Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H7U3_LEIBR

TriTrypDb:

LbrM.14.1400 , LBRM2903_140018700

Length:

569

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H7U3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7U3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.573
CLV_C14_Caspase3-7	245	249	PF00656	0.678
CLV_NRD_NRD_1	51	53	PF00675	0.597
CLV_NRD_NRD_1	567	569	PF00675	0.613
CLV_PCSK_KEX2_1	567	569	PF00082	0.613
CLV_PCSK_SKI1_1	391	395	PF00082	0.665
CLV_PCSK_SKI1_1	523	527	PF00082	0.572
DEG_Nend_UBRbox_1	1	4	PF02207	0.669
DEG_ODPH_VHL_1	185	196	PF01847	0.517
DEG_SPOP_SBC_1	111	115	PF00917	0.584
DEG_SPOP_SBC_1	323	327	PF00917	0.692
DEG_SPOP_SBC_1	450	454	PF00917	0.479
DOC_CYCLIN_yCln2_LP_2	200	206	PF00134	0.574
DOC_PP1_RVXF_1	357	363	PF00149	0.481
DOC_PP1_RVXF_1	389	396	PF00149	0.407
DOC_PP1_SILK_1	221	226	PF00149	0.479
DOC_PP2B_LxvP_1	200	203	PF13499	0.590
DOC_PP2B_LxvP_1	303	306	PF13499	0.535
DOC_PP4_FxxP_1	426	429	PF00568	0.754
DOC_USP7_MATH_1	118	122	PF00917	0.696
DOC_USP7_MATH_1	129	133	PF00917	0.711
DOC_USP7_MATH_1	155	159	PF00917	0.723
DOC_USP7_MATH_1	195	199	PF00917	0.682
DOC_USP7_MATH_1	252	256	PF00917	0.654
DOC_USP7_MATH_1	304	308	PF00917	0.636
DOC_USP7_MATH_1	315	319	PF00917	0.567
DOC_USP7_MATH_1	324	328	PF00917	0.659
DOC_USP7_MATH_1	440	444	PF00917	0.778
DOC_USP7_MATH_1	45	49	PF00917	0.732
DOC_USP7_MATH_1	451	455	PF00917	0.627
DOC_USP7_MATH_1	529	533	PF00917	0.598
DOC_WW_Pin1_4	158	163	PF00397	0.669
DOC_WW_Pin1_4	308	313	PF00397	0.778
DOC_WW_Pin1_4	397	402	PF00397	0.715
DOC_WW_Pin1_4	425	430	PF00397	0.756
DOC_WW_Pin1_4	438	443	PF00397	0.786
DOC_WW_Pin1_4	480	485	PF00397	0.614
DOC_WW_Pin1_4	525	530	PF00397	0.671
LIG_14-3-3_CanoR_1	146	152	PF00244	0.414
LIG_14-3-3_CanoR_1	211	217	PF00244	0.595
LIG_14-3-3_CanoR_1	296	303	PF00244	0.631
LIG_14-3-3_CanoR_1	359	365	PF00244	0.658
LIG_14-3-3_CanoR_1	446	455	PF00244	0.620
LIG_BRCT_BRCA1_1	131	135	PF00533	0.651
LIG_BRCT_BRCA1_1	190	194	PF00533	0.775
LIG_BRCT_BRCA1_1	290	294	PF00533	0.670
LIG_EH1_1	193	201	PF00400	0.501
LIG_EVH1_1	436	440	PF00568	0.616
LIG_FAT_LD_1	25	33	PF03623	0.644
LIG_FHA_1	117	123	PF00498	0.649
LIG_FHA_1	151	157	PF00498	0.439
LIG_FHA_1	163	169	PF00498	0.720
LIG_FHA_1	177	183	PF00498	0.482
LIG_FHA_1	276	282	PF00498	0.582
LIG_FHA_1	410	416	PF00498	0.699
