Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7U9_LEIBR

TriTrypDb:

LbrM.14.1460 , LBRM2903_140019300

Length:

806

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H7U9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7U9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	184	188	PF00656	0.393
CLV_C14_Caspase3-7	498	502	PF00656	0.679
CLV_C14_Caspase3-7	519	523	PF00656	0.562
CLV_C14_Caspase3-7	634	638	PF00656	0.698
CLV_C14_Caspase3-7	792	796	PF00656	0.521
CLV_NRD_NRD_1	131	133	PF00675	0.648
CLV_NRD_NRD_1	147	149	PF00675	0.392
CLV_NRD_NRD_1	212	214	PF00675	0.441
CLV_NRD_NRD_1	336	338	PF00675	0.668
CLV_NRD_NRD_1	36	38	PF00675	0.524
CLV_NRD_NRD_1	410	412	PF00675	0.598
CLV_NRD_NRD_1	469	471	PF00675	0.594
CLV_NRD_NRD_1	472	474	PF00675	0.798
CLV_NRD_NRD_1	491	493	PF00675	0.476
CLV_NRD_NRD_1	52	54	PF00675	0.539
CLV_NRD_NRD_1	596	598	PF00675	0.815
CLV_NRD_NRD_1	61	63	PF00675	0.550
CLV_NRD_NRD_1	645	647	PF00675	0.777
CLV_NRD_NRD_1	677	679	PF00675	0.582
CLV_NRD_NRD_1	784	786	PF00675	0.700
CLV_PCSK_FUR_1	145	149	PF00082	0.395
CLV_PCSK_FUR_1	34	38	PF00082	0.531
CLV_PCSK_KEX2_1	131	133	PF00082	0.648
CLV_PCSK_KEX2_1	147	149	PF00082	0.392
CLV_PCSK_KEX2_1	336	338	PF00082	0.668
CLV_PCSK_KEX2_1	36	38	PF00082	0.532
CLV_PCSK_KEX2_1	469	471	PF00082	0.645
CLV_PCSK_KEX2_1	474	476	PF00082	0.696
CLV_PCSK_KEX2_1	491	493	PF00082	0.628
CLV_PCSK_KEX2_1	52	54	PF00082	0.587
CLV_PCSK_KEX2_1	596	598	PF00082	0.815
CLV_PCSK_KEX2_1	61	63	PF00082	0.545
CLV_PCSK_KEX2_1	677	679	PF00082	0.582
CLV_PCSK_KEX2_1	783	785	PF00082	0.702
CLV_PCSK_KEX2_1	90	92	PF00082	0.651
CLV_PCSK_PC1ET2_1	474	476	PF00082	0.708
CLV_PCSK_PC1ET2_1	596	598	PF00082	0.815
CLV_PCSK_PC1ET2_1	90	92	PF00082	0.651
CLV_PCSK_PC7_1	470	476	PF00082	0.560
CLV_PCSK_SKI1_1	112	116	PF00082	0.677
CLV_PCSK_SKI1_1	148	152	PF00082	0.639
CLV_PCSK_SKI1_1	213	217	PF00082	0.593
CLV_PCSK_SKI1_1	237	241	PF00082	0.496
CLV_PCSK_SKI1_1	27	31	PF00082	0.532
CLV_PCSK_SKI1_1	400	404	PF00082	0.559
CLV_PCSK_SKI1_1	494	498	PF00082	0.619
CLV_PCSK_SKI1_1	541	545	PF00082	0.586
CLV_PCSK_SKI1_1	570	574	PF00082	0.664
CLV_PCSK_SKI1_1	693	697	PF00082	0.545
DEG_APCC_DBOX_1	493	501	PF00400	0.643
DEG_SPOP_SBC_1	739	743	PF00917	0.750
DOC_ANK_TNKS_1	725	732	PF00023	0.815
DOC_CKS1_1	611	616	PF01111	0.793
DOC_CYCLIN_RxL_1	131	143	PF00134	0.450
DOC_CYCLIN_RxL_1	21	33	PF00134	0.532
DOC_CYCLIN_RxL_1	210	220	PF00134	0.682
DOC_MAPK_gen_1	131	139	PF00069	0.438
DOC_MAPK_gen_1	145	154	PF00069	0.562
DOC_MAPK_gen_1	336	343	PF00069	0.653
DOC_MAPK_gen_1	34	43	PF00069	0.519
DOC_MAPK_gen_1	366	373	PF00069	0.655
DOC_MAPK_gen_1	411	417	PF00069	0.599
DOC_MAPK_MEF2A_6	366	373	PF00069	0.402
DOC_USP7_MATH_1	16	20	PF00917	0.536
DOC_USP7_MATH_1	188	192	PF00917	0.401
