Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4H7V0_LEIBR

TriTrypDb:

LbrM.14.1470 , LBRM2903_140019400

Length:

713

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H7V0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7V0

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	13
GO:0006793	phosphorus metabolic process	3	13
GO:0006796	phosphate-containing compound metabolic process	4	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009987	cellular process	1	13
GO:0016310	phosphorylation	5	13
GO:0019538	protein metabolic process	3	13
GO:0036211	protein modification process	4	13
GO:0043170	macromolecule metabolic process	3	13
GO:0043412	macromolecule modification	4	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13
GO:0000165	MAPK cascade	4	1
GO:0001932	regulation of protein phosphorylation	7	1
GO:0001934	positive regulation of protein phosphorylation	8	1
GO:0007165	signal transduction	2	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009966	regulation of signal transduction	4	1
GO:0009967	positive regulation of signal transduction	5	1
GO:0010562	positive regulation of phosphorus metabolic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010646	regulation of cell communication	4	1
GO:0010647	positive regulation of cell communication	5	1
GO:0019220	regulation of phosphate metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0023051	regulation of signaling	3	1
GO:0023056	positive regulation of signaling	4	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031399	regulation of protein modification process	6	1
GO:0031401	positive regulation of protein modification process	7	1
GO:0033674	positive regulation of kinase activity	6	1
GO:0035556	intracellular signal transduction	3	1
GO:0042325	regulation of phosphorylation	7	1
GO:0042327	positive regulation of phosphorylation	8	1
GO:0043085	positive regulation of catalytic activity	4	1
GO:0043405	regulation of MAP kinase activity	8	1
GO:0043406	positive regulation of MAP kinase activity	8	1
GO:0043408	regulation of MAPK cascade	6	1
GO:0043410	positive regulation of MAPK cascade	7	1
GO:0043549	regulation of kinase activity	5	1
GO:0044093	positive regulation of molecular function	3	1
GO:0045859	regulation of protein kinase activity	6	1
GO:0045860	positive regulation of protein kinase activity	7	1
GO:0045937	positive regulation of phosphate metabolic process	7	1
GO:0046777	protein autophosphorylation	6	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0048583	regulation of response to stimulus	3	1
GO:0048584	positive regulation of response to stimulus	4	1
GO:0050789	regulation of biological process	2	1
GO:0050790	regulation of catalytic activity	3	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051174	regulation of phosphorus metabolic process	5	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051247	positive regulation of protein metabolic process	6	1
GO:0051338	regulation of transferase activity	4	1
