100%
B2G679	Limosilactobacillus reuteri (strain JCM 1112)	46%	100%
B2HUY9	Acinetobacter baumannii (strain ACICU)	46%	100%
B2I8R0	Xylella fastidiosa (strain M23)	47%	100%
B2IJJ3	Beijerinckia indica subsp. indica (strain ATCC 9039 / DSM 1715 / NCIMB 8712)	48%	100%
B2J2A2	Nostoc punctiforme (strain ATCC 29133 / PCC 73102)	45%	100%
B2K9S8	Yersinia pseudotuberculosis serotype IB (strain PB1/+)	44%	100%
B2KER5	Elusimicrobium minutum (strain Pei191)	46%	100%
B2RGR2	Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / CIP 103683 / JCM 12257 / NCTC 11834 / 2561)	46%	100%
B2S0U9	Borrelia hermsii (strain HS1 / DAH)	43%	100%
B2S513	Brucella abortus (strain S19)	47%	100%
B2SGE5	Francisella tularensis subsp. mediasiatica (strain FSC147)	42%	100%
B2SNV6	Xanthomonas oryzae pv. oryzae (strain PXO99A)	44%	100%
B2TN52	Clostridium botulinum (strain Eklund 17B / Type B)	44%	100%
B2US14	Helicobacter pylori (strain Shi470)	47%	100%
B2V398	Clostridium botulinum (strain Alaska E43 / Type E3)	44%	100%
B2V9M1	Sulfurihydrogenibium sp. (strain YO3AOP1)	48%	100%
B2VI25	Erwinia tasmaniensis (strain DSM 17950 / CFBP 7177 / CIP 109463 / NCPPB 4357 / Et1/99)	44%	100%
B3E1Z8	Trichlorobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ)	45%	100%
B3EFN5	Chlorobium limicola (strain DSM 245 / NBRC 103803 / 6330)	46%	100%
B3EMW0	Chlorobium phaeobacteroides (strain BS1)	46%	100%
B3ER62	Amoebophilus asiaticus (strain 5a2)	43%	100%
B3PBD6	Cellvibrio japonicus (strain Ueda107)	44%	100%
B3PN94	Metamycoplasma arthritidis (strain 158L3-1)	44%	100%
B3QPR3	Chlorobaculum parvum (strain DSM 263 / NCIMB 8327)	47%	100%
B3R5S0	Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CCUG 44338 / CIP 107171 / LMG 19424 / R1)	45%	100%
B3WDL0	Lacticaseibacillus casei (strain BL23)	44%	100%
B4RB35	Phenylobacterium zucineum (strain HLK1)	46%	100%
B4RLC9	Neisseria gonorrhoeae (strain NCCP11945)	45%	100%
B4S5Y9	Prosthecochloris aestuarii (strain DSM 271 / SK 413)	45%	100%
B4SE31	Pelodictyon phaeoclathratiforme (strain DSM 5477 / BU-1)	48%	100%
B4SJB0	Stenotrophomonas maltophilia (strain R551-3)	48%	100%
B4U7S5	Hydrogenobaculum sp. (strain Y04AAS1)	44%	100%
B4UIM7	Anaeromyxobacter sp. (strain K)	45%	100%
B5E8U0	Citrifermentans bemidjiense (strain ATCC BAA-1014 / DSM 16622 / JCM 12645 / Bem)	47%	100%
B5ELV3	Acidithiobacillus ferrooxidans (strain ATCC 53993 / BNL-5-31)	47%	100%
B5RMF3	Borrelia duttonii (strain Ly)	44%	100%
B5RPU9	Borrelia recurrentis (strain A1)	44%	100%
B5Y8G6	Coprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / OCM 4 / BT)	45%	100%
B5YDB7	Dictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12)	46%	100%
B5YFZ0	Thermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87)	47%	100%
B5Z9V7	Helicobacter pylori (strain G27)	47%	100%
B6JGH9	Afipia carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5)	48%	100%
B6JPT2	Helicobacter pylori (strain P12)	47%	100%
B7GMG4	Anoxybacillus flavithermus (strain DSM 21510 / WK1)	47%	100%
B7GZR6	Acinetobacter baumannii (strain AB307-0294)	46%	100%
B7HFL3	Bacillus cereus (strain B4264)	46%	100%
B7HY76	Bacillus cereus (strain AH187)	46%	100%
B7I2R7	Acinetobacter baumannii (strain AB0057)	46%	100%
B7IHE6	Thermosipho africanus (strain TCF52B)	45%	100%
B7IQW9	Bacillus cereus (strain G9842)	46%	100%
B7J2G3	Borreliella burgdorferi (strain ZS7)	45%	100%
