F420_oxidored domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NADP oxidoreductase coenzyme F420-dependent, putative

Species:

Leishmania braziliensis

UniProt:

A4H7U8_LEIBR

TriTrypDb:

LbrM.14.1450 , LBRM2903_140019200

Length:

573

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H7U8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7U8

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	7
GO:0006520	amino acid metabolic process	3	7
GO:0006560	proline metabolic process	6	7
GO:0006561	proline biosynthetic process	7	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0008652	amino acid biosynthetic process	4	7
GO:0009058	biosynthetic process	2	7
GO:0009064	glutamine family amino acid metabolic process	5	7
GO:0009084	glutamine family amino acid biosynthetic process	6	7
GO:0009987	cellular process	1	7
GO:0016053	organic acid biosynthetic process	4	7
GO:0019752	carboxylic acid metabolic process	5	7
GO:0043436	oxoacid metabolic process	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044249	cellular biosynthetic process	3	7
GO:0044281	small molecule metabolic process	2	7
GO:0044283	small molecule biosynthetic process	3	7
GO:0046394	carboxylic acid biosynthetic process	5	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:1901566	organonitrogen compound biosynthetic process	4	7
GO:1901576	organic substance biosynthetic process	3	7
GO:1901605	alpha-amino acid metabolic process	4	7
GO:1901607	alpha-amino acid biosynthetic process	5	7
GO:0018130	heterocycle biosynthetic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0055129	L-proline biosynthetic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004735	pyrroline-5-carboxylate reductase activity	5	7
GO:0016491	oxidoreductase activity	2	7
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	3	7
GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	260	262	PF00675	0.486
CLV_NRD_NRD_1	458	460	PF00675	0.783
CLV_PCSK_KEX2_1	260	262	PF00082	0.401
CLV_PCSK_KEX2_1	457	459	PF00082	0.780
CLV_PCSK_SKI1_1	204	208	PF00082	0.346
CLV_PCSK_SKI1_1	260	264	PF00082	0.389
CLV_PCSK_SKI1_1	341	345	PF00082	0.454
CLV_PCSK_SKI1_1	428	432	PF00082	0.667
CLV_PCSK_SKI1_1	52	56	PF00082	0.488
CLV_Separin_Metazoa	201	205	PF03568	0.421
DEG_Nend_UBRbox_3	1	3	PF02207	0.479
DOC_CDC14_PxL_1	273	281	PF14671	0.473
DOC_CKS1_1	80	85	PF01111	0.707
DOC_CYCLIN_RxL_1	49	59	PF00134	0.488
DOC_CYCLIN_yCln2_LP_2	496	502	PF00134	0.558
DOC_MAPK_DCC_7	312	320	PF00069	0.528
DOC_MAPK_MEF2A_6	108	115	PF00069	0.362
DOC_MAPK_MEF2A_6	312	320	PF00069	0.528
DOC_MAPK_NFAT4_5	108	116	PF00069	0.354
DOC_PP1_RVXF_1	507	513	PF00149	0.624
DOC_PP2B_LxvP_1	395	398	PF13499	0.551
DOC_PP2B_LxvP_1	532	535	PF13499	0.506
DOC_PP4_FxxP_1	139	142	PF00568	0.421
DOC_PP4_FxxP_1	364	367	PF00568	0.659
DOC_USP7_MATH_1	19	23	PF00917	0.504
DOC_USP7_MATH_1	303	307	PF00917	0.692
