FCP1 homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NLI interacting factor-like phosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4H7U1_LEIBR

TriTrypDb:

LbrM.14.1380 , LBRM2903_140018500

Length:

279

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H7U1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7U1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004721	phosphoprotein phosphatase activity	3	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.558
CLV_C14_Caspase3-7	129	133	PF00656	0.496
CLV_NRD_NRD_1	185	187	PF00675	0.372
CLV_NRD_NRD_1	275	277	PF00675	0.485
CLV_PCSK_KEX2_1	185	187	PF00082	0.369
CLV_PCSK_KEX2_1	275	277	PF00082	0.494
CLV_PCSK_SKI1_1	143	147	PF00082	0.562
CLV_PCSK_SKI1_1	270	274	PF00082	0.491
CLV_PCSK_SKI1_1	5	9	PF00082	0.411
CLV_PCSK_SKI1_1	76	80	PF00082	0.261
CLV_PCSK_SKI1_1	98	102	PF00082	0.533
DEG_SCF_SKP2-CKS1_1	220	227	PF00560	0.411
DOC_ANK_TNKS_1	22	29	PF00023	0.411
DOC_PP1_RVXF_1	165	171	PF00149	0.513
DOC_USP7_MATH_1	103	107	PF00917	0.695
DOC_USP7_MATH_1	115	119	PF00917	0.684
DOC_USP7_MATH_1	126	130	PF00917	0.633
DOC_USP7_MATH_1	144	148	PF00917	0.559
DOC_USP7_MATH_1	151	155	PF00917	0.229
DOC_USP7_MATH_1	192	196	PF00917	0.392
DOC_WW_Pin1_4	105	110	PF00397	0.573
DOC_WW_Pin1_4	221	226	PF00397	0.411
LIG_14-3-3_CanoR_1	69	73	PF00244	0.411
LIG_BRCT_BRCA1_1	202	206	PF00533	0.411
LIG_EH1_1	257	265	PF00400	0.461
LIG_FHA_1	216	222	PF00498	0.411
LIG_FHA_1	69	75	PF00498	0.411
LIG_FHA_2	108	114	PF00498	0.605
LIG_FHA_2	13	19	PF00498	0.411
LIG_FHA_2	177	183	PF00498	0.364
LIG_FHA_2	196	202	PF00498	0.257
LIG_GBD_Chelix_1	8	16	PF00786	0.411
LIG_LIR_Gen_1	203	213	PF02991	0.375
LIG_LIR_Nem_3	182	187	PF02991	0.411
LIG_LIR_Nem_3	203	209	PF02991	0.375
LIG_MYND_1	2	6	PF01753	0.616
LIG_PCNA_yPIPBox_3	69	79	PF02747	0.261
LIG_PDZ_Class_2	274	279	PF00595	0.347
LIG_Pex14_2	170	174	PF04695	0.411
LIG_SH2_PTP2	235	238	PF00017	0.299
LIG_SH2_STAT5	235	238	PF00017	0.369
LIG_SUMO_SIM_par_1	158	163	PF11976	0.261
LIG_SUMO_SIM_par_1	216	224	PF11976	0.408
MOD_CDK_SPxK_1	105	111	PF00069	0.555
MOD_CDK_SPxK_1	221	227	PF00069	0.411
MOD_CK1_1	195	201	PF00069	0.358
MOD_CK1_1	61	67	PF00069	0.351
MOD_CK1_1	99	105	PF00069	0.630
MOD_CK2_1	107	113	PF00069	0.561
MOD_CK2_1	12	18	PF00069	0.411
MOD_Cter_Amidation	138	141	PF01082	0.692
MOD_GlcNHglycan	105	108	PF01048	0.739
MOD_GlcNHglycan	117	120	PF01048	0.662
MOD_GlcNHglycan	128	131	PF01048	0.695
MOD_GlcNHglycan	155	158	PF01048	0.261
MOD_GSK3_1	151	158	PF00069	0.378
MOD_GSK3_1	58	65	PF00069	0.349
MOD_GSK3_1	99	106	PF00069	0.571
MOD_N-GLC_1	115	120	PF02516	0.681
MOD_NEK2_1	12	17	PF00069	0.411
MOD_NEK2_1	90	95	PF00069	0.527
MOD_PIKK_1	160	166	PF00454	0.299
MOD_PIKK_1	68	74	PF00454	0.261
MOD_PKA_2	12	18	PF00069	0.411
MOD_PKA_2	58	64	PF00069	0.428
MOD_PKA_2	68	74	PF00069	0.402
MOD_Plk_1	115	121	PF00069	0.562
MOD_Plk_1	176	182	PF00069	0.465
MOD_Plk_1	200	206	PF00069	0.478
MOD_Plk_1	215	221	PF00069	0.411
MOD_Plk_1	32	38	PF00069	0.393
MOD_Plk_4	12	18	PF00069	0.411
MOD_Plk_4	155	161	PF00069	0.444
MOD_Plk_4	215	221	PF00069	0.454
MOD_Plk_4	58	64	PF00069	0.261
MOD_ProDKin_1	105	111	PF00069	0.575
MOD_ProDKin_1	221	227	PF00069	0.411
MOD_SUMO_for_1	246	249	PF00179	0.552
TRG_DiLeu_BaEn_1	216	221	PF01217	0.290
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.473
TRG_ENDOCYTIC_2	235	238	PF00928	0.411
TRG_ER_diArg_1	184	186	PF00400	0.369
TRG_ER_diArg_1	253	256	PF00400	0.524
TRG_ER_diArg_1	274	276	PF00400	0.605
TRG_NLS_MonoExtC_3	139	144	PF00514	0.726
TRG_NLS_MonoExtN_4	137	144	PF00514	0.765

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Q2	Leptomonas seymouri	59%	100%
A0A3S7WT65	Leishmania donovani	73%	100%
A4HW67	Leishmania infantum	72%	100%
E9APW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4QFL3	Leishmania major	71%	94%