B7J439	Acidithiobacillus ferrooxidans (strain ATCC 23270 / DSM 14882 / CIP 104768 / NCIMB 8455)	47%	100%
B7JGP1	Bacillus cereus (strain AH820)	46%	100%
B7JYG9	Rippkaea orientalis (strain PCC 8801)	47%	100%
B7KVA7	Methylorubrum extorquens (strain CM4 / NCIMB 13688)	46%	100%
B8CYJ3	Halothermothrix orenii (strain H 168 / OCM 544 / DSM 9562)	48%	100%
B8DBH0	Listeria monocytogenes serotype 4a (strain HCC23)	46%	100%
B8E008	Dictyoglomus turgidum (strain DSM 6724 / Z-1310)	47%	100%
B8E6W1	Shewanella baltica (strain OS223)	46%	100%
B8FJ72	Desulfatibacillum aliphaticivorans	48%	100%
B8FZ69	Desulfitobacterium hafniense (strain DSM 10664 / DCB-2)	48%	100%
B8G933	Chloroflexus aggregans (strain MD-66 / DSM 9485)	48%	100%
B8GG35	Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)	45%	100%
B8I2N8	Ruminiclostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10)	49%	100%
B8J189	Desulfovibrio desulfuricans (strain ATCC 27774 / DSM 6949 / MB)	48%	100%
B8JEW9	Anaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258)	45%	100%
B9DMF3	Staphylococcus carnosus (strain TM300)	45%	100%
B9E156	Clostridium kluyveri (strain NBRC 12016)	45%	100%
B9E8F5	Macrococcus caseolyticus (strain JCSC5402)	47%	100%
B9IRU8	Bacillus cereus (strain Q1)	46%	100%
B9JCX4	Agrobacterium radiobacter (strain K84 / ATCC BAA-868)	46%	100%
B9JV74	Agrobacterium vitis (strain S4 / ATCC BAA-846)	46%	100%
B9KAQ7	Thermotoga neapolitana (strain ATCC 49049 / DSM 4359 / NBRC 107923 / NS-E)	47%	100%
B9KZ44	Thermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2)	50%	100%
B9LKK8	Chloroflexus aurantiacus (strain ATCC 29364 / DSM 637 / Y-400-fl)	49%	100%
B9M0W5	Geotalea daltonii (strain DSM 22248 / JCM 15807 / FRC-32)	45%	100%
B9MAC8	Acidovorax ebreus (strain TPSY)	44%	100%
B9MR57	Caldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320)	47%	100%
C0QKX3	Desulforapulum autotrophicum (strain ATCC 43914 / DSM 3382 / VKM B-1955 / HRM2)	45%	100%
C0QQE4	Persephonella marina (strain DSM 14350 / EX-H1)	47%	100%
C0RIA2	Brucella melitensis biotype 2 (strain ATCC 23457)	47%	100%
C1CYT8	Deinococcus deserti (strain DSM 17065 / CIP 109153 / LMG 22923 / VCD115)	48%	100%
C1DEQ3	Azotobacter vinelandii (strain DJ / ATCC BAA-1303)	44%	100%
C1F0N9	Bacillus cereus (strain 03BB102)	46%	100%
C1F3Q7	Acidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / BCRC 80197 / JCM 7670 / NBRC 15755 / NCIMB 13165 / 161)	48%	100%
C1FTF1	Clostridium botulinum (strain Kyoto / Type A2)	45%	100%
C1KYV6	Listeria monocytogenes serotype 4b (strain CLIP80459)	46%	100%
C3L181	Clostridium botulinum (strain 657 / Type Ba4)	47%	100%
C3LFJ0	Bacillus anthracis (strain CDC 684 / NRRL 3495)	46%	100%
C3P1G5	Bacillus anthracis (strain A0248)	46%	100%
C4ZH69	Agathobacter rectalis (strain ATCC 33656 / DSM 3377 / JCM 17463 / KCTC 5835 / VPI 0990)	50%	100%
C5CEA8	Kosmotoga olearia (strain ATCC BAA-1733 / DSM 21960 / TBF 19.5.1)	45%	100%
C5CPY0	Variovorax paradoxus (strain S110)	42%	100%
C6E348	Geobacter sp. (strain M21)	47%	100%
D3DKC4	Hydrogenobacter thermophilus (strain DSM 6534 / IAM 12695 / TK-6)	45%	100%
E9APY0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9B057	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	98%
O13425	Candida albicans	49%	94%
O13426	Candida albicans (strain SC5314 / ATCC MYA-2876)	49%	99%
