Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7V1_LEIBR

TriTrypDb:

LbrM.14.1480 , LBRM2903_140019500

Length:

363

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H7V1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7V1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.621
CLV_MEL_PAP_1	254	260	PF00089	0.434
CLV_NRD_NRD_1	21	23	PF00675	0.551
CLV_NRD_NRD_1	256	258	PF00675	0.474
CLV_NRD_NRD_1	298	300	PF00675	0.539
CLV_NRD_NRD_1	98	100	PF00675	0.535
CLV_PCSK_FUR_1	21	25	PF00082	0.467
CLV_PCSK_KEX2_1	20	22	PF00082	0.464
CLV_PCSK_KEX2_1	200	202	PF00082	0.467
CLV_PCSK_KEX2_1	23	25	PF00082	0.488
CLV_PCSK_KEX2_1	256	258	PF00082	0.576
CLV_PCSK_KEX2_1	298	300	PF00082	0.544
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.467
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.428
CLV_PCSK_SKI1_1	125	129	PF00082	0.708
CLV_PCSK_SKI1_1	197	201	PF00082	0.479
CLV_PCSK_SKI1_1	323	327	PF00082	0.438
CLV_PCSK_SKI1_1	333	337	PF00082	0.355
CLV_PCSK_SKI1_1	89	93	PF00082	0.525
DEG_COP1_1	285	294	PF00400	0.584
DEG_Nend_Nbox_1	1	3	PF02207	0.552
DEG_SPOP_SBC_1	273	277	PF00917	0.307
DOC_CYCLIN_yCln2_LP_2	243	249	PF00134	0.320
DOC_CYCLIN_yCln2_LP_2	358	361	PF00134	0.383
DOC_MAPK_gen_1	298	306	PF00069	0.385
DOC_MAPK_gen_1	72	81	PF00069	0.433
DOC_MAPK_HePTP_8	204	216	PF00069	0.519
DOC_MAPK_MEF2A_6	207	216	PF00069	0.394
DOC_MAPK_MEF2A_6	298	306	PF00069	0.384
DOC_PP1_MyPhoNE_1	298	305	PF00149	0.440
DOC_PP1_RVXF_1	9	16	PF00149	0.585
DOC_PP2B_LxvP_1	243	246	PF13499	0.475
DOC_PP2B_LxvP_1	358	361	PF13499	0.488
DOC_USP7_MATH_1	121	125	PF00917	0.549
DOC_USP7_MATH_1	149	153	PF00917	0.655
DOC_USP7_MATH_1	156	160	PF00917	0.627
DOC_USP7_MATH_1	164	168	PF00917	0.522
DOC_USP7_MATH_1	187	191	PF00917	0.648
DOC_USP7_MATH_1	199	203	PF00917	0.689
DOC_USP7_MATH_1	231	235	PF00917	0.584
DOC_USP7_MATH_1	290	294	PF00917	0.623
DOC_USP7_MATH_1	317	321	PF00917	0.493
DOC_USP7_MATH_1	38	42	PF00917	0.633
DOC_USP7_MATH_1	49	53	PF00917	0.624
DOC_USP7_MATH_1	54	58	PF00917	0.544
DOC_WW_Pin1_4	145	150	PF00397	0.643
DOC_WW_Pin1_4	154	159	PF00397	0.633
DOC_WW_Pin1_4	165	170	PF00397	0.453
DOC_WW_Pin1_4	217	222	PF00397	0.522
DOC_WW_Pin1_4	233	238	PF00397	0.614
DOC_WW_Pin1_4	286	291	PF00397	0.445
LIG_14-3-3_CanoR_1	107	117	PF00244	0.591
LIG_14-3-3_CanoR_1	201	205	PF00244	0.516
LIG_14-3-3_CanoR_1	333	339	PF00244	0.276
LIG_APCC_ABBAyCdc20_2	11	17	PF00400	0.366
LIG_BRCT_BRCA1_1	336	340	PF00533	0.345
LIG_CaM_IQ_9	248	264	PF13499	0.425
LIG_FHA_1	14	20	PF00498	0.490
LIG_FHA_1	160	166	PF00498	0.530
LIG_FHA_1	209	215	PF00498	0.390
LIG_FHA_1	273	279	PF00498	0.565
LIG_FHA_1	320	326	PF00498	0.343
LIG_FHA_1	96	102	PF00498	0.638
LIG_FHA_2	183	189	PF00498	0.443
LIG_FHA_2	283	289	PF00498	0.652
LIG_FHA_2	295	301	PF00498	0.317
LIG_LIR_Apic_2	337	342	PF02991	0.266
LIG_LIR_Nem_3	12	18	PF02991	0.552
LIG_MLH1_MIPbox_1	336	340	PF16413	0.252