DOC_USP7_MATH_1	217	221	PF00917	0.423
DOC_USP7_MATH_1	269	273	PF00917	0.604
DOC_USP7_MATH_1	274	278	PF00917	0.597
DOC_USP7_MATH_1	393	397	PF00917	0.368
DOC_USP7_MATH_1	438	442	PF00917	0.629
DOC_USP7_MATH_1	446	450	PF00917	0.642
DOC_USP7_MATH_1	468	472	PF00917	0.756
DOC_USP7_MATH_1	585	589	PF00917	0.614
DOC_USP7_MATH_1	619	623	PF00917	0.812
DOC_USP7_MATH_1	626	630	PF00917	0.676
DOC_USP7_MATH_1	715	719	PF00917	0.662
DOC_USP7_MATH_1	739	743	PF00917	0.669
DOC_USP7_MATH_1	754	758	PF00917	0.558
DOC_USP7_MATH_1	765	769	PF00917	0.789
DOC_USP7_MATH_1	773	777	PF00917	0.628
DOC_WW_Pin1_4	546	551	PF00397	0.783
DOC_WW_Pin1_4	610	615	PF00397	0.768
DOC_WW_Pin1_4	622	627	PF00397	0.628
DOC_WW_Pin1_4	663	668	PF00397	0.715
DOC_WW_Pin1_4	721	726	PF00397	0.684
LIG_14-3-3_CanoR_1	159	167	PF00244	0.585
LIG_14-3-3_CanoR_1	170	175	PF00244	0.454
LIG_14-3-3_CanoR_1	298	306	PF00244	0.436
LIG_14-3-3_CanoR_1	34	43	PF00244	0.368
LIG_14-3-3_CanoR_1	516	525	PF00244	0.668
LIG_14-3-3_CanoR_1	565	570	PF00244	0.729
LIG_14-3-3_CanoR_1	589	593	PF00244	0.603
LIG_14-3-3_CanoR_1	620	627	PF00244	0.564
LIG_14-3-3_CanoR_1	663	667	PF00244	0.593
LIG_14-3-3_CanoR_1	763	773	PF00244	0.569
LIG_Actin_WH2_2	338	356	PF00022	0.641
LIG_AP2alpha_1	801	805	PF02296	0.674
LIG_APCC_ABBA_1	225	230	PF00400	0.573
LIG_BIR_II_1	1	5	PF00653	0.572
LIG_BRCT_BRCA1_1	740	744	PF00533	0.667
LIG_eIF4E_1	339	345	PF01652	0.639
LIG_FHA_1	141	147	PF00498	0.465
LIG_FHA_1	156	162	PF00498	0.611
LIG_FHA_1	178	184	PF00498	0.551
LIG_FHA_1	298	304	PF00498	0.494
LIG_FHA_1	329	335	PF00498	0.702
LIG_FHA_1	36	42	PF00498	0.366
LIG_FHA_1	516	522	PF00498	0.583
LIG_FHA_1	547	553	PF00498	0.791
LIG_FHA_1	6	12	PF00498	0.537
LIG_FHA_2	261	267	PF00498	0.672
LIG_FHA_2	297	303	PF00498	0.544
LIG_FHA_2	365	371	PF00498	0.578
LIG_FHA_2	376	382	PF00498	0.546
LIG_FHA_2	517	523	PF00498	0.562
LIG_FHA_2	529	535	PF00498	0.516
LIG_LIR_Apic_2	251	256	PF02991	0.466
LIG_LIR_Gen_1	19	30	PF02991	0.537
LIG_LIR_Gen_1	222	232	PF02991	0.422
LIG_LIR_Gen_1	653	664	PF02991	0.552
LIG_LIR_Gen_1	749	758	PF02991	0.780
LIG_LIR_Gen_1	798	805	PF02991	0.627
LIG_LIR_Nem_3	19	25	PF02991	0.536
LIG_LIR_Nem_3	222	227	PF02991	0.451
LIG_LIR_Nem_3	419	425	PF02991	0.549
LIG_LIR_Nem_3	637	643	PF02991	0.799
LIG_LIR_Nem_3	749	755	PF02991	0.776
LIG_Pex14_1	422	426	PF04695	0.649
LIG_Pex14_2	744	748	PF04695	0.755
LIG_Pex14_2	801	805	PF04695	0.674
LIG_PTB_Apo_2	509	516	PF02174	0.567
LIG_PTB_Phospho_1	509	515	PF10480	0.571
LIG_RPA_C_Fungi	187	199	PF08784	0.412
LIG_RPA_C_Fungi	432	444	PF08784	0.686
LIG_SH2_CRK	253	257	PF00017	0.466
LIG_SH2_CRK	426	430	PF00017	0.646
LIG_SH2_NCK_1	339	343	PF00017	0.643
LIG_SH2_SRC	228	231	PF00017	0.578
LIG_SH2_STAP1	228	232	PF00017	0.577
LIG_SH2_STAP1	339	343	PF00017	0.643