O13972	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	49%	100%
O23254	Arabidopsis thaliana	58%	99%
O51547	Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31)	45%	100%
O62585	Encephalitozoon cuniculi (strain GB-M1)	47%	100%
O66776	Aquifex aeolicus (strain VF5)	50%	100%
O85718	Acinetobacter radioresistens	47%	100%
P07511	Oryctolagus cuniculus	56%	96%
P14519	Oryctolagus cuniculus	54%	92%
P24060	Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)	47%	100%
P24531	Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)	46%	100%
P34896	Homo sapiens	56%	96%
P34897	Homo sapiens	54%	92%
P34898	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	50%	97%
P34899	Pisum sativum	57%	90%
P35623	Ovis aries	57%	96%
P37291	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	50%	99%
P37292	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	45%	95%
P39148	Bacillus subtilis (strain 168)	48%	100%
P49357	Flaveria pringlei	56%	90%
P49358	Flaveria pringlei	56%	90%
P50431	Mus musculus	56%	97%
P50432	Caenorhabditis elegans	54%	92%
P50433	Solanum tuberosum	56%	90%
P50435	Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1)	46%	100%
P56089	Helicobacter pylori (strain ATCC 700392 / 26695)	47%	100%
P56990	Neisseria meningitidis serogroup B (strain MC58)	45%	100%
P66803	Staphylococcus aureus (strain Mu50 / ATCC 700699)	46%	100%
P66804	Staphylococcus aureus (strain MW2)	46%	100%
P77962	Synechocystis sp. (strain PCC 6803 / Kazusa)	47%	100%
P99091	Staphylococcus aureus (strain N315)	46%	100%
Q01QZ0	Solibacter usitatus (strain Ellin6076)	48%	100%
Q031D7	Lactococcus lactis subsp. cremoris (strain SK11)	47%	100%
Q03A26	Lacticaseibacillus paracasei (strain ATCC 334 / BCRC 17002 / CCUG 31169 / CIP 107868 / KCTC 3260 / NRRL B-441)	44%	100%
Q03EK4	Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w)	48%	100%
Q03L77	Streptococcus thermophilus (strain ATCC BAA-491 / LMD-9)	47%	100%
Q03Y25	Leuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / DSM 20343 / BCRC 11652 / CCM 1803 / JCM 6124 / NCDO 523 / NBRC 100496 / NCIMB 8023 / NCTC 12954 / NRRL B-1118 / 37Y)	44%	100%
Q046F8	Lactobacillus gasseri (strain ATCC 33323 / DSM 20243 / BCRC 14619 / CIP 102991 / JCM 1131 / KCTC 3163 / NCIMB 11718 / NCTC 13722 / AM63)	47%	100%
Q04FR7	Oenococcus oeni (strain ATCC BAA-331 / PSU-1)	47%	100%
Q07MT9	Rhodopseudomonas palustris (strain BisA53)	46%	100%
Q086C9	Shewanella frigidimarina (strain NCIMB 400)	46%	100%
Q0ABQ9	Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)	48%	100%
Q0APF8	Maricaulis maris (strain MCS10)	46%	100%
Q0AUC3	Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)	51%	100%
Q0BMN1	Francisella tularensis subsp. holarctica (strain OSU18)	42%	100%
Q0C0I5	Hyphomonas neptunium (strain ATCC 15444)	46%	100%
Q0HL93	Shewanella sp. (strain MR-4)	46%	100%
Q0HXJ6	Shewanella sp. (strain MR-7)	45%	100%
Q0IDD8	Synechococcus sp. (strain CC9311)	48%	100%
Q0K7W0	Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)	45%	100%
Q0SMQ5	Borreliella afzelii (strain PKo)	46%	100%
Q0SRQ2	Clostridium perfringens (strain SM101 / Type A)	46%	100%
Q0TP32	Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A)	46%	100%
Q10104	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	52%	95%
Q111H1	Trichodesmium erythraeum (strain IMS101)	44%	100%