GO:0051347	positive regulation of transferase activity	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0065009	regulation of molecular function	2	1
GO:0071900	regulation of protein serine/threonine kinase activity	7	1
GO:0071902	positive regulation of protein serine/threonine kinase activity	8	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1902531	regulation of intracellular signal transduction	5	1
GO:1902533	positive regulation of intracellular signal transduction	6	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003824	catalytic activity	1	13
GO:0004672	protein kinase activity	3	13
GO:0005488	binding	1	13
GO:0005524	ATP binding	5	13
GO:0016301	kinase activity	4	13
GO:0016740	transferase activity	2	13
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	13
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	13
GO:0017076	purine nucleotide binding	4	13
GO:0030554	adenyl nucleotide binding	5	13
GO:0032553	ribonucleotide binding	3	13
GO:0032555	purine ribonucleotide binding	4	13
GO:0032559	adenyl ribonucleotide binding	5	13
GO:0035639	purine ribonucleoside triphosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0097159	organic cyclic compound binding	2	13
GO:0097367	carbohydrate derivative binding	2	13
GO:0140096	catalytic activity, acting on a protein	2	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13
GO:0004708	MAP kinase kinase activity	5	1
GO:0004712	protein serine/threonine/tyrosine kinase activity	4	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0019900	kinase binding	4	1
GO:0019901	protein kinase binding	5	1
GO:0051019	mitogen-activated protein kinase binding	6	1
GO:0004674	protein serine/threonine kinase activity	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	177	181	PF00656	0.320
CLV_C14_Caspase3-7	568	572	PF00656	0.522
CLV_C14_Caspase3-7	649	653	PF00656	0.550
CLV_NRD_NRD_1	226	228	PF00675	0.271
CLV_NRD_NRD_1	374	376	PF00675	0.460
CLV_NRD_NRD_1	452	454	PF00675	0.607
CLV_NRD_NRD_1	456	458	PF00675	0.599
CLV_NRD_NRD_1	464	466	PF00675	0.570
CLV_NRD_NRD_1	526	528	PF00675	0.654
CLV_PCSK_FUR_1	457	461	PF00082	0.628
CLV_PCSK_KEX2_1	156	158	PF00082	0.394
CLV_PCSK_KEX2_1	226	228	PF00082	0.271
CLV_PCSK_KEX2_1	374	376	PF00082	0.460
CLV_PCSK_KEX2_1	456	458	PF00082	0.618
CLV_PCSK_KEX2_1	459	461	PF00082	0.621
CLV_PCSK_KEX2_1	464	466	PF00082	0.589
CLV_PCSK_KEX2_1	525	527	PF00082	0.609
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.271
CLV_PCSK_PC1ET2_1	459	461	PF00082	0.597
CLV_PCSK_PC1ET2_1	525	527	PF00082	0.590
CLV_PCSK_PC7_1	460	466	PF00082	0.596
CLV_PCSK_SKI1_1	157	161	PF00082	0.271
CLV_PCSK_SKI1_1	232	236	PF00082	0.271
CLV_PCSK_SKI1_1	575	579	PF00082	0.564
CLV_PCSK_SKI1_1	604	608	PF00082	0.651
CLV_PCSK_SKI1_1	689	693	PF00082	0.495
DEG_APCC_DBOX_1	526	534	PF00400	0.532
DEG_APCC_DBOX_1	688	696	PF00400	0.496
DEG_SCF_FBW7_1	488	494	PF00400	0.536
DEG_SPOP_SBC_1	504	508	PF00917	0.526
DOC_ANK_TNKS_1	39	46	PF00023	0.506