DOC_USP7_MATH_1	349	353	PF00917	0.608
DOC_USP7_MATH_1	373	377	PF00917	0.648
DOC_WW_Pin1_4	138	143	PF00397	0.421
DOC_WW_Pin1_4	320	325	PF00397	0.588
DOC_WW_Pin1_4	79	84	PF00397	0.638
LIG_14-3-3_CanoR_1	224	234	PF00244	0.528
LIG_14-3-3_CanoR_1	245	250	PF00244	0.377
LIG_14-3-3_CanoR_1	341	346	PF00244	0.453
LIG_14-3-3_CanoR_1	359	365	PF00244	0.424
LIG_14-3-3_CanoR_1	412	418	PF00244	0.712
LIG_14-3-3_CanoR_1	485	489	PF00244	0.704
LIG_14-3-3_CanoR_1	548	556	PF00244	0.620
LIG_14-3-3_CanoR_1	95	101	PF00244	0.550
LIG_Actin_WH2_2	542	559	PF00022	0.616
LIG_APCC_ABBA_1	164	169	PF00400	0.421
LIG_APCC_ABBAyCdc20_2	52	58	PF00400	0.592
LIG_BRCT_BRCA1_1	360	364	PF00533	0.555
LIG_FHA_1	226	232	PF00498	0.530
LIG_FHA_1	246	252	PF00498	0.476
LIG_FHA_1	27	33	PF00498	0.610
LIG_FHA_1	287	293	PF00498	0.584
LIG_FHA_1	506	512	PF00498	0.624
LIG_FHA_2	118	124	PF00498	0.541
LIG_FHA_2	320	326	PF00498	0.614
LIG_FHA_2	34	40	PF00498	0.559
LIG_FHA_2	417	423	PF00498	0.721
LIG_FHA_2	435	441	PF00498	0.411
LIG_HCF-1_HBM_1	39	42	PF13415	0.530
LIG_LIR_Apic_2	136	142	PF02991	0.236
LIG_LIR_Apic_2	361	367	PF02991	0.653
LIG_LIR_Apic_2	383	388	PF02991	0.526
LIG_LIR_Gen_1	3	13	PF02991	0.537
LIG_LIR_Gen_1	422	430	PF02991	0.537
LIG_LIR_Gen_1	59	70	PF02991	0.465
LIG_LIR_Nem_3	3	8	PF02991	0.548
LIG_LIR_Nem_3	39	45	PF02991	0.439
LIG_LIR_Nem_3	415	420	PF02991	0.589
LIG_LIR_Nem_3	422	426	PF02991	0.531
LIG_LIR_Nem_3	467	471	PF02991	0.689
LIG_LIR_Nem_3	561	567	PF02991	0.542
LIG_LIR_Nem_3	59	65	PF02991	0.393
LIG_MYND_1	101	105	PF01753	0.623
LIG_MYND_1	86	90	PF01753	0.520
LIG_PCNA_PIPBox_1	200	209	PF02747	0.421
LIG_SH2_CRK	34	38	PF00017	0.549
LIG_SH2_CRK	468	472	PF00017	0.612
LIG_SH2_CRK	5	9	PF00017	0.543
LIG_SH2_NCK_1	550	554	PF00017	0.625
LIG_SH2_PTP2	423	426	PF00017	0.441
LIG_SH2_STAP1	5	9	PF00017	0.597
LIG_SH2_STAP1	550	554	PF00017	0.625
LIG_SH2_STAT5	423	426	PF00017	0.605
LIG_SH2_STAT5	43	46	PF00017	0.446
LIG_SH2_STAT5	433	436	PF00017	0.474
LIG_SH2_STAT5	550	553	PF00017	0.622
LIG_SH3_3	229	235	PF00018	0.682
LIG_SH3_3	293	299	PF00018	0.610
LIG_SH3_3	308	314	PF00018	0.649
LIG_SH3_3	385	391	PF00018	0.705
LIG_SH3_3	471	477	PF00018	0.537
LIG_SH3_3	498	504	PF00018	0.654
LIG_SH3_3	80	86	PF00018	0.626
LIG_SH3_3	99	105	PF00018	0.668
LIG_SUMO_SIM_anti_2	152	158	PF11976	0.482
LIG_SUMO_SIM_anti_2	187	193	PF11976	0.482
LIG_SUMO_SIM_par_1	247	252	PF11976	0.352
LIG_SUMO_SIM_par_1	316	323	PF11976	0.533
LIG_TRAF2_1	335	338	PF00917	0.582
LIG_TYR_ITIM	32	37	PF00017	0.575
LIG_TYR_ITIM	421	426	PF00017	0.473
LIG_WRC_WIRS_1	279	284	PF05994	0.593
LIG_WW_2	314	317	PF00397	0.670
LIG_WW_3	401	405	PF00397	0.700
MOD_CDK_SPxK_1	320	326	PF00069	0.589
MOD_CDK_SPxxK_3	138	145	PF00069	0.421
MOD_CK1_1	141	147	PF00069	0.497
MOD_CK1_1	152	158	PF00069	0.473
MOD_CK1_1	209	215	PF00069	0.575
MOD_CK1_1	230	236	PF00069	0.596
MOD_CK1_1	278	284	PF00069	0.671
MOD_CK1_1	306	312	PF00069	0.673