Q11NZ7	Cytophaga hutchinsonii (strain ATCC 33406 / DSM 1761 / CIP 103989 / NBRC 15051 / NCIMB 9469 / D465)	47%	100%
Q129K3	Polaromonas sp. (strain JS666 / ATCC BAA-500)	44%	100%
Q12Q48	Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)	45%	100%
Q14GZ5	Francisella tularensis subsp. tularensis (strain FSC 198)	42%	100%
Q17YS0	Helicobacter acinonychis (strain Sheeba)	47%	100%
Q183G0	Clostridioides difficile (strain 630)	47%	100%
Q1C5G0	Yersinia pestis bv. Antiqua (strain Antiqua)	44%	100%
Q1CKB8	Yersinia pestis bv. Antiqua (strain Nepal516)	44%	100%
Q1CUX5	Helicobacter pylori (strain HPAG1)	47%	100%
Q1D345	Myxococcus xanthus (strain DK1622)	48%	100%
Q1GGA4	Ruegeria sp. (strain TM1040)	48%	100%
Q1IS84	Koribacter versatilis (strain Ellin345)	49%	100%
Q1J1W0	Deinococcus geothermalis (strain DSM 11300 / AG-3a)	47%	100%
Q1LU81	Baumannia cicadellinicola subsp. Homalodisca coagulata	44%	100%
Q1MIU5	Rhizobium leguminosarum bv. viciae (strain 3841)	46%	100%
Q1MS11	Lawsonia intracellularis (strain PHE/MN1-00)	47%	100%
Q1QE01	Psychrobacter cryohalolentis (strain ATCC BAA-1226 / DSM 17306 / VKM B-2378 / K5)	46%	100%
Q1QMB9	Nitrobacter hamburgensis (strain DSM 10229 / NCIMB 13809 / X14)	47%	100%
Q1RGX5	Rickettsia bellii (strain RML369-C)	46%	100%
Q1WTR3	Ligilactobacillus salivarius (strain UCC118)	49%	100%
Q214H7	Rhodopseudomonas palustris (strain BisB18)	48%	100%
Q21NP8	Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)	47%	100%
Q21V29	Albidiferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118)	42%	100%
Q24MM6	Desulfitobacterium hafniense (strain Y51)	48%	100%
Q2A498	Francisella tularensis subsp. holarctica (strain LVS)	42%	100%
Q2F5L3	Bombyx mori	54%	100%
Q2FF15	Staphylococcus aureus (strain USA300)	45%	100%
Q2FWE5	Staphylococcus aureus (strain NCTC 8325 / PS 47)	46%	100%
Q2G646	Novosphingobium aromaticivorans (strain ATCC 700278 / DSM 12444 / CCUG 56034 / CIP 105152 / NBRC 16084 / F199)	49%	100%
Q2ILI1	Anaeromyxobacter dehalogenans (strain 2CP-C)	45%	100%
Q2IWS4	Rhodopseudomonas palustris (strain HaA2)	49%	100%
Q2JI36	Synechococcus sp. (strain JA-2-3B'a(2-13))	46%	100%
Q2JT50	Synechococcus sp. (strain JA-3-3Ab)	45%	100%
Q2KA25	Rhizobium etli (strain CFN 42 / ATCC 51251)	47%	100%
Q2KV15	Bordetella avium (strain 197N)	43%	100%
Q2LQM6	Syntrophus aciditrophicus (strain SB)	47%	100%
Q2NAR9	Erythrobacter litoralis (strain HTCC2594)	49%	100%
Q2NIT8	Aster yellows witches'-broom phytoplasma (strain AYWB)	45%	100%
Q2NZ83	Xanthomonas oryzae pv. oryzae (strain MAFF 311018)	44%	100%
Q2RFW7	Moorella thermoacetica (strain ATCC 39073 / JCM 9320)	47%	100%
Q2RTB8	Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1)	50%	100%
Q2S4G9	Salinibacter ruber (strain DSM 13855 / M31)	45%	100%
Q2SYS4	Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264)	43%	100%
Q2YN95	Brucella abortus (strain 2308)	47%	100%
Q2YUJ1	Staphylococcus aureus (strain bovine RF122 / ET3-1)	46%	100%
Q30P60	Sulfurimonas denitrificans (strain ATCC 33889 / DSM 1251)	46%	100%
Q31CS4	Prochlorococcus marinus (strain MIT 9312)	43%	100%
Q31FS6	Hydrogenovibrio crunogenus (strain DSM 25203 / XCL-2)	46%	100%
Q31RK5	Synechococcus elongatus (strain PCC 7942 / FACHB-805)	46%	100%
Q38WJ7	Latilactobacillus sakei subsp. sakei (strain 23K)	48%	100%
Q39V87	Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)	46%	100%