LIG_FHA_1	451	457	PF00498	0.449
LIG_FHA_1	481	487	PF00498	0.532
LIG_FHA_1	54	60	PF00498	0.713
LIG_FHA_2	378	384	PF00498	0.590
LIG_FHA_2	79	85	PF00498	0.574
LIG_GBD_Chelix_1	381	389	PF00786	0.556
LIG_LIR_Apic_2	423	429	PF02991	0.610
LIG_LIR_Gen_1	145	156	PF02991	0.604
LIG_LIR_Gen_1	390	397	PF02991	0.419
LIG_LIR_Gen_1	510	519	PF02991	0.593
LIG_LIR_Nem_3	145	151	PF02991	0.616
LIG_LIR_Nem_3	356	361	PF02991	0.641
LIG_LIR_Nem_3	390	395	PF02991	0.413
LIG_LIR_Nem_3	510	516	PF02991	0.598
LIG_LIR_Nem_3	550	556	PF02991	0.455
LIG_NRBOX	242	248	PF00104	0.714
LIG_Pex14_1	210	214	PF04695	0.557
LIG_Pex14_2	135	139	PF04695	0.688
LIG_SH2_CRK	214	218	PF00017	0.672
LIG_SH2_STAP1	544	548	PF00017	0.496
LIG_SH2_STAT5	207	210	PF00017	0.546
LIG_SH2_STAT5	372	375	PF00017	0.531
LIG_SH2_STAT5	384	387	PF00017	0.453
LIG_SH3_3	156	162	PF00018	0.725
LIG_SH3_3	35	41	PF00018	0.661
LIG_SH3_3	434	440	PF00018	0.634
LIG_SH3_3	492	498	PF00018	0.564
MOD_CDC14_SPxK_1	161	164	PF00782	0.610
MOD_CDK_SPxK_1	158	164	PF00069	0.580
MOD_CK1_1	113	119	PF00069	0.578
MOD_CK1_1	123	129	PF00069	0.739
MOD_CK1_1	150	156	PF00069	0.473
MOD_CK1_1	158	164	PF00069	0.604
MOD_CK1_1	188	194	PF00069	0.596
MOD_CK1_1	215	221	PF00069	0.606
MOD_CK1_1	255	261	PF00069	0.541
MOD_CK1_1	308	314	PF00069	0.792
MOD_CK1_1	318	324	PF00069	0.698
MOD_CK1_1	325	331	PF00069	0.608
MOD_CK1_1	341	347	PF00069	0.528
MOD_CK1_1	405	411	PF00069	0.524
MOD_CK1_1	428	434	PF00069	0.588
MOD_CK1_1	441	447	PF00069	0.660
MOD_CK1_1	449	455	PF00069	0.511
MOD_CK1_1	48	54	PF00069	0.703
MOD_CK2_1	215	221	PF00069	0.418
MOD_CK2_1	350	356	PF00069	0.516
MOD_CK2_1	48	54	PF00069	0.581
MOD_CK2_1	505	511	PF00069	0.784
MOD_CK2_1	78	84	PF00069	0.538
MOD_CMANNOS	67	70	PF00535	0.746
MOD_GlcNHglycan	115	118	PF01048	0.743
MOD_GlcNHglycan	122	125	PF01048	0.731
MOD_GlcNHglycan	20	24	PF01048	0.600
MOD_GlcNHglycan	239	242	PF01048	0.612
MOD_GlcNHglycan	256	260	PF01048	0.692
MOD_GlcNHglycan	307	310	PF01048	0.744
MOD_GlcNHglycan	313	316	PF01048	0.758
MOD_GlcNHglycan	343	346	PF01048	0.805
MOD_GlcNHglycan	373	376	PF01048	0.461
MOD_GlcNHglycan	407	410	PF01048	0.589
MOD_GlcNHglycan	430	433	PF01048	0.684
MOD_GlcNHglycan	448	451	PF01048	0.539
MOD_GlcNHglycan	47	50	PF01048	0.755
MOD_GlcNHglycan	507	510	PF01048	0.790
MOD_GlcNHglycan	530	534	PF01048	0.588
MOD_GlcNHglycan	59	62	PF01048	0.626