MOD_CK1_1	360	366	PF00069	0.648
MOD_CK1_1	519	525	PF00069	0.494
MOD_CK1_1	96	102	PF00069	0.549
MOD_CK2_1	117	123	PF00069	0.406
MOD_CK2_1	292	298	PF00069	0.544
MOD_CK2_1	319	325	PF00069	0.670
MOD_CK2_1	33	39	PF00069	0.506
MOD_CK2_1	332	338	PF00069	0.563
MOD_CK2_1	416	422	PF00069	0.730
MOD_CK2_1	434	440	PF00069	0.417
MOD_CMANNOS	512	515	PF00535	0.545
MOD_GlcNHglycan	15	18	PF01048	0.602
MOD_GlcNHglycan	208	211	PF01048	0.436
MOD_GlcNHglycan	216	219	PF01048	0.561
MOD_GlcNHglycan	305	308	PF01048	0.582
MOD_GlcNHglycan	351	354	PF01048	0.639
MOD_GlcNHglycan	375	378	PF01048	0.612
MOD_GlcNHglycan	518	521	PF01048	0.611
MOD_GlcNHglycan	551	554	PF01048	0.630
MOD_GSK3_1	133	140	PF00069	0.470
MOD_GSK3_1	19	26	PF00069	0.551
MOD_GSK3_1	209	216	PF00069	0.541
MOD_GSK3_1	230	237	PF00069	0.624
MOD_GSK3_1	245	252	PF00069	0.386
MOD_GSK3_1	271	278	PF00069	0.463
MOD_GSK3_1	297	304	PF00069	0.783
MOD_GSK3_1	412	419	PF00069	0.695
MOD_GSK3_1	530	537	PF00069	0.523
MOD_GSK3_1	544	551	PF00069	0.683
MOD_GSK3_1	90	97	PF00069	0.609
MOD_N-GLC_1	271	276	PF02516	0.460
MOD_NEK2_1	111	116	PF00069	0.397
MOD_NEK2_1	206	211	PF00069	0.546
MOD_NEK2_1	266	271	PF00069	0.537
MOD_NEK2_1	292	297	PF00069	0.544
MOD_NEK2_1	358	363	PF00069	0.551
MOD_NEK2_1	8	13	PF00069	0.512
MOD_NEK2_2	90	95	PF00069	0.528
MOD_PIKK_1	260	266	PF00454	0.380
MOD_PKA_1	260	266	PF00069	0.380
MOD_PKA_1	457	463	PF00069	0.595
MOD_PKA_2	260	266	PF00069	0.380
MOD_PKA_2	358	364	PF00069	0.541
MOD_PKA_2	403	409	PF00069	0.694
MOD_PKA_2	457	463	PF00069	0.682
MOD_PKA_2	484	490	PF00069	0.647
MOD_PKA_2	94	100	PF00069	0.527
MOD_PKB_1	457	465	PF00069	0.539
MOD_Plk_1	19	25	PF00069	0.617
MOD_Plk_1	271	277	PF00069	0.448
MOD_Plk_1	90	96	PF00069	0.528
MOD_Plk_4	111	117	PF00069	0.397
MOD_Plk_4	245	251	PF00069	0.369
MOD_Plk_4	271	277	PF00069	0.453
MOD_Plk_4	360	366	PF00069	0.648
MOD_Plk_4	380	386	PF00069	0.462
MOD_Plk_4	416	422	PF00069	0.605
MOD_Plk_4	46	52	PF00069	0.389
MOD_Plk_4	470	476	PF00069	0.693
MOD_Plk_4	8	14	PF00069	0.513
MOD_ProDKin_1	138	144	PF00069	0.421
MOD_ProDKin_1	320	326	PF00069	0.589
MOD_ProDKin_1	79	85	PF00069	0.640
TRG_DiLeu_BaEn_4	440	446	PF01217	0.605
TRG_DiLeu_BaLyEn_6	124	129	PF01217	0.416
TRG_ENDOCYTIC_2	167	170	PF00928	0.546
TRG_ENDOCYTIC_2	34	37	PF00928	0.469
TRG_ENDOCYTIC_2	42	45	PF00928	0.439
TRG_ENDOCYTIC_2	423	426	PF00928	0.640
TRG_ENDOCYTIC_2	468	471	PF00928	0.663
TRG_ENDOCYTIC_2	5	8	PF00928	0.545
TRG_ER_diArg_1	260	262	PF00400	0.401
TRG_ER_diArg_1	456	459	PF00400	0.696
TRG_Pf-PMV_PEXEL_1	334	338	PF00026	0.618
TRG_Pf-PMV_PEXEL_1	35	39	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	509	513	PF00026	0.548

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3F8	Leptomonas seymouri	40%	99%
A0A3S7WT63	Leishmania donovani	70%	99%
A4HW74	Leishmania infantum	69%	99%
E9APX5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	99%
Q4QFK6	Leishmania major	71%	99%