Q3A4L9	Syntrophotalea carbinolica (strain DSM 2380 / NBRC 103641 / GraBd1)	45%	100%
Q3A934	Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901)	47%	100%
Q3AN03	Synechococcus sp. (strain CC9605)	48%	100%
Q3APN5	Chlorobium chlorochromatii (strain CaD3)	47%	100%
Q3AW18	Synechococcus sp. (strain CC9902)	47%	100%
Q3B2I7	Chlorobium luteolum (strain DSM 273 / BCRC 81028 / 2530)	45%	100%
Q3BXI8	Xanthomonas campestris pv. vesicatoria (strain 85-10)	45%	100%
Q3IZN2	Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.)	47%	100%
Q3JP81	Burkholderia pseudomallei (strain 1710b)	43%	100%
Q3K5K9	Pseudomonas fluorescens (strain Pf0-1)	48%	100%
Q3K6J0	Pseudomonas fluorescens (strain Pf0-1)	45%	100%
Q3KDV1	Pseudomonas fluorescens (strain Pf0-1)	47%	100%
Q3SGX5	Thiobacillus denitrificans (strain ATCC 25259)	46%	100%
Q3SRV3	Nitrobacter winogradskyi (strain ATCC 25391 / DSM 10237 / CIP 104748 / NCIMB 11846 / Nb-255)	47%	100%
Q3SZ20	Bos taurus	54%	92%
Q46A52	Methanosarcina barkeri (strain Fusaro / DSM 804)	45%	100%
Q46HB6	Prochlorococcus marinus (strain NATL2A)	46%	100%
Q474L3	Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197)	45%	100%
Q47IH1	Dechloromonas aromatica (strain RCB)	45%	100%
Q47MD6	Thermobifida fusca (strain YX)	44%	100%
Q47XG4	Colwellia psychrerythraea (strain 34H / ATCC BAA-681)	47%	100%
Q48CP3	Pseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6)	48%	100%
Q48DU7	Pseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6)	45%	100%
Q49Z60	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	46%	100%
Q4FUZ8	Psychrobacter arcticus (strain DSM 17307 / VKM B-2377 / 273-4)	46%	100%
Q4K4P6	Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)	48%	100%
Q4K5R9	Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)	45%	100%
Q4L7Z4	Staphylococcus haemolyticus (strain JCSC1435)	44%	100%
Q4Q828	Leishmania major	59%	100%
Q4QFK2	Leishmania major	89%	100%
Q4UQT6	Xanthomonas campestris pv. campestris (strain 8004)	47%	100%
Q4ZM83	Pseudomonas syringae pv. syringae (strain B728a)	48%	100%
Q4ZNH2	Pseudomonas syringae pv. syringae (strain B728a)	45%	100%
Q54EW1	Dictyostelium discoideum	55%	97%
Q54Z26	Dictyostelium discoideum	57%	100%
Q57DY5	Brucella abortus biovar 1 (strain 9-941)	47%	100%
Q5E9P9	Bos taurus	56%	96%
Q5F8C0	Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090)	45%	100%
Q5FMC0	Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)	47%	100%
Q5FNK4	Gluconobacter oxydans (strain 621H)	46%	100%
Q5GW07	Xanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)	44%	100%
Q5HE87	Staphylococcus aureus (strain COL)	46%	100%
Q5HMB0	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	44%	100%
Q5HW65	Campylobacter jejuni (strain RM1221)	45%	100%
Q5KUI2	Geobacillus kaustophilus (strain HTA426)	48%	100%
Q5LD58	Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / NCTC 9343 / Onslow)	45%	100%
Q5M0B4	Streptococcus thermophilus (strain CNRZ 1066)	47%	100%
Q5M4W1	Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)	48%	100%
Q5N2P9	Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1)	46%	100%
Q5NFJ3	Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)	42%	100%
Q5RFK5	Pongo abelii	56%	96%
Q5SI56	Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)	50%	100%
Q5WB66	Alkalihalobacillus clausii (strain KSM-K16)	46%	100%