DOC_CKS1_1	385	390	PF01111	0.540
DOC_CKS1_1	394	399	PF01111	0.515
DOC_CKS1_1	488	493	PF01111	0.539
DOC_CYCLIN_yCln2_LP_2	395	401	PF00134	0.491
DOC_CYCLIN_yCln2_LP_2	7	13	PF00134	0.546
DOC_MAPK_DCC_7	575	584	PF00069	0.483
DOC_MAPK_gen_1	232	241	PF00069	0.272
DOC_MAPK_gen_1	453	463	PF00069	0.549
DOC_MAPK_MEF2A_6	575	584	PF00069	0.483
DOC_PP2B_LxvP_1	395	398	PF13499	0.481
DOC_PP2B_LxvP_1	620	623	PF13499	0.507
DOC_PP4_FxxP_1	274	277	PF00568	0.271
DOC_PP4_MxPP_1	1	4	PF00568	0.476
DOC_USP7_MATH_1	138	142	PF00917	0.500
DOC_USP7_MATH_1	198	202	PF00917	0.271
DOC_USP7_MATH_1	39	43	PF00917	0.569
DOC_USP7_MATH_1	405	409	PF00917	0.573
DOC_USP7_MATH_1	491	495	PF00917	0.529
DOC_USP7_MATH_1	57	61	PF00917	0.477
DOC_USP7_MATH_1	63	67	PF00917	0.439
DOC_USP7_MATH_1	661	665	PF00917	0.509
DOC_USP7_MATH_1	706	710	PF00917	0.526
DOC_USP7_MATH_2	127	133	PF00917	0.482
DOC_WW_Pin1_4	127	132	PF00397	0.616
DOC_WW_Pin1_4	35	40	PF00397	0.615
DOC_WW_Pin1_4	384	389	PF00397	0.557
DOC_WW_Pin1_4	393	398	PF00397	0.542
DOC_WW_Pin1_4	413	418	PF00397	0.546
DOC_WW_Pin1_4	425	430	PF00397	0.483
DOC_WW_Pin1_4	487	492	PF00397	0.587
DOC_WW_Pin1_4	588	593	PF00397	0.543
DOC_WW_Pin1_4	6	11	PF00397	0.543
LIG_14-3-3_CanoR_1	115	122	PF00244	0.419
LIG_14-3-3_CanoR_1	25	31	PF00244	0.495
LIG_14-3-3_CanoR_1	375	385	PF00244	0.536
LIG_14-3-3_CanoR_1	404	410	PF00244	0.574
LIG_14-3-3_CanoR_1	460	464	PF00244	0.589
LIG_14-3-3_CanoR_1	511	516	PF00244	0.596
LIG_14-3-3_CanoR_1	543	552	PF00244	0.586
LIG_14-3-3_CanoR_1	601	607	PF00244	0.682
LIG_14-3-3_CanoR_1	689	699	PF00244	0.497
LIG_Actin_WH2_2	593	609	PF00022	0.662
LIG_APCC_ABBA_1	183	188	PF00400	0.271
LIG_APCC_ABBAyCdc20_2	227	233	PF00400	0.394
LIG_BRCT_BRCA1_1	52	56	PF00533	0.481
LIG_BRCT_BRCA1_1	646	650	PF00533	0.496
LIG_deltaCOP1_diTrp_1	338	348	PF00928	0.271
LIG_FHA_1	180	186	PF00498	0.296
LIG_FHA_1	194	200	PF00498	0.227
LIG_FHA_1	263	269	PF00498	0.305
LIG_FHA_1	326	332	PF00498	0.271
LIG_FHA_1	394	400	PF00498	0.541
LIG_FHA_1	56	62	PF00498	0.479
LIG_FHA_2	287	293	PF00498	0.271
LIG_FHA_2	29	35	PF00498	0.571
LIG_FHA_2	360	366	PF00498	0.394
LIG_FHA_2	497	503	PF00498	0.531
LIG_LIR_Apic_2	271	277	PF02991	0.507
LIG_LIR_Apic_2	393	397	PF02991	0.493
LIG_LIR_Gen_1	53	63	PF02991	0.476
LIG_LIR_Nem_3	201	205	PF02991	0.433
LIG_LIR_Nem_3	53	59	PF02991	0.480
LIG_LIR_Nem_3	83	87	PF02991	0.397
LIG_Pex14_2	646	650	PF04695	0.496
LIG_SH2_CRK	84	88	PF00017	0.491
LIG_SH2_GRB2like	173	176	PF00017	0.271
LIG_SH2_SRC	334	337	PF00017	0.271
LIG_SH2_STAT3	550	553	PF00017	0.538
LIG_SH2_STAT5	173	176	PF00017	0.397
LIG_SH2_STAT5	189	192	PF00017	0.304
LIG_SH2_STAT5	273	276	PF00017	0.333
LIG_SH2_STAT5	334	337	PF00017	0.271
LIG_SH2_STAT5	394	397	PF00017	0.450
LIG_SH2_STAT5	550	553	PF00017	0.538
LIG_SH3_1	394	400	PF00018	0.455
LIG_SH3_3	128	134	PF00018	0.606
LIG_SH3_3	276	282	PF00018	0.271
LIG_SH3_3	382	388	PF00018	0.538
LIG_SH3_3	394	400	PF00018	0.517
LIG_SH3_3	411	417	PF00018	0.490