MOD_GSK3_1	112	119	PF00069	0.825
MOD_GSK3_1	147	154	PF00069	0.499
MOD_GSK3_1	158	165	PF00069	0.615
MOD_GSK3_1	185	192	PF00069	0.569
MOD_GSK3_1	212	219	PF00069	0.566
MOD_GSK3_1	304	311	PF00069	0.768
MOD_GSK3_1	318	325	PF00069	0.645
MOD_GSK3_1	328	335	PF00069	0.615
MOD_GSK3_1	340	347	PF00069	0.578
MOD_GSK3_1	373	380	PF00069	0.596
MOD_GSK3_1	393	400	PF00069	0.537
MOD_GSK3_1	405	412	PF00069	0.570
MOD_GSK3_1	446	453	PF00069	0.521
MOD_GSK3_1	48	55	PF00069	0.799
MOD_GSK3_1	525	532	PF00069	0.766
MOD_GSK3_1	558	565	PF00069	0.530
MOD_GSK3_1	57	64	PF00069	0.675
MOD_GSK3_1	73	80	PF00069	0.372
MOD_NEK2_1	147	152	PF00069	0.411
MOD_NEK2_1	236	241	PF00069	0.473
MOD_NEK2_1	28	33	PF00069	0.516
MOD_NEK2_1	348	353	PF00069	0.790
MOD_NEK2_1	373	378	PF00069	0.623
MOD_NEK2_1	395	400	PF00069	0.661
MOD_NEK2_2	129	134	PF00069	0.734
MOD_PIKK_1	275	281	PF00454	0.444
MOD_PK_1	558	564	PF00069	0.623
MOD_PKA_1	52	58	PF00069	0.578
MOD_PKA_2	57	63	PF00069	0.572
MOD_Plk_1	129	135	PF00069	0.575
MOD_Plk_1	176	182	PF00069	0.648
MOD_Plk_1	188	194	PF00069	0.671
MOD_Plk_1	529	535	PF00069	0.543
MOD_Plk_4	155	161	PF00069	0.671
MOD_Plk_4	189	195	PF00069	0.683
MOD_Plk_4	202	208	PF00069	0.493
MOD_Plk_4	212	218	PF00069	0.644
MOD_Plk_4	242	248	PF00069	0.487
MOD_Plk_4	288	294	PF00069	0.707
MOD_Plk_4	373	379	PF00069	0.584
MOD_Plk_4	451	457	PF00069	0.663
MOD_Plk_4	538	544	PF00069	0.423
MOD_Plk_4	78	84	PF00069	0.409
MOD_ProDKin_1	158	164	PF00069	0.677
MOD_ProDKin_1	308	314	PF00069	0.780
MOD_ProDKin_1	397	403	PF00069	0.715
MOD_ProDKin_1	425	431	PF00069	0.768
MOD_ProDKin_1	438	444	PF00069	0.780
MOD_ProDKin_1	480	486	PF00069	0.615
MOD_ProDKin_1	525	531	PF00069	0.670
MOD_SUMO_rev_2	314	324	PF00179	0.612
TRG_DiLeu_BaEn_1	84	89	PF01217	0.561
TRG_DiLeu_BaEn_4	356	362	PF01217	0.538
TRG_ENDOCYTIC_2	214	217	PF00928	0.667
TRG_ENDOCYTIC_2	358	361	PF00928	0.729
TRG_ER_diArg_1	1	4	PF00400	0.620
TRG_ER_diArg_1	566	568	PF00400	0.582
TRG_ER_diArg_1	94	97	PF00400	0.657
TRG_Pf-PMV_PEXEL_1	14	18	PF00026	0.657
TRG_Pf-PMV_PEXEL_1	419	423	PF00026	0.644
TRG_Pf-PMV_PEXEL_1	470	474	PF00026	0.600

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAA7	Leptomonas seymouri	25%	98%
A0A3S7WTC0	Leishmania donovani	63%	100%
A4HW69	Leishmania infantum	63%	100%
E9APX0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	100%
Q4QFL1	Leishmania major	63%	99%