Q5WYH4	Legionella pneumophila (strain Lens)	48%	100%
Q5X722	Legionella pneumophila (strain Paris)	48%	100%
Q5ZXK6	Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)	48%	100%
Q60V73	Caenorhabditis briggsae	54%	91%
Q62I16	Burkholderia mallei (strain ATCC 23344)	43%	100%
Q630T3	Bacillus cereus (strain ZK / E33L)	45%	100%
Q63RB4	Burkholderia pseudomallei (strain K96243)	43%	100%
Q64U78	Bacteroides fragilis (strain YCH46)	45%	100%
Q65DW5	Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46)	45%	100%
Q660S1	Borrelia garinii subsp. bavariensis (strain ATCC BAA-2496 / DSM 23469 / PBi)	45%	100%
Q667X1	Yersinia pseudotuberculosis serotype I (strain IP32953)	44%	100%
Q67N41	Symbiobacterium thermophilum (strain T / IAM 14863)	48%	100%
Q68W07	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	46%	100%
Q6AM21	Desulfotalea psychrophila (strain LSv54 / DSM 12343)	47%	100%
Q6CLQ5	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	48%	93%
Q6D246	Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)	44%	100%
Q6FA66	Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)	48%	100%
Q6FQ44	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	48%	96%
Q6FUP6	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	50%	99%
Q6G3L3	Bartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1)	46%	100%
Q6G7J7	Staphylococcus aureus (strain MSSA476)	46%	100%
Q6GEW2	Staphylococcus aureus (strain MRSA252)	46%	100%
Q6HAW9	Bacillus thuringiensis subsp. konkukian (strain 97-27)	45%	100%
Q6MLK1	Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIMB 9529 / HD100)	48%	100%
Q6N693	Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)	48%	100%
Q6YR37	Onion yellows phytoplasma (strain OY-M)	46%	100%
Q71WN9	Listeria monocytogenes serotype 4b (strain F2365)	46%	100%
Q72IH2	Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)	50%	100%
Q72XD7	Bacillus cereus (strain ATCC 10987 / NRS 248)	46%	100%
Q74CR5	Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)	48%	100%
Q74LC1	Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533)	46%	100%
Q758F0	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	47%	94%
Q75BQ6	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	47%	99%
Q7MAR0	Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W)	48%	100%
Q7MXW0	Porphyromonas gingivalis (strain ATCC BAA-308 / W83)	46%	100%
Q7N216	Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)	43%	100%
Q7ND67	Gloeobacter violaceus (strain ATCC 29082 / PCC 7421)	47%	100%
Q7NYI8	Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)	45%	100%
Q7S5N8	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	48%	85%
Q7U9J7	Parasynechococcus marenigrum (strain WH8102)	48%	100%
Q7UQN2	Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1)	45%	100%
Q7V335	Prochlorococcus marinus subsp. pastoris (strain CCMP1986 / NIES-2087 / MED4)	45%	100%
Q7V4U3	Prochlorococcus marinus (strain MIT 9313)	48%	100%
Q7VDS8	Prochlorococcus marinus (strain SARG / CCMP1375 / SS120)	45%	100%
Q7VFL1	Helicobacter hepaticus (strain ATCC 51449 / 3B1)	48%	100%
Q7VUW7	Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)	42%	100%
Q7W1I6	Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)	49%	100%
Q7W400	Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)	42%	100%
Q7WFD2	Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)	42%	100%