LIG_SH3_3	485	491	PF00018	0.539
LIG_SUMO_SIM_anti_2	158	163	PF11976	0.271
LIG_SUMO_SIM_anti_2	362	368	PF11976	0.271
LIG_SUMO_SIM_par_1	57	62	PF11976	0.501
LIG_TRAF2_1	204	207	PF00917	0.271
LIG_UBA3_1	98	102	PF00899	0.347
LIG_WRC_WIRS_1	202	207	PF05994	0.271
MOD_CDK_SPK_2	35	40	PF00069	0.532
MOD_CK1_1	130	136	PF00069	0.671
MOD_CK1_1	191	197	PF00069	0.271
MOD_CK1_1	201	207	PF00069	0.224
MOD_CK1_1	257	263	PF00069	0.271
MOD_CK1_1	383	389	PF00069	0.679
MOD_CK1_1	393	399	PF00069	0.591
MOD_CK1_1	443	449	PF00069	0.660
MOD_CK1_1	472	478	PF00069	0.591
MOD_CK1_1	479	485	PF00069	0.562
MOD_CK1_1	486	492	PF00069	0.539
MOD_CK1_1	494	500	PF00069	0.525
MOD_CK1_1	50	56	PF00069	0.493
MOD_CK1_1	503	509	PF00069	0.514
MOD_CK1_1	542	548	PF00069	0.605
MOD_CK1_1	596	602	PF00069	0.529
MOD_CK1_1	6	12	PF00069	0.554
MOD_CK1_1	609	615	PF00069	0.532
MOD_CK1_1	654	660	PF00069	0.521
MOD_CK1_1	66	72	PF00069	0.434
MOD_CK1_1	664	670	PF00069	0.527
MOD_CK1_1	694	700	PF00069	0.502
MOD_CK2_1	105	111	PF00069	0.353
MOD_CK2_1	201	207	PF00069	0.406
MOD_CK2_1	359	365	PF00069	0.375
MOD_CK2_1	543	549	PF00069	0.567
MOD_CK2_1	608	614	PF00069	0.686
MOD_Cter_Amidation	454	457	PF01082	0.602
MOD_GlcNHglycan	107	110	PF01048	0.360
MOD_GlcNHglycan	145	148	PF01048	0.424
MOD_GlcNHglycan	190	193	PF01048	0.271
MOD_GlcNHglycan	21	24	PF01048	0.555
MOD_GlcNHglycan	260	263	PF01048	0.243
MOD_GlcNHglycan	325	328	PF01048	0.271
MOD_GlcNHglycan	407	410	PF01048	0.672
MOD_GlcNHglycan	41	44	PF01048	0.588
MOD_GlcNHglycan	436	439	PF01048	0.621
MOD_GlcNHglycan	471	474	PF01048	0.562
MOD_GlcNHglycan	475	478	PF01048	0.536
MOD_GlcNHglycan	49	52	PF01048	0.603
MOD_GlcNHglycan	546	549	PF01048	0.596
MOD_GlcNHglycan	558	561	PF01048	0.595
MOD_GlcNHglycan	567	570	PF01048	0.645
MOD_GlcNHglycan	575	578	PF01048	0.555
MOD_GlcNHglycan	608	611	PF01048	0.578
MOD_GlcNHglycan	61	64	PF01048	0.437
MOD_GlcNHglycan	656	659	PF01048	0.530
MOD_GlcNHglycan	666	669	PF01048	0.535
MOD_GSK3_1	114	121	PF00069	0.402
MOD_GSK3_1	254	261	PF00069	0.319
MOD_GSK3_1	315	322	PF00069	0.205
MOD_GSK3_1	35	42	PF00069	0.584
MOD_GSK3_1	376	383	PF00069	0.590
MOD_GSK3_1	413	420	PF00069	0.589
MOD_GSK3_1	440	447	PF00069	0.607
MOD_GSK3_1	464	471	PF00069	0.583
MOD_GSK3_1	47	54	PF00069	0.578
MOD_GSK3_1	472	479	PF00069	0.559
MOD_GSK3_1	482	489	PF00069	0.528
MOD_GSK3_1	492	499	PF00069	0.517
MOD_GSK3_1	500	507	PF00069	0.517
MOD_GSK3_1	539	546	PF00069	0.637
MOD_GSK3_1	55	62	PF00069	0.580
MOD_GSK3_1	580	587	PF00069	0.518
MOD_GSK3_1	596	603	PF00069	0.549
MOD_GSK3_1	609	616	PF00069	0.627
MOD_GSK3_1	622	629	PF00069	0.497
MOD_GSK3_1	650	657	PF00069	0.514
MOD_GSK3_1	664	671	PF00069	0.508
MOD_GSK3_1	683	690	PF00069	0.489
MOD_GSK3_1	693	700	PF00069	0.512
MOD_GSK3_1	706	713	PF00069	0.496
MOD_N-GLC_1	376	381	PF02516	0.491
MOD_N-GLC_1	492	497	PF02516	0.532
MOD_N-GLC_1	584	589	PF02516	0.497
MOD_N-GLC_2	701	703	PF02516	0.506
MOD_NEK2_1	120	125	PF00069	0.531
MOD_NEK2_1	240	245	PF00069	0.419
MOD_NEK2_1	28	33	PF00069	0.532