LIG_SH2_STAP1	426	430	PF00017	0.646
LIG_SH2_STAP1	627	631	PF00017	0.555
LIG_SH2_STAT5	627	630	PF00017	0.552
LIG_SH3_3	668	674	PF00018	0.747
LIG_SH3_3	722	728	PF00018	0.561
LIG_SH3_3	750	756	PF00018	0.639
LIG_SH3_3	767	773	PF00018	0.711
LIG_SH3_3	776	782	PF00018	0.679
LIG_SH3_CIN85_PxpxPR_1	667	672	PF14604	0.704
LIG_SUMO_SIM_par_1	214	220	PF11976	0.532
LIG_SUMO_SIM_par_1	343	349	PF11976	0.554
LIG_TRAF2_1	263	266	PF00917	0.698
LIG_TRAF2_1	299	302	PF00917	0.640
LIG_TRAF2_1	531	534	PF00917	0.664
LIG_TYR_ITIM	424	429	PF00017	0.646
LIG_WRC_WIRS_1	103	108	PF05994	0.657
LIG_WW_3	769	773	PF00397	0.720
LIG_WW_3	780	784	PF00397	0.530
MOD_CDK_SPK_2	667	672	PF00069	0.704
MOD_CDK_SPK_2	721	726	PF00069	0.684
MOD_CDK_SPxxK_3	665	672	PF00069	0.705
MOD_CK1_1	323	329	PF00069	0.525
MOD_CK1_1	482	488	PF00069	0.688
MOD_CK1_1	503	509	PF00069	0.783
MOD_CK1_1	554	560	PF00069	0.833
MOD_CK1_1	588	594	PF00069	0.693
MOD_CK1_1	622	628	PF00069	0.710
MOD_CK1_1	629	635	PF00069	0.685
MOD_CK1_1	636	642	PF00069	0.665
MOD_CK1_1	657	663	PF00069	0.731
MOD_CK1_1	665	671	PF00069	0.668
MOD_CK1_1	738	744	PF00069	0.737
MOD_CK1_1	757	763	PF00069	0.598
MOD_CK2_1	17	23	PF00069	0.536
MOD_CK2_1	260	266	PF00069	0.702
MOD_CK2_1	296	302	PF00069	0.566
MOD_CK2_1	364	370	PF00069	0.579
MOD_CK2_1	375	381	PF00069	0.549
MOD_CK2_1	528	534	PF00069	0.564
MOD_Cter_Amidation	129	132	PF01082	0.646
MOD_Cter_Amidation	409	412	PF01082	0.519
MOD_Cter_Amidation	593	596	PF01082	0.558
MOD_Cter_Amidation	675	678	PF01082	0.582
MOD_GlcNHglycan	106	109	PF01048	0.531
MOD_GlcNHglycan	246	249	PF01048	0.629
MOD_GlcNHglycan	257	260	PF01048	0.654
MOD_GlcNHglycan	395	398	PF01048	0.366
MOD_GlcNHglycan	439	443	PF01048	0.600
MOD_GlcNHglycan	448	451	PF01048	0.620
MOD_GlcNHglycan	453	456	PF01048	0.557
MOD_GlcNHglycan	466	469	PF01048	0.753
MOD_GlcNHglycan	536	539	PF01048	0.795
MOD_GlcNHglycan	592	595	PF01048	0.638
MOD_GlcNHglycan	621	624	PF01048	0.803
MOD_GlcNHglycan	628	631	PF01048	0.773
MOD_GlcNHglycan	711	714	PF01048	0.726
MOD_GlcNHglycan	717	720	PF01048	0.547
MOD_GlcNHglycan	737	740	PF01048	0.634
MOD_GlcNHglycan	759	762	PF01048	0.640
MOD_GSK3_1	155	162	PF00069	0.639
MOD_GSK3_1	190	197	PF00069	0.621
MOD_GSK3_1	219	226	PF00069	0.632
MOD_GSK3_1	276	283	PF00069	0.555
MOD_GSK3_1	297	304	PF00069	0.470
MOD_GSK3_1	353	360	PF00069	0.464
MOD_GSK3_1	371	378	PF00069	0.359
MOD_GSK3_1	464	471	PF00069	0.815
MOD_GSK3_1	500	507	PF00069	0.682
MOD_GSK3_1	551	558	PF00069	0.720
MOD_GSK3_1	560	567	PF00069	0.678
MOD_GSK3_1	622	629	PF00069	0.695
MOD_GSK3_1	632	639	PF00069	0.613
MOD_GSK3_1	650	657	PF00069	0.720
MOD_GSK3_1	663	670	PF00069	0.695
MOD_GSK3_1	711	718	PF00069	0.664
MOD_GSK3_1	734	741	PF00069	0.639
MOD_LATS_1	168	174	PF00433	0.639