Q7WPH6	Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)	49%	100%
Q814V2	Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711)	45%	100%
Q81JY4	Bacillus anthracis	46%	100%
Q831F9	Enterococcus faecalis (strain ATCC 700802 / V583)	47%	100%
Q84WV0	Arabidopsis thaliana	50%	78%
Q87AS2	Xylella fastidiosa (strain Temecula1 / ATCC 700964)	47%	100%
Q87WC1	Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)	45%	100%
Q88AD1	Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)	47%	100%
Q88Q27	Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)	45%	100%
Q88R12	Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)	47%	100%
Q88UT5	Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)	47%	100%
Q8A9S7	Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50)	45%	100%
Q8CRN3	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	44%	100%
Q8EBN8	Shewanella oneidensis (strain MR-1)	45%	100%
Q8EM73	Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831)	46%	100%
Q8G1F1	Brucella suis biovar 1 (strain 1330)	47%	100%
Q8I566	Plasmodium falciparum (isolate 3D7)	48%	100%
Q8KC36	Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS)	48%	100%
Q8PCN4	Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)	47%	100%
Q8PPE3	Xanthomonas axonopodis pv. citri (strain 306)	45%	100%
Q8PZQ0	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	45%	100%
Q8R887	Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4)	46%	100%
Q8TK94	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	46%	100%
Q8UG75	Agrobacterium fabrum (strain C58 / ATCC 33970)	48%	100%
Q8XJ32	Clostridium perfringens (strain 13 / Type A)	46%	100%
Q8Y4B2	Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)	46%	100%
Q8YGG7	Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)	47%	100%
Q8YMW8	Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)	47%	100%
Q8Z2Z9	Salmonella typhi	43%	100%
Q8ZCR1	Yersinia pestis	44%	100%
Q927V4	Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)	46%	100%
Q92QU6	Rhizobium meliloti (strain 1021)	48%	100%
Q92XS8	Rhizobium meliloti (strain 1021)	45%	100%
Q94C74	Arabidopsis thaliana	54%	90%
Q94JQ3	Arabidopsis thaliana	55%	88%
Q97GV1	Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)	47%	100%
Q983B6	Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)	49%	100%
Q9A8J6	Caulobacter vibrioides (strain ATCC 19089 / CB15)	48%	100%
Q9CHW7	Lactococcus lactis subsp. lactis (strain IL1403)	47%	100%
Q9CZN7	Mus musculus	54%	92%
Q9HTE9	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	48%	100%
Q9HVI7	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	47%	100%
Q9I138	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	44%	100%
Q9K6G4	Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)	47%	100%
Q9LM59	Arabidopsis thaliana	50%	78%
Q9PET2	Xylella fastidiosa (strain 9a5c)	46%	100%
Q9RYB2	Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)	46%	100%
Q9SVM4	Arabidopsis thaliana	53%	99%
Q9SZJ5	Arabidopsis thaliana	55%	90%
Q9WZH9	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	44%	100%
Q9XAY7	Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491)	45%	100%
Q9XAZ1	Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18)	46%	100%
Q9XB01	Neisseria gonorrhoeae	45%	100%
Q9ZMP7	Helicobacter pylori (strain J99 / ATCC 700824)	47%	100%
V5BBD6	Trypanosoma cruzi	68%	100%