DEK_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7U4_LEIBR

TriTrypDb:

LbrM.14.1410 , LBRM2903_140018800

Length:

286

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H7U4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7U4

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	5
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	5
GO:0016043	cellular component organization	3	5
GO:0016310	phosphorylation	5	2
GO:0044237	cellular metabolic process	2	2
GO:0071840	cellular component organization or biogenesis	2	5

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	5
GO:0003677	DNA binding	4	5
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	5
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0097159	organic cyclic compound binding	2	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	271	275	PF00656	0.691
CLV_NRD_NRD_1	195	197	PF00675	0.539
CLV_NRD_NRD_1	60	62	PF00675	0.442
CLV_PCSK_KEX2_1	143	145	PF00082	0.666
CLV_PCSK_KEX2_1	195	197	PF00082	0.447
CLV_PCSK_KEX2_1	59	61	PF00082	0.439
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.666
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.572
CLV_PCSK_SKI1_1	144	148	PF00082	0.568
CLV_PCSK_SKI1_1	195	199	PF00082	0.439
CLV_PCSK_SKI1_1	205	209	PF00082	0.458
CLV_PCSK_SKI1_1	244	248	PF00082	0.597
CLV_PCSK_SKI1_1	61	65	PF00082	0.533
CLV_PCSK_SKI1_1	81	85	PF00082	0.560
DEG_SPOP_SBC_1	265	269	PF00917	0.600
DOC_MAPK_MEF2A_6	95	103	PF00069	0.536
DOC_PP2B_LxvP_1	118	121	PF13499	0.515
DOC_USP7_MATH_1	134	138	PF00917	0.738
DOC_USP7_MATH_1	178	182	PF00917	0.593
DOC_USP7_MATH_1	19	23	PF00917	0.303
DOC_USP7_MATH_1	265	269	PF00917	0.743
DOC_USP7_MATH_1	270	274	PF00917	0.699
DOC_USP7_MATH_1	54	58	PF00917	0.446
DOC_USP7_MATH_1	63	67	PF00917	0.450
DOC_USP7_MATH_1	76	80	PF00917	0.575
DOC_WW_Pin1_4	137	142	PF00397	0.674
DOC_WW_Pin1_4	198	203	PF00397	0.517
DOC_WW_Pin1_4	266	271	PF00397	0.725
DOC_WW_Pin1_4	280	285	PF00397	0.627
LIG_14-3-3_CanoR_1	144	149	PF00244	0.555
LIG_14-3-3_CanoR_1	214	218	PF00244	0.487
LIG_Actin_WH2_2	75	93	PF00022	0.556
LIG_BIR_II_1	1	5	PF00653	0.669
LIG_FHA_1	274	280	PF00498	0.503
LIG_FHA_2	199	205	PF00498	0.506
LIG_FHA_2	213	219	PF00498	0.413
LIG_GBD_Chelix_1	155	163	PF00786	0.506
LIG_LIR_Nem_3	192	197	PF02991	0.559
LIG_SH2_CRK	194	198	PF00017	0.454
LIG_SH3_3	276	282	PF00018	0.632
LIG_TRAF2_1	2	5	PF00917	0.730
LIG_WRC_WIRS_1	64	69	PF05994	0.509
MOD_CDC14_SPxK_1	140	143	PF00782	0.740
MOD_CDK_SPxK_1	137	143	PF00069	0.718
MOD_CDK_SPxxK_3	137	144	PF00069	0.761
MOD_CDK_SPxxK_3	198	205	PF00069	0.586
MOD_CK1_1	137	143	PF00069	0.593
MOD_CK1_1	273	279	PF00069	0.654
MOD_CK2_1	103	109	PF00069	0.544
MOD_CK2_1	212	218	PF00069	0.493
MOD_CK2_1	265	271	PF00069	0.713
MOD_Cter_Amidation	57	60	PF01082	0.565
MOD_GlcNHglycan	129	132	PF01048	0.656
MOD_GlcNHglycan	171	175	PF01048	0.620
MOD_GlcNHglycan	180	183	PF01048	0.472
MOD_GlcNHglycan	56	59	PF01048	0.428
MOD_GSK3_1	178	185	PF00069	0.671
MOD_GSK3_1	233	240	PF00069	0.466
MOD_GSK3_1	24	31	PF00069	0.579
MOD_GSK3_1	266	273	PF00069	0.642
MOD_NEK2_1	127	132	PF00069	0.733
MOD_NEK2_2	63	68	PF00069	0.441
MOD_PKA_2	213	219	PF00069	0.558
MOD_ProDKin_1	137	143	PF00069	0.677
MOD_ProDKin_1	198	204	PF00069	0.518
MOD_ProDKin_1	266	272	PF00069	0.725
MOD_ProDKin_1	280	286	PF00069	0.628
MOD_SUMO_rev_2	123	127	PF00179	0.563
TRG_ENDOCYTIC_2	194	197	PF00928	0.450
TRG_ER_diArg_1	194	196	PF00400	0.559
TRG_Pf-PMV_PEXEL_1	244	248	PF00026	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C3	Leptomonas seymouri	60%	83%
A0A1X0NNS7	Trypanosomatidae	36%	69%
A0A3Q8IC32	Leishmania donovani	77%	95%
A0A422MT09	Trypanosoma rangeli	43%	77%
A4HW70	Leishmania infantum	77%	95%
C9ZSU9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	94%
E9APX1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	93%
Q4QFL0	Leishmania major	78%	100%
V5AW13	Trypanosoma cruzi	40%	79%