LIG_Pex14_2	336	340	PF04695	0.493
LIG_SH2_STAP1	269	273	PF00017	0.472
LIG_SH2_STAT5	18	21	PF00017	0.553
LIG_SH2_STAT5	182	185	PF00017	0.454
LIG_SH2_STAT5	339	342	PF00017	0.274
LIG_SH3_3	1	7	PF00018	0.536
LIG_SH3_3	140	146	PF00018	0.617
LIG_SH3_3	163	169	PF00018	0.691
LIG_SH3_3	186	192	PF00018	0.575
LIG_SH3_3	324	330	PF00018	0.564
LIG_SH3_3	53	59	PF00018	0.659
LIG_TRAF2_1	151	154	PF00917	0.511
LIG_TRAF2_1	293	296	PF00917	0.482
LIG_TRAF2_1	64	67	PF00917	0.446
LIG_TRFH_1	145	149	PF08558	0.502
MOD_CDK_SPK_2	145	150	PF00069	0.505
MOD_CK1_1	108	114	PF00069	0.596
MOD_CK1_1	159	165	PF00069	0.601
MOD_CK1_1	238	244	PF00069	0.480
MOD_CK1_1	41	47	PF00069	0.603
MOD_CK2_1	282	288	PF00069	0.606
MOD_CK2_1	290	296	PF00069	0.672
MOD_CK2_1	307	313	PF00069	0.420
MOD_CK2_1	61	67	PF00069	0.473
MOD_GlcNHglycan	130	133	PF01048	0.638
MOD_GlcNHglycan	225	228	PF01048	0.559
MOD_GlcNHglycan	232	236	PF01048	0.486
MOD_GlcNHglycan	237	240	PF01048	0.515
MOD_GlcNHglycan	292	295	PF01048	0.531
MOD_GlcNHglycan	347	350	PF01048	0.424
MOD_GlcNHglycan	40	43	PF01048	0.653
MOD_GlcNHglycan	56	59	PF01048	0.572
MOD_GlcNHglycan	63	66	PF01048	0.496
MOD_GlcNHglycan	75	78	PF01048	0.435
MOD_GSK3_1	101	108	PF00069	0.613
MOD_GSK3_1	121	128	PF00069	0.553
MOD_GSK3_1	145	152	PF00069	0.651
MOD_GSK3_1	195	202	PF00069	0.695
MOD_GSK3_1	231	238	PF00069	0.578
MOD_GSK3_1	272	279	PF00069	0.504
MOD_GSK3_1	282	289	PF00069	0.592
MOD_GSK3_1	290	297	PF00069	0.595
MOD_GSK3_1	43	50	PF00069	0.523
MOD_LATS_1	205	211	PF00433	0.324
MOD_NEK2_1	195	200	PF00069	0.721
MOD_NEK2_1	260	265	PF00069	0.540
MOD_NEK2_1	345	350	PF00069	0.453
MOD_NEK2_1	43	48	PF00069	0.628
MOD_NEK2_2	334	339	PF00069	0.395
MOD_PIKK_1	149	155	PF00454	0.717
MOD_PIKK_1	280	286	PF00454	0.547
MOD_PIKK_1	47	53	PF00454	0.447
MOD_PK_1	200	206	PF00069	0.397
MOD_PK_1	307	313	PF00069	0.442
MOD_PKA_1	200	206	PF00069	0.490
MOD_PKA_2	108	114	PF00069	0.589
MOD_PKA_2	200	206	PF00069	0.537
MOD_PKB_1	107	115	PF00069	0.575
MOD_PKB_1	280	288	PF00069	0.562
MOD_Plk_4	208	214	PF00069	0.367
MOD_ProDKin_1	145	151	PF00069	0.641
MOD_ProDKin_1	154	160	PF00069	0.633
MOD_ProDKin_1	165	171	PF00069	0.443
MOD_ProDKin_1	217	223	PF00069	0.524
MOD_ProDKin_1	233	239	PF00069	0.621
MOD_ProDKin_1	286	292	PF00069	0.431
MOD_SUMO_rev_2	90	98	PF00179	0.500
TRG_DiLeu_BaLyEn_6	56	61	PF01217	0.590
TRG_ENDOCYTIC_2	10	13	PF00928	0.482
TRG_ER_diArg_1	107	110	PF00400	0.586
TRG_ER_diArg_1	19	22	PF00400	0.576
TRG_ER_diArg_1	256	258	PF00400	0.472
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHA6	Leptomonas seymouri	54%	100%
A0A1X0NNF4	Trypanosomatidae	28%	90%
A0A3S7WT74	Leishmania donovani	81%	100%
A0A422NFP0	Trypanosoma rangeli	36%	100%
A4HW77	Leishmania infantum	81%	100%
C9ZST9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9APX8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QFK3	Leishmania major	81%	100%
V5AW09	Trypanosoma cruzi	38%	100%