MOD_NEK2_1	367	372	PF00069	0.317
MOD_NEK2_1	376	381	PF00069	0.500
MOD_NEK2_1	584	589	PF00069	0.485
MOD_NEK2_1	600	605	PF00069	0.633
MOD_NEK2_1	606	611	PF00069	0.672
MOD_NEK2_1	650	655	PF00069	0.552
MOD_NEK2_1	683	688	PF00069	0.515
MOD_NEK2_1	691	696	PF00069	0.495
MOD_NEK2_1	699	704	PF00069	0.486
MOD_NEK2_1	91	96	PF00069	0.359
MOD_NEK2_2	138	143	PF00069	0.513
MOD_NEK2_2	51	56	PF00069	0.480
MOD_NEK2_2	602	607	PF00069	0.560
MOD_PIKK_1	242	248	PF00454	0.276
MOD_PIKK_1	33	39	PF00454	0.496
MOD_PIKK_1	347	353	PF00454	0.271
MOD_PIKK_1	476	482	PF00454	0.574
MOD_PIKK_1	483	489	PF00454	0.585
MOD_PKA_1	459	465	PF00069	0.605
MOD_PKA_2	114	120	PF00069	0.431
MOD_PKA_2	26	32	PF00069	0.497
MOD_PKA_2	359	365	PF00069	0.507
MOD_PKA_2	39	45	PF00069	0.533
MOD_PKA_2	443	449	PF00069	0.586
MOD_PKA_2	459	465	PF00069	0.576
MOD_PKA_2	467	473	PF00069	0.528
MOD_PKA_2	542	548	PF00069	0.584
MOD_PKA_2	600	606	PF00069	0.661
MOD_PKA_2	66	72	PF00069	0.406
MOD_PKA_2	697	703	PF00069	0.517
MOD_PKA_2	706	712	PF00069	0.520
MOD_Plk_1	157	163	PF00069	0.402
MOD_Plk_1	483	489	PF00069	0.542
MOD_Plk_1	500	506	PF00069	0.502
MOD_Plk_1	51	57	PF00069	0.509
MOD_Plk_1	548	554	PF00069	0.534
MOD_Plk_1	584	590	PF00069	0.482
MOD_Plk_1	651	657	PF00069	0.552
MOD_Plk_4	157	163	PF00069	0.281
MOD_Plk_4	254	260	PF00069	0.280
MOD_Plk_4	367	373	PF00069	0.271
MOD_Plk_4	380	386	PF00069	0.500
MOD_Plk_4	390	396	PF00069	0.602
MOD_Plk_4	51	57	PF00069	0.586
MOD_Plk_4	675	681	PF00069	0.536
MOD_ProDKin_1	127	133	PF00069	0.616
MOD_ProDKin_1	35	41	PF00069	0.616
MOD_ProDKin_1	384	390	PF00069	0.555
MOD_ProDKin_1	393	399	PF00069	0.545
MOD_ProDKin_1	413	419	PF00069	0.545
MOD_ProDKin_1	425	431	PF00069	0.487
MOD_ProDKin_1	487	493	PF00069	0.587
MOD_ProDKin_1	588	594	PF00069	0.543
MOD_ProDKin_1	6	12	PF00069	0.546
MOD_SUMO_for_1	142	145	PF00179	0.501
MOD_SUMO_for_1	155	158	PF00179	0.210
MOD_SUMO_for_1	74	77	PF00179	0.389
MOD_SUMO_rev_2	332	342	PF00179	0.205
TRG_DiLeu_BaEn_2	343	349	PF01217	0.271
TRG_ENDOCYTIC_2	202	205	PF00928	0.394
TRG_ENDOCYTIC_2	84	87	PF00928	0.495
TRG_ENDOCYTIC_2	88	91	PF00928	0.433
TRG_ER_diArg_1	25	28	PF00400	0.495
TRG_ER_diArg_1	374	376	PF00400	0.466
TRG_ER_diArg_1	463	465	PF00400	0.574
TRG_ER_diArg_1	526	528	PF00400	0.542
TRG_NLS_MonoExtN_4	524	529	PF00514	0.570
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.271
TRG_Pf-PMV_PEXEL_1	232	237	PF00026	0.262

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IND3	Leishmania donovani	26%	100%
A0A3S7XAX0	Leishmania donovani	24%	100%
A4HW76	Leishmania infantum	76%	89%
A4ICP8	Leishmania infantum	26%	100%
A4IDK3	Leishmania infantum	24%	100%
E9APX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
E9ASK6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AT06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
Q4Q1J2	Leishmania major	25%	100%
Q4Q1Z0	Leishmania major	26%	100%
Q4QFK4	Leishmania major	77%	100%
Q8BLF2	Mus musculus	23%	100%
Q9JM01	Rattus norvegicus	24%	100%