MOD_NEK2_1	140	145	PF00069	0.516
MOD_NEK2_1	260	265	PF00069	0.582
MOD_NEK2_1	312	317	PF00069	0.677
MOD_NEK2_1	320	325	PF00069	0.671
MOD_NEK2_1	353	358	PF00069	0.587
MOD_NEK2_1	371	376	PF00069	0.348
MOD_NEK2_1	387	392	PF00069	0.595
MOD_NEK2_1	505	510	PF00069	0.660
MOD_NEK2_1	552	557	PF00069	0.657
MOD_NEK2_1	642	647	PF00069	0.543
MOD_NEK2_1	789	794	PF00069	0.534
MOD_NEK2_2	556	561	PF00069	0.827
MOD_PIKK_1	121	127	PF00454	0.401
MOD_PIKK_1	190	196	PF00454	0.416
MOD_PIKK_1	328	334	PF00454	0.457
MOD_PIKK_1	353	359	PF00454	0.415
MOD_PIKK_1	371	377	PF00454	0.334
MOD_PIKK_1	468	474	PF00454	0.597
MOD_PIKK_1	505	511	PF00454	0.710
MOD_PK_1	170	176	PF00069	0.480
MOD_PK_1	565	571	PF00069	0.819
MOD_PKA_1	131	137	PF00069	0.570
MOD_PKA_1	576	582	PF00069	0.603
MOD_PKA_2	131	137	PF00069	0.640
MOD_PKA_2	177	183	PF00069	0.537
MOD_PKA_2	297	303	PF00069	0.620
MOD_PKA_2	35	41	PF00069	0.380
MOD_PKA_2	353	359	PF00069	0.541
MOD_PKA_2	387	393	PF00069	0.576
MOD_PKA_2	451	457	PF00069	0.709
MOD_PKA_2	468	474	PF00069	0.653
MOD_PKA_2	479	485	PF00069	0.559
MOD_PKA_2	515	521	PF00069	0.673
MOD_PKA_2	560	566	PF00069	0.716
MOD_PKA_2	588	594	PF00069	0.602
MOD_PKA_2	619	625	PF00069	0.572
MOD_PKA_2	662	668	PF00069	0.595
MOD_PKA_2	771	777	PF00069	0.717
MOD_PKA_2	83	89	PF00069	0.513
MOD_Plk_1	371	377	PF00069	0.394
MOD_Plk_1	500	506	PF00069	0.576
MOD_Plk_1	636	642	PF00069	0.697
MOD_Plk_2-3	652	658	PF00069	0.549
MOD_Plk_4	170	176	PF00069	0.383
MOD_Plk_4	223	229	PF00069	0.532
MOD_Plk_4	740	746	PF00069	0.541
MOD_ProDKin_1	546	552	PF00069	0.784
MOD_ProDKin_1	610	616	PF00069	0.769
MOD_ProDKin_1	622	628	PF00069	0.627
MOD_ProDKin_1	663	669	PF00069	0.713
MOD_ProDKin_1	721	727	PF00069	0.686
MOD_SUMO_rev_2	207	216	PF00179	0.434
MOD_SUMO_rev_2	272	277	PF00179	0.647
MOD_SUMO_rev_2	323	331	PF00179	0.479
TRG_DiLeu_BaEn_1	302	307	PF01217	0.443
TRG_DiLeu_BaLyEn_6	420	425	PF01217	0.548
TRG_ENDOCYTIC_2	22	25	PF00928	0.536
TRG_ENDOCYTIC_2	426	429	PF00928	0.646
TRG_ER_diArg_1	131	133	PF00400	0.648
TRG_ER_diArg_1	144	147	PF00400	0.426
TRG_ER_diArg_1	336	338	PF00400	0.646
TRG_ER_diArg_1	34	37	PF00400	0.523
TRG_ER_diArg_1	43	46	PF00400	0.536
TRG_ER_diArg_1	491	494	PF00400	0.562
TRG_ER_diArg_1	60	62	PF00400	0.405
TRG_ER_diArg_1	782	785	PF00400	0.697
TRG_NLS_MonoCore_2	594	599	PF00514	0.558
TRG_NLS_MonoExtC_3	472	477	PF00514	0.811
TRG_NLS_MonoExtN_4	470	477	PF00514	0.712
TRG_NLS_MonoExtN_4	595	600	PF00514	0.598
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	423	428	PF00026	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P321	Leptomonas seymouri	38%	100%
A0A3S5H6T0	Leishmania donovani	70%	100%
A4HW75	Leishmania infantum	69%	100%
E9APX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4QFK5	Leishmania major	69%	99%